Analysis of the risk factors for early death due to disease recurrence or progression within 1 year after hepatectomy in patients with hepatocellular carcinoma

Arii S, Yamaoka Y, Futagawa S, Inoue K, Kobayashi K, Kojiro M, Makuuchi M, Nakamura Y, Okita K, Yamada R: Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology. 2000, 32: 1224-1229. 10.1053/jhep.2000.20456.

Hasegawa K, Kokudo N, Imamura H, Matsuyama Y, Aoki T, Minagawa M, Sano K, Sugawara Y, Takayama T, Makuuchi M: Prognostic impact of anatomic resection for hepatocellular carcinoma. Ann Surg. 2005, 242: 252-259. 10.1097/01.sla.0000171307.37401.db.

Kamiyama T, Nakanishi K, Yokoo H, Kamachi H, Tahara M, Suzuki T, Shimamura T, Furukawa H, Matsushita M, Todo S: Recurrence patterns after hepatectomy of hepatocellular carcinoma: implication of Milan criteria utilization. Ann Surg Oncol. 2009, 16: 1560-1571. 10.1245/s10434-009-0407-7.

Kondo K, Chijiiwa K, Makino I, Kai M, Maehara N, Ohuchida J, Naganuma S: Risk factors for early death after liver resection in patients with solitary hepatocellular carcinoma. J Hepatobiliary Pancreat Surg. 2005, 12: 399-404. 10.1007/s00534-005-1009-9.

Adachi E, Maeda T, Matsumata T, Shirabe K, Kinukawa N, Sugimachi K, Tsuneyoshi M: Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma. Gastroenterology. 1995, 108: 768-775. 10.1016/0016-5085(95)90450-6.

Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, Sugawara Y, Minagawa M, Takayama T, Kawasaki S, Makuuchi M: Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol. 2003, 38: 200-207.

Poon RT, Fan ST, Ng IO, Lo CM, Liu CL, Wong J: Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma. Cancer. 2000, 89: 500-507. 10.1002/1097-0142(20000801)89:3<500::AID-CNCR4>3.0.CO;2-O.

Ikeda Y, Kajiyama K, Adachi E, Yamagata M, Shimada M, Yanaga K: Early recurrence after surgery of hepatocellular carcinoma. Hepatogastroenterology. 1995, 42: 469-472.

Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M, Rodes J: Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepato. 2001, 35: 421-430. 10.1016/S0168-8278(01)00130-1.

Makuuchi M, Kokudo N, Arii S, Futagawa S, Kaneko S, Kawasaki S, Matsuyama Y, Okazaki M, Okita K, Omata M, Saida Y, Takayama T, Yamaoka Y: Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan. Hepatol Res. 2008, 38: 37-51. 10.1111/j.1872-034X.2007.00216.x.

Regimbeau JM, Abdalla EK, Vauthey JN, Lauwers GY, Durand F, Nagorney DM, Ikai I, Yamaoka Y, Belghiti J: Risk factors for early death due torecurrence after liver resection for hepatocellular carcinoma: results of a multicenter study. J Surg Oncol. 2004, 85: 36-41. 10.1002/jso.10284.

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Haussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008, 359: 378-390. 10.1056/NEJMoa0708857.

Shah SA, Greig PD, Gallinger S, Cattral MS, Dixon E, Kim RD, Taylor BR, Grant DR, Vollmer CM: Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes. J Am Coll Surg. 2006, 202: 275-283. 10.1016/j.jamcollsurg.2005.10.005.

Adachi E, Maeda T, Kajiyama K, Kinukawa N, Matsumata T, Sugimachi K, Tsuneyoshi M: Factors correlated with portal venous invasion by hepatocellular carcinoma: univariate and multivariate analyses of 232 resected cases without preoperative treatments. Cancer. 1996, 77: 2022-2031. 10.1002/(SICI)1097-0142(19960515)77:10<2022::AID-CNCR9>3.0.CO;2-S.

Kosuge T, Makuuchi M, Takayama T, Yamamoto J, Shimada K, Yamasaki S: Long-term results after resection of hepatocellular carcinoma: experience of 480 cases. Hepatogastroenterology. 1993, 40: 328-332.

Lai EC, You KT, Ng IO, Shek TW: The pathological basis of resection margin for hepatocellular carcinoma. World J Surg. 1993, 17: 790-discussion 91

Yang LY, Wang W, Peng JX, Yang JQ, Huang GW: Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma. World J Gastroenterol. 2004, 10: 3569-3573.

Wang W, Yang LY, Huang GW, Lu WQ, Yang ZL, Yang JQ, Liu HL: Genomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosis. Br J Cancer. 2004, 90: 2349-2355.

Nomura F, Ohnishi K, Tanabe Y: Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels. Analysis of 606 patients. Cancer. 1989, 64: 1700-1707. 10.1002/1097-0142(19891015)64:8<1700::AID-CNCR2820640824>3.0.CO;2-Z.

Hanazaki K, Kajikawa S, Koide N, Adachi W, Amano J: Prognostic factors after hepatic resection for hepatocellular carcinoma with hepatitis C viral infection: univariate and multivariate analysis. Am J Gastroenterol. 2001, 96: 1243-1250. 10.1111/j.1572-0241.2001.03634.x.

Matsumoto Y, Suzuki T, Asada I, Ozawa K, Tobe T, Honjo I: Clinical classification of hepatoma in Japan according to serial changes in serum alpha-fetoprotein levels. Cancer. 1982, 49: 354-360. 10.1002/1097-0142(19820115)49:2<354::AID-CNCR2820490224>3.0.CO;2-J.

Smith JB: Occurrence of alpha-fetoprotein in acute viral hepatitis. Int J Cancer. 1971, 8: 421-424.

Silver HK, Gold P, Shuster J, Javitt NB, Freedman SO, Finlayson ND: Alpha(1)-fetoprotein in chronic liver disease. N Engl J Med. 1974, 291: 506-508. 10.1056/NEJM197409052911006.

Fujiyama S, Tanaka M, Maeda S, Ashihara H, Hirata R, Tomita K: Tumor markers in early diagnosis, follow-up and management of patients with hepatocellular carcinoma. Oncology. 2002, 62 (Suppl 1): 57-63.

Lok AS, Lai CL: Alpha-Fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in the early detection of hepatocellular carcinoma. Hepatology. 1989, 9: 110-115. 10.1002/hep.1840090119.

Yamanaka J, Yamanaka N, Nakasho K, Tanaka T, Ando T, Yasui C, Kuroda N, Takata M, Maeda S, Matsushita K, Uematsu K, Okamoto E: Clinicopathologic analysis of stage II-III hepatocellular carcinoma showing early massive recurrence after liver resection. Gastroenterol Hepatol. 2000, 15: 1192-1198. 10.1046/j.1440-1746.2000.02323.x.

Takayasu K, Arii S, Kudo M, Ichida T, Matsui O, Izumi N, Matsuyama Y, Sakamoto M, Nakashima O, Ku Y, Kokudo N, Makuuchi M: Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines. J Hepatol. 2012, 56: 886-892. 10.1016/j.jhep.2011.10.021.

Llovet JM, Bustamante J, Castells A, Vilana R, Ayuso Mdel C, Sala M, Bru C, Rodes J, Bruix J: Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology. 1999, 29: 62-67. 10.1002/hep.510290145.

Kamiyama T, Nakanishi K, Yokoo H, Tahara M, Nakagawa T, Kamachi H, Taguchi H, Shirato H, Matsushita M, Todo S: Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Int J Clin Oncol. 2007, 12: 363-368. 10.1007/s10147-007-0701-y.

Minagawa M, Makuuchi M, Takayama T, Ohtomo K: Selection criteria for hepatectomy in patients with hepatocellular carcinoma and portal vein tumor thrombus. Ann Surg. 2001, 233: 379-384. 10.1097/00000658-200103000-00012.

Nagano H, Sakon M, Eguchi H, Kondo M, Yamamoto T, Ota H, Nakamura M, Wada H, Damdinsuren B, Marubashi S, Miyamoto A, Takeda Y, Dono K, Umeshit K, Nakamori S, Monden M: Hepatic resection followed by IFN-alpha and 5-FU for advanced hepatocellular carcinoma with tumor thrombus in the major portal branch. Hepatogastroenterology. 2007, 54: 172-179.