Liệu pháp kháng androgen trong ung thư tuyến tiền liệt kháng castrate: liệu liệu pháp nền GnRH agonist có quan trọng không?

Springer Science and Business Media LLC - Tập 33 - Trang 1079-1085 - 2014
Axel S. Merseburger1, Peter Hammerer2, Francois Rozet3, Thierry Roumeguère4, Orazio Caffo5, Fernando Calais da Silva6, Antonio Alcaraz7
1Department of Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany
2Department of Urology, Academic Hospital Braunschweig, Brunswick, Germany
3Department of Urology, L’Institut Mutualiste Montsouris, Paris, France
4Department of Urology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
5Department of Medical Oncology, Santa Chiara Hospital, Trento, Italy
6Department of Urology, Centro Hospitalar Lisboa Central, Lisbon, Portugal
7Department of Urology, Hospital Clínic Universitat de Barcelona, Barcelona, Spain

Tóm tắt

Số lượng ngày càng tăng các phương pháp điều trị để điều trị ung thư tuyến tiền liệt kháng castrate di căn (mCRPC) đang tồn tại, và với những lựa chọn mới này, nhiều câu hỏi về việc tối ưu hóa điều trị vẫn chưa được giải đáp. Một khuyến nghị có thể bị bỏ qua bởi các bác sĩ là liệu pháp kháng androgen (ADT) nên được duy trì khi CRPC phát triển và khi điều trị với bất kỳ chất mới nào được bắt đầu. Tuy nhiên, để nhấn mạnh khuyến nghị này, việc kiểm tra các bằng chứng về việc duy trì ADT trong các tình huống lâm sàng khác nhau là rất hữu ích. Tuyên bố này, phản ánh quan điểm của các tác giả, cung cấp một cuộc thảo luận về các bằng chứng này và lý do đứng sau khuyến nghị rằng ADT nên được tiếp tục trong trường hợp CRPC.

Từ khóa

#Ung thư tuyến tiền liệt kháng castrate #liệu pháp kháng androgen #liệu pháp GnRH agonist #điều trị ung thư #CRPC

Tài liệu tham khảo

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