Anti-urolithiatic, antibacterial, anti-inflammatory and analgesic effects of Erica arborea flowers and leaves hydromethanolic extracts: An ethnopharmacological study

Aboalhaija, 2022, Chemical evaluation, in vitro and in vivo anticancer activity of Lavandula angustifolia grown in Jordan, Molecules, 27, 1 Abutaha, N., AL-Zharani, M., Alotaibi, A., Anne, M., Cordero, W., Bepari, A., Alarifi, S., 2021.In vitro and in vivo investigation of polypharmacology of propolis extract as anticancer, antibacterial, anti-inflammatory, and chemical properties. Chem.2(1), 864–874. Ahmed, 2016, In vitro urolithiasis models: An evaluation of prophylactic management against kidney stones, J. Pharmacogn. Phytochem., 5, 28 Ahmed, 2016, Antiurolithiatic plants: Formulations used in different countries and cultures, Pak. J. Pharm. Sci., 29, 2129 Ahmed, 2016, Antiurolithiatic plants: Multidimensional pharmacology, J. Pharmacogn. Phytochem., 5, 04 Ahmed, 2017, World J. Pharm. Pharm. Sci., 6, 156 Ahmed, 2018, The mechanistic insight of polyphenols in calcium oxalate urolithiasis mitigation, Biomed. Pharmacother., 106, 1292, 10.1016/j.biopha.2018.07.080 Akkol, 2007, Evaluation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey, J. Ethnopharmacol., 116, 251, 10.1016/j.jep.2007.11.023 Alinjhad, 2016, Determination of the anti-inflammatory property of tannins from the rind of calamansi (Citrus microcarpa, Rutaceae), J. Int. Oral. Health., 8, 546 Amezouar, R.F., Badri, W., Hseine, M., Bourhim, M., Fougrach., H., 2013. Antioxidant and anti-inflammatory activities of Moroccan Erica arborea L. J. Pathol. Biol.61, 254–258. Amroun, 2021, In-vivo anti-inflammatory activity and safety assessment of the aqueous extract of Algerian Erica arborea L. (Ericaceae) aerial parts, J. Ethnopharmacol., 271, 10.1016/j.jep.2021.113881 Ay, 2007, Antioxidant activity of Erica arborea, Fitoterapia, 78, 571, 10.1016/j.fitote.2007.03.024 Banothu, 2017, Phytochemical screening and evaluation of in vitro antioxidant and antimicrobial activities of theindigenous medicinal plant Albizia odoratissima, Pharm. Bio., 55, 1155, 10.1080/13880209.2017.1291694 Bekkai, 2022, Determination of the phenolic profile by liquid chromatography, evaluation of antioxidant activity and toxicity of Moroccan Erica multiflora, Erica scoparia, and Calluna vulgaris (Ericaceae), Molecules, 27, 3979, 10.3390/molecules27133979 Bitchagno, 2015, Lemairones A and B: two new antibacterial tetra flavonoids from the leaves of Zanthoxylum lemairei (Rutaceae), Phytochem. Lett., 14, 1, 10.1016/j.phytol.2015.08.012 Cárdeno, 2014, Extra virgin olive oil polyphenolic extracts down-regulate inflammatory responses in LPS-activated murine peritoneal macrophages suppressing NF-B and MAPK signaling pathways, Food Funct., 5, 1270, 10.1039/C4FO00014E Ćetković, 2007, Antioxidant potential, lipid peroxidation inhibition and antimicrobial activities of Sature jamontana L. subsp. kitaibelii extracts, Int. J. Mol. Sci., 8, 1013, 10.3390/i8101013 Cushnie, 2011, Recent advances in understanding the antibacterial properties of flavonoids, Int. J. Antimicrob., 38, 99, 10.1016/j.ijantimicag.2011.02.014 Darias, D., Martin-Herrera, S., Abdala, D., 2001. Fuente, plants used in urinary pathologies in the Canary Islands. Pharm. Biol,39, 170–180. Demsie, D.G., Yimer, E.M., Berhe, A.H., Altaye, B.M., Berhe, D.F., 2019. Anti- nociceptive and anti-inflammatory activities of crude root extract and solvent fractions of Cucumis ficifolius in mice model. J. Pain. Res. 12, 1399–1409. Da Silva, 2018, Comparative analysis of Lacistema pubescensand dexamethasone on topical treatment of skin inflammation in a chronic disease model and side effects, J. Pharm. Pharmacol.70, (4),, 576, 10.1111/jphp.12886 Demsie, 2019, Anti-nociceptive and anti-inflammatory activities of crude root extract and solvent fractions of Cucumis ficifolius in mice model, J. Pain. Res., 12, 1399, 10.2147/JPR.S193029 Eddaikra, 2019, Leishmanicidal and cytotoxic activity of Algerian medicinal plants on leishmania major and leishmania infantum, J. Med. Microbiol. Infect. Dis., 7, 66 Elisha, 2017, The antibacterial activity of extracts of nine plant species with good activity against Escherichia coli against five other bacteria and cytotoxicity of extracts, BMC Complement. Altern. Med., 17, 133, 10.1186/s12906-017-1645-z Fyad, 2020, Analgesic and anti-inflammatory activity of aqueous extract of Bubonium graveolens, Biomed. Res. Ther., 7, 4002, 10.15419/bmrat.v7i9.632 Dias, T.L.M.F., Melo, G.M.A., Da Silva, Y.K.C., Queiroz, AC., Goulart H.F., Alexandre-Moreira, M.S., Santana, A.E.G., Uchôa, V.T., 2018. Antinociceptive and anti-inflammatory activities of the ethanolic extract, of fractions and of epicatechin isolated from the stem bark of Ximenia americana L. (Oleacaceae). R.V.Q. 10 (1), 86-101. Guendouze-Bouchefa, N., Madani, K., Chibane, M., Boulekbache makhlouf, L., Hauchard, D., Kiendrebeog, M., Stévigny, C., Ndjolookusa, P., Duez, P., 2015. Phenolic compounds, antioxidant and antibacterial activities of three Ericaceae from Algeria. Ind Crop Prod.70, 459–466. Karbab, 2019, Phenolic contents, in vitro antioxidant, and in vivo anti-inflammatory studies of aqueous extract from Pituranthos scoparius (Coss. & Dur.) growing in Algeria, Iran. J. Pharmacol. Ther., 17, 1 Karbab, 2020, Anti-inflammatory, analgesic activity and toxicity of Pituranthos scoparius stem extract: An ethnopharmacological study in rat and mouse models, J. Ethnopharmacol., 258, 10.1016/j.jep.2020.112936 Karbab, 2020, Total phenolic contents and antioxidant capacity of aqueous extract from Pituranthos scoparius (Coss. & Dur.) growing in Algeria, J. Drug Deliv. Therap., 10, 125, 10.22270/jddt.v10i3.4096 Karbab, 2021, Ethnomedicinal documentation and anti-inflammatory effects of n-butanol extract and of four compounds isolated from the stems of Pituranthos scoparius: an in vitro and in vivo investigation, J. Ethnopharmacol., 267, 10.1016/j.jep.2020.113488 Karbab, A., 2020. Extraction, isolation, structure elucidation and evaluation of toxicity, anti-inflammatory and analgesic activity of Pituranthos scoparius constituents. Thesis of 3rdcycle doctorate in biology (Biochemistry).1-128. Khan, 2020, The analgesic potential of glycosides derived from medicinal plants, J. Pharm. Sci., 28, 387 Kivçak, 2013, Antioxidant, Antimicrobial and cytotoxic activities of Erica bocquetii p. f. stevens and Erica arborea L, J. Health Sci., 2, 52 Kumar, 2021, Antiurolithiasis, antioxidant, anti-inflammatory, analgesic, and diuretic activity of ethanolic extract of seeds of Caesalpinia bonducella, Int. J. Pharm. Investig., 11, 306, 10.5530/ijpi.2021.3.54 Luís, 2011, Bioactive compounds, RP-HPLC analysis of phenolics, and antioxidant activity of some Portuguese shrub species extracts, Nat. Prod. Commun., 6, 1863 Ly, 2021, Anti-urolithic, anti-inflammatory and anti-bacterial properties of various extracts from Musa balbisiana Colla fruits, Pharm. Sci. Asia, 48, 388, 10.29090/psa.2021.04.20.109 Mammate, N., El oumari, F.E., Imtara, H., Belchkar, S., Lahrichi, A., Alqahtani, A.S., Noman, O.M., Tarayrah, M., Houssaini, T.S., 2022. Antioxidant and anti-urolithiatic activity of aqueous and ethanolic extracts from Saussurea costus (Falc) Lispich using scanning electron microscopy. Life. 12, 1026. Marquez-García, 2009, Phenolics composition in Erica sp. differentially exposed to metal pollution in the iberian southwestern pyritic belt, Bioresour. Technol., 100, 446, 10.1016/j.biortech.2008.04.070 Mueller, M., Annfeon, k., Puttipan, R., Unger, F.M., Viernstein, H., Okonogi, S. 2015. Antiinflammatory, antibacterial, and antioxydant activities of the medicinal plants.Int.J Pharm. Pharm. Sci. 11, 123-128 Nakalembe, 2019, Analgesic and anti-Inflammatory activity of total crude leaf extract of Phytolacca dodecandra in wistar albino rats, Neurosci. Med., 10, 259, 10.4236/nm.2019.103020 OECD., 2008. Guidelines for the testing of chemicals. Acute oral toxicity procedure. 425, 27. Pavlovic, D., Lakušic, B., Kitic, D., Milutinović, M., Kostić, M., Miladinović, B., Kovaĉević, N., 2014. Antimicrobial activity of selected plant species of genera Arbutus L., Bruckenthalia Rchb., Callunasalisb. And Erica L (Ericaceae). Acta. Fac. Medicae. Naissensis. 31, 81–85. Pharm, 2020, Total phenolic, total flavonoid contents and antioxidant potential of Common Bean (Phaseolus vulgaris L.) in Vietnam, AIMS Agric. Food., 5, 635 Rea, 2018, Age and age-related diseases: Role of inflammation triggers and cytokines, Front. Immunol., 9, 1, 10.3389/fimmu.2018.00586 Reygaert, Wanda. C., 2014. The antimicrobial possibilities of green tea. Front Microbiol.5, 434. Rodrigues, 2016, Evidence of bioactive compounds from Vernonia polyanthes leaves with topical anti-inflammatory potential, Int. J. Mol. Sci., 17, 1929, 10.3390/ijms17121929 Salem, 2020, Anti-urolithiatic and anti-inflammatory activities through a different mechanism of actions of Cissus gongylodes corroborated its ethnopharmacological historic, J. Ethnopharmacol., 10 Subedi, N.K., Rahman, S., Akbar, M.A., 2016. Analgesic and antipyretic activities of methanol extract and its fraction from the root of Schoenoplectus grossus. Evid. Based. Complement. Altern. Med. 3820704, 8. Taiwo, 2019, Antimicrobial and antioxidant properties of kaempferol-3-O-glucoside and 1-(4-Hydroxyphenyl) -3-phenylpropan-1-one isolated from the leaves of Annona muricata (Linn.), JPRI, 26, 1, 10.9734/jpri/2019/v26i330138 Vargas, 2021, Antibacterial fatty acids: an update of possible mechanisms of actionand implications in the development of the next-generation of antibacterial agents, Prog. Lipid Res., 82, 10109 Villegas-Aguilar, 2020, Pleiotropic biological effects of dietary phenolic compounds and their metabolites on energy metabolism, inflammation and aging, Molecules, 25, 1, 10.3390/molecules25030596 Yaici, 2019, Evaluation of the content of phenolic compounds, antioxidant and antimicrobial properties of Erica arborea L. (Ericaceae) in traditional medicine of setifian Tell in the east Algerian, Phytotherapie., 16, 353 Yimer, 2020, Evaluation of analgesic and anti-inflammatory activities of 80% methanol extract of Echinops kebericho M. (Asteraceae), J. Inflamm. Res., 13, 647, 10.2147/JIR.S267154 Yonezawa, 2018, Anti-inflammatory efects of olive-derived hydroxytyrosol on lipopolysaccharide-induced inflammation in RAW264.7 cell, J. Vet. Sci., 80, 1801 Zeng, 2019, Protective roles of flavonoids and flavonoid-rich plant extracts against urolithiasis: a review, Crit. Rev. Food Sci. Nutr., 59, 2125, 10.1080/10408398.2018.1439880 Zengin, 2019, Chemical composition and bio-functional perspectives of Erica arborea L. extracts obtained by different extraction techniques, Ind. Crops Prod., 142, 10.1016/j.indcrop.2019.111843