Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in the management of diabetes-centric complications
Tài liệu tham khảo
Zhao, 2008, Structure and function of angiotensin converting enzyme and its inhibitors, Chin J Biotechnol, 24, 171, 10.1016/S1872-2075(08)60007-2
Taddei, 2016, Unraveling the pivotal role of bradykinin in ACE inhibitor activity, Am J of Cardiovasc Drugs, 16, 309, 10.1007/s40256-016-0173-4
Brown, 1998, Angiotensin-converting enzyme inhibitors, Circulation, 97, 1411, 10.1161/01.CIR.97.14.1411
Hanif, 2010, Reinventing the ACE inhibitors: some old and new implications of ACE inhibition, Hypertens Res, 33, 11, 10.1038/hr.2009.184
Ribeiro-Oliveira, 2008, The renin-angiotensin system and diabetes: an update, Vasc Health Risk Manag, 4, 787
Tangvarasittichai, 2015, Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus, World J Diabetes, 6, 456, 10.4239/wjd.v6.i3.456
Ighodaro, 2018, Molecular pathways associated with oxidative stress in diabetes mellitus, Biomed Pharmacother, 108, 656, 10.1016/j.biopha.2018.09.058
Cho, 2019, Association between insulin resistance, hyperglycemia, and coronary artery disease according to the presence of diabetes, Sci Rep, 9, 6129, 10.1038/s41598-019-42700-1
Burrell, 1997, Mode of action of angiotensin converting enzyme inhibitors, 547
He, 2019, Progress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targets, Fitoterapia, 134, 270, 10.1016/j.fitote.2019.02.033
Rinayanti A, Radji M, Mun’im A, Suyatna FD. Screening angiotensin converting enzyme (ACE) inhibitor activity of antihypertensive medicinal plants from Indonesia. Int J Pharm Teach Pract 2013; 4(1): 527–32.
De Lange-Jacobs, 2020, An overview of the potential use of ethno-medicinal plants targeting the renin-angiotensin system in the treatment of hypertension, Molecules, 25, 2114, 10.3390/molecules25092114
Lacaille-Dubois, 2001, Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants, Phytomedicine, 8, 47, 10.1078/0944-7113-00003
Al Disi, 2016, Anti-hypertensive herbs and their mechanisms of action: part I, Front Pharmacol, 6, 323, 10.3389/fphar.2015.00323
McFarlane, 2003, Mechanisms by which angiotensin-converting enzyme inhibitors prevent diabetes and cardiovascular disease, Am J Cardiol, 91, 30, 10.1016/S0002-9149(03)00432-6
Hsueh, 2011, Renin-angiotensin-aldosterone system in diabetes and hypertension, J Clin Hypertens, 13, 224, 10.1111/j.1751-7176.2011.00449.x
Ramalingam, 2017, The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance, Biochim Biophys Acta Mol Basis Dis, 1863, 1106, 10.1016/j.bbadis.2016.07.019
Chawla, 2010, Role of the renin angiotensin system in diabetic nephropathy, World J Diabetes, 1, 141, 10.4239/wjd.v1.i5.141
Muniyappa, 2013, Metabolic actions of angiotensin II and insulin: a microvascular endothelial balancing act, Mol Cell Endocrinol, 378, 59, 10.1016/j.mce.2012.05.017
Nakashima, 2006, Angiotensin II regulates vascular and endothelial dysfunction: recent topics of angiotensin II type-1 receptor signaling in the vasculature, Curr Vasc Pharmacol, 4, 67, 10.2174/157016106775203126
Janus, 2016, Insulin resistance and endothelial dysfunction constitute a common therapeutic target in cardiometabolic disorders, Mediators Inflamm, 2016, 3634948, 10.1155/2016/3634948
Huang, 2018, The PI3K/AKT pathway in obesity and type 2 diabetes, Int J Biol Sci, 14, 1483, 10.7150/ijbs.27173
Tokarz, 2018, The cell biology of systemic insulin function, J Cell Biol, 217, 2273, 10.1083/jcb.201802095
Thomas, 2019, Hyperinsulinemia: an early indicator of metabolic dysfunction, J Endoc Soc, 3, 1727, 10.1210/js.2019-00065
Tunduguru, 2017, Promoting glucose transporter-4 vesicle trafficking along cytoskeletal tracks: PAK-ing them out, Front Endocrinol, 8, 329, 10.3389/fendo.2017.00329
Velloso, 2006, The multi-faceted cross-talk between the insulin and angiotensin II signaling systems, Diabetes Metab Res Rev, 22, 98, 10.1002/dmrr.611
Zhou, 2014, Link between insulin resistance and hypertension: what is the evidence from evolutionary biology?, Diabetol Metab Synd, 6, 1
Farbstein, 2012, HDL dysfunction in diabetes: causes and possible treatments, Expert Rev Cardiovasc Ther, 10, 353, 10.1586/erc.11.182
Ray, 2005, NADPH oxidase and endothelial cell function, Clin Sci, 109, 217, 10.1042/CS20050067
Yang, 2019, Advanced glycation end products: potential mechanism and therapeutic target in cardiovascular complications under diabetes, Oxid Med Cell Longev, 2019, 9570616, 10.1155/2019/9570616
Muñoz, 2020, Angiotensin II induces increased myocardial expression of receptor for advanced glycation end products (RAGE), monocyte/macrophage infiltration and circulating endothelin-1 in rats with experimental diabetes, Can J Diabetes, 44, 651, 10.1016/j.jcjd.2020.03.010
Wiecek, 2003, Role of angiotensin II in the progression of diabetic nephropathy—therapeutic implications, Nephrol Dial Transplant, 18, 16, 10.1093/ndt/gfg1036
Petrie, 2018, Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms, Can J Cardiol, 34, 575, 10.1016/j.cjca.2017.12.005
Herman, 2020
Sarafidis, 2017, A review of chemical therapies for treating diabetic hypertension, Expert Opin Pharmacother, 18, 909, 10.1080/14656566.2017.1328054
Heart Outcomes Prevention Evaluation Study Investigators; Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, et al. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. New Engl J Med 2000; 342(3): 145–53.
Tocci, 2011, Angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and diabetes: a meta-analysis of placebo-controlled clinical trials, Am J Hypertens, 24, 582, 10.1038/ajh.2011.8
Schofield, 2016, Diabetes dyslipidemia. Diabetes Ther, 7, 203, 10.1007/s13300-016-0167-x
Cordonnier, 2001, Role of ACE inhibitors in patients with diabetes mellitus, Drugs, 61, 1883, 10.2165/00003495-200161130-00001
Harris, 2005, Angiotensin-converting enzyme inhibition in diabetic nephropathy: it’s all the RAGE, J Am Soc Nephrol, 16, 2251, 10.1681/ASN.2005060595
Hwang, 2019, Angiotensin-converting enzyme inhibitors attenuated advanced glycation end products-induced renal tubular hypertrophy via enhancing nitric oxide signaling, J Cell Physiol, 234, 17473, 10.1002/jcp.28369
Kurtz, 2004, Antidiabetic mechanisms of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists: beyond the renin-angiotensin system, J Hypertens, 22, 2253, 10.1097/00004872-200412000-00003
Jordan, 2017, Improved insulin sensitivity with angiotensin receptor neprilysin inhibition in individuals with obesity and hypertension, Clin Pharmacol Ther, 101, 254, 10.1002/cpt.455
Parish, 1992, Adverse effects of angiotensin converting enzyme (ACE) inhibitors. An update, Drug Saf, 7, 14, 10.2165/00002018-199207010-00004
Wijesekara, 2010, Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: prospects in the pharmaceutical industry, Mar Drugs, 8, 1080, 10.3390/md8041080
Raval, 2020, Understanding molecular upsets in diabetic nephropathy to identify novel targets and treatment opportunities, Drug Discov Today, 25, 862, 10.1016/j.drudis.2020.01.008
Khan, 2007, Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, 85
Materson, 1994, Angiotensin-converting enzyme inhibitors in hypertension. A dozen years of experience, Arch Intern Med, 154, 513, 10.1001/archinte.1994.00420050059006
Branch, 2007, Adverse effects of angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers in pregnancy, Adverse Drug React Bull, 246, 943, 10.1097/00012995-200724600-00001
Jao CL, Huang SL, Hsu KC. Angiotensin I-converting enzyme inhibitory peptides: inhibition mode, bioavailability, and antihypertensive effects. BioMedicine 2012; 2(4): 130–6
Ni, 2012, Inhibition mechanism and model of an angiotensin I-converting enzyme (ACE)-inhibitory hexapeptide from yeast (Saccharomyces cerevisiae), PLoS One, 7, 10.1371/journal.pone.0037077
Sato, 2002, Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats, J Agric Food Chem, 50, 6245, 10.1021/jf020482t
Margalef, 2017, Natural angiotensin converting enzyme (ACE) inhibitors with antihypertensive properties, 45
Al Shukor, 2013, Angiotensin-converting enzyme inhibitory effects by plant phenolic compounds: a study of structure activity relationships, J Agric Food Chem, 61, 11832, 10.1021/jf404641v
Alu’Datt, 2017, Profiles of free and bound phenolics extracted from Citrus fruits and their roles in biological systems: content and antioxidant, anti-diabetic and anti-hypertensive properties, Food Funct, 8, 3187, 10.1039/C7FO00212B
Hai-Bang, 2015, Structure-activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme, Phytochem Lett, 12, 243, 10.1016/j.phytol.2015.04.021
Inokuchi, 1984, Inhibitors of angiotensin converting enzyme in crude drugs. I, Chem Pharm Bull, 32, 3615, 10.1248/cpb.32.3615
Yun, 1981, Screening of plant materials for the inhibitory activities against angiotensin converting enzyme, Kor J Pharmacog, 12, 51
Hansen, 1995, In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE), J Ethnopharmacol, 48, 43, 10.1016/0378-8741(95)01286-M
Butt, 2009, Garlic: nature’s protection against physiological threats, Crit Rev Food Sci Nutr, 49, 538, 10.1080/10408390802145344
Hyun, 2009, Inhibitory activities of Cassia tora and its anthraquinone constituents on angiotensin-converting enzyme, Phytother Res, 23, 178, 10.1002/ptr.2579
Jabeen, 2013, Hypotensive, angiotensin converting enzyme (ACE) inhibitory and diuretic activities of the aqueous-methanol extract of Ipomoea reniformis, Iran J Pharm Res, 12, 769
Men, 2013, Chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall, Acta Pharm Sin B, 3, 328, 10.1016/j.apsb.2013.07.003
Liu, 2010, Antioxidant and angiotensin converting enzyme (ACE) inhibitory activities of ethanol extract and pure flavonoids from Adinandra nitida leaves, Pharm Biol, 48, 1432, 10.3109/13880209.2010.490223
Xie, 2012, Antihypertensive activity of Rosa rugosa Thunb. flowers: angiotensin I converting enzyme inhibitor, J Ethnopharmacol, 144, 562, 10.1016/j.jep.2012.09.038
Gasparotto Junior, 2011, Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: evidence for the inhibition of angiotensin converting enzyme, J Ethnopharmacol, 134, 363, 10.1016/j.jep.2010.12.026
Sharifi, 2013, Discovery of new angiotensin converting enzyme (ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay, DARU J Pharm Sci, 21, 74, 10.1186/2008-2231-21-74
Deo, 2016, In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes, BMC Complement Altern Med, 16, 435, 10.1186/s12906-016-1421-5
Simaratanamongkol, 2014, Identification of a new angiotensin-converting enzyme (ACE) inhibitor from Thai edible plants, Food Chem, 165, 92, 10.1016/j.foodchem.2014.05.080
Hussain, 2018, Identification of hypotensive biofunctional compounds of Coriandrum sativum and evaluation of their angiotensin-converting enzyme (ACE) inhibition potential, Oxid Med Cell Longev, 2018, 4643736, 10.1155/2018/4643736
Duncan, 1999, Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors, J Ethnopharmacol, 68, 63, 10.1016/S0378-8741(99)00097-5
Shimizu, 1999, Effects of angiotensin I-converting enzyme inhibitor from Ashitaba (Angelica keiskei) on blood pressure of spontaneously hypertensive rats, J Nutr Sci Vitaminol, 45, 375, 10.3177/jnsv.45.375
Kouchmeshky, 2012, Investigation of angiotensin converting enzyme inhibitory effects of medicinal plants used in traditional Persian medicine for treatment of hypertension: screening study, Thrita Stud J Med Sci, 1, 13
Adsersen, 1997, Plants from Réunion island with alleged antihypertensive and diuretic effects—an experimental and ethnobotanical evaluation, J Ethnopharmacol, 58, 189, 10.1016/S0378-8741(97)00100-1
Salehabadi, 2019, Evaluation of angiotensin converting enzyme inhibitors by SPR biosensor and theoretical studies, Enzyme Microb Technol, 120, 117, 10.1016/j.enzmictec.2018.10.010
Nyman, 1998, Ethnomedicinal information and in vitro screening for angiotensin-converting enzyme inhibition of plants utilized as traditional medicines in Gujarat, Rajasthan and Kerala (India), J Ethnopharmacol, 60, 247, 10.1016/S0378-8741(97)00158-X
Loh, 2011, In vitro inhibitory potential of selected Malaysian plants against key enzymes involved in hyperglycemia and hypertension, Malays J Nutr, 17, 77
Rivera-Mondragón, 2017, Selection of chemical markers for the quality control of medicinal plants of the genus Cecropia, Pharm Biol, 55, 1500, 10.1080/13880209.2017.1307421
Chaudhary, 2013, Angiotensin converting enzyme inhibition activity of fennel and coriander oils from India, Nat Prod Commun, 8, 671
Castro Braga, 2000, Screening the Brazilian flora for antihypertensive plant species for in vitro angiotensin-I-converting enzyme inhibiting activity, Phytomedicine, 7, 245, 10.1016/S0944-7113(00)80011-2
Phoboo, 2015, In vitro assays of anti-diabetic and anti-hypertensive potential of some traditional edible plants of Qatar, J Med Active Plants, 4, 22
Kiss, 2004, Compounds from Epilobium angustifolium inhibit the specific metallopeptidases ACE, NEP and APN, Planta Med, 70, 919, 10.1055/s-2004-832617
Wu, 2011, Yuan L. In vitro studies of Gynura divaricata (L.) DC extracts as inhibitors of key enzymes relevant for type 2 diabetes and hypertension, J Ethnopharmacol, 136, 305, 10.1016/j.jep.2011.04.059
Lestari, 2017, Inhibition activity of angiotensin converting enzyme (ACE) and determination of total phenolic and flavonoid compound from bitter melon leaves (Momordica charantia L.), Pharmacogn J, 9, 252, 10.5530/pj.2017.2.43
Chaudhary, 2015, Angiotensin-converting enzyme (ACE) inhibitory potential of standardized Mucuna pruriens seed extract, Pharm Biol, 53, 1614, 10.3109/13880209.2014.996820
Lasboi, 2017, Angiotensin I-converting enzyme inhibitory activity, total phenolic and flavonoid content of extract and fraction of jam fruit leaves (Muntingia calabura L.), Asian J Pharm Clin Res, 10, 166, 10.22159/ajpcr.2017.v10s5.23123
Saputri, 2015, Inhibition of angiotensin converting enzyme (ACE) activity by some Indonesia edible plants, Int J Pharm Sci Res, 6, 1054
Sharifi, 2013, Isolation, identification and molecular docking studies of a new isolated compound, from Onopordon acanthium: a novel angiotensin converting enzyme (ACE) inhibitor, J Ethnopharmacol, 148, 934, 10.1016/j.jep.2013.05.046
Park, 2010, The antioxidant, angiotensin converting enzyme inhibition activity, and phenolic compounds of bamboo shoot extracts, LWT Food Sci Technol, 43, 655, 10.1016/j.lwt.2009.11.005
Jabeen, 2012, Evaluation of prunes for hypotensive, angiotensin converting enzyme (ACE) inhibitory and diuretic activities in rats, J Med Plants Res, 6, 1361
Rodríguez-García, 2019, Antioxidant, antihypertensive, anti-hyperglycemic, and antimicrobial activity of aqueous extracts from twelve native plants of the Yucatan coast, PLoS One, 14, e0213493, 10.1371/journal.pone.0213493
Chaudhary, 2012, ACE inhibition activity of standardized extract and fractions of Terminalia bellerica, Orient Pharm Exp Med, 12, 273, 10.1007/s13596-012-0076-0
Huh, 2015, Inhibition of angiotensin converting enzyme (ACE) by Viola mandshurica extraction, Eur J Adv Res Biol Life Sci, 3, 5
Pihlanto, 2013, Antihypertensive properties of plant protein derived peptides, 145
Hsu, 2002, Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities, J Agric Food Chem, 50, 6109, 10.1021/jf0203287
Huang, 2011, Sweet potato storage root defensin and its tryptic hydrolysates exhibited angiotensin converting enzyme inhibitory activity in vitro, Bot Stud, 52, 257
Huang, 2011, Sweet potato storage root thioredoxin h2 and their peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activity in vitro, Bot Stud, 52, 15
Pihlanto, 2008, ACE-inhibitory and antioxidant properties of potato (Solanum tuberosum), Food Chem, 109, 104, 10.1016/j.foodchem.2007.12.023
Wang, 2019, Angiotensin-converting enzyme inhibiting ability of ethanol extracts, steviol glycosides and protein hydrolysates from Stevia leaves, Food Funct, 10, 7967, 10.1039/C9FO02127B
Megías, 2009, Purification of angiotensin converting enzyme inhibitory peptides from sunflower protein hydrolysates by reverse-phase chromatography following affinity purification, LWT Food Sci Technol, 42, 228, 10.1016/j.lwt.2008.05.003
Boschin, 2014, Optimization of the enzymatic hydrolysis of lupin (Lupinus) proteins for producing ACE-inhibitory peptides, J Agric Food Chem, 62, 1846, 10.1021/jf4039056
García, 2016, Apricot and other seed stones: amygdalin content and the potential to obtain antioxidant, angiotensin I converting enzyme inhibitor and hypocholesterolemic peptides, Food Funct, 7, 4693, 10.1039/C6FO01132B
Ishiguro, 2012, Hypotensive effect of a sweet potato protein digest in spontaneously hypertensive rats and purification of angiotensin I-converting enzyme inhibitory peptides, Food Chem, 131, 774, 10.1016/j.foodchem.2011.09.038
Yang, 2003, Isolation and antihypertensive effect of angiotensin I-converting enzyme (ACE) inhibitory peptides from spinach Rubisco, J Agric Food Chem, 51, 4897, 10.1021/jf026186y
Rho, 2009, Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract, Process Biochem, 44, 490, 10.1016/j.procbio.2008.12.017
Iwai, 2007, Ingestion of Apios americana Medikus tuber suppresses blood pressure and improves plasma lipids in spontaneously hypertensive rats, Nutr Res, 27, 218, 10.1016/j.nutres.2007.01.012
Marczak, 2003, New antihypertensive peptides isolated from rapeseed, Peptides, 24, 791, 10.1016/S0196-9781(03)00174-8
Kim, 2004, Characterization of antihypertensive angiotensin I-converting enzyme inhibitor from Saccharomyces cerevisiae, J Microb Biotechnol, 14, 1318
Alu’datt, 2012, Antioxidant, antidiabetic, and antihypertensive effects of extracted phenolics and hydrolyzed peptides from barley protein fractions, Int J Food Prop, 15, 781, 10.1080/10942912.2010.503357
Jimsheena, 2010, Arachin derived peptides as selective angiotensin I-converting enzyme (ACE) inhibitors: structure-activity relationship, Peptides, 31, 1165, 10.1016/j.peptides.2010.02.022
Kang, 2012, Characterization of new antihypertensive angiotensin I-converting enzyme inhibitory peptides from Korean traditional rice wine, J Microb Biotechnol, 22, 339, 10.4014/jmb.1109.09015
Yodjun, 2012, Angiotensin I-converting enzyme inhibitory proteins and peptides from the rhizomes of Zingiberaceae plants, Appl Biochem Biotechnol, 166, 2037, 10.1007/s12010-012-9630-y
Wu, 2020, Anti-hypertensive and angiotensin-converting enzyme inhibitory effects of Radix astragali and its bioactive peptide AM-1, J Ethnopharmacol, 254, 10.1016/j.jep.2020.112724
Lau, 2014, Novel angiotensin I-converting enzyme inhibitory peptides derived from edible mushroom Agaricus bisporus (J.E. Lange) Imbach identified by LC-MS/MS, Food Chem, 148, 396, 10.1016/j.foodchem.2013.10.053
Gu, 2015, Separation, purification, and identification of angiotensin I-converting enzyme inhibitory peptides from walnut (Juglans regia L.) hydrolyzate, Int J Food Prop, 18, 266, 10.1080/10942912.2012.716476
Kwon, 2010, Flavonoids from the buds of Rosa damascena inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and angiotensin I-converting enzyme, J Agric Food Chem, 58, 882, 10.1021/jf903515f
Ojeda, 2010, Inhibition of angiotensin converting enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa, J Ethnopharmacol, 127, 7, 10.1016/j.jep.2009.09.059
Tsutsumi, 1998, In vitro screening of angiotensin I-converting enzyme inhibitors from Japanese cedar (Cryptomeria japonica), J Wood Sci, 44, 463, 10.1007/BF00833411
Liu, 2003, Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme, Life Sci, 73, 1543, 10.1016/S0024-3205(03)00481-8
Jenis, 2017, Phytochemical profile and angiotensin I converting enzyme (ACE) inhibitory activity of Limonium michelsonii Lincz, J Nat Med, 71, 650, 10.1007/s11418-017-1095-4
Lucas-Filho, 2010, ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E, Schulz. Phytomedicine, 17, 383, 10.1016/j.phymed.2009.09.008
Shafaei, 2016, Flavonoids-rich Orthosiphon stamineus extract as new candidate for angiotensin I-converting enzyme inhibition: a molecular docking study, Molecules, 21, 1500, 10.3390/molecules21111500
Loizzo, 2008, In vitro inhibitory activities of plants used in Lebanon traditional medicine against angiotensin converting enzyme (ACE) and digestive enzymes related to diabetes, J Ethnopharmacol, 119, 109, 10.1016/j.jep.2008.06.003
Oh, 2003, Four glycosides from the leaves of Abeliophyllum distichum with inhibitory effects on angiotensin converting enzyme, Phytother Res, 17, 811, 10.1002/ptr.1199
Li, 2008, Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa, Phytomedicine, 15, 386, 10.1016/j.phymed.2007.09.013
Oh, 2002, Angiotensin converting enzyme inhibitors from Cuscuta japonica Choisy, J Ethnopharmacol, 83, 105, 10.1016/S0378-8741(02)00216-7
Lagemann, 2012, Activity-guided discovery of (S)-malic acid 1′-O-β-gentiobioside as an angiotensin I-converting enzyme inhibitor in lettuce (Lactuca sativa), J Agric Food Chem, 60, 7211, 10.1021/jf3022157
Oh, 2004, Isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum, Biol Pharm Bull, 27, 2035, 10.1248/bpb.27.2035
Hansen, 1996, Angiotensin converting enzyme (ACE) inhibitory flavonoids from Erythroxylum laurifolium, Phytomedicine, 2, 313, 10.1016/S0944-7113(96)80075-4
Madaka, 2018, Angiotensin-converting enzyme inhibitory activity of Senna garrettiana active compounds: potential markers for standardized herbal medicines, Pharmacogn Mag, 14, S335, 10.4103/pm.pm_325_17
Yan, 2017, Megastigmane glycosides from leaves of Eucommia ulmoides Oliver with ACE inhibitory activity, Fitoterapia, 116, 121, 10.1016/j.fitote.2016.12.001
Shimada, 2014, Angiotensin I-converting enzyme (ACE) inhibitory activity of ursolic acid isolated from Thymus vulgaris L, Food Sci Technol Res, 20, 711, 10.3136/fstr.20.711
Attard, 2006, The potential angiotensin-converting enzyme inhibitory activity of oleanolic acid in the hydroethanolic extract of Crataegus monogyna Jacq, Nat Prod Commun, 1, 381
Hivrale, 2013, Angiotensin-converting enzyme inhibitory potential of harmaline isolated from Peganum harmala L. seeds, J Herbs Spices Med Plants, 19, 48, 10.1080/10496475.2012.736925
Kang, 2002, Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels, Vasc Pharmacol, 39, 281, 10.1016/S1537-1891(03)00005-3
Oh, 2003, Angiotensin converting enzyme (ACE) inhibitory alkaloids from Fritillaria ussuriensis, Planta Med, 69, 564, 10.1055/s-2003-40659
An, 2010, Puqienine E: an angiotensin converting enzyme inhibitory steroidal alkaloid from Fritillaria puqiensis, Fitoterapia, 81, 149, 10.1016/j.fitote.2009.08.012
Xing, 2014, ACE and platelet aggregation inhibitors from Tamarix hohenackeri Bunge (host plant of Herba Cistanches) growing in Xinjiang, Pharmacogn Mag, 10, 111, 10.4103/0973-1296.131021
Bhullar, 2013, Curcumin and its carbocyclic analogs: structure-activity in relation to antioxidant and selected biological properties, Molecules, 18, 5389, 10.3390/molecules18055389
Ali, 2019, Angiotensin-I-converting enzyme inhibitory activity of coumarins from Angelica decursiva, Molecules, 24, 3937, 10.3390/molecules24213937
Silva, 2011, Hancornia speciosa Gomes induces hypotensive effect through inhibition of ACE and increase on NO, J Ethnopharmacol, 137, 709, 10.1016/j.jep.2011.06.031
Munir, 2013, South Asian herbal plants as anti-hypertensive agents—a review, Sci Int, 1, 2, 10.5567/sciintl.2013.2.12
Madeswaran, 2015, Evaluation of inhibitory affinity potential of the alkaloids against crystal structure of human angiotensin-converting enzyme using Lamarckian genetic algorithm, Orient Pharm Exp Med, 15, 183, 10.1007/s13596-015-0188-4
Yoshii, 2001, Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks, Comp Biochem Physiol C Toxicol Pharmacol, 128, 27, 10.1016/S1532-0456(00)00172-1
Hell, 2018, Effect of seaweed flakes addition on the development of bioactivities in functional Camembert-type cheese, Int J Food Sci Technol, 53, 1054, 10.1111/ijfs.13681
Herrera-Arellano, 2007, Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial, Planta Med, 73, 6, 10.1055/s-2006-957065
Selvakumar, 2018, Antihypertensive and diuretic action of Adathodai Ilai Chooranam—a Siddha mono-herbal formulation, Eur J Biomed Pharm Sci, 5, 319
Persson, 2008, Effects of Ginkgo biloba extract EGb 761 and its terpenelactones on angiotensin converting enzyme activity and nitric oxide production in human endothelial cells, J Trad Med, 3, 42
Sane, 2018, The effect of a polyherbal oral formulation in the management of essential hypertension: an open label, pilot clinical study, Int J Basic Clin Pharmacol, 7, 1427, 10.18203/2319-2003.ijbcp20182694
Zhao, 2014, Chaihuang-Yishen granule inhibits diabetic kidney disease in rats through blocking TGF-β/Smad3 signaling, PLoS One, 9, 10.1371/journal.pone.0090807
Zhang, 2019, Effects and mechanisms of Danshen-Shanzha herb-pair for atherosclerosis treatment using network pharmacology and experimental pharmacology, J Ethnopharmacol, 229, 104, 10.1016/j.jep.2018.10.004
Sheng, 2014, Chinese medicinal formula Fufang Xueshuantong capsule could inhibit the activity of angiotensin converting enzyme, Biotechnol Biotechnol Equip, 28, 322, 10.1080/13102818.2014.911611
Shen, 2019, Effects of 12-week supplementation of a polyherbal formulation in old adults with prehypertension/hypertension: a randomized, double-blind, placebo-controlled trial, Evid Based Compl Altern Med, 2019, 7056872
Kokram, 2016, Angiotensin-I converting enzyme inhibitory activity of mushroom Lentinus polychrous Lév. and its development of healthy drink recipes, Biocatal Agric Biotechnol, 8, 121, 10.1016/j.bcab.2016.08.015
Ghelani, 2014, Evaluation of polyherbal formulation (SJT-HT-03) for antihypertensive activity in albino rats, Ayu, 35, 452, 10.4103/0974-8520.159034
Moumita, 2018, Study of soy-fortified green tea curd formulated using potential hypocholesterolemic and hypotensive probiotics isolated from locally made curd, Food Chem, 268, 558, 10.1016/j.foodchem.2018.06.114
Chen, 2018, Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure, J Ethnopharmacol, 219, 359, 10.1016/j.jep.2017.12.011
Carmona, 2013, Herbal medicines: old and new concepts, truths and misunderstandings, Braz J Pharmacogn, 23, 379, 10.1590/S0102-695X2013005000018
Schuhladen, 2019, Bioactive glasses meet phytotherapeutics: the potential of natural herbal medicines to extend the functionality of bioactive glasses, Biomaterials, 217, 10.1016/j.biomaterials.2019.119288
Pan, 2013, New perspectives on how to discover drugs from herbal medicines: CAM’s outstanding contribution to modern therapeutics, Evid Based Compl Altern Med, 2013
Ezzat, 2019, Phytochemicals as sources of drugs, 3
Botelho Lourenço, 2017, Fetopathies associated with exposure to angiotensin converting enzyme inhibitor from Tropaeolum majus L, Drug Chem Toxicol, 40, 281, 10.1080/01480545.2016.1212366
Somanadhan, 1999, An ethnopharmacological survey for potential angiotension converting enzyme inhibitors from Indian medicinal plants, J Ethnopharmacol, 65, 103, 10.1016/S0378-8741(98)00201-3
