Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: a double-blind, randomised, placebo-controlled trial

Lancet Diabetes and Endocrinology,The - Tập 2 - Trang 944-953 - 2014
Katsuyuki Ando1, Hiroshi Ohtsu2, Shunya Uchida3, Shinya Kaname4, Yoshihiro Arakawa1, Toshiro Fujita1
1The University of Tokyo, Tokyo, Japan
2Juntendo University, Tokyo, Japan
3Teikyo University, Tokyo, Japan
4Kyorin University, Tokyo, Japan

Tài liệu tham khảo

Ihle, 1996, Angiotensin-converting enzyme inhibition in nondiabetic progressive renal insufficiency: a controlled double-blind trial, Am J Kidney Dis, 27, 489, 10.1016/S0272-6386(96)90158-4 1997, Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy, Lancet, 349, 1857, 10.1016/S0140-6736(96)11445-8 Ruggenenti, 1998, Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial, Lancet, 352, 1252, 10.1016/S0140-6736(98)04433-X Lewis, 1993, The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy, N Engl J Med, 329, 1456, 10.1056/NEJM199311113292004 de Zeeuw, 2004, Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL, Kidney Int, 65, 2309, 10.1111/j.1523-1755.2004.00653.x Nagase, 2006, Enhanced aldosterone signalingin the early nephropathy of rats with metabolic syndrome: possible contribution of fat derived factors, J Am Soc Nephrol, 17, 3438, 10.1681/ASN.2006080944 Nagase, 2006, Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker, Hypertension, 47, 1084, 10.1161/01.HYP.0000222003.28517.99 White, 2003, Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension, Hypertension, 41, 1021, 10.1161/01.HYP.0000067463.13172.EA Williams, 2004, Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension, Am J Cardiol, 93, 990, 10.1016/j.amjcard.2004.01.007 Rossing, 2005, Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: a randomized, double-masked, cross-over study, Diabetes Care, 28, 2106, 10.2337/diacare.28.9.2106 Sato, 2003, Effectiveness of aldosterone blockade in patients with diabetic nephropathy, Hypertension, 41, 64, 10.1161/01.HYP.0000044937.95080.E9 Epstein, 2006, Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes, Clin J Am Soc Nephrol, 1, 940, 10.2215/CJN.00240106 Mehdi, 2009, Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy, J Am Soc Nephrol, 20, 2641, 10.1681/ASN.2009070737 Yano, 2011, Efficacy of eplerenone added to renin-angiotensin blockade in elderly hypertensive patients: the Jichi-Eplerenone Treatment (JET) study, J Renin Angiotensin Aldosterone Syst, 12, 340, 10.1177/1470320310390404 Ando, 2010, Hypertens Res, 33, 616, 10.1038/hr.2010.46 Schulz, 2010, CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials, Ann Intern Med, 152, 726, 10.7326/0003-4819-152-11-201006010-00232 Matsuo, 2009, Revised equations for estimated GFR from serum creatinine in Japan, Am J Kidney Dis, 53, 982, 10.1053/j.ajkd.2008.12.034 Kawasaki, 1993, A simple method for estimating 24 h urinary sodium and potassium excretion from second morning voiding urine specimen in adults, Clin Exp Pharmacol Physiol, 20, 7, 10.1111/j.1440-1681.1993.tb01496.x Hollenberg, 2004, Aldosterone in the development and progression of renal injury, Kidney Int, 66, 1, 10.1111/j.1523-1755.2004.00701.x McCarron, 2013, Normal range of human dietary sodium intake: a perspective based on 24-hour urinary sodium excretion worldwide, Am J Hypertens, 26, 1218, 10.1093/ajh/hpt139 Jafar, 2001, Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data, Ann Intern Med, 135, 73, 10.7326/0003-4819-135-2-200107170-00007 Levey, 2009, Proteinuria as a surrogate outcome in CKD: report of a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration, Am J Kidney Dis, 54, 205, 10.1053/j.ajkd.2009.04.029 de Zeeuw, 2011, CKD treatment: time to alter the focus to albuminuria?, Adv Chronic Kidney Dis, 18, 222, 10.1053/j.ackd.2011.06.005 Bomback, 2007, The incidence and implications of aldosterone breakthrough, Nat Clin Pract Nephrol, 3, 486, 10.1038/ncpneph0575 Vegter, 2012, Sodium intake, ACE inhibition, and progression to ESRD, J Am Soc Nephrol, 23, 165, 10.1681/ASN.2011040430 Vogt, 2008, Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan, J Am Soc Nephrol, 19, 999, 10.1681/ASN.2007060693 Shibata, 2011, Rac1 GTPase in rodent kidneys is essential or salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway, J Clin Invest, 121, 3233, 10.1172/JCI43124 Shibata, 2008, Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease, Nat Med, 14, 1370, 10.1038/nm.1879 Fu, 2012, Aldosterone blunts tubuloglomerular feedback by activating macula densa mineralocorticoid receptors, Hypertension, 59, 599, 10.1161/HYPERTENSIONAHA.111.173195 Epstein, 2009, Hyperkalemia as a constraint to therapy with combination renin-angiotensin system blockade: the elephant in the room, J Clin Hypertens, 11, 55, 10.1111/j.1751-7176.2008.00071.x Shavit, 2012, Aldosterone blockade and the mineralocorticoid receptor in the management of chronic kidney disease: current concepts and emerging treatment paradigms, Kidney Int, 81, 955, 10.1038/ki.2011.505 Fried, 2013, Combined angiotensin inhibition for the treatment of diabetic nephropathy, N Engl J Med, 369, 1892, 10.1056/NEJMoa1303154 Gaede, 2008, Effect of a multifactorial intervention on mortality in type 2 diabetes, N Engl J Med, 358, 580, 10.1056/NEJMoa0706245 Rossing, 2005, Enhanced renoprotective effects of ultra-high doses of irbesartan in patients with type 2 diabetes and microalbuminuria, Kidney Int, 68, 1190, 10.1111/j.1523-1755.2005.00511.x Mente, 2014, Validation and comparison of three formulae to estimate sodium and potassium excretion from a single morning fasting urine compared to 24-h measures in 11 countries, J Hypertens, 32, 1005, 10.1097/HJH.0000000000000122