Phân tích các đa hình gen thường gặp như là yếu tố tiên lượng ở bệnh nhân ung thư vú có hạch bạch huyết dương tính

Journal of Cancer Research and Clinical Oncology - Tập 136 - Trang 1813-1819 - 2010
Gudrun Knechtel1, Günter Hofmann1, Armin Gerger1, Wilfried Renner2, Tanja Langsenlehner3, Joanna Szkandera1, Gerald Wolf4, Hellmut Samonigg1, Peter Krippl5, Uwe Langsenlehner6
1Department of Internal Medicine, Division of Oncology, Medical University Graz, Graz, Austria
2Clinical Institute of Medical and Laboratory Diagnostics, Medical University Graz, Graz, Austria
3Clinic of Therapeutic Radiology and Oncology, Medical University Graz, Graz, Austria
4Department of Radiology and Nuclear Medicine, General Hospital Leoben, Leoben, Austria
5Department of Internal Medicine, Regional Hospital of Fuerstenfeld, Fuerstenfeld, Austria
6Internal Outpatient Department, Steiermaerkische Gebietskrankenkasse, Graz, Austria

Tóm tắt

Phụ nữ mắc ung thư vú có liên quan đến hạch bạch huyết tại chỗ có nguy cơ cao tái phát tại chỗ hoặc phát triển di căn. Dữ liệu gần đây cho thấy rằng đa hình germline là một yếu tố quan trọng trước đây chưa được nhận ra trong sự tiến triển và di căn của ung thư vú. Chúng tôi đã đánh giá ảnh hưởng của 16 đa hình germline phổ biến được chọn lọc đến thời gian sống không bệnh và tổng thời gian sống của 216 phụ nữ được chẩn đoán mắc ung thư vú hạch bạch huyết dương tính. Alen ít gặp của FAS 1377G>A có liên quan đáng kể đến thời gian sống không bệnh kéo dài (P = 0.012, tỷ lệ rủi ro tái phát (RR) = 0.557, khoảng tin cậy (CI) 95% = 0.353–0.878) trong phân tích đơn biến. Sau khi điều chỉnh cho các yếu tố tiên lượng ung thư vú đã biết, mối liên hệ vẫn giữ được ý nghĩa thống kê (P = 0.050, RR = 0.500, CI = 0.309–0.809). Trong phân tích tổng thời gian sống, chúng tôi phát hiện một mối liên hệ đáng kể của các đa hình FAS 1377G>A (P = 0.040, RR = 0.451, CI = 0.496–1.188) và IL10 592C>A (P = 0.020, RR = 1.707, CI = 1.087–2.680) trong hồi quy Cox đơn biến. Tác động này vẫn giữ nguyên ý nghĩa thống kê trong phân tích đa biến cho đa hình IL10 592C>A (P = 0.013, RR 1.841, CI 1.140–2.973). Không có mối liên hệ nào được tìm thấy cho các đa hình MTHFR 677C>T, VEGF 936C>T, CCND1 870G>A, TGFB1 29T>C, FASLG 844C>T, FAS 670A>G, GPB3 825C>T, ITGA2 807C>T, ITGA2 1648G>A, ITGB3 176T>C, MMP1 -1607 1G/2G, MMP3 5A/6A, PTGS2 8473T>C, IL10 592C>A và SULT1A1 638G>A và sống không bệnh hoặc tổng thời gian sống. Dữ liệu của chúng tôi cho thấy rằng các đa hình FAS 1377G>A và IL10 592C>A có thể điều chỉnh thời gian sống không bệnh và tổng thời gian sống ở phụ nữ mắc ung thư vú có hạch bạch huyết dương tính.

Từ khóa

#đa hình gen #ung thư vú #hạch bạch huyết dương tính #tiên lượng #sống không bệnh #tổng thời gian sống

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