Anti-inflammatory activity of phytochemicals from medicinal plants and their nanoparticles: A review

Abdelhafez, 2020, Anti-Inflammatory Potential of Green Synthesized Silver Nanoparticles of the Soft Coral Nephthea Sp. Supported by Metabolomics Analysis and Docking Studies, Int. J. Nanomed., 15, 5345, 10.2147/IJN.S239513 Abo-EL-Sooud, 2018, Phytochemical, Anti-Inflammatory, Anti-Ulcerogenic and Hypoglycemic Activities of Periploca angustifolia L Extracts in Rats, Clin Phytosci., 4, 6, 10.1186/s40816-018-0087-6 Abozeid, 2020, Synthesis of Novel Naphthalene-Heterocycle Hybrids with Potent Antitumor, Anti-Inflammatory and Antituberculosis Activities, RSC Adv., 10, 42998, 10.1039/D0RA08526J Adebayo, 2015, The Anti-Inflammatory and Antioxidant Activity of 25 Plant Species Used Traditionally to Treat Pain in Southern African, BMC Complement. Altern. Med., 15, 1, 10.1186/s12906-015-0669-5 Adegbola, 2017, Antioxidant and Anti-Inflammatory Medicinal Plants Have Potential Role in the Treatment of Cardiovascular Disease, Am. J. Cardiovasc. Dis., 7, 19 Afreen, 2020, Phytochemical-Assisted Biosynthesis of Silver Nanoparticles from Ajuga bracteosa for Biomedical Applications, Mater. Res. Express., 7, 1, 10.1088/2053-1591/aba5d0 Agarwal, H., Shanmugam, V.K., 2020. A Review on Anti-Inflammatory Activity of Green Synthesized Zinc Oxide Nanoparticle: Mechanism-Based Approach; Elsevier Inc., 94, ISBN 4558171412. Agarwal, 2019, Anti-Inflammatory Mechanism of Various Metal and Metal Oxide Nanoparticles Synthesized Using Plant Extracts: A Review, Biomed. Pharmacother., 109, 2561, 10.1016/j.biopha.2018.11.116 Agić, 2021, Coumarin Derivatives Act as Novel Inhibitors of Human Dipeptidyl Peptidase III: Combined in Vitro and in Silico Study, Pharmaceuticals, 14, 1, 10.3390/ph14060540 Ahmed, 2020, Biochemical Profile and Bioactive Potential of Thirteen Wild Folk Medicinal Plants from Balochistan, Pakistan, PLoS One, 15, 1, 10.1371/journal.pone.0231612 Alhakmani, 2013, Estimation of Total Phenolic Content, in-Vitro Antioxidant and Anti-Inflammatory Activity of Flowers of Moringa oleifera, Asian Pac. J. Trop. Biomed., 3, 623, 10.1016/S2221-1691(13)60126-4 Al-Otibi, 2021, Biosynthesis of Silver Nanoparticles Using Malva parviflora and Their Antifungal Activity, Saudi J. Biol. Sci., 28, 2229, 10.1016/j.sjbs.2021.01.012 Ammulu, 2021, Phytoassisted Synthesis of Magnesium Oxide Nanoparticles from Pterocarpus Marsupium Rox.b Heartwood Extract and Its Biomedical Applications, J. Genet. Eng. Biotechnol., 19, 1, 10.1186/s43141-021-00119-0 Anyasor, 2019, Evaluation of Anti-Inflammatory Activity of Justicia secunda Vahl Leaf Extract Using in Vitro and in Vivo Inflammation Models, Clin. Phytoscience, 5, 1, 10.1186/s40816-019-0137-8 Arifin, 2015, In Vitro Anti-Inflammatory Activities of Red Gemor (Nothaphoebe Cf Umbelliflora), J. Med. Bioeng., 4, 312 Arranz, 2015, Supercritical Fluid Extraction as an Alternative Process to Obtain Essential Oils with Anti-Inflammatory Properties from Marjoram and Sweet Basil, Ind. Crops Prod., 67, 121, 10.1016/j.indcrop.2015.01.012 Asadi-Samani, 2015, Medicinal Plants with Hepatoprotective Activity in Iranian Folk Medicine, Asian Pac. J. Trop. Biomed., 5, 146, 10.1016/S2221-1691(15)30159-3 Asif, 2020, COVID-19 and Therapy with Essential Oils Having Antiviral, Anti-Inflammatory, and Immunomodulatory Properties, Inflammopharmacology, 28, 1153, 10.1007/s10787-020-00744-0 Asmamaw, 2018, Assessment of Medicinal Plants and Their Conservation Status in Case of Daligaw Kebela, Gozamen Werda, East Gojjam Zone. J. Biodiver, Bioprospect. Dev., 5, 1 August, 2018, Antinociceptive and Anti-Inflammatory Effects of Flavonoids Rich Fraction of Solanum incanum (Lin) Root Extracts in Mice, J. Phytopharm., 7, 399, 10.31254/phyto.2018.7408 Ayertey, 2020, Anti-Inflammatory Activity and Mechanism of Action of Ethanolic Leaf Extract of Morinda lucida Benth, J. Tradit. Complement. Med., 11, 249, 10.1016/j.jtcme.2020.07.001 Azab, 2016, Anti-Inflammatory Activity of Natural Products, Molecules, 21, 1, 10.3390/molecules21101321 Aziz, 2018, Anti-Inflammatory Effects of Luteolin: A Review of in Vitro, in Vivo, and in Silico Studies, J. Ethnopharmacol., 225, 342, 10.1016/j.jep.2018.05.019 Bachheti, 2021, Algae-, Fungi-, and Yeast-Mediated Biological Synthesis of Nanoparticles and Their Various Biomedical Applications, 701 Bachheti, R.K., Konwarh, R., Gupta, V., Husen, A., Joshi, A., 2019. Green Synthesis of Iron Oxide Nanoparticles: Cutting Edge Technology and Multifaceted Applications. In In Nanomaterials and Plant Potential; Husen, A., Iqbal, M., Eds.; Springer, Cham, 239–259. Bachheti, A., Sharma, A., Bachheti, R.K., Husen, A., Pandey, D.P., 2020. Plant Allelochemicals and Their Various Applications. In Co-Evolution of Secondary Metabolites; Mérillon, J.M., Ramawat, K.G., Eds.; Springer International Publishing: Cham, 441–465. ISBN 978-3-319-96397-6. Bailey-shaw, 2017, In-Vitro Evaluation of the Anti-Inflammatory Potential of Selected Jamaican Plant Extracts Using the Bovine Serum albumin Protein Denaturation Assay, Int. J. Pharm. Sci. Rev. Res., 47, 145 Benly, 2015, Role of Histamine in Acute Inflammation, J. Pharm. Sci. Res., 7, 373 Beshah, 2020, Ethnopharmacological, Phytochemistry and Other Potential Applications of Dodonaea Genus: A Comprehensive Review, Curr. Res. Biotechnol., 2, 103, 10.1016/j.crbiot.2020.09.002 Beyene, 2017, Synthesis Paradigm and Applications of Silver Nanoparticles (AgNPs), a Review, Sustain. Mater. Technol., 13, 18 Borquaye, L.S., Laryea, M.K., Gasu, E.N., Boateng, M.A., Baffour, P.K., Kyeremateng, A., Doh, G., Anti-Inflammatory and Antioxidant Activities of Extracts of Reissantia Indica, Cissus cornifolia, and Grosseria vignei. Cogent. Biol. 6, 1–13. doi:10.1080/23312025.2020.1785755. Bouhlali, 2016, In Vitro Antioxidant and Anti-Inflammatory Properties of Selected Moroccan Medicinal Plants, J. Appl. Pharm. Sci., 6, 156, 10.7324/JAPS.2016.60525 Bunte, 2019, Polyphenols in the Prevention and Treatment of Periodontal Disease: A Systematic Review of in Vivo, Ex Vivo and in Vitro Studies, Fitoterapia, 132, 30, 10.1016/j.fitote.2018.11.012 Candiracci, 2012, Anti-Inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-Activated N13 Microglial Cells, J. Agric. Food Chem., 60, 12304, 10.1021/jf302468h Castro, 2014, In Vivo and in Vitro Anti-Inflammatory Activity of Cryptostegia grandiflora Roxb, Ex r. Br. Leaves. Biol. Res., 47, 1 Chakraborty, 2012, Antiinflammatory, Antinociceptive and Antioxidant Activities of Phyllanthus acidus L, Extracts. Asian Pac. J. Trop. Biomed., 2 Chatter, 2011, In Vivo and in Vitro Anti-Inflammatory Activity of Neorogioltriol, a New Diterpene Extracted from the Red Algae Laurencia glandulifera, Mar Drugs, 9, 1293, 10.3390/md9071293 Cheng, 2021, Epigallocatechin-3-gallate-loaded Liposomes Favor Anti-inflammation of Microglia Cells and Promote Neuroprotection, Int. J. Mol. Sci., 22, 1 Chmit, 2014, Antibacterial and Antibiofilm Activities of Polysaccharides, Essential Oil, and Fatty Oil Extracted from Laurus nobilis Growing in Lebanon, Asian Pac. J. Trop. Med., 7, 546, 10.1016/S1995-7645(14)60288-1 Christopher, 2015, Optimization of Parameters for Biosynthesis of Silver Nanoparticles Using Leaf Extract of Aegle marmelos, Brazilian Arch. Biol. Technol., 58, 702, 10.1590/S1516-89132015050106 Cooper, 2017, Alzheimer Disease: Clues from Traditional and Complementary Medicine, J. Tradit. Complement. Med., 7, 380, 10.1016/j.jtcme.2016.12.003 Da Silveira, 2014, A Review on Anti-Inflammatory Activity of Phenylpropanoids Found in Essential Oils, Molecules, 19, 1459, 10.3390/molecules19021459 Dawid-Pać, 2013, Medicinal Plants Used in Treatment of Inflammatory Skin Diseases, Postep. Dermatologii Alergol., 30, 170, 10.5114/pdia.2013.35620 De, 2017, Study the Antioxidant and in Vitro Anti-Inflammatory Activity by Membrane Stabilization Method of Amaranthus gangeticus Leaf Extract, J. Pharmacogn. Phytochem., 6, 103 Devasvaran, 2021, Green Synthesis of Metallic Nanoparticles Using Pectin as a Reducing Agent: A Systematic Review of the Biological Activities, Pharm. Biol., 59, 494, 10.1080/13880209.2021.1910716 Devi, 2015, Kaempferol and Inflammation: From Chemistry to Medicine, Pharmacol. Res., 99, 1, 10.1016/j.phrs.2015.05.002 Dharmadeva, 2018, In Vitro Anti–inflammatory Activity of Ficus racemosa L. Bark Using Albumin Denaturation Method, Pharmacol. Study, 39, 239 Dinarello, 2010, Anti-inflammatory agents: present and future, Cell, 140, 935, 10.1016/j.cell.2010.02.043 Djuichou, 2019, In Vitro Anti-Inflammatory and in Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats, Evidence-Based Complement. Altern. Med., 2019, 1, 10.1155/2019/3612481 Dragos, 2017, Phytomedicine in Joint Disorders, Nutrients, 9, 1, 10.3390/nu9010070 Eldalawy, 2021, Phenotypic, Anatomical and Phytochemical Investigation of Iraqi Silybum marianum, J. Phys. Conf. Ser., 1879, 1, 10.1088/1742-6596/1879/2/022029 Elisha, 2016, The Anti-Arthritic, Anti-Inflammatory, Antioxidant Activity and Relationships with Total Phenolics and Total Flavonoids of Nine South African Plants Used Traditionally to Treat Arthritis, BMC Complement. Altern. Med., 16, 1, 10.1186/s12906-016-1301-z Fangkrathok, 2013, In Vivo and in Vitro Anti-Inflammatory Activity of Lentinus polychrous Extract, J. Ethnopharmacol., 147, 631, 10.1016/j.jep.2013.03.055 Fraternale, 2016, Chemical Composition and “in Vitro” Anti-Inflammatory Activity of Vitis Vinifera L. (Var. Sangiovese) Tendrils Extract, J. Funct. Foods, 20, 291, 10.1016/j.jff.2015.11.013 Fyad, 2020, Sekkoum, K., 2020. Analgesic and Anti-Inflammatory Activity of Aqueous Extract of Bubonium graveolens, Biomed. Res. Ther., 7, 4002, 10.15419/bmrat.v7i9.632 Gemechu, 2021, Ethnomedicinal Uses, Phytochemisty and Pharmacological Activities of Rumex nervosus, J. Anal. Pharm. Res., 10, 65, 10.15406/japlr.2021.10.00367 Ghasemian, 2016, Review of Anti-Inflammatory Herbal Medicines, Adv. Pharmacol. Sci., 2016, 1 Gonfa, 2021, Phytochemical Investigation and Potential Pharmacologically Active Compounds of Rumex nepalensis: An Appraisal, Beni-Suef Univ. J. Basic Appl. Sci., 10, 1, 10.1186/s43088-021-00110-1 Govindasamy, 2018, Green Approach for Synthesis of Zinc Oxide Nanoparticles from Andrographis paniculata Leaf Extract and Evaluation of Their Antioxidant, Anti-Diabetic, and Anti-Inflammatory Activities, Biopro. Biosyst. Eng., 41, 21, 10.1007/s00449-017-1840-9 Grando, 1999, Medicinal Plants Used on Arthritis Treatment: An Overview through Patent Analysis, J. Pharmacogn. Phytochem., 6, 1999 Groiss, 2017, Structural Characterization, Antibacterial and Catalytic Effect of Iron Oxide Nanoparticles Synthesised Using the Leaf Extract of Cynometra ramiflora, J. Mol. Struct., 1128, 572, 10.1016/j.molstruc.2016.09.031 Gul, 2021, Grass-Mediated Biogenic Synthesis of Silver Nanoparticles and Their Drug Delivery Evaluation: A Biocompatible Anti-Cancer Therapy, Chem. Eng. J., 407, 1, 10.1016/j.cej.2020.127202 Gumisiriza, 2019, Medicinal Plant Species Used by Local Communities around Queen Elizabeth National Park, Maramagambo Central Forest Reserve and Ihimbo Central Forest Reserve, South Western Uganda, J. Ethnopharmacol., 239, 1, 10.1016/j.jep.2019.111926 Gupta, 2020, Anti-Neuroinflammatory Potential of Tylophora indica (Burm. F) Merrill and Development of an Efficient in Vitro Propagation System for Its Clinical Use, PLoS One, 15, 1, 10.1371/journal.pone.0230142 Hailu, 2021, Diversity in Capsule and Seed Morphological and Phytochemical Features and Essential Oil Composition of Korarima (Aframomum corrorima (Braun) P.C. M. Jansen) Collections from Ethiopia, Biochem. Syst. Ecol., 97, 1, 10.1016/j.bse.2021.104275 Hamid, 2022, Design, Synthesis, and Anti-Inflammatory Activity of Some Coumarin Schiff Base Derivatives. In Silico and in Vitro Study, Drug Des. Devel., Ther, 2275, 10.2147/DDDT.S364746 Heinrich, 2021, Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity-An Update and Forward Look, Molecules, 26, 1, 10.3390/molecules26071836 Hemlata, 2020, Biosynthesis of Silver Nanoparticles Using Cucumis prophetarum Aqueous Leaf Extract and Their Antibacterial and Antiproliferative Activity against Cancer Cell Lines, ACS Omega, 5, 5520, 10.1021/acsomega.0c00155 Hosseinzadeh, 2015, The Application of Medicinal Plants in Traditional and Modern Medicine: A Review of Thymus vulgaris, Int. J. Clin. Med., 6, 635, 10.4236/ijcm.2015.69084 Hossen, 2015, In Vitro and in Vivo Anti-Inflammatory Activity of Phyllanthus acidus Methanolic Extract, J. Ethnopharmacol., 168, 217, 10.1016/j.jep.2015.03.043 Huang, 2020, Synthesis, Optimization and Characterization of Silver Nanoparticles Using the Catkin Extract of Piper Longum for Bactericidal Effect against Food-Borne Pathogens via Conventional and Mathematical Approaches, Bioorg. Chem., 103, 1, 10.1016/j.bioorg.2020.104230 Idm’hand, E., Msanda, F., Cherifi, K.,, 2020, Medicinal Uses, Phytochemistry and Pharmacology of Ammodaucus leucotrichus, Clin. Phytosci., 6, 1 Islam, 2019, Antioxidant and Anti-Inflammatory Activity of Heritiera fomes (Buch.-Ham), a Mangrove Plant of the Sundarbans, Orient. Pharm. Exp. Med., 20, 189, 10.1007/s13596-019-00401-0 Jahangir, 2015, In Vivo and in Vitro Anti-Inflammatory Activities of Persicaria chinensis Methanolic Extract Targeting Src/Syk/NF-ΚB, J. Ethnopharmacol., 159, 9, 10.1016/j.jep.2014.10.064 Jasemi, 2020, Medicinal Plants and Phytochemicals for the Treatment of Pulmonary Hypertension, Front. Pharmacol., 11, 1, 10.3389/fphar.2020.00145 Jele, 2021, Determination of Volatile Terpenes in Coriander Cold Pressed Oil by Vacuum Assisted Sorbent Extraction (VASE), Molecules, 26, 1 Jorge, 2020, Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by Scaptotrigona affinis postica. In Silico, in Vitro, and in Vivo Studies, Antioxidants, 9, 1 Jung, 2016, Hepatoprotective Effect of Licorice, the Root of Glycyrrhiza uralensis Fischer, in Alcohol-Induced Fatty Liver Disease, BMC Complement. Altern. Med., 16, 1 Justo, 2015, Evaluation of in Vitro Anti-Inflammatory Effects of Crude Ginger and Rosemary Extracts Obtained through Supercritical CO2 Extraction on Macrophage and Tumor Cell Line: The Influence of Vehicle Type, BMC Complement. Altern. Med., 15, 1, 10.1186/s12906-015-0896-9 Kadhim, 2016, Medicinal Plants Used for Treatment of Rheumatoid arthritis, Int. J. Pharm. Clin. Res., 8, 1685 Karimi, 2013, Antifungal, Anti-Inflammatory and Cytotoxicity Activities of Three Varieties of Labisia pumila Benth: From Microwave Obtained Extracts, BMC Complement. Altern. Med., 13, 1, 10.1186/1472-6882-13-20 Kerdar, 2019, Clinical, in Vitro and Phytochemical, Studies of Scrophularia striata Mouthwash on Chronic Periodontitis Disease, J. Ethnopharmacol., 239, 10.1016/j.jep.2019.111872 Khazdair, 2019, Neuroprotective Potency of Some Spice Herbs, a Literature Review, J. Tradit. Complement. Med., 9, 98, 10.1016/j.jtcme.2018.01.002 Kiani, 2019, Calligonum comosum (Escanbil) Extract Exerts Anti-Angiogenic, Anti-Proliferative and Anti-Inflammatory Effects on Endometriotic Lesions, J. Ethnopharmacol., 239, 1, 10.1016/j.jep.2019.111918 Kim, 2017, Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders, Biomol. Ther., 25, 91, 10.4062/biomolther.2016.187 Kırmızıbekmez, 2019, Phenolic Compounds from the Aerial Parts of Clematis viticella L. and Their in Vitro Anti-Inflammatory Activities, Nat. Prod. Res., 33, 2541, 10.1080/14786419.2018.1448815 Kosala, 2018, In Vitro and in Vivo Anti-Inflammatory Activities of Coptosapelta flavescens Korth Root’s Methanol Extract, J. Appl. Pharm. Sci., 8, 42, 10.7324/JAPS.2018.8907 Kusuma, 2019, An Optimization of Microwave Hydrodistillation Extraction of Vetiver Oil Using a Face-Centered Central Composite Design, J. Chem. Technol. Metall., 54, 803 Lam, 2016, Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities, Int. J. Mol. Sci., 17, 1, 10.3390/ijms17040465 Li, 2019, Natural Products in Licorice for the Therapy of Liver Diseases: Progress and Future Opportunities, Pharmacol. Res., 144, 210, 10.1016/j.phrs.2019.04.025 Li, 2018, Salvia miltiorrhiza Burge (Danshen): A Golden Herbal Medicine in Cardiovascular Therapeutics, Acta Pharmacol. Sin., 39, 802, 10.1038/aps.2017.193 Liang, 2018, Anti-Inflammatory Effects of Gingerol on Lipopolysaccharide-Stimulated RAW 264.7 Cells by Inhibiting NF-ΚB Signaling Pathway, Inflammation, 41, 835, 10.1007/s10753-018-0737-3 Lim, 2018, The Anti-Neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-ΚB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice with Lipopolysaccharide, Front. Pharmacol., 9, 1, 10.3389/fphar.2018.00462 Liperoti, 2017, Herbal Medications in Cardiovascular Medicine, J. Am. Coll. Cardiol., 69, 1188, 10.1016/j.jacc.2016.11.078 Maione, 2016, Medicinal Plants with Anti-Inflammatory Activities, Nat. Prod. Res., 6419, 1 Malik, 2019, An Ethnobotanical Study of Medicinal Plants Used to Treat Skin Diseases in Northern Pakistan, BMC Complement. Altern. Med., 19, 1, 10.1186/s12906-019-2605-6 Marliyah, 2015, In Vitro Anti-Inflammatory Activity of Seed Extract of Zea Mays (L.), J. Glob. Biosci., 4, 2168 Mbendana, 2019, Practices at Herbal (Muthi) Markets in Gauteng, South Africa and Their Impact on the Health of the Consumers: A Case Study of KwaMai-Mai and Marabastad Muthi Markets, South African J. Bot., 126, 30, 10.1016/j.sajb.2019.05.004 Meng, 2021, Anti-Inflammatory Action and Mechanisms of Resveratrol, Molecules, 26, 1, 10.3390/molecules26010229 Miguel, 2010, Antioxidant and Anti-Inflammatory Activities of Essential Oils, Molecules, 15, 9252, 10.3390/molecules15129252 Montes-Garcia, 2021, Chemical Sensing with Au and Ag Nanoparticles, Chem. Soc. Rev., 50, 1269, 10.1039/D0CS01112F Muniyappan, 2021, Green Synthesis of Gold Nanoparticles Using Curcuma pseudomontana Isolated Curcumin: Its Characterization, Antimicrobial, Antioxidant and Anti- Inflammatory Activities, Environ. Chem. Ecotoxicol., 3, 117, 10.1016/j.enceco.2021.01.002 Murugananthan, 2013, Anti-Arthritic and Anti-Inflammatory Constituents from Medicinal Plants, J. Appl. Pharm. Sci., 3, 161 Mustarichie, 2017, Isolation, Identification, and Characteristic of Essential Oil of Iler (Plectranthus scutellarioides (L.) R.Br) Leaves, J. Pharm. Sci. Res., 9, 2301 Mutuma, 2020, Phytochemical and Anti-Inflammatory Analysis of Prunus Africana Bark Extract, Res. J. Pharmacogn., 7, 31 N’guessan, 2021, Ethanolic Extract of Nymphaea lotus L. (Nymphaeaceae) Leaves Exhibits in Vitro Antioxidant, in Vivo Anti-Inflammatory and Cytotoxic Activities on Jurkat and MCF-7 Cancer Cell Lines, BMC Complement. Med. Ther., 21, 1, 10.1186/s12906-020-03195-w Nava-Ochoa, 2021, Nano-Sized Carriers for Capsaicinoids with Topic Analgesic and Anti-Inflammatory Effects, J. Biotechnol., 333, 77, 10.1016/j.jbiotec.2021.04.009 Naz, 2017, Antimicrobial Activity, Toxicity and Anti-Inflammatory Potential of Methanolic Extracts of Four Ethnomedicinal Plant Species from Punjab, Pakistan. BMC Complement. Altern. Med., 17, 1 Nemudzivhadi, 2014, In Vitro Assessment of Cytotoxicity, Antioxidant, and Anti-Inflammatory Activities of Ricinus communis (Euphorbiaceae) Leaf Extracts, Evidence-Based Complement. Altern. Med., 2014, 1, 10.1155/2014/625961 Netala, 2018, Biogenesis of silver nanoparticles using leaf extract of Indigofera hirsuta L. and their potential biomedical applications (3-in-1 system), Artif. Cells Nanomed. Biotechnol., 46, 1138, 10.1080/21691401.2018.1446967 Nigussie, 2020, Ethiopian Medicinal Plants Used for Their Anti-Inflammatory, Wound Healing or Anti-Infective Activities: Protocol for Systematic Literature Review and Meta-Analysis, BMJ Open Sci., 4, 1 Niu, 2014, The Anti-Inflammatory Effects of Caragana tangutica Ethyl Acetate Extract, J. Ethnopharmacol., 152, 99, 10.1016/j.jep.2013.12.026 Nunes, 2020, Plants as Sources of Anti-Inflammatory Agents, Molecules, 25, 1, 10.3390/molecules25163726 Nworu, 2015, Anti-inflammatory medicinal plants and the molecular mechanisms underlying their activities, Afr J Tradit Complement Altern Med, 12, 52 Oguntibeju, 2018, Medicinal Plants with Anti-Inflammatory Activities from Selected Countries and Regions of Africa, J. Inflamm. Res., 11, 307, 10.2147/JIR.S167789 Okaiyeto, 2021, Plant-Based Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Salvia officinalis: Characterization and Its Antiplasmodial Activity, J. Clust. Sci., 32, 101, 10.1007/s10876-020-01766-y Olaokun, 2017, Phytochemical Screening, Antioxidant, Anti-Inflammatory, and Glucose Utilization Activities of Three South African Plants Used Traditionally to Treat Diseases, Biol. Med., 9, 1, 10.4172/0974-8369.1000412 Osman, 2016, In Vitro Xanthine Oxidase and Albumin Denaturation Inhibition Assay of Barringtonia racemosa L. and Total Phenolic Content Analysis for Potential Anti-Inflammatory Use in Gouty Arthritis, J. Intercult. Ethnopharmacol., 5, 343, 10.5455/jice.20160731025522 Otunola, 2018, Chemical Composition, Antibacterial and in Vitro Anti-Inflammatory Potentials of Essential Oils from Different Plant Parts of Moringa oleifera Lam, Am. J. Biochem. Biotechnol., 14, 210, 10.3844/ajbbsp.2018.210.220 Owolabi, 2018, Phytochemical Analysis, Antioxidant and Anti-Inflammatory Potential of Feretia apodanthera Root Bark Extracts, BMC Complement. Altern. Med., 18, 1, 10.1186/s12906-017-2070-z Parvin, 2015, Evaluation of in Vitro Anti-Inflammatory and Antibacterial Potential of Crescentia cujete Leaves and Stem Bark Pharmacology and Toxicology, BMC Res. Notes, 8, 1, 10.1186/s13104-015-1384-5 Paul, 2021, Aloe Vera Gel Homogenate Shows Anti-Inflammatory Activity through Lysosomal Membrane Stabilization and Downregulation of TNF-α and Cox-2 Gene Expressions in Inflammatory Arthritic animals, Futur. J. Pharm. Sci., 7, 1, 10.1186/s43094-020-00163-6 Paun, 2020, In Vitro Evaluation of Antidiabetic and Anti-Inflammatory Activities of Polyphenolic-Rich Extracts from Anchusa officinalis and Melilotus officinalis, ACS Omega, 5, 13014, 10.1021/acsomega.0c00929 Pendota, 2014, Anti-Inflammatory, Antioxidant and in Silico Studies of Buddleja salviifolia (L). Lam Leaf Constituents, South African J. Bot., 93, 79, 10.1016/j.sajb.2014.03.012 Perera, 2016, In Vitro Anti-Inflammatory and Anti-Oxidant Activities of Sri Lankan Medicinal Plants, Ind. Crops Prod., 94, 610, 10.1016/j.indcrop.2016.09.009 Rajakumar, 2018, Green Approach for Synthesis of Zinc Oxide Nanoparticles from Andrographis paniculata Leaf Extract and Evaluation of their Antioxidant, Anti-diabetic, and Anti-inflammatory Activities, Bioprocess Biosys. Eng., 41, 21, 10.1007/s00449-017-1840-9 Ram, 2011, Medicinal Plants Useful for Treating Chronic Obstructive Pulmonary Disease (COPD): Current Status and Future Perspectives, Fitoterapia, 82, 141, 10.1016/j.fitote.2010.09.005 Rauf, 2015, Suppression of Inflammatory Response by Chrysin, a Flavone Isolated from Potentilla evestita Th. Wolf. in Silico Predictive Study on Its Mechanistic Effect, Fitoterapia, 103, 129, 10.1016/j.fitote.2015.03.019 Ribeiro, 2018, Brazilian Medicinal Plants with Corroborated Anti-Inflammatory Activities, Pharm. Biol., 56, 253, 10.1080/13880209.2018.1454480 Roy, 2014, Medicinal Plants Used in Liver Protection, UK J. Pharm. Biosci., 2, 23 Sadalage, 2021, Optimally Biosynthesized, PEGylated Gold Nanoparticles Functionalized with Quercetin and Camptothecin Enhance Potential Anti-Inflammatory, Anti-Cancer and Anti-Angiogenic Activities, J. Nanobiotechnol., 19, 1, 10.1186/s12951-021-00836-1 Saha, 2015, In Silico Binding Affinity to Cyclooxygenase-II and Green Synthesis of Benzylpyrazolyl Coumarin Derivatives, RSC Adv., 5, 100978, 10.1039/C5RA16643H Saki, 2014, The Most Common Native Medicinal Plants Used for Psychiatric and Neurological Disorders in Urmia City, Northwest of Iran, Asian Pac. J. Trop. Dis., 4, 895, 10.1016/S2222-1808(14)60754-4 Saleh, 2021, The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in TLR4/NF-ΚB-Mediated Inflammation, Front. Immunol., 12, 1, 10.3389/fimmu.2021.606069 Sangeetha, 2016, In Vitro Anti-Inflammatory Activity of Different Parts of Pedalium murex (L.), Int. J. Herb. Med., 4, 31 Sangiovanni, 2015, The Effect of in Vitro Gastrointestinal Digestion on the Anti-Inflammatory Activity of Vitis vinifera, Food Funct., 2015, 1 Santana, 2016, Evidences of herbal medicine-derived natural products effects in inflammatory lung diseases, Mediators Inflamm., 2016, 10.1155/2016/2348968 Sarveswaran, 2017, In-vitro assays to investigate the anti-inflammatory activity of herbal Extracts: a review, World J. Pharm. Res., 6, 1 Seiwerth, 2019, Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract, Planta Med., 85, 608, 10.1055/a-0835-6806 Sepahvand, 2014, Chemical Composition, Antioxidant Activity and Antibacterial Effect of Essential Oil of the Aerial Parts of Salvia sclareoides, Asian Pac. J. Trop. Med., 7, 491, 10.1016/S1995-7645(14)60280-7 Shah, 2021, Chitosan Elicitation Impacts Flavonolignan Biosynthesis in Silybum marianum (L.) Gaertn Cell Suspension and Enhances Antioxidant and Anti-Inflammatory Activities of Cell Extracts, Molecules, 26, 1, 10.3390/molecules26040791 Shahrajabian, 2019, Chinese Star Anise and Anise, Magic Herbs in Traditional Chinese Medicine and Modern Pharmaceutical Science, Asian J. Med. Biol. Res., 5, 162, 10.3329/ajmbr.v5i3.43584 Shaito, 2020, Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety, Front. Pharmacol., 11, 1, 10.3389/fphar.2020.00422 Shal, 2018, Anti-Neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer’s Disease, Front. Pharmacol., 9, 1, 10.3389/fphar.2018.00548 Sharma, 2017, Antioxidant Activity of Selected Medicinal Plants of Nepal, Int. J. Med. Biomed. Sci., 2, 1 Sharma, 2021, Insights into the Synthesis and Mechanism of Green Synthesized Antimicrobial Nanoparticles, Answer to the Multidrug Resistance, Mater. Today Chem., 19 Silveira, 2013, A Review on Anti-Inflammatory Activity of Monoterpenes, Molecules, 18, 1227, 10.3390/molecules18011227 Singh, 2018, In Vitro Anti-Inflammatory Activity of Spherical Silver Nanoparticles and Monodisperse Hexagonal Gold Nanoparticles by Fruit Extract of Prunus serrulata: A Green Synthetic Approach, Artif. Cells Nanomed. Biotechnol., 46, 2022 Singh, 2020, Medicinal Plants Used against Various Inflammatory Biomarkers for the Management of Rheumatoid arthritis, J. Pharm. Pharmacol., 72, 1306, 10.1111/jphp.13326 Siriwatanametanon, 2010, Traditionally Used Thai Medicinal Plants. In Vitro Anti-Inflammatory, Anticancer and Antioxidant Activities, J. Ethnopharmacol., 130, 196, 10.1016/j.jep.2010.04.036 Soliman, 2021, Enhancement of Curcumin Anti-Inflammatory Effect via Formulation into Myrrh Oil-Based Nanoemulgel, Polymers, 13, 1, 10.3390/polym13040577 Sumathi, 2016, In Vitro Anti-Inflammatory Acitivty of Flower Extract of Couroupita guianensis Aubl, Innovare J. Ayurvedic. Siences, 4, 4 Suroowan, 2016, A Comparative Ethnopharmacological Analysis of Traditional Medicine Used against Respiratory Tract Diseases in Mauritius, J. Ethnopharmacol., 177, 61, 10.1016/j.jep.2015.11.029 Syed, 2014, Anti-Inflammatory Studies on Acalypha indica L. Leaves by Membrane Stabilization, Indian J. Nat. Prod. Resour., 5, 195 Taleb, 2016, Chemical Characterisation and the Anti-Inflammatory, Anti-Angiogenic and Antibacterial Properties of Date Fruit (Phoenix dactylifera L.), J. Ethnopharmacol., 194, 457, 10.1016/j.jep.2016.10.032 Tasneem, 2019, Molecular Pharmacology of Inflammation: Medicinal Plants as Anti-Inflammatory Agents, Pharmacol. Res., 139, 126, 10.1016/j.phrs.2018.11.001 Thirumalaisamy, 2018, Screening of Anti-Inflammatory Phytocompounds from Crateva adansonii Leaf Extracts and Its Validation by in Silico Modeling, J. Genet. Eng. Biotechnol., 16, 711, 10.1016/j.jgeb.2018.03.004 Tresch, 2019, Medicinal Plants as Therapeutic Options for Topical Treatment in Canine Dermatology, BMC Vet. Res., 15, 1, 10.1186/s12917-019-1854-4 Tyavambiza, 2021, The Antimicrobial and Anti-Inflammatory Effects of Silver Nanoparticles Synthesised from Cotyledon orbiculata Aqueous Extract, Nanomaterials, 11, 1, 10.3390/nano11051343 Utami, 2020, In Silico Anti-Inflammatory Activity Evaluation of Some Bioactive Compound from Ficus religiosa through Molecular Docking Approach, J. Phys. Conf. Ser., 1563, 1, 10.1088/1742-6596/1563/1/012024 Vaou, 2021, Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives, Microorganisms, 9, 2041, 10.3390/microorganisms9102041 Verma, 2019, Applications of Silver Nanoparticles in Diverse Sectors, Int. J. Nano. Dimens., 10, 18 Vilas, 2016, Biosynthesis of Au and Au/Ag Alloy Nanoparticles Using Coleus aromaticus Essential Oil and Evaluation of Their Catalytic, Antibacterial and Antiradical Activities, J. Mol. Liq., 221, 179, 10.1016/j.molliq.2016.05.066 Vogl, 2013, Ethnopharmacological in Vitro Studies on Austria’s Folk Medicine-An Unexplored Lore in Vitro Anti-Inflammatory Activities of 71 Austrian Traditional Herbal Drugs, J. Ethnopharmacol., 149, 750, 10.1016/j.jep.2013.06.007 Wambugu, 2011, Medicinal Plants Used in the Management of Chronic Joint Pains in Machakos and Makueni Counties, Kenya. J. Ethnopharmacol., 137, 945, 10.1016/j.jep.2011.06.038 Wedler, 2014, In Vitro Anti-Inflammatory and Wound-Healing Potential of a Phyllostachys edulis Leaf Extract-Identification of Isoorientin as an Active Compound, Planta Med., 80, 1678, 10.1055/s-0034-1383195 Woo, 2019, Lignans with Melanogenesis Effects from Premna serratifolia Wood, Fitoterapia, 133, 35, 10.1016/j.fitote.2018.12.008 Xia, 2020, Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products, Evidence-Based Complement. Altern. Med., 2020, 1 Xu, 2020, Silver Nanoparticles: Synthesis, Medical Applications and Biosafety, Theranostics, 10, 8996, 10.7150/thno.45413 Yadav, 2018, Ameliorative Effect of Biofabricated ZnO Nanoparticles of Trianthema portulacastrum Linn. on Dermal Wounds via Removal of Oxidative Stress and Inflammation, RSC Adv., 8, 21621, 10.1039/C8RA03500H Yang, 2020, Advances in Pharmacological Activities of Terpenoids, Nat. Prod. Commun., 15, 1 Yang, 2015, Molecular Mechanism of Protopanaxadiol Saponin Fraction-Mediated Anti-Inflammatory Actions, J. Ginseng Res., 39, 61, 10.1016/j.jgr.2014.06.002 Yang, 2019, Sesquiterpenoids and Triterpenoids from Secamone lanceolata Blume with Inhibitory Effects on Nitric Oxide Production, Fitoterapia, 133, 5, 10.1016/j.fitote.2018.11.016 Yasin, 2015, Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy’s Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond, Int. J. Mol. Sci., 16, 30075, 10.3390/ijms161226210 Yesmin, 2020, Membrane Stabilization as a Mechanism of the Anti-Inflammatory Activity of Ethanolic Root Extract of Choi (Piper Chaba), Clin. Phytosci., 6, 1, 10.1186/s40816-020-00207-7 Yu, 2015, Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver, Molecules, 20, 13041, 10.3390/molecules200713041 Zaluski, 2016, Phytochemical Content and Pharma-Nutrition Study on Eleutherococcus senticosus Fruits Intractum, Oxid. Med. Cell. Longev., 2016, 1, 10.1155/2016/9270691 Zammel, 2021, Antioxidant and Anti-Inflammatory Effects of Zingiber officinale Roscoe and Allium subhirsutum. In Silico, Biochemical and Histological Study, Foods, 10, 1, 10.3390/foods10061383 Zhang, 2021, Comparation of the Phytotoxicity between Chemically and Green Synthesized Silver Nanoparticles, Sci. Total Environ., 752, 1, 10.1016/j.scitotenv.2020.142264 Zhang, 2013, Recent Advances in Natural Products from Plants for Treatment of Liver Diseases, Eur. J. Med. Chem., 63, 570, 10.1016/j.ejmech.2012.12.062 Zhang, 2020, Iridoid Glycosides from Morinda officinalis How. Exert Anti-Inflammatory and Anti-Arthritic Effects through Inactivating MAPK and NF-ΚB Signaling Pathways, BMC Complement. Med. Ther., 20, 172, 10.1186/s12906-020-02895-7