Analysis of fall-related adverse events among older adults using the Japanese Adverse Drug Event Report (JADER) database

Haruna Hatahira1, Shiori Hasegawa1, Sayaka Sasaoka1, Yamato Kato1, Junko Abe2, Yumi Motooka1, Akiho Fukuda1, Misa Naganuma1, Shin-ichi Nakao1, Ririka Mukai1, Kazuyo Shimada1, Kouseki Hirade3, Takeshi Kato3, Mitsuhiro Nakamura1
1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku nishi, Gifu, 501-1196, Japan
2Medical Database Co., Ltd., 3-11-10 Higashi, Shibuya-ku, Tokyo, 150-0011, Japan
3Department of Pharmacy, Kizawa Memorial Hospital, Kobi-cho, Shimo-kobi 590, Minokamo-shi, Gifu, 505-8503, Japan

Tóm tắt

Từ khóa


Tài liệu tham khảo

O’Loughlin JL, Robitaille Y, Boivin JF, Suissa S. Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. Am J Epidemiol. 1993;137:342–54.

Bergland A. Risk factors for serious fall related injury in elderly women living at home. Inj Prev. 2004;10:308–13.

Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing. 2006;35(Suppl 2):ii37–41.

Guideline for the prevention of falls in older persons. American Geriatrics Society, British geriatrics society, and American Academy of Orthopaedic surgeons panel on falls prevention. J Am Geriatr Soc. 2001;49:664–72.

Kannus P, Sievänen H, Palvanen M, Järvinen T, Parkkari J. Prevention of falls and consequent injuries in elderly people. Lancet. 2005;366:1885–93.

Ferreri S, Roth MT, Casteel C, Demby KB, Blalock SJ. Methodology of an ongoing, randomized controlled trial to prevent falls through enhanced pharmaceutical care. Am J Geriatr Pharmacother. 2008;6:61–81.

Deandrea S, Lucenteforte E, Bravi F, Foschi R, La Vecchia C, Negri E. Risk factors for falls in community-dwelling older people. Epidemiology. 2010;21:658–68.

Hartikainen S, Lönnroos E, Louhivuori K. Medication as a risk factor for falls: critical systematic review. J Gerontol A Biol Sci Med Sci. 2007;62:1172–81.

Woolcott JC, Richardson KJ, Wiens MO, Patel B, Marin J, Khan KM, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169:1952–60.

Ham AC, Swart KMA, Enneman AW, van Dijk SC, Oliai Araghi S, van Wijngaarden JP, et al. Medication-related fall incidents in an older, ambulant population: the B-PROOF study. Drugs Aging. 2014;31:917–27.

Bloch F, Thibaud M, Dugué B, Brèque C, Rigaud AS, Kemoun G. Psychotropic drugs and falls in the elderly people: updated literature review and meta-analysis. J Aging Health. 2011;23:329–46.

de Vries M, Seppala LJ, Daams JG, van de Glind EMM, Masud T, van der Velde N; EUGMS Task and Finish Group on Fall-Risk-Increasing Drugs. Fall-risk-increasing drugs: a systematic review and meta-analysis: I. cardiovascular drugs. J Am Med Dir Assoc 2018;19:371.e1–371.e9.

Seppala LJ, Wermelink AMAT, de Vries M, Ploegmakers KJ, van de Glind EMM, Daams JG, et al.; EUGMS task and Finish group on fall-risk-increasing drugs. Fall-risk-increasing drugs: a systematic review and meta-analysis: II. Psychotropics. J Am Med Dir Assoc 2018;19:371.e11–371.e17.

Seppala LJ, van de Glind EMM, Daams JG, Ploegmakers KJ, de Vries M, Wermelink AMAT, et al.; EUGMS Task and Finish Group on Fall-Risk-Increasing Drugs. Fall-Risk-Increasing Drugs: A Systematic Review and Meta-analysis: III. Others. J Am Med Dir Assoc. 2018;19:372.e1–372.e8.

The American geriatrics society 2015 Beers criteria update expert panel. American geriatrics society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63:2227–46.

Japan Geriatric Society. Guidelines for Medical Treatment and its Safety in the elderly 2015 (In Japanese). Tokyo: Medical View Co., Ltd; 2005.

Berdot S, Bertrand M, Dartigues JF, Fourrier A, Tavernier B, Ritchie K, et al. Inappropriate medication use and risk of falls--a prospective study in a large community-dwelling elderly cohort. BMC Geriatr. 2009;9:30.

Ray WA, Thapa PB, Gideon P. Benzodiazepines and the risk of falls in nursing home residents. J Am Geriatr Soc. 2000;48:682–5.

Stockl KM, Le L, Zhang S, Harada AS. Clinical and economic outcomes associated with potentially inappropriate prescribing in the elderly. Am J Manag Care. 2010;16:e1–10.

Ray WA. Psychotropic drugs and injuries among the elderly: a review. J Clin Psychopharmacol. 1992;12:386–96.

Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: I. psychotropic drugs. J Am Geriatr Soc. 1999;47:30–9.

Park H, Satoh H, Miki A, Urushihara H, Sawada Y. Medications associated with falls in older people: systematic review of publications from a recent 5-year period. Eur J Clin Pharmacol. 2015;71:1429–40.

Neutel CI, Perry S, Maxwell C. Medication use and risk of falls. Pharmacoepidemiol Drug Saf. 2002;11:97–104.

Ziere G, Dieleman JP, Hofman A, Pols HA, van der Cammen TJ, Stricker BH. Polypharmacy and falls in the middle age and elderly population. Br J Clin Pharmacol. 2006;61:218–23.

Lawlor DA, Patel R, Ebrahim S. Association between falls in elderly women and chronic diseases and drug use: cross sectional study. BMJ. 2003;327:712–7.

Baranzini F, Diurni M, Ceccon F, Poloni N, Cazzamalli S, Costantini C, et al. Fall-related injuries in a nursing home setting: is polypharmacy a risk factor? BMC Health Serv Res. 2009;9:228.

Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, et al. Association of polypharmacy with fall risk among geriatric outpatients. Geriatr Gerontol Int. 2011;11:438–44.

Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, et al. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int. 2012;12:425–30.

Helgadóttir B, Laflamme L, Monárrez-Espino J, Möller J. Medication and fall injury in the elderly population; do individual demographics, health status and lifestyle matter? BMC Geriatr. 2014;14:92.

Weber V, White A, McIlvried R. An electronic medical record (EMR)-based intervention to reduce polypharmacy and falls in an ambulatory rural elderly population. J Gen Intern Med. 2008;23:399–404.

Tromp AM, Pluijm SM, Smit JH, Deeg DJ, Bouter LM, Lips P. Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly. J Clin Epidemiol. 2001;54:837–44.

Zia A, Kamaruzzaman SB, Tan MP. The consumption of two or more fall risk-increasing drugs rather than polypharmacy is associated with falls. Geriatr Gerontol Int. 2017;17:463–70.

Bate A, Evans SJ. Quantitative signal detection using spontaneous ADR reporting. Pharmacoepidemiol Drug Saf. 2009;18:427–36.

Fukuda A, Tahara K, Hane Y, Matsui T, Sasaoka S, Hatahira H, et al. Comparison of the adverse event profiles of conventional and liposomal formulations of doxorubicin using the FDA adverse event reporting system. PLoS One. 2017;12:e0185654.

Kato Y, Umetsu R, Abe J, Ueda N, Nakayama Y, Kinosada Y, et al. Hyperglycemic adverse events following antipsychotic drug administration in spontaneous adverse event reports. J Pharm Heal Care Sci. 2015;1:15.

Abe J, Umetsu R, Uranishi H, Suzuki H, Nishibata Y, Kato Y, et al. Analysis of polypharmacy effects in older patients using Japanese adverse drug event report database. PLoS One. 2017;12:e0190102.

Fujiwara M, Kawasaki Y, Yamada H. A pharmacovigilance approach for post-marketing in Japan using the Japanese adverse drug event report (JADER) database and association analysis. PLoS One. 2016;11:e0154425.

Hatahira H, Abe J, Hane Y, Matsui T, Sasaoka S, Motooka Y, et al. Drug-induced gingival hyperplasia: a retrospective study using spontaneous reporting system. J Pharm Heal Care Sci. 2017;3:19.

Hasegawa S, Matsui T, Hane Y, Abe J, Hatahira H, Motooka Y, et al. Thromboembolic adverse event study of combined estrogen-progestin preparations using Japanese adverse drug event report database. PLoS One. 2017;12:e0182045.

Naganuma M, Motooka Y, Sasaoka S, Hatahira H, Hasegawa S, Fukuda A, et al. Analysis of adverse events of renal impairment related to platinum-based compounds using the Japanese adverse drug event report database. SAGE Open Med. 2018;6:1–11.

Lamoth CJ, van Deudekom FJ, van Campen JP, Appels BA, de Vries OJ, Pijnappels M. Gait stability and variability measures show effects of impaired cognition and dual tasking in frail people. J Neuroeng Rehabil. 2011;8:2.

Ijmker T, Lamoth CJ. Gait and cognition: the relationship between gait stability and variability with executive function in persons with and without dementia. Gait Posture. 2012;35:126–30.

Montero-Odasso M, Muir SW, Hall M, Doherty TJ, Kloseck M, Beauchet O, et al. Gait variability is associated with frailty in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2011;66:568–76.

de Groot MH, Van der Jagt-Willems HC, van Campen JP, Lems WF, Beijnen JH, Lamoth CJ. A flexed posture in elderly patients is associated with impairments in postural control during walking. Gait Posture. 2014;39:767–72.

Alvarez SA. Chi-squared computation for association rules: preliminary results. Technical report, BCCS-2003–01 July; 2003.

Yildirim P. Association patterns in open data to explore ciprofloxacin adverse events. Appl Clin Inform. 2015;6:728–47.

Butt DA, Mamdani M, Austin PC, Tu K, Gomes T, Glazier RH. The risk of falls on initiation of antihypertensive drugs in the elderly. Osteoporos Int. 2013;24:2649–57.

Weiner DK, Hanlon JT, Studenski SA. Effects of central nervous system polypharmacy on falls liability in community-dwelling elderly. Gerontology. 1998;44:217–21.

Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Kivelä SL. Psychotropic drugs and the risk of fractures in old age: a prospective population-based study. BMC Public Health. 2010;10:396.

Lai SW, Liao KF, Liao CC, Muo CH, Liu CS, Sung FC. Polypharmacy correlates with increased risk for hip fracture in the elderly: a population-based study. Medicine (Baltimore). 2010;89:295–9.

Haleem S, Lutchman L, Mayahi R, Grice JE, Parker MJ. Mortality following hip fracture: trends and geographical variations over the last 40 years. Injury. 2008;39:1157–63.

Huang ES, Karter AJ, Danielson KK, Warton EM, Ahmed AT. The association between the number of prescription medications and incident falls in a multi-ethnic population of adult type-2 diabetes patients: the diabetes and aging study. J Gen Intern Med. 2010;25:141–6.

Zint K, Haefeli WE, Glynn RJ, Mogun H, Avorn J, Stürmer T. Impact of drug interactions, dosage, and duration of therapy on the risk of hip fracture associated with benzodiazepine use in older adults. Pharmacoepidemiol Drug Saf. 2010;19:1248–55.

French DD, Chirikos TN, Spehar A, Campbell R, Means H, Bulat T. Effect of concomitant use of benzodiazepines and other drugs on the risk of injury in a veterans population. Drug Saf. 2005;28:1141–50.

Aparasu RR, Mort JR. Inappropriate prescribing for the elderly: beers criteria-based review. Ann Pharmacother. 2000;34:338–46.

Lau DT, Kasper JD, Potter DE, Lyles A, Bennett RG. Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents. Arch Intern Med. 2005;165:68–74.

Richardson K, Bennett K, Kenny RA. Polypharmacy including falls risk-increasing medications and subsequent falls in community-dwelling middle-aged and older adults. Age Ageing. 2015;44:90–6.

American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American geriatrics society updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012;60: 616–631.

Dalleur O, Boland B, Losseau C, Henrard S, Wouters D, Speybroeck N, et al. Reduction of potentially inappropriate medications using the STOPP criteria in frail older inpatients: a randomised controlled study. Drugs Aging. 2014;31:291–8.

O’Mahony D, O’Sullivan D, Byrne S, O’Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44:213–8.

De Geest S, Steeman E, Leventhal ME, Mahrer-Imhof R, Hengartner-Kopp B, Conca A, et al. Complexity in caring for an ageing heart failure population: concomitant chronic conditions and age related impairments. Eur J Cardiovasc Nurs. 2004;3:263–70.

Huang AR, Mallet L, Rochefort CM, Eguale T, Buckeridge DL, Tamblyn R. Medication-related falls in the elderly. Drugs Aging. 2012;29:359–76.

Chen Y, Zhu LL, Zhou Q. Effects of drug pharmacokinetic/pharmacodynamic properties, characteristics of medication use, and relevant pharmacological interventions on fall risk in elderly patients. Ther Clin Risk Manag. 2014;10:437–8.

Tan JL, Eastment JG, Poudel A, Hubbard RE. Age-related changes in hepatic function: an update on implications for drug therapy. Drugs Aging. 2015;32:999–1008.

Panel on prevention of falls in older persons, American geriatrics society and British geriatrics society. Summary of the updated American geriatrics society/British geriatrics society clinical practice guideline for prevention of falls in older persons. J Am Geriatr Soc. 2011;59:148–57.

Poluzzi E, Raschi E, Piccinni C, De Ponti F. Data mining techniques in pharmacovigilance: analysis of the publicly accessible FDA adverse event reporting system (AERS). INTECH; 2012. p. 265–302.