Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions

Kasiewicz, 2017, Recent advances in biomaterials for the treatment of diabetic foot ulcers, Biomater. Sci., 5, 1962, 10.1039/C7BM00264E Ahmed, 2005, Advanced glycation endproducts--role in pathology of diabetic complications, Diabetes Res. Clin. Pract., 67, 3, 10.1016/j.diabres.2004.09.004 Kang, 2021, Self-assembled elastin-like polypeptide fusion protein coacervates as competitive inhibitors of advanced glycation end-products enhance diabetic wound healing, J. Contr. Release, 333, 176, 10.1016/j.jconrel.2021.03.032 Han, 2020, Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1alpha/PDK4 pathway, Mol. Cell. Endocrinol., 514, 10.1016/j.mce.2020.110878 Jin, 2015, Advanced glycation end products enhance macrophages polarization into M1 phenotype through activating RAGE/NF-kappaB pathway, BioMed Res. Int., 2015, 10.1155/2015/732450 Klopfleisch, 2016, Macrophage reaction against biomaterials in the mouse model - phenotypes, functions and markers, Acta Biomater., 43, 3, 10.1016/j.actbio.2016.07.003 He, 2022, A vehicle-free antimicrobial polymer hybrid gold nanoparticle as synergistically therapeutic platforms for Staphylococcus aureus infected wound healing, Adv. Sci., 9, 10.1002/advs.202105223 Davis, 2018, Dysfunctional wound healing in diabetic foot ulcers: new crossroads, Curr. Diabetes Rep., 18, 2, 10.1007/s11892-018-0970-z Qian, 2022, Immunoregulation in diabetic wound repair with a photoenhanced glycyrrhizic acid hydrogel scaffold, Adv. Mater., 34, 10.1002/adma.202200521 Edwards, 2004, Bacteria and wound healing, Curr. Opin. Infect. Dis., 17, 91, 10.1097/00001432-200404000-00004 Jahan, 2021, Gliclazide alters macrophages polarization state in diabetic atherosclerosis in vitro via blocking AGE-RAGE/TLR4-reactive oxygen species-activated NF-kbeta nexus, Eur. J. Pharmacol., 894, 10.1016/j.ejphar.2021.173874 Zhou, 2016, Metformin inhibits advanced glycation end products-induced inflammatory response in murine macrophages partly through AMPK activation and RAGE/NFkappaB pathway suppression, J. Diabetes Res., 10.1155/2016/4847812 Matoori, 2021, Advanced bandages for diabetic wound healing, Sci. Transl. Med., 13, 10.1126/scitranslmed.abe4839 McWhorter, 2015, Physical and mechanical regulation of macrophage phenotype and function, Cell. Mol. Life Sci., 72, 1303, 10.1007/s00018-014-1796-8 Atcha, 2021, Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing, Nat. Commun., 12, 3256, 10.1038/s41467-021-23482-5 McWhorter, 2013, Modulation of macrophage phenotype by cell shape, Proc. Natl. Acad. Sci. USA, 110, 17253, 10.1073/pnas.1308887110 Niu, 2021, HA-coated collagen nanofibers for urethral regeneration via in situ polarization of M2 macrophages, J. Nanobiotechnol., 19, 283, 10.1186/s12951-021-01000-5 Yang, 2019, Stimulation of osteogenesis and angiogenesis by micro/nano hierarchical hydroxyapatite via macrophage immunomodulation, Nanoscale, 11, 17699, 10.1039/C9NR05730G Li, 2021, Tailoring materials for modulation of macrophage fate, Adv. Mater., 33, 10.1002/adma.202004172 Augustine, 2020, Cerium oxide nanoparticle incorporated electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) membranes for diabetic wound healing applications, ACS Biomater. Sci. Eng., 6, 58, 10.1021/acsbiomaterials.8b01352 Zhang, 2021, Applications of poly(caprolactone)-based nanofibre electrospun scaffolds in tissue engineering and regenerative medicine, Curr. Stem Cell Res. Ther., 16, 414, 10.2174/1574888X15666201014145703 Ahmed, 2021, Nanofibrous epsilon-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo, Bioact. Mater., 6, 2070 Yuan, 2022, Nano-silver functionalized polysaccharides as a platform for wound dressings: a review, Int. J. Biol. Macromol., 194, 644, 10.1016/j.ijbiomac.2021.11.108 Zhu, 2021, Metallic ions encapsulated in electrospun nanofiber for antibacterial and angiogenesis function to promote wound repair, Front. Cell Dev. Biol., 9 Hassan, 2021, Polycaprolactone based electrospun matrices loaded with Ag/hydroxyapatite as wound dressings: morphology, cell adhesion, and antibacterial activity, Int. J. Pharm., 593, 10.1016/j.ijpharm.2020.120143 Cheng, 2021, Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities, Acta Biomater., 124, 219, 10.1016/j.actbio.2021.02.002 Liu, 2010, A biomimetic hydrogel based on methacrylated dextran-graft-lysine and gelatin for 3D smooth muscle cell culture, Biomaterials, 31, 1158, 10.1016/j.biomaterials.2009.10.040 Mao, 2018, Coaxial hydro-nanofibrils for self-assembly of cell sheets producing skin bilayers, ACS Appl. Mater. Interfaces, 10, 43503, 10.1021/acsami.8b17740 Wang, 2019, Alginate/gelatin blended hydrogel fibers cross-linked by Ca(2+) and oxidized starch: preparation and properties, Mater. Sci. Eng. C Mater. Biol. Appl., 99, 1469, 10.1016/j.msec.2019.02.091 Klose, 2009, Towards more realistic in vitro release measurement techniques for biodegradable microparticles, Pharm. Res. (N. Y.), 26, 691, 10.1007/s11095-008-9747-4 Zhang, 2010, Influence of silica particle internalization on adhesion and migration of human dermal fibroblasts, Biomaterials, 31, 8465, 10.1016/j.biomaterials.2010.07.060 Abraham, 2019, Targeting the NF-kappaB signaling pathway in chronic tendon disease, Sci. Transl. Med., 11, 10.1126/scitranslmed.aav4319 Eming, 2014, Wound repair and regeneration: mechanisms, signaling, and translation, Sci. Transl. Med., 6, 265sr6, 10.1126/scitranslmed.3009337 Shi, 2013, Advanced glycation end products delay corneal epithelial wound healing through reactive oxygen species generation, Mol. Cell. Biochem., 383, 253, 10.1007/s11010-013-1773-9 Aljohi, 2018, Momordica charantia extracts protect against inhibition of endothelial angiogenesis by advanced glycation endproducts in vitro, Food Funct., 9, 5728, 10.1039/C8FO00297E Grice, 2010, Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response, Proc. Natl. Acad. Sci. USA, 107, 14799, 10.1073/pnas.1004204107 Schirmer, 2016, U. Freudenberg, StarPEG-heparin hydrogels to protect and sustainably deliver IL-4, Adv. Healthc. Mater., 5, 3157, 10.1002/adhm.201600797 Sato, 1999, Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing, Biochem. Biophys. Res. Commun., 265, 194, 10.1006/bbrc.1999.1455 Schoenenberger, 2020, Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo, Biomaterials, 249, 10.1016/j.biomaterials.2020.120034 Li, 2021, Biophysical and biochemical cues of biomaterials Guide mesenchymal stem cell behaviors, Front. Cell Dev. Biol., 9 Zhu, 2020, Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration, Int. J. Oral Sci., 12, 6, 10.1038/s41368-020-0073-y He, 2020, Improved osteointegration by SEW2871-encapsulated multilayers on micro-structured titanium via macrophages recruitment and immunomodulation, Appl. Mater. Today, 20 Saino, 2011, Effect of electrospun fiber diameter and alignment on macrophage activation and secretion of proinflammatory cytokines and chemokines, Biomacromolecules, 12, 1900, 10.1021/bm200248h Garg, 2013, Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds, Biomaterials, 34, 4439, 10.1016/j.biomaterials.2013.02.065 Barth, 2013, The effect of surface roughness on RAW 264.7 macrophage phenotype, J. Biomed. Mater. Res., 101, 2679, 10.1002/jbm.a.34562 Lv, 2018, Unveiling the mechanism of surface hydrophilicity-modulated macrophage polarization, Adv. Healthc. Mater., 7, 10.1002/adhm.201800675 Chen, 2019, Nanostructural surfaces with different elastic moduli regulate the immune response by stretching macrophages, Nano Lett., 19, 3480, 10.1021/acs.nanolett.9b00237 Vogel, 2014, Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation, J. Neuroinflammation, 11, 23, 10.1186/1742-2094-11-23 Reeves, 2015, Controlled release of cytokines using silk-biomaterials for macrophage polarization, Biomaterials, 73, 272, 10.1016/j.biomaterials.2015.09.027 Behm, 2012, Cytokines, chemokines and growth factors in wound healing, J. Eur. Acad. Dermatol. Venereol., 26, 812, 10.1111/j.1468-3083.2011.04415.x Lucas, 2010, Differential roles of macrophages in diverse phases of skin repair, J. Immunol., 184, 3964, 10.4049/jimmunol.0903356 Bhowmick, 2004, TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia, Science, 303, 848, 10.1126/science.1090922 Martin, 2021, Macrophage phenotypes in tissue repair and the foreign body response: implications for biomaterial-based regenerative medicine strategies, Acta Biomater., 133, 4, 10.1016/j.actbio.2021.03.038 Singampalli, 2020, The role of an IL-10/hyaluronan Axis in dermal wound healing, Front. Cell Dev. Biol., 8, 636, 10.3389/fcell.2020.00636 Tidball, 2005, Inflammatory processes in muscle injury and repair, Am. J. Physiol. Regul. Integr. Comp. Physiol., 288, R345, 10.1152/ajpregu.00454.2004 Sapudom, 2017, Fibroblast fate regulation by time dependent TGF-beta1 and IL-10 stimulation in biomimetic 3D matrices, Biomater. Sci., 5, 1858, 10.1039/C7BM00286F Wynn, 2016, Macrophages in tissue repair, regeneration, and fibrosis, Immunity, 44, 450, 10.1016/j.immuni.2016.02.015 Zhu, 2020, Modulation of macrophages by bioactive glass/sodium alginate hydrogel is crucial in skin regeneration enhancement, Biomaterials, 256, 10.1016/j.biomaterials.2020.120216 Sun, 2014, Advances in skin grafting and treatment of cutaneous wounds, Science, 346, 941, 10.1126/science.1253836 Vishwakarma, 2016, Engineering immunomodulatory biomaterials to tune the inflammatory response, Trends Biotechnol., 34, 470, 10.1016/j.tibtech.2016.03.009 Seetharaman, 2020, Cytoskeletal crosstalk in cell migration, Trends Cell Biol., 30, 720, 10.1016/j.tcb.2020.06.004 Lawson, 2018, Rho GTPase signaling complexes in cell migration and invasion, J. Cell Biol., 217, 447, 10.1083/jcb.201612069 Lin, 2017, LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration, Mol. Biol. Cell, 28, 1054, 10.1091/mbc.e15-04-0218 Bersini, 2020, Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling, Life Sci. Alliance, 3, 10.26508/lsa.201900623