Androgens and endometrium: New insights and new targets

Abraham, 1974, Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle, J. Clin. Endocrinol. Metab., 39, 340, 10.1210/jcem-39-2-340 Aghajanova, 2009, Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis, Biol. Reprod., 80, 105, 10.1095/biolreprod.108.070300 Allen, 2008, Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC), Endocr. Relat. Cancer, 15, 485, 10.1677/ERC-07-0064 Apparao, 2002, Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome, Biol. Reprod., 66, 297, 10.1095/biolreprod66.2.297 Attar, 2009, Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis, J. Clin. Endocrinol. Metab., 94, 623, 10.1210/jc.2008-1180 Audet-Walsh, 2011, Profiling of endogenous estrogens, their precursors, and metabolites in endometrial cancer patients: association with risk and relationship to clinical characteristics, J. Clin. Endocrinol. Metab., 96, E330, 10.1210/jc.2010-2050 Barry, 2014, Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis, Hum. Reprod. Update, 20, 748, 10.1093/humupd/dmu012 Bellofiore, 2017, First evidence of a menstruating rodent: the spiny mouse (Acomys cahirinus), Am. J. Obstet. Gynecol., 216, 10.1016/j.ajog.2016.07.041 Brasted, 2003, Mimicking the events of menstruation in the murine uterus, Biol. Reprod., 69, 1273, 10.1095/biolreprod.103.016550 Bui, 2013, Dynamics of serum testosterone during the menstrual cycle evaluated by daily measurements with an ID-LC-MS/MS method and a 2nd generation automated immunoassay, Steroids, 78, 96, 10.1016/j.steroids.2012.10.010 Bukulmez, 2008, Inflammatory status influences aromatase and steroid receptor expression in endometriosis, Endocrinology, 149, 1190, 10.1210/en.2007-0665 Burris, 2013, Nuclear receptors and their selective pharmacologic modulators, Pharmacol. Rev., 65, 710, 10.1124/pr.112.006833 Burton, 2003, Local levonorgestrel regulation of androgen receptor and 17beta-hydroxysteroid dehydrogenase type 2 expression in human endometrium, Hum. Reprod., 18, 2610, 10.1093/humrep/deg510 Caldwell, 2017, Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome, Proc. Natl. Acad. Sci. U. S. A., 114, E3334, 10.1073/pnas.1616467114 Carneiro, 2008, Androgen receptor and 5alpha-reductase are expressed in pelvic endometriosis, BJOG, 115, 113, 10.1111/j.1471-0528.2007.01521.x Catalano, 2011, Comprehensive expression analysis of prostanoid enzymes and receptors in the human endometrium across the menstrual cycle, Mol. Hum. Reprod., 17, 182, 10.1093/molehr/gaq094 Chadha, 1994, Androgen receptor expression in human ovarian and uterine tissue of long-term androgen-treated transsexual women, Hum. Pathol., 25, 1198, 10.1016/0046-8177(94)90037-X Chandrasekhar, 1991, Regulation of uterine progesterone receptors by the nonsteroidal anti-androgen hydroxyflutamide, Biol. Reprod., 45, 78, 10.1095/biolreprod45.1.78 Chandrasekhar, 1990, Implantation delay and anti-deciduogenic activity in the rat by the anti-androgen, hydroxyflutamide, Biol. Reprod., 42, 120, 10.1095/biolreprod42.1.120 Chang, 2013, Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells, Nucl. Recept Signal, 11, e001, 10.1621/nrs.11001 Chang, 1988, Molecular cloning of human and rat complementary DNA encoding androgen receptors, Science, 240, 324, 10.1126/science.3353726 Chen, 2011, Cytochrome P450 17 (CYP17) is involved in endometrial cancinogenesis through apoptosis and invasion pathways, Mol. Carcinog., 50, 16, 10.1002/mc.20680 Chia, 2015, Targeting the androgen receptor in breast cancer, Curr. Oncol. Rep., 17, 4, 10.1007/s11912-014-0427-8 Choi, 2015, Development and characterization of uterine glandular epithelium specific androgen receptor knockout mouse model, Biol. Reprod., 93, 1, 10.1095/biolreprod.115.132241 Cloke, 2008, The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium, Endocrinology, 149, 4462, 10.1210/en.2008-0356 Cousins, 2016, Androgens regulate scarless repair of the endometrial “wound” in a mouse model of menstruation, FASEB J., 30, 2802, 10.1096/fj.201600078R Cousins, 2016, Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling, Sci. Rep., 6, 36748, 10.1038/srep36748 Cousins, 2014, Evidence from a mouse model that epithelial cell migration and mesenchymal-epithelial transition contribute to rapid restoration of uterine tissue integrity during menstruation, PLoS One, 9, e86378, 10.1371/journal.pone.0086378 Cousins, 2016, Hypoxyprobe reveals dynamic spatial and temporal changes in hypoxia in a mouse model of endometrial breakdown and repair, BMC Res. Notes, 9, 30, 10.1186/s13104-016-1842-8 Dalla Valle, 2006, Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue, J. Endocrinol., 190, 129, 10.1677/joe.1.06811 Dart, 2013, Visualising androgen receptor activity in male and female mice, PLoS One, 8, e71694, 10.1371/journal.pone.0071694 Das, 2009, De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis, Proc. Natl. Acad. Sci. U. S. A., 106, 12542, 10.1073/pnas.0901647106 Dassen, 2007, Estrogen metabolizing enzymes in endometrium and endometriosis, Hum. Reprod., 22, 3148, 10.1093/humrep/dem310 de Ziegler, 1998, The hormonal control of endometrial receptivity: estrogen (E2) and progesterone, J. Reprod. Immunol., 39, 149, 10.1016/S0165-0378(98)00019-9 Delvoux, 2009, Increased production of 17beta-estradiol in endometriosis lesions is the result of impaired metabolism, J. Clin. Endocrinol. Metab., 94, 876, 10.1210/jc.2008-2218 Diao, 2008, Effects of androgen on embryo implantation in the mouse delayed-implantation model, Fertil. Steril., 90, 1376, 10.1016/j.fertnstert.2007.07.1341 Dunselman, 2014, ESHRE guideline: management of women with endometriosis, Hum. Reprod., 29, 400, 10.1093/humrep/det457 Ferenczy, 1976, Studies on the cytodynamics of human endometrial regeneration. I. Scanning electron microscopy, Am. J. Obstet. Gynecol., 124, 64, 10.1016/0002-9378(76)90013-2 Fitzpatrick, 2012, Incidence and risk factors for placenta accreta/increta/percreta in the UK: a national case-control study, PLoS One, 7, e52893, 10.1371/journal.pone.0052893 Freis, 2017, Effects of a hyperandrogenaemic state on the proliferation and decidualization potential in human endometrial stromal cells, Arch. Gynecol. Obstet., 295, 1005, 10.1007/s00404-017-4295-y Fujimoto, 1994, The effect of estrogen and androgen on androgen receptors and mRNA levels in uterine leiomyoma, myometrium and endometrium of human subjects, J. Steroid Biochem. Mol. Biol., 50, 137, 10.1016/0960-0760(94)90020-5 Fujimoto, 1995, Effects of estradiol and testosterone on the synthesis, expression and degradation of androgen receptor in human uterine endometrial fibroblasts, J. Biomed. Sci., 2, 160, 10.1007/BF02253067 Futterweit, 1986, Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals, J. Clin. Endocrinol. Metab., 62, 16, 10.1210/jcem-62-1-16 Gaide Chevronnay, 2012, Regulation of matrix metalloproteinases activity studied in human endometrium as a paradigm of cyclic tissue breakdown and regeneration, Biochim. Biophys. Acta, 1824, 146, 10.1016/j.bbapap.2011.09.003 Gao, 2007, Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs), Drug Discov. Today, 12, 241, 10.1016/j.drudis.2007.01.003 Garry, 2009, A re-appraisal of the morphological changes within the endometrium during menstruation: a hysteroscopic, histological and scanning electron microscopic study, Hum. Reprod., 24, 1393, 10.1093/humrep/dep036 Geese, 2001, Biochemical characterization and tissue distribution of human SULT2B1, Biochem. Biophys. Res. Commun., 288, 280, 10.1006/bbrc.2001.5746 Gibson, 2013, Endometrial Intracrinology–generation of an estrogen-dominated microenvironment in the secretory phase of women, J. Clin. Endocrinol. Metab., 98, E1802, 10.1210/jc.2013-2140 Gibson, 2014, “Evidence of androgen action in endometrial and ovarian cancers.”, Endocr. Relat. Cancer, 21, T203, 10.1530/ERC-13-0551 Gibson, 2016, Intracrine androgens enhance decidualization and modulate expression of human endometrial receptivity genes, Sci. Rep., 6, 19970, 10.1038/srep19970 Gibson, 2016, Regulation of androgen action during establishment of pregnancy, J. Mol. Endocrinol., 57, R35, 10.1530/JME-16-0027 Gill, 2008, Metalloproteinases and their inhibitors: regulators of wound healing, Int. J. Biochem. Cell Biol., 40, 1334, 10.1016/j.biocel.2007.10.024 Gilliver, 2006, Androgens modulate the inflammatory response during acute wound healing, J. Cell Sci., 119, 722, 10.1242/jcs.02786 Gilliver, 2007, Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing, Lab. Invest, 87, 871, 10.1038/labinvest.3700627 Gilliver, 2009, 5alpha-dihydrotestosterone (DHT) retards wound closure by inhibiting re-epithelialization, J. Pathol., 217, 73, 10.1002/path.2444 Giudice, 2004, Endometriosis, Lancet, 364, 1789, 10.1016/S0140-6736(04)17403-5 Graham, 1991, Mechanism of control of trophoblast invasion in situ, J. Cell Physiol., 148, 228, 10.1002/jcp.1041480207 Hembree, 2009, Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline, J. Clin. Endocrinol. Metab., 94, 3132, 10.1210/jc.2009-0345 Hirai, 1994, Androgen receptor mRNA in the rat ovary and uterus, J. Steroid Biochem. Mol. Biol., 49, 1, 10.1016/0960-0760(94)90294-1 Horie, 1992, Immunohistochemical localization of androgen receptor in the human endometrium, decidua, placenta and pathological conditions of the endometrium, Hum. Reprod., 7, 1461, 10.1093/oxfordjournals.humrep.a137595 Huhtinen, 2012, Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels, J. Clin. Endocrinol. Metab., 97, 4228, 10.1210/jc.2012-1154 Huhtinen, 2014, Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions, J. Clin. Endocrinol. Metab., 99, E2188, 10.1210/jc.2014-1913 Hukkanen, 1998, Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium, Pharmacol. Toxicol., 82, 93, 10.1111/j.1600-0773.1998.tb01404.x Ito, 2016, In situ androgen and estrogen biosynthesis in endometrial cancer: focus on androgen actions and intratumoral production, Endocr. Relat. Cancer, 23, R323, 10.1530/ERC-15-0470 Ito, 2002, Expression of androgen receptor and 5alpha-reductases in the human normal endometrium and its disorders, Int. J. Cancer, 99, 652, 10.1002/ijc.10394 Ito, 2006, 17Beta-hydroxysteroid dehydrogenases in human endometrium and its disorders, Mol. Cell Endocrinol., 248, 136, 10.1016/j.mce.2005.11.038 Kaitu'u-Lino, 2007, Estrogen is not essential for full endometrial restoration after breakdown: lessons from a mouse model, Endocrinology, 148, 5105, 10.1210/en.2007-0716 Kajihara, 2014, Androgens modulate the morphological characteristics of human endometrial stromal cells decidualized in vitro, Reprod. Sci., 21, 372, 10.1177/1933719113497280 Kajihara, 2012, Androgen signaling in decidualizing human endometrial stromal cells enhances resistance to oxidative stress, Fertil. Steril., 97, 185, 10.1016/j.fertnstert.2011.10.017 Kamal, 2016, Androgen receptors are acquired by healthy postmenopausal endometrial epithelium and their subsequent loss in endometrial cancer is associated with poor survival, Br. J. Cancer, 114, 688, 10.1038/bjc.2016.16 Kiechl, 2000, No association between dehydroepiandrosterone sulfate and development of atherosclerosis in a prospective population study (Bruneck Study), Arterioscler. Thromb. Vasc. Biol., 20, 1094, 10.1161/01.ATV.20.4.1094 Labied, 2006, Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium, Mol. Endocrinol., 20, 35, 10.1210/me.2005-0275 Labrie, 1988, Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate, Endocrinology, 123, 1412, 10.1210/endo-123-3-1412 Labrie, 1997, Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging, J. Clin. Endocrinol. Metab., 82, 2396, 10.1210/jcem.82.8.4160 Labrie, 2011, Wide distribution of the serum dehydroepiandrosterone and sex steroid levels in postmenopausal women: role of the ovary?, Menopause, 18, 30, 10.1097/gme.0b013e3181e195a6 Ledford, 1976, Biochemical and morphological changes following artificially stimulated decidualization in the mouse uterus, Biol. Reprod., 15, 529, 10.1095/biolreprod15.4.529 Lee, 2007, Mouse models of implantation, Trends Endocrinol. Metab., 18, 234, 10.1016/j.tem.2007.06.002 Lessey, 1996, Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation, Fertil. Steril., 65, 477, 10.1016/S0015-0282(16)58140-0 Leyendecker, 2002, Endometriosis results from the dislocation of basal endometrium, Hum. Reprod., 17, 2725, 10.1093/humrep/17.10.2725 Lubahn, 1988, Cloning of human androgen receptor complementary DNA and localization to the X chromosome, Science, 240, 327, 10.1126/science.3353727 Ludwig, 1991, Microarchitecture of the human endometrium by scanning electron microscopy: menstrual desquamation and remodeling, Ann. N. Y. Acad. Sci., 622, 28, 10.1111/j.1749-6632.1991.tb37848.x Lund, 1991, Hormonal regulation of cytochrome P-450 gene expression, Adv. Pharmacol., 22, 325, 10.1016/S1054-3589(08)60040-X Luu-The, 2013, Assessment of steroidogenesis and steroidogenic enzyme functions, J. Steroid Biochem. Mol. Biol., 137, 176, 10.1016/j.jsbmb.2013.05.017 Luu-The, 1995, Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene, DNA Cell Biol., 14, 511, 10.1089/dna.1995.14.511 Lydon, 1995, Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities, Genes Dev., 9, 2266, 10.1101/gad.9.18.2266 Macklon, 2008, The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation, Reprod. Sci., 15, 357, 10.1177/1933719107311781 Makieva, 2016, Androgen-induced relaxation of uterine myocytes is mediated by blockade of both Ca flux and MLC phosphorylation, J. Clin. Endocrinol. Metab., 10.1210/jc.2015-2851 March, 2011, Asherman's syndrome, Semin. Reprod. Med., 29, 83, 10.1055/s-0031-1272470 Marshall, 2011, In silico analysis identifies a novel role for androgens in the regulation of human endometrial apoptosis, J. Clin. Endocrinol. Metab., 96, E1746, 10.1210/jc.2011-0272 Maslyanskaya, 2017, Polycystic ovary syndrome: an under-recognized cause of abnormal uterine bleeding in adolescents admitted to a Children's hospital, J. Pediatr. Adolesc. Gynecol., 30, 349, 10.1016/j.jpag.2016.11.009 Massafra, 2000, Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle, J. Endocrinol., 167, 447, 10.1677/joe.0.1670447 Mertens, 1996, Androgen receptor content in human endometrium, Eur. J. Obstet. Gynecol. Reprod. Biol., 70, 11, 10.1016/S0301-2115(96)02567-5 Mertens, 2001, Androgen, estrogen and progesterone receptor expression in the human uterus during the menstrual cycle, Eur. J. Obstet. Gynecol. Reprod. Biol., 98, 58, 10.1016/S0301-2115(00)00554-6 Michael, 1997, A CRE-like sequence that binds CREB and contributes to cAMP-dependent regulation of the proximal promoter of the human aromatase P450 (CYP19) gene, Mol. Cell Endocrinol., 134, 147, 10.1016/S0303-7207(97)00178-0 Miki, 2002, Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues, J. Clin. Endocrinol. Metab., 87, 5760, 10.1210/jc.2002-020670 Miller, 1986, Histological changes in the genital tract in transsexual women following androgen therapy, Histopathology, 10, 661, 10.1111/j.1365-2559.1986.tb02520.x Milne, 2005, Leukocyte populations and steroid receptor expression in human first-trimester decidua; regulation by antiprogestin and prostaglandin E analog, J. Clin. Endocrinol. Metab., 90, 4315, 10.1210/jc.2004-2338 Minjarez, 2001, Regulation of uterine 5 alpha-reductase type 1 in mice, Biol. Reprod., 65, 1378, 10.1095/biolreprod65.5.1378 Muechler, 1987, The androgen receptor of the human endometrium, Endocr. Res., 13, 69, 10.1080/07435808709023664 Nantermet, 2005, Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways, Endocrinology, 146, 564, 10.1210/en.2004-1132 Narvekar, 2004, Low-dose mifepristone inhibits endometrial proliferation and up-regulates androgen receptor, J. Clin. Endocrinol. Metab., 89, 2491, 10.1210/jc.2003-031945 Noyes, 1975, Dating the endometrial biopsy, Am. J. Obstet. Gynecol., 122, 262, 10.1016/S0002-9378(16)33500-1 Onstad, 2016, Addressing the role of obesity in endometrial cancer risk, prevention, and treatment, J. Clin. Oncol., 34, 4225, 10.1200/JCO.2016.69.4638 Park, 2013, Inhibitory effects of androstenedione on endometrial cells: implications for poor reproductive outcome among women with androgen excess, Eur. J. Obstet. Gynecol. Reprod. Biol., 171, 295, 10.1016/j.ejogrb.2013.09.022 Payne, 1992, Hormonal regulation of steroidogenic enzyme gene expression in Leydig cells, J. Steroid Biochem. Mol. Biol., 43, 895, 10.1016/0960-0760(92)90317-C Pelletier, 2000, Localization of androgen and estrogen receptors in rat and primate tissues, Histol. Histopathol., 15, 1261 Pelletier, 2000, Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs, J. Endocrinol., 165, 359, 10.1677/joe.0.1650359 Pelletier, 2004, Localization and estrogenic regulation of androgen receptor mRNA expression in the mouse uterus and vagina, J. Endocrinol., 180, 77, 10.1677/joe.0.1800077 Pelletier, 1999, Immunocytochemical localization of type 5 17beta-hydroxysteroid dehydrogenase in human reproductive tissues, J. Histochem Cytochem, 47, 731, 10.1177/002215549904700602 Perrone, 2009, Effect of long-term testosterone administration on the endometrium of female-to-male (FtM) transsexuals, J. Sex. Med., 6, 3193, 10.1111/j.1743-6109.2009.01380.x Pomari, 2015, Intracrine sex steroid synthesis and signaling in human epidermal keratinocytes and dermal fibroblasts, FASEB J., 29, 508, 10.1096/fj.14-251363 Qin, 2016, DHEA improves the antioxidant capacity of endometrial stromal cells and improves endometrium receptivity via androgen receptor, Eur. J. Obstet. Gynecol. Reprod. Biol., 198, 120, 10.1016/j.ejogrb.2016.01.016 Ramsey, 1976, Interactions of the trophoblast and maternal tissues in three closely related primate species, Am. J. Obstet. Gynecol., 124, 647, 10.1016/0002-9378(76)90068-5 Rhee, 2003, Expression of 3beta-hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium, Exp. Mol. Med., 35, 160, 10.1038/emm.2003.22 Rizner, 2006, AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer, Mol. Cell Endocrinol., 248, 126, 10.1016/j.mce.2005.10.009 Salonia, 2008, Menstrual cycle-related changes in circulating androgens in healthy women with self-reported normal sexual function, J. Sex. Med., 5, 854, 10.1111/j.1743-6109.2008.00791.x Sanderson, 2017, New concepts for an old problem: the diagnosis of endometrial hyperplasia, Hum. Reprod. Update, 23, 232 Schauwaers, 2007, Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model, Proc. Natl. Acad. Sci. U. S. A., 104, 4961, 10.1073/pnas.0610814104 Selak, 2007, Danazol for pelvic pain associated with endometriosis, Cochrane Database Syst. Rev., CD000068 Simitsidellis, 2016, A role for androgens in epithelial proliferation and formation of glands in the mouse uterus, Endocrinology, 10.1210/en.2015-2032 Slayden, 2001, Progesterone antagonists increase androgen receptor expression in the rhesus macaque and human endometrium, J. Clin. Endocrinol. Metab., 86, 2668 Suzuki, 2003, Steroid sulfatase and estrogen sulfotransferase in normal human tissue and breast carcinoma, J. Steroid Biochem. Mol. Biol., 86, 449, 10.1016/S0960-0760(03)00356-X Tamaya, 1979, Steroid receptor levels and histology of endometriosis and adenomyosis, Fertil. Steril., 31, 396, 10.1016/S0015-0282(16)43935-X Tanaka, 2015, The role of 5α-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma, Mol. Cell Endocrinol., 401, 56, 10.1016/j.mce.2014.11.022 Tangen, 2016, Androgen receptor as potential therapeutic target in metastatic endometrial cancer, Oncotarget, 7, 49289, 10.18632/oncotarget.10334 Taylor, 2005, Quantitative histomorphometric analysis of gonadal steroid receptor distribution in the normal human endometrium through the menstrual cycle, Histochem Cell Biol., 123, 463, 10.1007/s00418-004-0748-z Toraldo, 2012, Topical androgen antagonism promotes cutaneous wound healing without systemic androgen deprivation by blocking beta-catenin nuclear translocation and cross-talk with TGF-beta signaling in keratinocytes, Wound Repair Regen., 20, 61, 10.1111/j.1524-475X.2011.00757.x Tsai, 2001, Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells, J. Clin. Endocrinol. Metab., 86, 5765, 10.1210/jcem.86.12.8082 Tuckerman, 2000, Do androgens have a direct effect on endometrial function? An in vitro study, Fertil. Steril., 74, 771, 10.1016/S0015-0282(00)00711-1 Urban, 2011, Gynecologic malignancies in female-to-male transgender patients: the need of original gender surveillance, Am. J. Obstet. Gynecol., 204, e9, 10.1016/j.ajog.2010.12.057 Vienonen, 2004, Expression of nuclear receptors and cofactors in human endometrium and myometrium, J. Soc. Gynecol. Investig., 11, 104, 10.1016/j.jsgi.2003.09.003 Walters, 2007, Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility, Endocrinology, 148, 3674, 10.1210/en.2007-0248 Walters, 2009, Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function, Endocrinology, 150, 3274, 10.1210/en.2008-1750 Whitaker, 2017, Selective progesterone receptor modulator (SPRM) ulipristal acetate (UPA) and its effects on the human endometrium, Hum. Reprod., 32, 531 Xu, 2015, Expression and regulation of androgen receptor in the mouse uterus during early pregnancy and decidualization, Mol. Reprod. Dev., 10.1002/mrd.22532 Yang, 2015, Integrative analysis reveals regulatory programs in endometriosis, Reprod. Sci., 22, 1060, 10.1177/1933719115592709 Yang, 2010, Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes, Carcinogenesis, 31, 827, 10.1093/carcin/bgp328 Yarrow, 2012, Intracrine and myotrophic roles of 5α-reductase and androgens: a review, Med. Sci. Sports Exerc, 44, 818, 10.1249/MSS.0b013e31823bfcbf Yeh, 2002, Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues, Proc. Natl. Acad. Sci. U. S. A., 99, 13498, 10.1073/pnas.212474399 Youngblood, 1992, Isolation and characterization of the mouse P450 17 alpha-hydroxylase/C17-20-lyase gene (Cyp17): transcriptional regulation of the gene by cyclic adenosine 3',5'-monophosphate in MA-10 Leydig cells, Mol. Endocrinol., 6, 927 Zang, 2008, Effects of testosterone and estrogen treatment on the distribution of sex hormone receptors in the endometrium of postmenopausal women, Menopause, 15, 233, 10.1097/gme.0b013e318148bb99 Zhang, 1996, Maintenance of decidual cell reaction by androgens in the mouse, Biol. Reprod., 55, 519, 10.1095/biolreprod55.3.519