Anti-Scl-70 (topo-I) antibodies in SLE: Myth or reality?

von Mühlen, 1995, Autoantibodies in the diagnosis of systemic rheumatic diseases, Semin Arthritis Rheum, 24, 323, 10.1016/S0049-0172(95)80004-2 Ho, 2003, The clinical relevance of autoantibodies in scleroderma, Arthritis Res Ther, 5, 80 Mahler, 2007, Novel aspects of autoantibodies to the PM/Scl complex: Clinical, genetic and diagnostic insights, Autoimmun Rev, 6, 432, 10.1016/j.autrev.2007.01.013 Schulte-Pelkum, 2007, Latest update on the Ro/SS-A autoantibody system, Autoimmun Rev, 8, 632, 10.1016/j.autrev.2009.02.010 Walker, 2007, Update on autoantibodies in systemic sclerosis, Curr Opin Rheumatol, 19, 580, 10.1097/BOR.0b013e3282e7d8f9 Hudson, 2010, Systemic sclerosis: establishing diagnostic criteria, Medicine, 89, 159, 10.1097/MD.0b013e3181dde28d Sherer, 2004, Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients, Semin Arthritis Rheum, 34, 501, 10.1016/j.semarthrit.2004.07.002 Sharp, 1999, Overlap syndromes: mixed connective tissue disease and Sjögren's syndrome, 551 Czömpöly, 2009, Anti-topoisomerase I autoantibodies in systemic sclerosis, Autoimmun Rev, 8, 692, 10.1016/j.autrev.2009.02.018 Stinton, 2007, A clinical approach to autoantibody testing in systemic autoimmune rheumatic disorders, Autoimmun Rev, 7, 77, 10.1016/j.autrev.2007.08.003 Ghirardello, 2009, Commercial blot assays in the diagnosis of systemic rheumatic diseases, Autoimmun Rev, 8, 645, 10.1016/j.autrev.2009.02.012 Fritzler, 2006, The emergence of multiplexed technologies as diagnostic platforms in systemic autoimmune diseases, Curr Med Chem, 13, 2503, 10.2174/092986706778201639 Chan, 2007, AutoAbSC. Org—Autoantibody Standardization Committee in 2006, Autoimmun Rev, 6, 577, 10.1016/j.autrev.2007.05.001 Dellavance, 2009, Redefining the Scl-70 indirect immunofluorescence pattern: Autoantibodies to DNA topoisomerase I yield a specific compound immunofluorescence pattern, Rheumatology, 48, 632, 10.1093/rheumatology/kep070 Stojanov, 1995, Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma, Lupus, 4, 314, 10.1177/096120339500400414 Kameda, 1997, Coexistence of serum anti-DNA topoisomerase I and anti-Sm antibodies: Report of 3 cases, J Rheumatol, 24, 400 Koenig, 2008, Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis, Arthritis Rheum, 58, 3902, 10.1002/art.24038 Dick, 2002, Coexistence of antitopoisomerase I and anticentromere antibodies in patients with systemic sclerosis, Ann Rheum Dis, 61, 121, 10.1136/ard.61.2.121 Gussin, 2001, Anti-topoisomerase I (anti-Scl-70) antibodies in patients with systemic lupus erythematosus, Arthritis Rheum, 44, 376, 10.1002/1529-0131(200102)44:2<376::AID-ANR56>3.0.CO;2-2 Mahler, 2007, Challenges and controversies in autoantibodies associated with systemic rheumatic diseases, Curr Rheumatol Rev, 3, 67, 10.2174/157339707779815722 Mahler, 2005, Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen, Arthritis Res Ther, 7, R704, 10.1186/ar1729 Tan, 1982, The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, 25, 1271, 10.1002/art.1780251101 Radice, 2006, A new oligonucleotide-based ELISA for the detection of anti-double-stranded DNA antibodies, Autoimmunity, 39, 113, 10.1080/08916930500448422 Hoffman, 2004, Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus, Ann Rheum Dis, 63, 1155, 10.1136/ard.2003.013417 Eissfeller, 2005, Comparison of different test systems for simultaneous autoantibody detection in connective tissue diseases, Ann NY Acad Sci, 1050, 327, 10.1196/annals.1313.035 Fritzler, 2006, Analysis of human sera that are polyreactive in an addressable laser bead immunoassay, Clin Immunol, 120, 349, 10.1016/j.clim.2006.03.007 Shovman, 2005, Multiplexed AtheNA multi-lyte immunoassay for ANA screening in autoimmune diseases, Autoimmunity, 38, 105, 10.1080/08916930400022707 Zandman-Goddard, 2005, The homogeneous multiplexed system—a new method for autoantibody profile in systemic lupus erythematosus, Clin Dev Immunol, 12, 107, 10.1080/17402520500116723 Hanly, 2010, Measurement of autoantibodies using multiplex methodology in patients with systemic lupus erythematosus, J Immunol Meth, 352, 147, 10.1016/j.jim.2009.10.003 Hanly, 2010, Comparison between multiplex assays for autoantibody detection in systemic lupus erythematosus, J Immunol Meth, 358, 75, 10.1016/j.jim.2010.04.005 Tang, 2010, Clinical and serologic correlations and autoantibody clusters in systemic lupus erythematosus: a retrospective review of 917 patients in South China, Medicine, 89, 62, 10.1097/MD.0b013e3181cb449c Mahler, 2004, Technical and clinical evaluation of anti-ribosomal P protein immunoassays, J Clin Lab Anal, 18, 215, 10.1002/jcla.20026 Reveille, 2004, Predictive value of autoantibodies for activity of systemic lupus erythematosus, Lupus, 13, 290, 10.1191/0961203303lu1015oa Prestigiacomo T, Watkins M, Binder SR. Anti-topoisomerase I (anti-Scl70) autoantibodies are specific to scleroderma and are not present in patients with SLE. In from animal models to human genetics: Research on the induction and pathogenity of autoantibodies. Eds. Conrad K., Bachmann M.P., Chan E.K.L., Fritzler M.J., Humbel, Sack U., Shoenfeld Y. Page 365-8. Hanke, 2009, Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort, Arthritis Res Ther, 11, R28, 10.1186/ar2622 Biagini, 2007, Analytical performance of the AtheNA MultiLyte ANA II assay in sera from lupus patients with multiple positive ANAs, Anal Bioanal Chem, 388, 613, 10.1007/s00216-007-1243-x Martins, 2004, Evaluation of multiplexed fluorescent microsphere immunoassay for detection of autoantibodies to nuclear antigens, Clin Diagn Lab Immunol, 11, 1054, 10.1128/CDLI.11.6.1054-1059.2004 Hénault, 2004, Direct binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis, Arthritis Rheum, 50, 3265, 10.1002/art.20515 Hénault, 2006, DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti-topoisomerase I autoantibodies from systemic sclerosis patients, Arthritis Rheum, 54, 963, 10.1002/art.21646 Simon, 2009, Naturally occurring and disease-associated auto-antibodies against topoisomerase I: a fine epitope mapping study in systemic sclerosis and systemic lupus erythematosus, Int Immunol, 21, 415, 10.1093/intimm/dxp008 Kessenbrock, 2007, Synthetic peptides: the future of patient management in systemic rheumatic diseases?, Curr Med Chem, 14, 2831, 10.2174/092986707782360150