Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial

Lancet Respiratory Medicine,The - Tập 10 - Trang 1137-1146 - 2022
Alexander P J Vlaar1, Martin Witzenrath2, Pieter van Paassen3, Leo M A Heunks1, Bruno Mourvillier4, Sanne de Bruin1, Endry H T Lim1, Matthijs C Brouwer5, Pieter R Tuinman1, José F K Saraiva6, Gernot Marx7, Suzana M Lobo8, Rodrigo Boldo9, Jesus A Simon-Campos10, Alexander D Cornet11, Anastasia Grebenyuk12, Johannes M Engelbrecht13, Murimisi Mukansi14, Philippe G Jorens15, Robert Zerbib16
1Department of Intensive Care, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, Netherlands
2Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, German Center for Lung Research, Berlin, Germany
3Department of Immunology, Maastricht UMC+, Maastricht, Netherlands
4Medical Intensive Care Unit, University Hospital of Reims, Reims, France
5Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, Netherlands
6Instituto de Pesquisa Clínica de Campinas, Sao Paulo, Brazil
7Uniklinik RWTH Aachen, Klinik für Operative Intensivmedizin und Intermediate Care, Aachen, Germany
8Hospital de Base, São José Do Rio Preto, Brazil
9Associação Educadora São Carlos, Hospital Mãe de Deus, Centro de Pesquisa, Porto Alegre, Brazil
10General Hospital Agustin O'Horán, Köhler and Milstein Research, Mérida, Mexico
11Medisch Spectrum Twente, Enschede, Netherlands
12MUZ City Clinical Hospital 5, Barnaul, Russia
13Vergelegen Mediclinic, Cape Town, South Africa
14Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa
15Antwerp University Hospital, Edegem, Belgium
16InflaRx, Jena, Germany

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Lancet Respiratory Medicine,The

Tập 10

1137-1146

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