Anti‐HTLV III ELISA and Western Blot Testing in a Blood Donor Population: Implications for Donor Notification

Vox Sanguinis - Tập 51 Số 2 - Trang 143-147 - 1986
Steven Kleinman1, Hoda Anton‐Guirgis2, B. Dwight Culver2, Thomas H. Taylor2, Harry E. Prince1, Harold S. Kaplan3
1American Red Cross Blood Services, Los Angeles‐Orange Counties Region, Los Angeles, Calif.
2University of California, Irvine, Calif.
3New York University Medical Center, New York, N. Y. USA

Tóm tắt

Abstract. We have evaluated the western blot (WB) test for distinguishing anti‐HTLV III ELISA‐positive donors who have likely been exposed to HTLV III from those that are false positives. Of 1,955 donors, 26 were positive for anti‐HTLV III by ELISA testing. Only 6 (23%) were positive by WB: 5 of these 6 were male homosexuals with multiple partners and 5 of 6 had low Th/Ts ratios. The WB‐positive donors gave the highest absorbance values in the anti‐HTLV III ELISA assay. The immunologic abnormalities in the WB‐positive donors suggest that they should be notified of their test results. We conclude that basing a donor notification policy on WB results is the optimum public health strategy for blood banks at the present time.

Từ khóa


Tài liệu tham khảo

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Vox Sanguinis

Tập 51 Số 2

143-147

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