Analysis of motility and mucociliary function of tracheal epithelial cilia

Afzelius, 1976, A human syndrome caused by immotile cilia, Science, 193, 317, 10.1126/science.1084576 Afzelius, 2004, Cilia-related diseases, Journal of Pathology, 204, 470, 10.1002/path.1652 Aiello, 1972, The metachronal wave of lateral cilia of Mytilus edulis, Journal of Cell Biology, 54, 493, 10.1083/jcb.54.3.493 Becker-Heck, 2011, The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation, Nature Genetics, 43, 79, 10.1038/ng.727 Boisvieux-Ulrich, 1991, Determination of ciliary polarity precedes differentiation in the epithelial cells of quail oviduct, Biology of the Cell, 72, 3, 10.1016/0248-4900(91)90072-U Boon, 2014, MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia, Nature Communications, 5, 4418, 10.1038/ncomms5418 Bustamante-Marin, 2017, Cilia and mucociliary clearance, Cold Spring Harbor Perspectives in Biology, 9, 10.1101/cshperspect.a028241 Bustamante-Marin, 2019, Lack of GAS2L2 causes PCD by impairing cilia orientation and Mucociliary clearance, American Journal of Human Genetics, 104, 229, 10.1016/j.ajhg.2018.12.009 Chilvers, 2003, Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia, Journal of Allergy and Clinical Immunology, 112, 518, 10.1016/S0091-6749(03)01799-8 Christopher, 2014, The effects of temperature and anesthetic agents on ciliary function in murine respiratory epithelia, Frontiers in Pediatrics, 2, 111, 10.3389/fped.2014.00111 Clare, 2014, Basal foot MTOC organizes pillar MTs required for coordination of beating cilia, Nature Communications, 5, 4888, 10.1038/ncomms5888 Clary-Meinesz, 1992, Temperature effect on the ciliary beat frequency of human nasal and tracheal ciliated cells, Biology of the Cell, 76, 335, 10.1016/0248-4900(92)90436-5 Delmotte, 2006, Ciliary beat frequency is maintained at a maximal rate in the small airways of mouse lung slices, American Journal of Respiratory Cell and Molecular Biology, 35, 110, 10.1165/rcmb.2005-0417OC Fliegauf, 2007, When cilia go bad: Cilia defects and ciliopathies, Nature Reviews. Molecular Cell Biology, 8, 880, 10.1038/nrm2278 Francis, 2013, Ex vivo method for high resolution imaging of cilia motility in rodent airway epithelia, Journal of Visualized Experiments, 78, 50343 Frisch, 1968, Development of order during ciliogenesis, The Anatomical Record, 162, 221, 10.1002/ar.1091620209 Hastie, 1986, Isolation of cilia from porcine tracheal epithelium and extraction of dynein arms, Cell Motility and the Cytoskeleton, 6, 25, 10.1002/cm.970060105 Hoegger, 2014, Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs, Proceedings of the National Academy of Sciences of the United States of America, 111, 2355, 10.1073/pnas.1323633111 Hosie, 2014, Primary ciliary dyskinesia: Overlooked and undertreated in children, Journal of Paediatrics and Child Health, 50, 952, 10.1111/jpc.12628 Ikegami, 2010, Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry, Proceedings of the National Academy of Sciences of the United States of America, 107, 10490, 10.1073/pnas.1002128107 Iskandar, 2019, A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment, Internal and Emergency Medicine, 14, 863, 10.1007/s11739-019-02055-x Jain, 1993, Modulation of airway epithelial cell ciliary beat frequency by nitric oxide, Biochemical and Biophysical Research Communications, 191, 83, 10.1006/bbrc.1993.1187 Kamiya, 2020, Influenza a virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium, Respiratory Research, 21, 282, 10.1186/s12931-020-01555-1 Katoh, 2018, Three-dimensional tracking of microbeads attached to the tip of single isolated tracheal cilia beating under external load, Scientific Reports, 8, 15562, 10.1038/s41598-018-33846-5 Katsumata, 2022, Effects of long-acting muscarinic antagonists on promoting ciliary function in airway epithelium, BMC Pulmonary Medicine, 22, 186, 10.1186/s12890-022-01983-3 Knowles, 2002, Mucus clearance as a primary innate defense mechanism for mammalian airways, Journal of Clinical Investigation, 109, 571, 10.1172/JCI0215217 Knowles, 2014, Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype, American Journal of Respiratory and Critical Care Medicine, 189, 707, 10.1164/rccm.201311-2047OC Komatani-Tamiya, 2012, Procaterol-stimulated increases in ciliary bend amplitude and ciliary beat frequency in mouse bronchioles, Cellular Physiology and Biochemistry, 29, 511, 10.1159/000338505 Kunimoto, 2012, Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet, Cell, 148, 189, 10.1016/j.cell.2011.10.052 Lechtreck, 2008, Mutations in Hydin impair ciliary motility in mice, Journal of Cell Biology, 180, 633, 10.1083/jcb.200710162 Lee, 2013, Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion, FASEB Journal, 27, 5094, 10.1096/fj.13-234476 Ma, 1999, Extracellular sodium regulates airway ciliary motility by inhibiting a P2X receptor, Nature, 400, 894, 10.1038/23743 Merveille, 2011, CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs, Nature Genetics, 43, 72, 10.1038/ng.726 Mitchell, 2007, Positive feedback mechanism governs the polarity and motion of motile cilia, Nature, 447, 97, 10.1038/nature05771 Park, 2008, Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells, Nature Genetics, 40, 871, 10.1038/ng.104 Raidt, 2014, Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia, European Respiratory Journal, 44, 1579, 10.1183/09031936.00052014 Rutland, 1990, Random ciliary orientation. A cause of respiratory tract disease, The New England Journal of Medicine, 323, 1681, 10.1056/NEJM199012133232406 Sanderson, 1981, Ciliary activity of cultured rabbit tracheal epithelium: Beat pattern and metachrony, Journal of Cell Science, 47, 331, 10.1242/jcs.47.1.331 Satir, 1963, Studies on cilia. The fixation of the metachronal wave, Journal of Cell Biology, 18, 345, 10.1083/jcb.18.2.345 Schwabe, 2008, Primary ciliary dyskinesia associated with normal axoneme ultrastructure is caused by DNAH11 mutations, Human Mutation, 29, 289, 10.1002/humu.20656 Sears, 2021, Induction of ciliary orientation by matrix patterning and characterization of mucociliary transport, Biophysical Journal, 120, 1387, 10.1016/j.bpj.2021.01.041 Sears, 2015, Continuous mucociliary transport by primary human airway epithelial cells in vitro, The American Journal of Physiology - Lung Cellular and Molecular Physiology, 309, L99, 10.1152/ajplung.00024.2015 Shah, 2009, Motile cilia of human airway epithelia are chemosensory, Science, 325, 1131, 10.1126/science.1173869 Simet, 2010, Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function, American Journal of Respiratory Cell and Molecular Biology, 43, 635, 10.1165/rcmb.2009-0297OC Sleigh, 1988, The propulsion of mucus by cilia, American Review of Respiratory Disease, 137, 726, 10.1164/ajrccm/137.3.726 Takeuchi, 2016, Recent advances in primary ciliary dyskinesia, Auris Nasus Larynx, 43, 229, 10.1016/j.anl.2015.09.012 Takeyama, 1993, Effect of macrolide antibiotics on ciliary motility in rabbit airway epithelium in-vitro, Journal of Pharmacy and Pharmacology, 45, 756, 10.1111/j.2042-7158.1993.tb07104.x Tamaoki, 1995, Role of NO generation in beta-adrenoceptor-mediated stimulation of rabbit airway ciliary motility, American Journal of Physiology, 268, C1342, 10.1152/ajpcell.1995.268.6.C1342 Tamaoki, 1998, Vasopressin stimulates ciliary motility of rabbit tracheal epithelium: Role of V1b receptor-mediated Ca2+ mobilization, American Journal of Respiratory Cell and Molecular Biology, 19, 293, 10.1165/ajrcmb.19.2.3134 Ueno, 2012, Mouse respiratory cilia with the asymmetric axonemal structure on sparsely distributed ciliary cells can generate overall directional flow, Nanomedicine: Nanotechnology, Biology and Medicine, 8, 1081, 10.1016/j.nano.2012.01.004 Verdugo, 1982, Introduction: Mucociliary function in mammalian epithelia, Progress in Clinical and Biological Research, 80, 1 Wallingford, 2010, Planar cell polarity signaling, cilia and polarized ciliary beating, Current Opinion in Cell Biology, 22, 597, 10.1016/j.ceb.2010.07.011 Wallmeier, 2014, Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia, Nature Genetics, 46, 646, 10.1038/ng.2961 Yin, 2019, Mice with a deletion of Rsph1 exhibit a low level of Mucociliary clearance and develop a primary ciliary dyskinesia phenotype, American Journal of Respiratory Cell and Molecular Biology, 61, 312, 10.1165/rcmb.2017-0387OC