Androgen receptors and their biology

Vitamins and Hormones - Tập 62 - Trang 199-230 - 2001
Dolores J Lamb1,2, Nancy L Weigel2, Marco Marcell2,3
1Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
2Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, Texas 77030 USA
3Department of Medicine, Baylor College of Medicine, Houston, Texas 77030 USA

Tài liệu tham khảo

Abdullah, 1998, Spinobulbar muscular atrophy: Polyglutamine-expanded androgen receptor is proteolytically resistant in vitro and processed abnormally in transfected cells, Hum. Mol. Genet., 7, 379, 10.1093/hmg/7.3.379 Aiman, 1979, Androgen insensitivity as a cause of infertility in otherwise normal men, N. Engl. J. Med., 300, 223, 10.1056/NEJM197902013000503 Albers, 1997, Etiologic classification of severe hypospadias: Implications for prognosis and management, J. Pediatr., 131, 386, 10.1016/S0022-3476(97)80063-7 Alen, 1999, Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1 alpha with multiple steroid receptors and identification of an internally deleted ELE1 beta isoform, Mol. Endocrinol., 13, 117, 10.1210/me.13.1.117 Allen, 1992, Methylation of Hpall and Hhal sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation, Am. J. Hum. Genet., 51, 1229 Allera, 1995, Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias, J. Clin. Endocrinol. Metab., 80, 2697, 10.1210/jc.80.9.2697 Batch, 1993, Phenotypic variation and detection of carrier status in the partial androgen insensitivity syndrome, Arch. Dis. Child., 68, 453, 10.1136/adc.68.4.453 Batch, 1993, Mutations of the androgen receptor gene identified in perineal hypospadias, J. Med. Genet., 30, 198, 10.1136/jmg.30.3.198 Batch, 1992, Role of the androgen receptor in male sexual differentiation, Horm. Res., 38, 226, 10.1159/000182548 Berrevoets, 1998, Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2), Mol. Endocrinol., 12, 1172, 10.1210/me.12.8.1172 Biancalana, 1992, Moderate instability of the trinucleotide repeat in spino bulbar muscular atrophy, Hum. Mol. Genet., 1, 255, 10.1093/hmg/1.4.255 Boffa, 1996, Invasion of the CAG triplet repeats by a complementary peptide nucleic acid inhibits transcription of the androgen receptor and TATA-binding protein genes and corre lates with refolding of an active nucleosome containing a unique AR gene sequence, J. Biol. Chem., 271, 13228, 10.1074/jbc.271.22.13228 Brady, 1999, Tip60 is a nuclear hormone receptor coactivator, J. Biol. Chem., 274, 17599, 10.1074/jbc.274.25.17599 Brinkmann, 1989, The human androgen receptor: Domain structure, genomic organization and regulation of expression, J. Steroid Biochem., 34, 307, 10.1016/0022-4731(89)90098-8 Brinkmann, 1988, In situ photolabelling of the human androgen receptor, J. Steroid Biochem., 30, 257, 10.1016/0022-4731(88)90102-1 Brinkmann, 1985, Photoaffinity labeling of androgen receptors with 17 β-hydroxy-17 α-[3H]methyl-4,9,11-estratrien-3-one, Biochem. Biophys. Res. Commun., 126, 163, 10.1016/0006-291X(85)90586-8 Brooks, 1995, Spinal and bulbar muscular atrophy: A trinucleotide-repeat expansion neurodegenerative disease, Trends Neurosci., 18, 459, 10.1016/0166-2236(95)94497-S Bubendorf, 1999, Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays, Cancer Res., 59, 803 Castagnaro, 1993, Androgen receptor gene mutations and p53 gene analysis in advanced prostate cancer, Verh. Dtsch. Ges. Pathol., 77, 119 Chamberlain, 1994, The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function, Nucleic Acids Res., 22, 3181, 10.1093/nar/22.15.3181 Chang, 1988, Molecular cloning of human and rat complementary DNA encoding androgen receptors, Science, 240, 324, 10.1126/science.3353726 Choong, 1996, Reduced androgen receptor gene expression with first exon CAG repeat expansion, Mol. Endocrinol., 10, 1527, 10.1210/me.10.12.1527 Chung, 1999, Clonal analysis of a solitary follicular nodule of the thyroid with the polymerase chain reaction method, Mod. Pathol., 12, 265 Clay, 1993, Transcriptional repression of the glycoprotein hormone alpha subunit gene by androgen may involve direct binding of androgen receptor to the proximal promoter, J. Biol. Chem., 268, 13556, 10.1016/S0021-9258(19)38685-5 Cohen, 1996, Androgen-induced proliferation in the developing larynx of Xenopus laevis is regulated by thyroid hormone, Dev. Biol., 178, 113, 10.1006/dbio.1996.0202 Craft, 1999, A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase, Nat. Med., 5, 280, 10.1038/6495 Culig, 1993, Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone, Mol. Endocrinol., 7, 1541, 10.1210/me.7.12.1541 Culig, 1995, Activation of the androgen receptor by polypeptide growth factors and cellular regulators, World J. Urol., 13, 285, 10.1007/BF00185971 Culig, 1995, Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor and epidermal growth factor, Eur. Urol., 27, 45, 10.1159/000475232 Culig, 1994, Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor, Cancer Res., 54, 5474 Culig, 1997, Androgen receptor gene mutations in prostate cancer. Implications for disease progression and therapy, Drugs Aging., 10, 50, 10.2165/00002512-199710010-00005 Culig, 1997, Synergistic activation of androgen receptor by androgen and luteinizing hormone-releasing hormone in prostatic carcinoma cells, Prostate., 32, 106, 10.1002/(SICI)1097-0045(19970701)32:2<106::AID-PROS5>3.0.CO;2-K Culig, 1998, Expression, structure, and function of androgen receptor in advanced prostatic carcinoma, Prostates, 35, 63, 10.1002/(SICI)1097-0045(19980401)35:1<63::AID-PROS9>3.0.CO;2-I Culig, 1997, Hyperactive androgen receptor in prostate cancer: What does it mean for new therapy concepts?, Histol. Histopathol., 12, 781 Culig, 1999, Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system, Br. J. Cancer, 81, 242, 10.1038/sj.bjc.6690684 Culig, 1993, DNA sequence of the androgen receptor in prostatic tumor cell lines and tissue specimens assessed by means of the polymerase chain reaction, Prostate, 22, 11, 10.1002/pros.2990220103 Culig, 1996, Activation of two mutant androgen receptors from human prostatic carcinoma by adrenal androgens and metabolic derivatives of testosterone, Cancer Detect. Prev., 20, 68 Delabesse, 1995, Quantitative nonradioactive clonality analysis of human leukemic cells and progenitors using the human androgen receptor (AR) gene, Leukemia, 9, 1578 Delabesse, 1997, Molecular analysis of clonality in Kaposi's sarcoma, J. Clin. Pathol., 50, 664, 10.1136/jcp.50.8.664 de Vere, 1997, Human androgen receptor expression in prostate cancer following androgen ablation, Eur. Urol., 31, 1, 10.1159/000474409 deVere White, 1999, Use of a yeast assay to detect functional alterations in p53 in prostate cancer: Review and future directions, Prostate, 41, 134, 10.1002/(SICI)1097-0045(19991001)41:2<134::AID-PROS8>3.0.CO;2-E Dowsing, 1999, Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene, Lancet, 354, 640, 10.1016/S0140-6736(98)08413-X El Kassar, 1995, Clonal analysis of haemopoietic cells in essential thrombocythaemia, Br. J. Haematol., 90, 131, 10.1111/j.1365-2141.1995.tb03391.x Elo, 1995, Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol, J. Clin. Endocrinol. Metab., 80, 3494, 10.1210/jc.80.12.3494 Evans, 1996, Low incidence of androgen receptor gene mutations in human prostatic tumors using single strand conformation polymorphism analysis, Prostate., 28, 162, 10.1002/(SICI)1097-0045(199603)28:3<162::AID-PROS3>3.0.CO;2-H Fenton, 1997, Functional characterization of mutant androgen receptors from androgen-independent prostate cancer, Clin. Cancer Res., 3, 1383 Ferraris, 1997, Polyclonal origin of medullary carcinoma of the thyroid in multiple endocrine neoplasia type 2, Hum. Genet., 99, 202, 10.1007/s004390050339 Fujimoto, 1999, Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate, J. Biol. Chem., 274, 8316, 10.1074/jbc.274.12.8316 Gaddipati, 1994, Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers, Cancer Res., 54, 2861 Gaffey, 1996, Clonal analysis of focal nodular hyperplasia of the liver, Am. J. Pathol., 148, 1089 Ghadessy, 1999, Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions, J. Clin. Invest., 103, 1517, 10.1172/JCI4289 Giovannucci, 1999, The CAG repeat within the androgen receptor gene and benign prostatic hyperplasia, Urology, 53, 121, 10.1016/S0090-4295(98)00468-3 Giovannucci, 1999, CAG repeat within the androgen receptor gene and incidence of surgery for benign prostatic hyperplasia in U.S. physicians, Prostate, 39, 130, 10.1002/(SICI)1097-0045(19990501)39:2<130::AID-PROS8>3.0.CO;2-# Giovannucci, 1997, The CAG repeat within the androgen receptor gene and its relationship to prostate cancer, 94, 3320 Gorski, 1968, Hormone receptors: Studies on the interaction of estrogen with the uterus, Rec. Prog. Horm. Res., 24, 45 Green, 1996, Clonality of tuberous sclerosis harmatomas shown by non-random X-chromosome inactivation, Hum. Genet., 97, 240, 10.1007/BF02265273 Grino, 1988, A mutation of the androgen receptor associated with partial androgen resistance, familial gynecomastia, and fertility, J. Clin. Endocrinol. Metab., 66, 754, 10.1210/jcem-66-4-754 He, 1999, Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain, J. Biol. Chem., 274, 37219, 10.1074/jbc.274.52.37219 Heckert, 1997, Transcriptional repression of the alpha-subunit gene by androgen receptor occurs independently of DNA binding but requires the DNA-binding and ligand-binding domains of the receptor, Mol. Endocrinol., 11, 1497, 10.1210/me.11.10.1497 Hobisch, 1998, Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor, Cancer Res., 58, 4640 Hsiao, 1999, Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells, J. Biol. Chem., 274, 22373, 10.1074/jbc.274.32.22373 Hsiao, 1999, The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator, J. Biol. Chem., 274, 20229, 10.1074/jbc.274.29.20229 Hutson, 1986, Testicular feminization: A model for testicular descent in mice and men, J. Pediatr Surg., 21, 195, 10.1016/S0022-3468(86)80830-2 Igarashi, 1992, Strong correlation between the number of CAG repeats in androgen receptor genes and the clinical onset of features of spinal and bulbar muscular atrophy, Neurology, 42, 2300, 10.1212/WNL.42.12.2300 Imperato-McGinley, 1974, Steroid 5alpha-reductase deficiency in man: An inherited form of male pseudohermaphroditism, Science, 186, 1213, 10.1126/science.186.4170.1213 Ingles, 1997, Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor, J. Natl. Cancer Inst., 89, 166, 10.1093/jnci/89.2.166 Jensen, 1968, A two-step mechanism for the interaction of estradiol with rat uterus, 59, 32 Joyce, 1998, High dose bicalutamide for androgen independent prostate cancer: Effect of prior hormonal therapy, J. Urol., 159, 149, 10.1016/S0022-5347(01)64039-4 Kang, 1999, Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor, J. Biol. Chem., 274, 8570, 10.1074/jbc.274.13.8570 Keller, 1996, The androgen receptor: A mediator of diverse responses, Front. Biosci., 1, d59, 10.2741/A116 Kemp, 1989, Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous, 86, 7505 Kim, 1998, Clinical significance of clonality in thyroid nodules, Br. J. Surg., 85, 1125, 10.1046/j.1365-2168.1998.00783.x Klocker, 1994, Androgen receptor alterations in prostatic carcinoma, Prostate, 25, 266, 10.1002/pros.2990250506 Klocker, 1994, Androgen signal transduction and prostatic carcinoma, World J. Urol., 12, 99, 10.1007/BF00184245 Klocker, 1992, Point mutation in the DNA binding domain of the androgen receptor in two families with Reifenstein syndrome, Am. J. Hum. Genet., 50, 1318 Klocker, 1995, Androgen receptor alterations in patients with disturbances in male sexual development and in prostatic carcinoma, Urol. Int., 54, 2, 10.1159/000282684 Kobayashi, 1998, Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner, Biochem. Biophys. Res. Commun., 252, 145, 10.1006/bbrc.1998.9624 Koivisto, 1999, Androgen receptor gene amplification increases tissue PSA protein expression in hormone-refractory prostate carcinoma, J. Pathol., 189, 219, 10.1002/(SICI)1096-9896(199910)189:2<219::AID-PATH423>3.0.CO;2-F Koivisto, 1999, Amplification of the androgen receptor gene is associated with P53 mutation in hormone-refractory recurrent prostate cancer, J. Pathol., 187, 237, 10.1002/(SICI)1096-9896(199901)187:2<237::AID-PATH224>3.0.CO;2-I Koivisto, 1995, Analysis of genetic changes underlying local recurrence of prostate carcinoma during androgen deprivation therapy, Am. J. Pathol., 147, 1608 Koivisto, 1998, Androgen receptor gone and hormonal therapy failure of prostate cancer, Am. J. Pathol., 152, 1 Koivisto, 1997, Androgen receptor gene amplification: A possible molecular mechanism for androgen deprivation therapy failure in prostate cancer, Cancer Res., 57, 314 Koivisto, 1996, Androgen receptor gene amplification: A novel molecular mechanism for endocrine therapy resistance in human prostate cancer, Scand. J. Clin. Lab. Invest. Suppl., 226, 57, 10.3109/00365519609168299 Krohn, 1998, Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations, J. Clin. Endocrinol. Metab., 83, 130, 10.1210/jc.83.1.130 Kurachi, 1994, Regulatory mechanism of human factor IX gene: Protein binding at the Leyden-specific region, Biochemistry, 33, 1580, 10.1021/bi00172a039 Lamb, D. J., Ittman, M., Weigel, N. L., and Marcelli, M. (19xx). Influence of DNA extraction from paraffin-embedded prostate cancer tissue on the analysis of androgen receptor mutations. [Abstract]. Langley, 1998, Intermolecular NH2-/carboxylterminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity, J. Biol. Chem., 273, 92, 10.1074/jbc.273.1.92 Langley, 1995, Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer, J. Biol. Chem., 270, 29983, 10.1074/jbc.270.50.29983 Lanz, 1999, A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex, Cell, 97, 17, 10.1016/S0092-8674(00)80711-4 La Spada, 1992, Meiotic stability and genotype-phenotype correlation of the trinucleotide repeat in X-linked spinal and bulbar muscular atrophy, Nat. Genet., 2, 301, 10.1038/ng1292-301 La Spada, 1991, Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy, Nature, 352, 77, 10.1038/352077a0 Legius, 1999, Association between CAG repeat number in the androgen receptor and male infertility in a Belgian study, Clin. Genet., 56, 166, 10.1034/j.1399-0004.1999.560214.x Li, 1998, Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy, Ann. Neurol., 44, 249, 10.1002/ana.410440216 Li, 1998, Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy, Am. J. Pathol., 153, 695, 10.1016/S0002-9440(10)65612-X Lobaccaro, 1993, Androgen receptor gene mutation in male breast cancer, Hum. Mol. Genet., 2, 1799, 10.1093/hmg/2.11.1799 Lubahn, 1988, The human androgen receptor: Complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate, Mol. Endocrinol., 2, 1265, 10.1210/mend-2-12-1265 Lubahn, 1988, Cloning of human androgen receptor complementary DNA and localization to the X chromosome, Science, 240, 327, 10.1126/science.3353727 Lumbroso, 1997, Codonusage variants in the polymorphic (GGN)n trinucleotide repeat of the human androgen receptor gene, Hum. Genet., 101, 43, 10.1007/s004390050583 Ma, 1999, Multiple signal input and output domains of the 160kilodalton nuclear receptor coactivator proteins, Mol. Cell. Biol., 19, 6164, 10.1128/MCB.19.9.6164 MacLean, 1996, Spinal and bulbar muscular atrophy: Androgen receptor dysfunction caused by a trinucleotide repeat expansion, J. Neurol. Sci., 135, 149, 10.1016/0022-510X(95)00284-9 Makridakis, 1997, A prevalent missense substitution that modulates activity of prostatic steroid 5-alpha-reductase, Cancer Res., 57, 1020 Mangiarini, 1997, Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation, Nat. Genet., 15, 197, 10.1038/ng0297-197 Marcelli, 2000, Androgen receptor mutations in prostate cancer, Cancer Res., 60, 944 Mashal, 1994, Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata, Genes Chrom. Cancer, 11, 1, 10.1002/gcc.2870110102 Mashal, 1993, Clonal analysis by study ofX chromosome inactivation in formalin-fixed paraffin-embedded tissue, Cancer Res., 53, 4676 McGuire, 1991, Estrogen receptor variants in clinical breast cancer, Mol. Endocrinol., 5, 1571, 10.1210/mend-5-11-1571 McKenna, 1999, Nuclear receptor coregulators: Cellular and molecular biology, Endocr Rev., 20, 321, 10.1210/er.20.3.321 Mhatre, 1993, Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy, Nat. Genet., 5, 184, 10.1038/ng1093-184 Mitsumori, 1999, Androgen receptor CAG repeat length polymorphism in benign prostatic hyperplasia (BPH): Correlation with adenoma growth, Prostate, 41, 253, 10.1002/(SICI)1097-0045(19991201)41:4<253::AID-PROS5>3.0.CO;2-9 Miyake, 1994, Androgen receptor expression in the preputial gland and its sebocytes, J. Invest. Dermatol., 103, 721, 10.1111/1523-1747.ep12398601 Moilanen, 1998, Activation of androgen receptor function by a novel nuclear protein kinase, Mol. Biol. Cell., 9, 2527, 10.1091/mbc.9.9.2527 Morris, 1953 Nakajima, 1997, Effects of androgen receptor polyglutamine tract expansion on proliferation of NG108-15 cells, Neurosci. Lett., 222, 83, 10.1016/S0304-3940(97)13348-1 Nakamura, 1994, Exonic trinucleotide repeats and expression of androgen receptor gene in spinal cord from X-linked spinal and bulbar muscular atrophy, J. Neurol. Sci., 122, 74, 10.1016/0022-510X(94)90054-X Nasu, 1998, Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells, Nat. Med., 4, 1062, 10.1038/2048 Nazareth, 1996, Activation of the human androgen receptor through a protein kinase A signaling pathway, J. Biol. Chem., 271, 19900, 10.1074/jbc.271.33.19900 Nazareth, 1999, A C619Y mutation in the human androgen receptor causes inactivation and mislo calization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1), Mol. Endocrinol., 13, 2065, 10.1210/me.13.12.2065 Nitsche, 1996, Differential display RT PCR of total RNA fromhuman foreskin fibroblasts for investigation of androgen-dependent gene expression, Am. J. Med. Genet., 63, 231, 10.1002/(SICI)1096-8628(19960503)63:1<231::AID-AJMG40>3.0.CO;2-M Newmark, 1992, Androgen receptor gene mutations in human prostate cancer, 89, 6319 Nordenskjold, 1999, Screening for mutations in candidate genes for hypospadias, Urol. Res., 27, 49, 10.1007/s002400050088 Nupponen, 1998, Genetic alterations in hormone-refractory recurrent prostate carcinomas, Am. J. Pathol., 153, 141, 10.1016/S0002-9440(10)65554-X Ochiai, 1996, Clonal analysis of hepatocellular carcinoma, Gan To Kagaku Ryoho, 23, 182 Olsen, 1998, Androgens accelerate thymocyte apoptosis, Endocrinology, 139, 748, 10.1210/en.139.2.748 Olsen, 1994, Induction of immature thymocyte proliferation after castration of normal male mice, Endocrinology, 134, 107, 10.1210/en.134.1.107 Palmberg, 1997, Androgen receptor gene amplification in a recurrent prostate cancer after monotherapy with the nonsteroidal potent antiandrogen Casodex (bica lutamide) with a subsequent favorable response to maximal androgen blockade, Eur. Urol., 31, 216, 10.1159/000474453 Papandreou, 1998, Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression, Nat Med., 4, 50, 10.1038/nm0198-050 Paradis, 1997, Evidence for the polyclonal nature of focal nodular hyperplasia of the liver by the study of X-chromosome inactivation, Hepatology, 26, 891, 10.1002/hep.510260414 Park, 1995, X chromosome inactivation and microsatellite instability in early and advanced bilateral ovarian carcinomas, Cancer Res., 55, 4793 Parkar, 1996, Polymerase chain reaction analysis of oestrogen and androgen receptor expression in human gingival and periodontal tissue, Arch. Oral Biol., 41, 979, 10.1016/S0003-9969(96)00053-2 Paz, 1997, A genetic sequence change in the 3′-noncoding region of the androgen receptor gene in prostate carcinoma, Eur. Urol., 31, 209, 10.1159/000474452 Peterziel, 1995, Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand binding, Int. J. Cancer, 63, 544, 10.1002/ijc.2910630415 Piao, 1997, Clonality of large regenerative nodules in liver cirrhosis, Liver, 17, 251, 10.1111/j.1600-0676.1997.tb01026.x Platz, 1998, The androgen receptor gene GGN microsatellite and prostate cancer risk, Cancer Epidemiol. Biomarkers Prev., 7, 379 Quade, 1997, Disseminated peritoneal leiomyomatosis: Clonality analysis by X chromosome inactivation and cytogenetics of a clinically benign smooth muscle proliferation, Am. J. Pathol., 150, 2153 Quigley, 1995, Androgen receptor defects: Historical, clinical, and molecular perspectives, Endocr Rev., 16, 271, 10.1210/edrv-16-3-271 Ris-Stalpers, 1993, Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity, Biochem. Biophys. Res. Commun., 196, 173, 10.1006/bbrc.1993.2231 Roche, 1992, A consensus DNA-binding site for the androgen receptor, Mol. Endocrinol., 6, 2229, 10.1210/me.6.12.2229 Rodien, 1996, Different phenotypes in a family with androgen insensitivity caused by the same M780I point mutation in the androgen receptor gene, J. Clin. Endocrinol. Metab., 81, 2994, 10.1210/jc.81.8.2994 Ross, 1998, Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility, Cancer Res., 58, 4497 Ruizeveld de Winter, 1994, Androgen receptor status in localized and locally progressive hormone refractory human prostate cancer, Am. J. Pathol., 144, 735 Sawaya, 1998, Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne, J. Cutan. Med. Surg., 3, 9, 10.1177/120347549800300103 Schoenberg, 1994, Microsatellite mutation (CAG24 → 18) in the androgen receptor gene in human prostate cancer, Biochem. Biophys. Res. Commun., 198, 74, 10.1006/bbrc.1994.1011 Shimada, 1995, X-linked recessive bulbospinal neuronopathy: Clinical phenotypes and CAG repeat size in androgen receptor gene, Muscle Nerve, 18, 1378, 10.1002/mus.880181206 Shimazaki, 1997, Mechanism on androgen-independent progression of prostate cancer, Nippon Rinsho, 55, 1143 Stenoien, 1999, Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone, Hum. Mol. Genet., 8, 731, 10.1093/hmg/8.5.731 Stanford, 1997, Polymorphic repeats in the androgen receptor gene: Molecular markers of prostate cancer risk, Cancer Res., 57, 1194 Sutherland, 1996, Androgen receptor gene mutations are rarely associated with isolated penile hypospadias, J. Urol., 156, 828, 10.1016/S0022-5347(01)65830-0 Suzuki, 1996, Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: Relation to antiandrogen withdrawal syndrome, Prostate., 29, 153, 10.1002/1097-0045(199609)29:3<153::AID-PROS2990290303>3.0.CO;2-5 Suzuki, 1993, Androgen receptor gene mutations in human prostate cancer, J. Steroid Biochem. Mol. Biol., 46, 759, 10.1016/0960-0760(93)90316-O Takahashi, 1995, Prevalence of androgen receptor gene mutations in latent prostatic carcinomas from Japanese men, Cancer Res., 55, 1621 Tan, 1997, Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells, Mol. Endocrinol., 11, 450, 10.1210/me.11.4.450 Taplin, 1999, Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist, Cancer Res., 59, 2511 Taplin, 1995, Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer, N. Engl. J. Med., 332, 1393, 10.1056/NEJM199505253322101 Tilley, 1996, Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence, Clin. Cancer Res., 2, 277 Tilley, 1989, Characterization and expression of a cDNA encoding the human androgen receptor, 86, 327 Tilley, 1999 Tilley, 1990, Androgen receptor gene expression in human prostate carcinoma cell lines, Cancer Res., 50, 5382 Toft, 1966, A receptor molecule for estrogens: Isolation from the rat uterus and preliminary characterization, 55, 1574 Trapman, 1988, Cloning, structure and expression of a cDNA encoding the human androgen receptor, Biochem. Biopshys. Res. Commun., 153, 241, 10.1016/S0006-291X(88)81214-2 Tut, 1997, Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility, J. Clin. Endocrinol. Metab., 82, 3777, 10.1210/jc.82.11.3777 Van Deerlin, 1997, Evidence for the oligoclonal origin of the granulosa cell population of the mature human follicle, J. Clin. Endocrinol. Metab., 82, 3019, 10.1210/jc.82.9.3019 Veldscholte, 1992, The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens, J. Steroid Biochem. Mol. Biol., 41, 665, 10.1016/0960-0760(92)90401-4 Veldscholte, 1990, A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens, Biochem. Biophys. Res. Commun., 173, 534, 10.1016/S0006-291X(05)80067-1 Visakorpi, 1995, In vivo amplification of the androgen receptor gene and progression of human prostate cancer, Nat. Genet., 9, 401, 10.1038/ng0495-401 Viselli, 1995, Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes, Mol. Cell. Endocrinol., 109, 19, 10.1016/0303-7207(95)03479-Q Viselli, 1997, Androgens alter B cell development in normal male mice, Cell Immunol., 182, 99, 10.1006/cimm.1997.1227 Viselli, 1995, Castration alters peripheral immune function in normal male mice, Immunology, 84, 337 Voeller, 1991, v-rasH expression confers hormoneindependent in vitro growth to LNCaP prostate carcinoma cells, Mol. Endocrinol., 5, 209, 10.1210/mend-5-2-209 Vottero, 1999, Androgen receptor-mediated hypersensitivity to androgens in women with nonhyperandrogenic hirsutism: Skewing of X-chromosome inactivation, J. Clin. Endocrinol. Metab., 84, 1091, 10.1210/jc.84.3.1091 Walsh, 1998, Patterns of X chromosome inactivation in sporadic basal cell carcinomas: Evidence for clonality, J. Am. Acad. Dermatol., 38, 49, 10.1016/S0190-9622(98)70538-9 Walsh, 1996, Clonality of basal cell carcinoma-Molecular analysis of an interesting case, J. Invest. Dermatol., 106, 579, 10.1111/1523-1747.ep12344982 Wang, 1997, Androgen receptor gene mutations in prostate cancer, Nippon Hinyokika Gakkai Zasshi, 88, 550 Warner, 1990, X-linked spinal muscular atrophy (Kennedy's syndrome): A kindred with hypobetalipoproteinemia, Arch. Neurol., 47, 1117, 10.1001/archneur.1990.00530100087018 Watanabe, 1997, Genetic alterations of androgen receptor gene in Japanese human prostate cancer, Jpn. J. Clin. Oncol., 27, 389, 10.1093/jjco/27.6.389 Wiener, 1998, Androgen receptor gene alterations are not associated with isolated cryptorchidism, J. Urol., 160, 863, 10.1016/S0022-5347(01)62823-4 Wiener, 1997, Molecular biology and function of the androgen receptor in genital devlopment, J. Urol., 157, 1377, 10.1016/S0022-5347(01)64995-4 Wilbert, 1983, Characterization of the cytosol androgen receptor of the human prostate, J. Clin. Endocrinol. Metab., 56, 113, 10.1210/jcem-56-1-113 Wilson, 1976, Binding properties of androgen receptors: Evidence for identical receptors in rat testis, epididymis, and prostate, J. Biol. Chem., 251, 5620, 10.1016/S0021-9258(17)33103-4 Yeh, 1996, Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells, 93, 5517 Yeh, 1998, From estrogen to androgen receptor: a new pathway for sex hormones in prostate, 95, 5527