Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study

Shigaku = Odontology - Tập 103 - Trang 314-321 - 2014
Chieko Kudo1, Wee Soo Shin2, Masato Minabe3,4, Kazuo Harai5,6, Kai Kato7, Hiroaki Seino8, Eiji Goke9, Nobuhiro Sasaki10, Takemasa Fujino11, Nobuichi Kuribayashi12, Youko Onuki Pearce13, Masato Taira14, Hiroshi Maeda15, Shogo Takashiba15
1Department of Pathophysiology–Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
2Sekimachi Medical Clinic, Tokyo, Japan
3Bunkyo Do-ri Dental Clinic, Chiba, Japan
4Division of Periodontology, Department of Oral Science, Kanagawa Dental University, Kanagawa, Japan
5Matsumoto Dental Office, Tokyo, Japan
6Harai Dental Office, Tokyo, Japan
7Mejiro Medical-Road Dental Clinic, Tokyo, Japan
8Tomiya Central Hospital, Miyagi, Japan
9Goke Dental Clinic, Tokyo, Japan
10Katsutadai Dental Clinic, Chiba, Japan
11Kyodo Dental Clinic, Tokyo, Japan
12Misaki Internal Medicine Clinic, Chiba, Japan
13Pearce Clinic, Chiba, Japan
14Taira Clinic, Chiba, Japan
15Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan

Tóm tắt

It has been revealed that atherosclerosis and periodontal disease may have a common mechanism of “chronic inflammation”. Several reports have indicated that periodontal infection is related to atherosclerosis, but none have yet reported such an investigation through the cooperation of local clinics. This study was performed in local Japanese clinics to examine the relationship between periodontal disease and atherosclerosis under collaborative medical and dental care. A pilot multicenter cross-sectional study was conducted on 37 medical patients with lifestyle-related diseases under consultation in participating medical clinics, and 79 periodontal patients not undergoing medical treatment but who were seen by participating dental clinics. Systemic examination and periodontal examination were performed at baseline, and the relationships between periodontal and atherosclerosis-related clinical markers were analyzed. There was a positive correlation between LDL-C level and plasma IgG antibody titer to Porphyromonas gingivalis. According to the analysis under adjusted age, at a cut-off value of 5.04 for plasma IgG titer to Porphyromonas gingivalis, the IgG titer was significantly correlated with the level of low-density lipoprotein cholesterol (LDL-C). This study suggested that infection with periodontal bacteria (Porphyromonas gingivalis) is associated with the progression of atherosclerosis. Plasma IgG titer to Porphyromonas gingivalis may be useful as the clinical risk marker for atherosclerosis related to periodontal disease. Moreover, the application of the blood examination as a medical check may lead to the development of collaborative medical and dental care within the local medical clinical system for the purpose of preventing the lifestyle-related disease.

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