Anti-hyperalgesic effects of two sphingosine derivatives in different acute and chronic models of hyperalgesia in mice

Yekkirala, 2017, Breaking barriers to novel analgesic drug development, Nat Rev Drug Discov, 16, 545, 10.1038/nrd.2017.87 Furgeson, 2006, Structural optimization of a smart doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors, J Control Release, 110, 362, 10.1016/j.jconrel.2005.10.006 Mair, 2011, Genetic evidence for involvement of neuronally expressed S1P1 receptor in nociceptor sensitization and inflammatory pain, PLoS One, 6, e17268, 10.1371/journal.pone.0017268 Lucas, 2003, LAAE-14, a new in vitro inhibitor of intracellular calcium mobilization, modulates acute and chronic inflammation, Biochem Pharmacol, 65, 1539, 10.1016/S0006-2952(03)00120-5 Buzzi, 2010, New antinociceptive agents related to dihydrosphingosine, Pharmacol Rep, 62, 849, 10.1016/S1734-1140(10)70344-3 Quintão, 2005, The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice, Anesth Analg, 101, 1763, 10.1213/01.ane.0000184182.03203.61 Santodomingo-Garzón, 2006, Atorvastatin inhibits inflammatory hypernociception, Br J Pharmacol, 149, 14, 10.1038/sj.bjp.0706836 Corrêa, 1993, Evidence for participation of B1 and B2 kinin receptors in formalin – induced nociceptive response in the mouse, Br J Pharmacol, 110, 193, 10.1111/j.1476-5381.1993.tb13791.x Kassuya, 2007, Intraplantar PGE2 causes nociceptive behaviour and mechanical allodynia: the role of prostanoid E receptors and protein kinases, Br J Pharmacol, 150, 727, 10.1038/sj.bjp.0707149 Khasar, 2005, Estrogen regulates adrenal medullary function producing sexual dimorphism in nociceptive threshold and beta – adrenergic receptor – mediated hyperalgesia in the rat, Eur J Neurosci, 21, 3379, 10.1111/j.1460-9568.2005.04158.x de Campos, 1996, Antioedematogenic and antinociceptive actions of NPC 18521, a novel bradykinin B2 receptor antagonist, Eur J Pharmacol, 316, 2, 10.1016/S0014-2999(96)00661-9 Malmberg, 1998, Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates, Pain, 76, 215, 10.1016/S0304-3959(98)00045-1 Alvarez, 2007, Autocrine and paracrine roles of sphingosine-1-phosphate, Trends Endocrinol Metab, 18, 300, 10.1016/j.tem.2007.07.005 Salvemini, 2013, Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain, Trends Pharmacol Sci, 34, 110, 10.1016/j.tips.2012.12.001 Xie, 2012, Knockdown of thesphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion, Neurosci Lett, 515, 61, 10.1016/j.neulet.2012.03.019 Zhang, 2015, Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors, Biol Chem., 396, 783, 10.1515/hsz-2014-0276 Salvemini, 1996, Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation, Br J Pharmacol, 118, 829, 10.1111/j.1476-5381.1996.tb15475.x Morris, 2003, Carrageenan-induced paw edema in the rat and mouse, Methods Mol Biol, 225, 115 Henriques, 1987, Mouse paw edema A new model for inflammation?, Braz J Med Biol Res, 20, 243 Cunha, 2005, A cascade of cytokines mediates mechanical inflammatory hypernociception in mice, Proc Natl Acad Sci USA, 102, 1755, 10.1073/pnas.0409225102 Wirotanseng, 2013, Gq rather than G11 preferentially mediates nociceptor sensitization, Mol Pain, 9, 54, 10.1186/1744-8069-9-54 Hall, 1988, Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C, J Biol Chem, 263, 4460, 10.1016/S0021-9258(18)68948-3 Kollmann, 2012, Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly, Immunity, 37, 771, 10.1016/j.immuni.2012.10.014 Prado, 2002, Mechanisms regulating the expression, self – maintenance, and signaling – function of the bradykinin B2 and B1 receptors, J Cell Physiol, 193, 275, 10.1002/jcp.10175 Smith, 2000, Prostaglandin E2 – induced sensitization of bradykinin – evoked response in rat dorsal root ganglion neurons is mediated by cAMP – dependent protein kinase A, Eur J Neurosci, 12, 3250, 10.1046/j.1460-9568.2000.00218.x Kohno, 2008, Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity, J Neurosci, 28, 4533, 10.1523/JNEUROSCI.5349-07.2008 Cunha, 2007, TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor, Eur J Pharmacol, 573, 221, 10.1016/j.ejphar.2007.07.007 Wang, 2011, GRK2 in sensory neurons regulates epinephrine – induced signaling and duration of mechanical hyperalgesia, Pain, 152, 1649, 10.1016/j.pain.2011.03.010 Samad, 2001, Interleukin-1_-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity, Nature, 410, 471, 10.1038/35068566 Kitano, 2006, Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression, Arthritis Rheum, 54, 742, 10.1002/art.21668 Lai, 2008, Antiinflammatory effects of sphingosine kinase modulation in inflammatory arthritis, J Immunol, 181, 8010, 10.4049/jimmunol.181.11.8010 Smolen, 2007, New therapies for treatment of rheumatoid arthritis, Lancet, 370, 1861, 10.1016/S0140-6736(07)60784-3 Coste, 2008, Antinociceptive activity of the S1P-receptor agonist FTY720, J Cell Mol Med, 12, 995, 10.1111/j.1582-4934.2008.00160.x Salvemini, D. Saint Louis University Methods of treating pain, US/2012/0039866A1. Coyle, 1995, Female rats are more susceptible to the development of neuropathic pain using the partial sciatic nerve ligation (PSNL) model, Neurosci Lett, 186, 135, 10.1016/0304-3940(95)11304-F Mendell, 2003, Clinical practice: painful sensory neuropathy, N Engl J Med, 348, 1243, 10.1056/NEJMcp022282 Sommer, 2004, Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia, Neurosci Lett, 361, 184, 10.1016/j.neulet.2003.12.007