Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke

Burchfiel, 1995, Effects of smoking and smoking cessation on longitudinal decline in pulmonary function, Am J Respir Crit Care Med, 151, 1778, 10.1164/ajrccm.151.6.7767520 Saetta, 1999, Airway inflammation in chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 160, S17, 10.1164/ajrccm.160.supplement_1.6 Barnes, 2004, COPD–a neglected disease, Lancet, 364, 564, 10.1016/S0140-6736(04)16866-9 Halbert, 2006, Global burden of COPD: systematic review and meta-analysis, Eur Respir J, 28, 523, 10.1183/09031936.06.00124605 Barnes, 2004, Prospects for new drugs for chronic obstructive pulmonary disease, Lancet, 364, 985, 10.1016/S0140-6736(04)17025-6 Ito, 2007, Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease, J Pharmacol Exp Ther, 321, 1, 10.1124/jpet.106.111674 Birrell, 2006, IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic, Mol Pharmacol, 69, 1791, 10.1124/mol.105.019521 Medicherla, 2008, p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation, J Pharmacol Exp Ther, 324, 921, 10.1124/jpet.107.127092 Newton, 2007, Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors, J Pharmacol Exp Ther, 321, 734, 10.1124/jpet.106.118125 Adcock, 2006, Kinase inhibitors and airway inflammation, Eur J Pharmacol, 533, 118, 10.1016/j.ejphar.2005.12.054 de Boer, 2007, Future therapeutic treatment of COPD: struggle between oxidants and cytokines, Int J Chron Obstruct Pulmon Dis, 2, 205 Yao, 2008, Targeting Lung Inflammation: Novel Therapies for the Treatment of COPD, Curr Respir Med Rev, 4, 57, 10.2174/157339808783497873 Di Stefano, 2002, Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD, Eur Respir J, 20, 556, 10.1183/09031936.02.00272002 Caramori, 2003, Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations, Thorax, 58, 348, 10.1136/thorax.58.4.348 Rajendrasozhan, 2008, Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD, Antioxid Redox Signal, 10, 799, 10.1089/ars.2007.1938 Rajendrasozhan, 2008, SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 177, 861, 10.1164/rccm.200708-1269OC Rahman, 2006, Oxidative stress and redox regulation of lung inflammation in COPD, Eur Respir J, 28, 219, 10.1183/09031936.06.00053805 Szulakowski, 2006, The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 174, 41, 10.1164/rccm.200505-725OC Baldwin, 2001, Series introduction: the transcription factor NF-kappaB and human disease, J Clin Invest, 107, 3, 10.1172/JCI11891 Barnes, 2001, Cytokine modulators as novel therapies for airway disease, Eur Respir J Suppl, 34, 67s, 10.1183/09031936.01.00229901 Marwick, 2004, Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs, Am J Respir Cell Mol Biol, 31, 633, 10.1165/rcmb.2004-0006OC Li, 1999, The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis, J Exp Med, 189, 1839, 10.1084/jem.189.11.1839 Yao, 2008, Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice, Am J Pathol, 172, 1222, 10.2353/ajpath.2008.070765 O'Connell, 1998, Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells, J Biol Chem, 273, 30410, 10.1074/jbc.273.46.30410 Hawiger, 1999, IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells, Blood, 94, 1711, 10.1182/blood.V94.5.1711 Li, 1999, Severe liver degeneration in mice lacking the IkappaB kinase 2 gene, Science, 284, 321, 10.1126/science.284.5412.321 Kishore, 2003, A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts, J Biol Chem, 278, 32861, 10.1074/jbc.M211439200 Coish, 2006, Small molecule inhibitors of IKK kinase activity, Expert Opin Ther Pat, 16, 1, 10.1517/13543776.16.1.1 Mbalaviele, 2009, A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models, J Pharmacol Exp Ther, 329, 14, 10.1124/jpet.108.143800 Sommers, 2009, Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation, J Pharmacol Exp Ther, 330, 377, 10.1124/jpet.108.147538 Chiang, 2010, Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IkappaB kinase-2 (IKK-2) target safety and efficacy, J Pharm Sci, 99, 1278, 10.1002/jps.21909 Yao, 2008, Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice, Am J Respir Cell Mol Biol, 39, 7, 10.1165/rcmb.2007-0342OC Ghosh, 2002, Missing pieces in the NF-kappaB puzzle, Cell, 109, S81, 10.1016/S0092-8674(02)00703-1 Yamamoto, 2004, IkappaB kinases: key regulators of the NF-kappaB pathway, Trends Biochem Sci, 29, 72, 10.1016/j.tibs.2003.12.003 Chen, 2004, Shaping the nuclear action of NF-kappaB, Nat Rev Mol Cell Biol, 5, 392, 10.1038/nrm1368 Brown, 2009, Dysregulated apoptosis and NFkappaB expression in COPD subjects, Respir Res, 10, 24, 10.1186/1465-9921-10-24 Agusti, 2003, Systemic effects of chronic obstructive pulmonary disease, Eur Respir J, 21, 347, 10.1183/09031936.03.00405703 Gan, 2004, Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis, Thorax, 59, 574, 10.1136/thx.2003.019588 Edwards, 2009, Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease, Pharmacol Ther, 121, 1, 10.1016/j.pharmthera.2008.09.003 Kim, 2003, Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages, Cell Signal, 15, 299, 10.1016/S0898-6568(02)00086-4 Adenuga, 2007, Oxidative Stress, Histone Deacetylase and Corticosteroid Resistance in Severe Asthma and COPD, Curr Respir Med Rev, 3, 57, 10.2174/157339807779941857 De Stefano, 2009, Oligonucleotide decoy to NF-kappaB slowly released from PLGA microspheres reduces chronic inflammation in rat, Pharmacol Res, 60, 33, 10.1016/j.phrs.2009.03.012 Karimi, 2006, Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages, Respir Res, 7, 66, 10.1186/1465-9921-7-66 Doukas, 2009, Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease, J Pharmacol Exp Ther, 328, 758, 10.1124/jpet.108.144311 Kent, 2009, J Pharmacol Exp Ther, 328, 458, 10.1124/jpet.108.142950 Fox, 2009, The role of animal models in the pharmacological evaluation of emerging anti-inflammatory agents for the treatment of COPD, Curr Opin Pharmacol, 9, 231, 10.1016/j.coph.2009.03.001