Animal board invited review: The contribution of adipose stores to milk fat: implications on optimal nutritional strategies to increase milk fat synthesis in dairy cows

Albornoz, 2019, Diet starch concentration and starch fermentability affect markers of inflammatory response and oxidant status in dairy cows during the early postpartum period, Journal of Dairy Science, 103, 1 AlZahal, 2008, Effects of monensin and dietary soybean oil on milk fat percentage and milk fatty acid profile in lactating dairy cows, Journal of Dairy Science, 91, 1166, 10.3168/jds.2007-0232 Annison, 1974, Glucose and fatty acid metabolism in cows producing milk of low fat content, The Journal of Agricultural Science, 82, 87, 10.1017/S0021859600050255 Auldist, 2000, Contribution of nutrition to seasonal variation of milk composition in New Zealand Friesian and US Holstein dairy cows, Asian Australasian Journal of Animal Sciences, 13, 513 Bailey, 2005, Economic returns to Holstein and Jersey herds under multiple component pricing, Journal of Dairy Science, 88, 2269, 10.3168/jds.S0022-0302(05)72903-9 Bauman, 2000, Biosynthesis of conjugated linoleic acid in ruminants, Journal of Animal Science, 77, E1, 10.2527/jas2000.77E-Suppl1f Bauman, 1980, Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis, Journal of Dairy Science, 63, 1514, 10.3168/jds.S0022-0302(80)83111-0 Bauman, 2001, Regulation and nutritional manipulation of milk fat: low-fat milk syndrome, Livestock Production Science, 70, 15, 10.1016/S0301-6226(01)00195-6 Bauman, 2008, Regulation of fat synthesis by conjugated linoleic acid: Lactation and the ruminant model, Journal of Nutrition, 138, 403, 10.1093/jn/138.2.403 Bell, 1995, Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation, Journal of Animal Science, 73, 2804, 10.2527/1995.7392804x Bernal-Santos, 2003, Production responses of dairy cows to dietary supplementation with conjugated linoleic acid (CLA) during the transition period and early lactation, Journal of Dairy Science, 86, 3218, 10.3168/jds.S0022-0302(03)73925-3 Block, 2001, Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance, Journal of Endocrinology, 171, 339, 10.1677/joe.0.1710339 Body, 1988, The lipid composition of adipose tissue, Progress in Lipid Research, 27, 39, 10.1016/0163-7827(88)90004-5 Boerman, 2015, Effects of partly replacing dietary starch with fiber and fat on milk production and energy partitioning, Journal of Dairy Science, 98, 7264, 10.3168/jds.2015-9467 Bradford, 2006, Propionate challenge tests have limited value for investigating bovine metabolism, Journal of Nutrition, 136, 1915, 10.1093/jn/136.7.1915 Bradford, 2009, Daily injection of tumor necrosis factor-{alpha} increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle, Journal of Nutrition, 139, 1451, 10.3945/jn.109.108233 Busato, 2002, Body condition scores in dairy cows: associations with metabolic and endocrine changes in healthy dairy cows, Journal of Veterinary Medicine Series, 49, 455, 10.1046/j.1439-0442.2002.00476.x Chirivi, 2022, Lipopolysaccharide induces lipolysis and insulin resistance in adipose tissue from dairy cows, Journal of Dairy Science, 105, 842, 10.3168/jds.2021-20855 Chouinard, 1999, Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows, Journal of Nutrition, 129, 1579, 10.1093/jn/129.8.1579 Contreras, 2017, Adipose tissue lipolysis and remodeling during the transition period of dairy cows, Journal of Animal Science and Biotechnology, 8, 41, 10.1186/s40104-017-0174-4 Contreras, 2018, Symposium review: Modulating adipose tissue lipolysis and remodeling to improve immune function during the transition period and early lactation of dairy cows, Journal of Dairy Science, 101, 2737, 10.3168/jds.2017-13340 Corl, 2006, Short Communication: Regulation of milk fat yield and fatty acid composition by insulin, Journal of Dairy Science, 89, 4172, 10.3168/jds.S0022-0302(06)72462-6 Dalmas, 2019, Innate immune priming of insulin secretion, Current Opinion in Immunology, 56, 44, 10.1016/j.coi.2018.10.005 Davis, 1970, Low-fat milk syndrome, 545 De Koster, 2015, Insulin response of the glucose and fatty acid metabolism in dry dairy cows across a range of body condition scores, Journal of Dairy Science, 98, 4580, 10.3168/jds.2015-9341 De Koster, 2013, Insulin resistance in dairy cows, Veterinary Clinical North America Food Animal Practice, 29, 299, 10.1016/j.cvfa.2013.04.002 De Koster, 2018, Short communication: Effects of body fat mobilization on macrophage infiltration in adipose tissue of early lactation dairy cows, Journal of Dairy Science, 101, 7608, 10.3168/jds.2017-14318 Depreester, 2018, Influence of adipocyte size and adipose depot on the number of adipose tissue macrophages and the expression of adipokines in dairy cows at the end of pregnancy, Journal of Dairy Science, 101, 6542, 10.3168/jds.2017-13777 Duffield, 2008, A Meta-Analysis of the Impact of Monensin in Lactating Dairy Cattle. Part 1. Metabolic Effects, Journal of Dairy Science, 91, 1334, 10.3168/jds.2007-0607 Duffield, 2012, Overview of meta-analysis of monensin in dairy cattle, Veterinary Clinics: Food Animal Practice, 28, 107 Duhem, 1991 Eknæs, 2006, Changes in body reserves and milk quality throughout lactation in dairy goats, Small Ruminant Research, 63, 1, 10.1016/j.smallrumres.2004.11.016 Emmanuel, 2007, Acidosis and lipopolysaccharide from Escherichia coli B:055 cause hyper-permeability of rumen and colon tissues, Journal of Dairy Science, 90, 5552, 10.3168/jds.2007-0257 Enjalbert, 1998, Duodenal infusions of palmitic, stearic or oleic acids differently affect mammary gland metabolism of fatty acids in lactating dairy cows, Journal of Nutrition, 128, 1525, 10.1093/jn/128.9.1525 Etherton, 1998, Biology of somatotropin in growth and lactation of domestic animals, Physiology Review, 78, 745, 10.1152/physrev.1998.78.3.745 Fellner, 1997, Effect of nigericin, monensin, and tetronasin on biohydrogenation in continuous flow-through ruminal fermenters, Journal of Dairy Science, 80, 921, 10.3168/jds.S0022-0302(97)76015-6 Fenelon, 1999, The effect of milk fat on Cheddar cheese yield and its prediction, using modifications of the Van Slyke cheese yield formula, Journal of Dairy Science, 82, 2287, 10.3168/jds.S0022-0302(99)75477-9 Ganeshan, 2014, Metabolic regulation of immune responses, Annual Review of Immunology, 32, 609, 10.1146/annurev-immunol-032713-120236 Garcia, 2017, Invited Review: Ruminal microbes, microbial products, and systemic inflammation, The Professional Animal Scientist, 33, 635, 10.15232/pas.2017-01663 Glascock, 1983, Partition of circulating triglycerides between formation of milk fat and other metabolic pathways in sheep, Journal of Agriculture Science Cambridge, 101, 33, 10.1017/S0021859600036339 Griinari, 1997, The role of insulin in the regulation of milk protein synthesis in dairy cows, Journal of Dairy Science, 80, 2361, 10.3168/jds.S0022-0302(97)76187-3 Guo, 2013, Changes in feed intake, nutrient digestion, plasma metabolites, and oxidative stress parameters in dairy cows with subacute ruminal acidosis and its regulation with pelleted beet pulp, Journal of Animal Science and Biotechnology, 4, 1, 10.1186/2049-1891-4-31 Hartmann, 1964, The uptake of plasma lipid and some non-lipid constituents by the mammary gland of the cow, Australian Journal of Biological Sciences, 17, 935, 10.1071/BI9640935 Harvatine, 2006, SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA, Journal of Nutrition, 136, 2468, 10.1093/jn/136.10.2468 Harvatine, 2009, Expression of enzymes and key regulators of lipid synthesis is upregulated in adipose tissue during CLA-induced milk fat depression in dairy cows, Journal of Nutrition, 139, 849, 10.3945/jn.108.099994 He, 2012, Effect of dietary fat blend enriched in oleic or linoleic acid and monensin supplementation on dairy cattle performance, milk fatty acid profiles, and milk fat depression, Journal of Dairy Science, 95, 1447, 10.3168/jds.2011-4635 Heck, 2009, Seasonal variation in the Dutch bovine raw milk composition, Journal of Dairy Science, 92, 4745, 10.3168/jds.2009-2146 Henno, 2021, Effect of monensin on milk fatty acid profile in dairy cows and on the use of fatty acids for early diagnosis of elevated blood plasma concentrations of non-esterified fatty acids and hyperketonemia, Journal of Dairy Science, 104, 10355, 10.3168/jds.2020-20041 Herdt, 1988, Fuel homeostasis in the ruminant, Veterinary Clinics of North America: Food Animal Practice, 4, 213 Hoeben, 2000, Role of endotoxin and TNF-α in the pathogenesis of experimentally induced coliform mastitis in periparturient cows, Journal of Dairy Research, 67, 503, 10.1017/S0022029900004489 Holtenius, 2003, Effects of feeding intensity during the dry period. 2. Metabolic and hormonal responses, Journal of Dairy Science, 86, 883, 10.3168/jds.S0022-0302(03)73671-6 Hou, 2021, Comparing responses of dairy cows to short-term and long-term heat stress in climate-controlled chambers, Journal of Dairy Science, 104, 2346, 10.3168/jds.2020-18946 Ipharraguerre, 2003, Usefulness of ionophores for lactating dairy cows: A review, Animal Feed Science and Technology, 106, 39, 10.1016/S0377-8401(03)00065-8 Jenkins, 2008, Board-invited review: Recent advances in biohydrogenation of unsaturated fatty acids within the rumen microbial ecosystem, Journal of Animal Science, 86, 397, 10.2527/jas.2007-0588 Jensen, 2000, Invited review: The composition of bovine milk lipids: January 1995 to December 2000, Journal of Dairy Science, 85, 295, 10.3168/jds.S0022-0302(02)74079-4 Jensen, 1994, Regulation of lipoprotein lipase activity and mRNA in the mammary gland of the lactating mouse, Biochemical Journal, 298, 321, 10.1042/bj2980321 Jensen, 2007, Insulin dose response analysis of free fatty acid kinetics, Metabolism, 56, 68, 10.1016/j.metabol.2006.08.022 Jocken, 2008, Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity, Physiology & Behavior, 94, 219, 10.1016/j.physbeh.2008.01.002 Kaneko, 2019, The role of interleukin-1 in general pathology, Inflammation and Regeneration, 39, 12, 10.1186/s41232-019-0101-5 Khafipour, 2009, Alfalfa pellet-induced subacute ruminal acidosis in dairy cows increases bacterial endotoxin in the rumen without causing inflammation, Journal of Dairy Science, 92, 1712, 10.3168/jds.2008-1656 Khiaosa-Ard, 2018, Diet-induced inflammation: From gut to metabolic organs and the consequences for the health and longevity of ruminants, Research in Veterinary Science, 120, 17, 10.1016/j.rvsc.2018.08.005 Kittivachra, 2007, Factors affecting lactose quantity in raw milk, Songklanakarin Journal of Science Technology, 29, 937 Knapp, 1991, Response of lactating dairy cows to fat supplementation during heat stress, Journal of Dairy Science, 74, 2573, 10.3168/jds.S0022-0302(91)78435-X Kushibiki, 2003, Metabolic and lactational responses during recombinant bovine tumor necrosis factor-alpha treatment in lactating cows, Journal of Dairy Science, 86, 819, 10.3168/jds.S0022-0302(03)73664-9 Kvidera, 2017, Glucose requirements of an activated immune system in lactating Holstein cows, Journal of Dairy Science, 100, 2360, 10.3168/jds.2016-12001 Kvidera, 2017, Intentionally induced intestinal barrier dysfunction causes inflammation, affects metabolism, and reduces productivity in lactating Holstein cows, Journal of Dairy Science, 100, 4113, 10.3168/jds.2016-12349 Larsen, 2009, Effect of abomasal glucose infusion on splanchnic and whole-body glucose metabolism in periparturient dairy cows, Journal of Dairy Science, 92, 1071, 10.3168/jds.2008-1453 Lean, 2013, Energy and protein nutrition management of transition dairy cows, Veterinary Clinical North America Food Animal Practice, 29, 337, 10.1016/j.cvfa.2013.03.005 Li, 2021, The lag response of daily milk yield to heat stress in dairy cows, Journal of Dairy Science, 104, 981, 10.3168/jds.2020-18183 Liesman, 1988, Mammary lipoprotein lipase in plasma of cows after parturition or prolactin infusion, Lipids, 23, 504, 10.1007/BF02535528 Lindegaard, 2013, Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin, Diabetologia, 56, 2034, 10.1007/s00125-013-2964-3 Liu, 2016, Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat‐stressed pigs, Experimental Physiology, 101, 801, 10.1113/EP085746 Liu, 2020, Effects of supplementing Holstein cows with soybean oil compared with palmitic acid–enriched triglycerides on milk production and nutrient partitioning, Journal of Dairy Science, 103, 8151, 10.3168/jds.2019-18100 Loor, 1998, Exogenous conjugated linoleic acid isomers reduce bovine milk fat concentration and yield by inhibiting de novo fatty acid synthesis, Journal of Nutrition, 128, 2411, 10.1093/jn/128.12.2411 Mackle, 1999, Effects of insulin and amino acids on Milk protein concentration and yield from dairy cows, Journal of Dairy Science, 82, 1512, 10.3168/jds.S0022-0302(99)75378-6 Magata, 2015, Comparison of bacterial endotoxin lipopolysaccharide concentrations in the blood, ovarian follicular fluid and uterine fluid: a clinical case of bovine metritis, Journal of Veterinary Medical Science, 77, 81, 10.1292/jvms.14-0333 Malau-Aduli, 1997, A comparison of the fatty acid composition of triacylglycerols in adipose tissue from Limousin and Jersey cattle, Australian Journal of Agricultural Research, 48, 715, 10.1071/A96083 Mann, 2022, Symposium review: The role of adipose tissue in transition dairy cows: Current knowledge and future opportunities, Journal of Dairy Science, 105, 3687, 10.3168/jds.2021-21215 Mann, 2015, Dry period plane of energy: Effects on feed intake, energy balance, milk production, and composition in transition dairy cows, Journal of Dairy Science, 98, 3366, 10.3168/jds.2014-9024 Mann, 2016, Short communication: Association of milk fatty acids with early lactation hyperketonemia and elevated concentration of non-esterified fatty acids, Journal of Dairy Science, 99, 5851, 10.3168/jds.2016-10920 Maratou, 2007, Glucose transporter expression on the plasma membrane of resting and activated white blood cells, European Journal of Clinical Investigation, 37, 282, 10.1111/j.1365-2362.2007.01786.x Martel, 2014, Continuous low-dose infusion of tumor necrosis factor alpha in adipose tissue elevates adipose tissue interleukin-10 abundance and fails to alter metabolism in lactating dairy cows, Journal of Dairy Science, 97, 4897, 10.3168/jds.2013-7777 Maxin, 2010, Additive effects of trans-10, cis-12 conjugated linoleic acid and propionic acid on milk fat content and composition in dairy cows, Journal of Dairy Research, 77, 295, 10.1017/S0022029910000233 Maxin, 2011, Response of milk fat concentration and yield to nutrient supply in dairy cows, Animal, 5, 1299, 10.1017/S1751731111000206 Maxin, 2011, Combined effects of trans-10, cis-12 conjugated linoleic acid, propionate, and acetate on milk fat yield and composition in dairy cows, Journal of Dairy Science, 94, 2051, 10.3168/jds.2010-3844 McCarthy, 2015, Metabolism of early-lactation dairy cows as affected by dietary starch and monensin supplementation, Journal of Dairy Science, 98, 3351, 10.3168/jds.2014-8821 McClymont, 1962, Depression of blood glycerides and milk fat synthesis by glucose infusion, Proceeding Nutrition Society, 21, R41 McFadden, 2019, Invited review: Sphingolipid biology in the dairy cow: The emerging role of ceramide, Journal of Dairy Science, 102, 7619, 10.3168/jds.2018-16095 McGuire, 1995, Role of insulin in the regulation of mammary synthesis of fat and protein, Journal of Dairy Science, 78, 816, 10.3168/jds.S0022-0302(95)76693-0 McNamara, 1991, Regulation of adipose tissue metabolism in support of lactation, Journal of Dairy Science, 74, 706, 10.3168/jds.S0022-0302(91)78217-9 Miller, 1991, Patterns of nutrient uptake by the mammary glands of lactating dairy cows, Journal of Dairy Science, 74, 3791, 10.3168/jds.S0022-0302(91)78571-8 Muccioli, 2010, The endocannabinoid system links gut microbiota to adipogenesis, Molecular Systems Biology, 6, 392, 10.1038/msb.2010.46 Nielsen, 1994, Changes in mammary uptake of free fatty acids, triglyceride, cholesterol and phospholipid in relation to milk synthesis during lactation in goats, Comparative Biochemistry and Physiology Part A: Physiology, 109, 857, 10.1016/0300-9629(94)90233-X Palmquist, 2020, Origin of fatty acids and influence of nutritional factors on milk fat Palmquist, 1978, Turnover of lipoproteins and transfer to milk fat of dietary (1-carbon-14) linoleic acid in lactating cows, Journal of Dairy Science, 61, 561, 10.3168/jds.S0022-0302(78)94410-7 Perfield, 2007, Trans-9, cis-11 conjugated linoleic acid reduces milk fat synthesis in lactating dairy cows, Journal of Dairy Science, 90, 2211, 10.3168/jds.2006-745 Pires, 2019, Undernutrition modified metabolic responses to intramammary lipopolysaccharide but had limited effects on selected inflammation indicators in early-lactation cows, Journal of Dairy Science, 102, 5347, 10.3168/jds.2018-15446 Pires, 2022, Milk metabolites and fatty acids as noninvasive biomarkers of metabolic status and energy balance in early-lactation cows, Journal of Dairy Science, 105, 201, 10.3168/jds.2021-20465 Popper, 2002 Pullen, 1989, Effect on days of lactation and methionine hydroxy Analog on incorporation of plasma fatty acids into plasma triglycerides, Journal of Dairy Science, 72, 49, 10.3168/jds.S0022-0302(89)79079-2 Rhoads, 2009, Effects of heat stress and plane of nutrition on lactating Holstein cows: I. Production, metabolism, and aspects of circulating somatotropin, Journal of Dairy Science, 92, 1986, 10.3168/jds.2008-1641 Rico, 2015, Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation, Journal of Dairy Science, 98, 7757, 10.3168/jds.2015-9519 Rico, 2013, Induction of and recovery from milk fat depression occurs progressively in dairy cows switched between diets that differ in fiber and oil concentration, Journal of Dairy Science, 96, 6621, 10.3168/jds.2013-6820 Rico, 2014, Effect of monensin on recovery from diet-induced milk fat depression, Journal of Dairy Science, 97, 2376, 10.3168/jds.2013-7486 Rico, 2015, Effect of diet fermentability and unsaturated fatty acid concentration on recovery from diet-induced milk fat depression, Journal of Dairy Science, 98, 7930, 10.3168/jds.2014-8990 Rico, 2015, Rapid changes in key ruminal microbial populations during the induction of and recovery from diet-induced milk fat depression in dairy cows, British Journal of Nutrition, 114, 358, 10.1017/S0007114515001865 Rico, 2017, Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation, PLoS ONE, 12, e0176787, 10.1371/journal.pone.0176787 Roche, 2009, Invited review: Body condition score and its association with dairy cow productivity, health, and welfare, Journal of dairy science, 92, 5769, 10.3168/jds.2009-2431 Ruiz González, 2023, Increased dietary vitamin D3 and Ca partially alleviate heat stress symptoms and inflammation in lactating Holstein cows independently of dietary concentrations of vitamin E and Se, Journal of Dairy Science, 10.3168/jds.2022-22345 Rukkwamsuk, 2000, Interrelation of fatty acid composition in adipose tissue, serum, and liver of dairy cows during the development of fatty liver postpartum, Journal of Dairy Science, 83, 52, 10.3168/jds.S0022-0302(00)74854-5 Rulquin, 2007, Effet des nutriments énergétiques sur la production et la teneur en matière grasse du lait de vache, INRA Productions Animales, 20, 163, 10.20870/productions-animales.2007.20.2.3448 Russell, 2003, Ionophore resistance of ruminal bacteria and its potential impact on human health, FEMS Microbiology Reviews, 27, 65, 10.1016/S0168-6445(03)00019-6 Russell, 1989, Effect of ionophores on ruminal fermentation, Applied and Environmental Microbiology, 55, 1, 10.1128/aem.55.1.1-6.1989 Salfer, 2019, Annual rhythms of milk and milk fat and protein production in dairy cattle in the United States, Journal of Dairy Science, 102, 742, 10.3168/jds.2018-15040 Sandri, 2020, Transient reductions in milk fat synthesis and their association with the ruminal and metabolic profile in dairy cows fed high-starch, low-fat diets, Animal, 14, 2523, 10.1017/S1751731120001585 Schären, 2017, Differential effects of monensin and a blend of essential oils on rumen microbiota composition of transition dairy cows, Journal of Dairy Science, 100, 2765, 10.3168/jds.2016-11994 Shingfield, 2007, Role of biohydrogenation intermediates in milk fat depression, European Journal of Lipid Science and Technology, 109, 799, 10.1002/ejlt.200700026 Suojala, 2013, Treatment for bovine Escherichia coli mastitis–an evidence-based approach, Journal of Veterinary Pharmacology and Therapeutics, 36, 521, 10.1111/jvp.12057 Tyznik, 1951, The relation of roughage intake to the fat content of the milk and the level of fatty acids in the rumen, Journal of Dairy Science, 34, 493 Urrutia, 2019, Effect of dietary supplementation of sodium acetate and calcium butyrate on milk fat synthesis in lactating dairy cows, Journal of Dairy Science, 102, 5172, 10.3168/jds.2018-16024 Urrutia, 2017, Effect of conjugated linoleic acid and acetate on milk fat synthesis and adipose lipogenesis in lactating dairy cows, Journal of Dairy Science, 100, 5792, 10.3168/jds.2016-12369 Urrutia, 2017, Acetate dose-dependently stimulates milk fat synthesis in lactating dairy cows, Journal of Nutrition, 147, 763, 10.3945/jn.116.245001 Uyeno, 2010, An rRNA-based analysis for evaluating the effect of heat stress on the rumen microbial composition of Holstein heifers, Anaerobe, 16, 27, 10.1016/j.anaerobe.2009.04.006 Van Knegsel, 2007, Effect of glucogenic vs. lipogenic diets on energy balance, blood metabolites, and reproduction in primiparous and multiparous dairy cows in early lactation, Journal of Dairy Science, 90, 3397, 10.3168/jds.2006-837 Van Soest, 1994 Verdier-Metz, 2001, Relationship between milk fat and protein contents and cheese yield, Animal Research, 50, 365, 10.1051/animres:2001138 Vernay, 2012, Local and systemic response to intramammary lipopolysaccharide challenge during long-term manipulated plasma glucose and insulin concentrations in dairy cows, Journal of Dairy Science, 95, 2540, 10.3168/jds.2011-5188 Verstrepen, 2008, TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme, Cellular and Molecular Life Sciences, 65, 2964, 10.1007/s00018-008-8064-8 Waldron, 2006, Acute experimental mastitis is not causal toward the development of energy-related metabolic disorders in early postpartum dairy cows, Journal of Dairy Science, 89, 596, 10.3168/jds.S0022-0302(06)72123-3 West, 1972, Studies on the mode of uptake of blood triglycerides by the mammary gland of the lactating goat. The uptake and incorporation into milk fat and mammary lymph of labelled glycerol, fatty acids and triglycerides, Biochemical Journal, 126, 477, 10.1042/bj1260477 Wheelock, 2010, Effects of heat stress on energetic metabolism in lactating Holstein cows, Journal of Dairy Science, 93, 644, 10.3168/jds.2009-2295 Yuan, 2013, TNFα altered inflammatory responses, impaired health and productivity, but did not affect glucose or lipid metabolism in early-lactation dairy cows, PLoS ONE, 8, e80316, 10.1371/journal.pone.0080316 Zachut, 2022, Symposium review: Mechanistic insights into adipose tissue inflammation and oxidative stress in periparturient dairy cows, Journal of Dairy Science, 105, 3670, 10.3168/jds.2021-21225 Zebeli, 2012, Meta-analysis reveals threshold level of rapidly fermentable dietary concentrate that triggers systemic inflammation in cattle, Journal of Dairy Science, 95, 2662, 10.3168/jds.2011-5080