Angiotensin II Induces Renal Plasminogen Activator Inhibitor-1 and Cyclooxygenase-2 Expression Post-Transcriptionally via Activation of the mRNA-Stabilizing Factor Human-Antigen R

Boffa, 2003, Regression of renal vascular and glomerular fibrosis: role of angiotensin II receptor antagonism and matrix metalloproteinases, J Am Soc Nephrol, 14, 1132, 10.1097/01.ASN.0000060574.38107.3B Rüster, 2006, Renin-angiotensin-aldosterone system and progression of renal disease, J Am Soc Nephrol, 17, 2985, 10.1681/ASN.2006040356 Ma, 2000, Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1, Kidney Int, 58, 2425, 10.1046/j.1523-1755.2000.00426.x Fogo, 2001, Mechanisms in nephrosclerosis and hypertension-beyond hemodynamics, J Nephrol, 14, S63 Eddy, 2006, Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action, J Am Soc Nephrol, 17, 2999, 10.1681/ASN.2006050503 Kaikita, 2001, Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition, Circulation, 104, 839, 10.1161/hc3301.092803 Eddy, 2002, Plasminogen activator inhibitor-1 and the kidney, Am J Physiol, 283, F209 Wolf, 1993, Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-β, J Clin Invest, 92, 1366, 10.1172/JCI116710 Eddy, 1996, Molecular insights into renal interstitial fibrosis, J Am Soc Nephrol, 7, 2495, 10.1681/ASN.V7122495 Montuori, 2002, Post-transcriptional regulation of gene expression in the plasminogen activation system, Biol Chem, 383, 47, 10.1515/BC.2002.005 Heaton, 2003, Posttranscriptional regulation of PAI-1 gene expression, Thromb Haemost, 89, 959, 10.1055/s-0037-1613396 Westerhausen, 1991, Multiple transforming growth factor-beta-inducible elements regulate expression of the plasminogen activator inhibitor type-1 gene in Hep G2 cells, J Biol Chem, 266, 1092, 10.1016/S0021-9258(17)35287-0 Fattal, 1992, Post-transcriptional regulation of expression of plasminogen activator inhibitor type 1 mRNA by insulin and insulin-like growth factor 1, J Biol Chem, 267, 12412, 10.1016/S0021-9258(18)42289-2 Hao, 2008, Physiological regulation of prostaglandins in the kidney, Annu Rev Physiol, 70, 357, 10.1146/annurev.physiol.70.113006.100614 Feng, 1995, Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-α and lipopolysaccharide, J Clin Invest, 95, 1669, 10.1172/JCI117842 Jaimes, 2005, Up-regulation of glomerular COX-2 by angiotensin II: role of reactive oxygen species, Kidney Int, 68, 2143, 10.1111/j.1523-1755.2005.00670.x Dixon, 2000, Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3′-untranslated region, J Biol Chem, 275, 11750, 10.1074/jbc.275.16.11750 Sheng, 2000, Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA, J Biol Chem, 275, 6628, 10.1074/jbc.275.9.6628 Doller, 2007, Protein kinase Cα-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2, Mol Biol Cell, 18, 2137, 10.1091/mbc.e06-09-0850 Doller, 2008, Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cδ elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA, Mol Cell Biol, 28, 2608, 10.1128/MCB.01530-07 Dixon, 2001, Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells, J Clin Invest, 108, 1657, 10.1172/JCI12973 Sengupta, 2003, The RNA-binding protein HuR regulates the expression of cyclooxygenase-2, J Biol Chem, 278, 25227, 10.1074/jbc.M301813200 Cok, 2003, The proximal region of the 3′-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U, J Biol Chem, 278, 36157, 10.1074/jbc.M302547200 Gauer, 2007, IL-18 is expressed in the intercalated cell of human kidney, Kidney Int, 72, 1081, 10.1038/sj.ki.5002473 Pfeilschifter, 1991, Transforming growth factor β 2 inhibits interleukin 1 β- and tumour necrosis factor α-induction of nitric oxide synthase in rat renal mesangial cells, Biochem Biophys Res Commun, 175, 372, 10.1016/0006-291X(91)91574-V Dignam, 1983, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nucleic Acids Res, 11, 1475, 10.1093/nar/11.5.1475 Eberhardt, 2002, Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-κB and Ets transcription factors, Mol Endocrinol, 16, 1752, 10.1210/me.2001-0278 Fan, 1998, Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs, EMBO J, 17, 3448, 10.1093/emboj/17.12.3448 Aschrafi, 2003, Regulatory functions of protein kinase C isoenzymes in the kidney, Curr Top Biochem Res, 5, 27 Jaimes, 2008, Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species, Am J Physiol, 294, F385 Irigoyen, 1999, The plasminogen activator system: biology and regulation, Cell Mol Life Sci, 56, 104, 10.1007/PL00000615 Maurer, 1999, An AU-rich sequence in the 3′-UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR, Nucleic Acids Res, 27, 1664, 10.1093/nar/27.7.1664 Chen, 2001, AU binding proteins recruit the exosome to degrade ARE-containing mRNAs, Cell, 107, 451, 10.1016/S0092-8674(01)00578-5 Nickenig, 1996, Enhanced angiotensin receptor type 1 mRNA degradation and induction of polyribosomal mRNA binding proteins by angiotensin II in vascular smooth muscle cells, Mol Pharmacol, 50, 743 Doller, 2008, Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR, Cell Signal, 20, 2165, 10.1016/j.cellsig.2008.05.007 Tang, 2000, Biphasic actions of prostaglandin E(2) on the renal afferent arteriole: role of EP(3) and EP(4) receptors, Circ Res, 86, 663, 10.1161/01.RES.86.6.663 Zhang, 2006, Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT1 and AT2 receptors, Proc Natl Acad Sci USA, 103, 16045, 10.1073/pnas.0602176103 Schlöndorff, 1987, Angiotensin II stimulates phospholipases C and A2 in cultured rat mesangial cells, Am J Physiol, 253, C113, 10.1152/ajpcell.1987.253.1.C113 Faour, 2001, Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibroblasts, J Biol Chem, 276, 31720, 10.1074/jbc.M104036200 Yu, 2007, Long-term, high-dosage candesartan suppresses inflammation and injury in chronic kidney disease: nonhemodynamic renal protection, J Am Soc Nephrol, 18, 750, 10.1681/ASN.2006070770