Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

JHEP Reports - Tập 6 - Trang 100918 - 2024
Rubén Rodríguez-Agudo1,2, Irene González-Recio1,2, Marina Serrano-Maciá1,2, Miren Bravo1,2, Petar Petrov2,3, Delia Blaya2,4, Jose María Herranz2,5, María Mercado-Gómez1,2, Claudia María Rejano-Gordillo1,2, Sofía Lachiondo-Ortega1,2, Clàudia Gil-Pitarch1,2, Mikel Azkargorta2,6, Sebastiaan Martijn Van Liempd7, Luis Alfonso Martinez-Cruz1,2, A.L. Simão8, Félix Elortza2,6, César Martín9, Yulia A. Nevzorova2,10,11, Francisco Javier Cubero2,10, Teresa C. Delgado1,2
1Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, Spain
2Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Health Institute, Madrid, Spain
3Experimental Hepatology Joint Research Unit, IIS Hospital La Fe and Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, Spain
4Liver Cell Plasticity and Tissue Repair Lab, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain
5Instituto de Investigaciones Sanitarias de Navarra-IdiSNA, Pamplona, Spain
6Proteomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, Spain
7Metabolomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain
8Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal
9Biofisika Institute (UPV/EHU, CSIC) and Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Leioa, Spain
10Department of Immunology, Ophthalmology and ENT Complutense University School of Medicine Madrid Spain, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain
11Department of Internal Medicine III, University Hospital, RWTH Aachen, Germany

Tài liệu tham khảo

Harden, 1906, The alcoholic ferment of yeast-juice. Part II.—the coferment of yeast-juice, Proc R Soc Lond B Biol Sci, 78, 369, 10.1098/rspb.1906.0070 Xie, 2020, NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential, Signal Transduct Target Ther, 5, 227, 10.1038/s41392-020-00311-7 Cabezas, 2022, Management of alcohol-related liver disease and its complications, Clin Drug Investig, 42, 47, 10.1007/s40261-022-01143-9 Jiang, 2020, Alcohol metabolizing enzymes, microsomal ethanol oxidizing system, cytochrome P450 2E1, catalase, and aldehyde dehydrogenase in alcohol-associated liver disease, Biomedicines, 8, 50, 10.3390/biomedicines8030050 Lemasters, 2006, Voltage-dependent anion channel (VDAC) as mitochondrial governator - thinking outside the box, Biochim Biophys Acta Mol Basis Dis, 1762, 181, 10.1016/j.bbadis.2005.10.006 Lieber, 1975, Effect of chronic alcohol consumption on ethanol and acetaldehyde metabolism, Adv Exp Med Biol, 59, 185, 10.1007/978-1-4757-0632-1_14 Addolorato, 2016, Treatment of alcohol use disorders in patients with alcoholic liver disease, J Hepatol, 65, 618, 10.1016/j.jhep.2016.04.029 Xu, 2019, MicroRNAs in alcoholic liver disease: recent advances and future applications, J Cell Physiol, 234, 382, 10.1002/jcp.26938 Fernández-Tussy, 2019, miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease, Mol Metab, 29, 40, 10.1016/j.molmet.2019.08.008 Idalsoaga, 2020, Non-alcoholic fatty liver disease and alcohol-related liver disease: two intertwined entities, Front Med (Lausanne), 7, 448, 10.3389/fmed.2020.00448 Craciun, 2020, Nonalcoholic fatty liver disease versus alcohol-related liver disease: is it really so different?, Curr Pharm Des, 26, 1093, 10.2174/1381612826666200122152417 Fernández-Ramos, 2018, MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis, Cell Death Dis, 9, 958, 10.1038/s41419-018-1014-y Rodríguez-Agudo, 2022, Methionine cycle rewiring by targeting miR-873-5p modulates ammonia metabolism to protect the liver from acetaminophen, Antioxidants, 11, 897, 10.3390/antiox11050897 Hong, 2018, Nicotinamide N-methyltransferase interacts with enzymes of the methionine cycle and regulates methyl donor metabolism, Biochemistry, 57, 5775, 10.1021/acs.biochem.8b00561 Bertola, 2013, Mouse model of chronic and binge ethanol feeding (the NIAAA model), Nat Protoc, 8, 627, 10.1038/nprot.2013.032 Blaya, 2016, Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation, Gut, 65, 1535, 10.1136/gutjnl-2015-311314 Argemi, 2019, Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis, Nat Commun, 10, 3126, 10.1038/s41467-019-11004-3 Niu, 2022, Noninvasive proteomic biomarkers for alcohol-related liver disease, Nat Med, 28, 1277, 10.1038/s41591-022-01850-y Benedé-Ubieto, 2021, An experimental DUAL model of advanced liver damage, Hepatol Commun, 5, 1051, 10.1002/hep4.1698 Ribeiro, 2004, Hepatocyte apoptosis, expression of death receptors, and activation of NF-κB in the liver of nonalcoholic and alcoholic steatohepatitis patients, Am J Gastroenterol, 99, 1708, 10.1111/j.1572-0241.2004.40009.x Nagy, 2016, Linking pathogenic mechanisms of alcoholic liver disease with clinical phenotypes, Gastroenterology, 150, 1756, 10.1053/j.gastro.2016.02.035 Marí, 2014, Mitochondrial cholesterol accumulation in alcoholic liver disease: role of ASMase and endoplasmic reticulum stress, Redox Biol, 3, 100, 10.1016/j.redox.2014.09.005 Lieber, 1968, Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding, Science, 162, 917, 10.1126/science.162.3856.917 Cederbaum, 2012, Alcohol metabolism, Clin Liver Dis, 16, 667, 10.1016/j.cld.2012.08.002 Shi, 2022, Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease, Biomaterials, 288, 10.1016/j.biomaterials.2022.121720 Khodaee, 2014, Endoplasmic reticulum membrane potassium channel dysfunction in high fat diet induced stress in rat hepatocytes, EXCLI J, 13, 1075 Grynkiewicz, 1985, A new generation of Ca2+ indicators with greatly improved fluorescence properties, J Biol Chem, 260, 3440, 10.1016/S0021-9258(19)83641-4 Lin, 2019, Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters, Nat Commun, 10, 2516, 10.1038/s41467-019-10329-3 Nevzorova, 2020, Animal models for liver disease–a practical approach for translational research, J Hepatol, 73, 423, 10.1016/j.jhep.2020.04.011 Lieber, 1965, Effects of prolonged ethanol intake: production of fatty liver despite adequate diets, J Clin Invest, 44, 1009, 10.1172/JCI105200 Donohue, 2007, Alcohol-induced steatosis in liver cells, World J Gastroenterol, 13, 4974, 10.3748/wjg.v13.i37.4974 Ren, 2020, Emerging roles of SIRT1 in alcoholic liver disease, Int J Biol Sci, 16, 3174, 10.7150/ijbs.49535 Zhao, 2022, Emerging roles of Sirtuins in alleviating alcoholic liver Disease: a comprehensive review, Int Immunopharmacol, 108, 108712, 10.1016/j.intimp.2022.108712 Zee, 2013, Validation of protein acetylation by mass spectrometry, Methods Mol Biol, 1–11, 10.1007/978-1-62703-305-3_1 Manley, 2015, Role of farnesoid X receptor and bile acids in alcoholic liver disease, Acta Pharm Sin B, 5, 158, 10.1016/j.apsb.2014.12.011 Muthiah, 2022, Development of alcohol-associated hepatitis is associated with specific changes in gut-modified bile acids, Hepatol Commun, 6, 1073, 10.1002/hep4.1885 Ciocan, 2018, Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis, Aliment Pharmacol Ther, 48, 961, 10.1111/apt.14949 Wu, 2014, Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease, Biochem Biophys Res Commun, 443, 68, 10.1016/j.bbrc.2013.11.057 Nowak, 2020, The impact of acute or chronic alcohol intake on the NF-κB signaling pathway in alcohol-related liver disease, Int J Mol Sci, 21, 1, 10.3390/ijms21249407 Kauppinen, 2013, Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders, Cell Signal, 25, 1939, 10.1016/j.cellsig.2013.06.007 Parker, 2020, Nicotinamide adenine dinucleotide metabolome is functionally depressed in patients undergoing liver transplantation for alcohol-related liver disease, Hepatol Commun, 4, 1183, 10.1002/hep4.1530 Sambeat, 2019, Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage, Nat Commun, 10, 4291, 10.1038/s41467-019-12262-x Song, 2020, ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development, J Hepatol, 73, 783, 10.1016/j.jhep.2020.04.038 Roberti, 2021, Nicotinamide N-methyltransferase: at the crossroads between cellular metabolism and epigenetic regulation, Mol Metab, 45, 10.1016/j.molmet.2021.101165 Kleiner, 2005, Design and validation of a histological scoring system for nonalcoholic fatty liver disease, Hepatology, 41, 1313, 10.1002/hep.20701 Liang, 2022, Nicotinamide N-methyltransferase and liver diseases, Genes Dis, 10, 1883, 10.1016/j.gendis.2022.03.019 Way, 2022, Key signaling in alcohol-associated liver disease: the role of bile acids, Cells, 11, 1374, 10.3390/cells11081374 Bergheim, 2005, Treatment of alcoholic liver disease, Dig Dis, 23, 275, 10.1159/000090175 Shmulewitz, 2021, The World Health Organization risk drinking levels measure of alcohol consumption: prevalence and health correlates in nationally representative surveys of US adults, 2001-2002 and 2012-2013, Am J Psychiatry, 178, 548, 10.1176/appi.ajp.2020.20050610 Bala, 2016, The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis, J Hepatol, 64, 1378, 10.1016/j.jhep.2016.01.035 Hwang, 2017, Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells, Cell Mol Life Sci, 74, 3347, 10.1007/s00018-017-2527-8 Zhao, 2019, Celastrol protects from cholestatic liver injury through modulation of SIRT1-FXR signaling, Mol Cell Proteomics, 18, 520, 10.1074/mcp.RA118.000817 Yeung, 2004, Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase, EMBO J, 23, 2369, 10.1038/sj.emboj.7600244 Yang, 2022, Regulation of SIRT1 and its roles in inflammation, Front Immunol, 13