Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial
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Coleman, 2013, Latest research and treatment of advanced-stage epithelial ovarian cancer, Nat Rev Clin Oncol, 10, 211, 10.1038/nrclinonc.2013.5
Burger, 2007, Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study, J Clin Oncol, 25, 5165, 10.1200/JCO.2007.11.5345
Cannistra, 2007, Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer, J Clin Oncol, 25, 5180, 10.1200/JCO.2007.12.0782
Kaye, 2007, Bevacizumab for the treatment of epithelial ovarian cancer: will this be its finest hour?, J Clin Oncol, 25, 5150, 10.1200/JCO.2007.13.6150
Du Bois, 2013, AGO-OVAR 12: A randomized placebo-controlled GCIG/ENGOT-intergroup phase III trial of standard frontline chemotherapy +/- nintedanib for advanced ovarian cancer [abstract], Int J Gyn Cancer, 23, PL01
Burger, 2011, Incorporation of bevacizumab in the primary treatment of ovarian cancer, N Engl J Med, 365, 2473, 10.1056/NEJMoa1104390
Perren, 2011, A phase 3 trial of bevacizumab in ovarian cancer, N Engl J Med, 365, 2484, 10.1056/NEJMoa1103799
Du Bois, 2013, Proc Am Soc J Clin Oncol, 31
Stockler, 2014, Patient-reported outcome results from the open-label phase III AURELIA trial evaluating bevacizumab-containing therapy for platinum-resistant ovarian cancer, J Clin Oncol, 32, 1309, 10.1200/JCO.2013.51.4240
Aghajanian, 2012, OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer, J Clin Oncol, 30, 2039, 10.1200/JCO.2012.42.0505
Ledermann, 2013, Randomised double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum sensitive ovarian cancer: results of the ICON6 trial, Eur J Cancer, 49
Coxon, 2010, Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody, Mol Cancer Ther, 9, 2641, 10.1158/1535-7163.MCT-10-0213
Herbst, 2009, Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors, J Clin Oncol, 27, 3557, 10.1200/JCO.2008.19.6683
Karlan, 2012, Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer, J Clin Oncol, 30, 362, 10.1200/JCO.2010.34.3178
Monk, 2013, Incidence and management of edema associated with trebananib (AMG 386), Gynecol Oncol, 130, 636, 10.1016/j.ygyno.2013.05.023
Baird, 2010, Weekly paclitaxel in the treatment of recurrent ovarian cancer, Nat Rev Clin Oncol, 7, 575, 10.1038/nrclinonc.2010.120
Eisenhauer, 2009, New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1), Eur J Cancer, 45, 228, 10.1016/j.ejca.2008.10.026
Basen-Engquist, 2001, Reliability and validity of the functional assessment of cancer therapy-ovarian, J Clin Oncol, 19, 1809, 10.1200/JCO.2001.19.6.1809
Rustin, 2011, Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG), Int J Gynecol Cancer, 21, 419, 10.1097/IGC.0b013e3182070f17
Collett, 2003
Lin, 1993, Checking the Cox model with cumulative sums of Martingale-based residuals, Biometrika, 80, 557, 10.1093/biomet/80.3.557
Herzog, 2014, Ovarian cancer clinical trial endpoints: Society of Gynecologic Oncology white paper, Gynecol Oncol, 132, 8, 10.1016/j.ygyno.2013.11.008
Pfisterer, 2006, Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: an intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG, J Clin Oncol, 24, 4699, 10.1200/JCO.2006.06.0913
Monk, 2010, Trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer, J Clin Oncol, 28, 3107, 10.1200/JCO.2009.25.4037
Broglio, 2009, Detecting an overall survival benefit that is derived from progression-free survival, J Natl Cancer Inst, 101, 1642, 10.1093/jnci/djp369
Eskens, 2006, The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review, Eur J Cancer, 42, 3127, 10.1016/j.ejca.2006.09.015
Colombo, 2013, Optimizing treatment of the partially platinum-sensitive ovarian cancer patient, Future Oncol, 9, 19, 10.2217/fon.13.206
Peeters, 2013, A randomised, double-blind, placebo-controlled phase 2 study of trebananib (AMG 386) in combination with FOLFIRI in patients with previously treated metastatic colorectal carcinoma, Br J Cancer, 108, 503, 10.1038/bjc.2012.594
Eatock, 2011, Randomized, double-blind, placebo-controlled phase II study of AMG 386 in combination with cisplatin and capecitabine (CX) in patients (pts) with metastatic gastroesophageal adenocarcinoma, Proc Am Soc Clin Oncol, 29