An updated review of genus Cistus L. since 2014: traditional uses, phytochemistry, and pharmacological properties
Tóm tắt
Genus Cistus L. (Cistaceae) occurs mainly in the Mediterranean region. Many plants of this genus have been used in different folk medicines since ancient times, mainly against peptic ailments and skin disorders, such as burns, wounds, and infections. Over the last years, Cistus species have attracted great interest due to the variety of their bioactive compounds and pharmacological activities. Comprehensive research of previously published literature was performed for the collection of the available data on the traditional uses, phytochemistry, and pharmacological properties of the genus Cistus since 2014, using electronic databases with several key search words. A total of 66 published scientific studies was examined. Over the last years, 111 secondary metabolites have been described in Cistus taxa. In vitro and in vivo studies, as well as a clinical study are included, highlighting the interesting pharmacological aspects of these plants. This review summarizes and discusses the current knowledge of the traditional uses, phytochemistry, and biological activities of Cistus plants, revealing the uncharted scientific territory and may provide critical information for future perspectives on these plants.
Tài liệu tham khảo
Ahmad M, Zafar M, Shahzadi N et al (2018) Ethnobotanical importance of medicinal plants traded in herbal markets of Rawalpindi-Pakistan. J Herb Med 11:78–89
Alarcόn R, de Santanaya MP, Priestley C et al (2015) Medicinal and local food plants in the south of Alava (Basque Country, Spain). J Ethnopharmacol 176:207–224
Al-Khalil S (1995) A survey of plants used in Jordanian traditional medicine. Int J Pharmacog 33(4):317–323
Aničić N, Patelou E, Papanikolaou A et al (2021) Comparative metabolite and gene expression analyses in combination with gene characterization revealed the patterns of flavonoids accumulation during Cistus creticus subsp. creticus fruit development. Front. Plant Sci. 12:619634
Attaguile G, Russo A, Campisi A et al (2000) Antioxidant activity and protective effect on DNA cleavage of extracts from Cistus incanus L. and Cistus monspeliensis L. Cell Biol Toxicol. 16(2):83–90
Benali T, Bouyahya A, Habbadi K et al (2020) Chemical composition and antibacterial activity of the essential oil and extracts of Cistus ladaniferus subsp. ladanifer and Mentha suaveolens against phytopathogenic bacteria and their ecofriendly management of phytopathogenic bacteria. Biocatal. Agric. Biotechnol. 28:101696
Benbelaïd F, Khadir A, Benziane Y, et al (2020) Chemical screening and biological activities of extracts from Cistus munbyi pomel, Curr. Tradit. Med. 7(2)
Boy FR, Casquete R, Martínez A et al (2021) Antioxidant, antihypertensive and antimicrobial properties of phenolic compounds obtained from native plants by different extraction methods. Int J Environ Res Public Health 18:2475
Bouyahya A, Abrini J, Et-Touys A, Bakri Y et al (2017) Indigenous knowledge of the use of medicinal plants in the North-West of Morocco and their biological activities. Eur J Integr Med 13:9–25
Bouyahya A, Bakri Y, Et-Touys A (2018a) In vitro antiproliferative activity of selected medicinal plants from the North-West of Morocco on several cancer cell lines. Eur J Integr Med 18:23–29
Bouyahya A, Et-Touys A, Dakka N et al (2018b) Antileishmanial potential of medicinal plants extracts from North-West of Morocco. Beni Suef Univ J BASIC Appl Sci 7:50–54
Carev I, Maravić A, Ilić N et al (2020) UPLC-MS/MS phytochemical analysis of two Croatian Cistus species and their biological activity. Life 10(7):112
Çaşkurlu A, Karadag AE, Kose YB et al (2020) In vitro antifungal activity of Cistus creticus L. against plant pathogenic fungi. Acta Pharm Sci 58:413–419
Chaves N, Escudero C, Gutierrez-Merino C (1997) Role of ecological variables in the seasonal variation of flavonoid content of Cistus ladanifer exudate. J Chem Ecol 23(3):579–603
Cos P, Vlietinck AJ, Berghe DV et al (2006) Anti-infective potential of natural products: how to develop a stronger in vitro “proof-of-concept.” J Ethnopharmacol 106:290–302
Demetzos C, Katerinopoulos H, Kouvarakis A et al (1997) Composition and antimicrobial activity of the essential oil of Cistus creticus subsp. eriocephalus. Planta Medica 63(5):477–479
Dimcheva V, Karsheva M (2018) Cistus incanus from Strandja Mountain as a source of bioactive antioxidants. Plants 7(1):8
Eddouks M, Ajebli M, Hebi M (2017) Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia). Morocco J Ethnopharmacol 198:516–530
Youbi EHE, A, El Mansouri L, Boukhira S, et al (2016a) In Vivo Anti-inflammatory and analgesic effects of aqueous extract of Cistus ladanifer L. From Morocco Am J Ther 23:e1554–e1559
El Kabbaoui M, Chda A, Azdad O et al (2016) Evaluation of hypoglycemic and hypolipidemic activities of aqueous extract of Cistus ladaniferus in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 6(12):1044–1049
El Kabbaoui M, Chda A, El-Akhal J et al (2017) Acute and sub-chronic toxicity studies of the aqueous extract from leaves of Cistus ladaniferus L. in mice and rats. J. Ethnopharmacol. 209(14): 147–156
Emre G, Dogan A, Haznedaroglu MZ et al (2021) An ethnobotanical study of medicinal plants in Mersin (Turkey). Front Pharmacol 12:1565
Ergül Bozkurt AE (2021) Folk medicinal plants used for the treatment of gynecological disorders by the rural population of Zorlu Village (Turkey). Ethnobot. Res. Appl. 22
Euro+Med (2006-): Euro+Med PlantBase - the information resource for Euro-Mediterranean plant diversity. Published on the Internet http://ww2.bgbm.org/EuroPlusMed/. Accessed on 13 Sept 2021
Fatiha EA, Nazha A, Fouad Z et al (2018) Ethnomedicinal evaluation of medicinal plants used against gastrointestinal disorders in the Western Middle Atlas Region (Morocco) Annu. Res Rev Biol 28(2):1–11
Fecka I, Włodarczyk M, Starzec A (2020) Isolation and structure elucidation of cistusin: a new ellagitannin from Cistus x incanus L. leaves. Ind. Crops Prod. 158:112971
Gafner S (2018) Scientific journals increasingly skeptical of antioxidant research. HerbalEGram 15: American Botanical Council
Gaweł-Bęben K, Kukula-Koch W, Hoian U et al (2020) Characterization of Cistus × incanus L. and Cistus ladanifer L. extracts as potential multifunctional antioxidant ingredients for skin protecting cosmetics. Antioxidants 9(3):202
Gertsch J (2009) How scientific is the science in ethnopharmacology? Historical perspectives and epistemological problems. J Ethnopharmacol 122:177–183
Guerreiro O, Alves SP, Duarte MF (2015) Cistus ladanifer L. shrub is rich in saturated and branched chain fatty acids and their concentration increases in the Mediterranean dry season. Lipids 50:493–501
Gürbüz P, Demirezer LÖ, Güvenalp Z et al (2015) Isolation and structure elucidation of uncommon secondary metabolites from Cistus salviifolius L. Rec Nat Prod 9(2):175–183
Gürdal B, Kültür S (2013) An ethnobotanical study of medicinal plants in Marmaris (Muğla, Turkey). J Ethnopharmacol 146(1):113–126
Güzel Y, Güzelşemme M, Miski M (2015) Ethnobotany of medicinal plants used in Antakya: a multicultural district in Hatay Province of Turkey. J Ethnopharmacol 174:118–152
Guzmán B, Vargas P (2005) Systematics, character evolution, and biogeography of Cistus L. (Cistaceae) based on ITS, TRNL-TRNF, and Matk Sequences. Mol. Phylogenet. Evol. 37(3):644–660
Hachi M, Ouafae B, Hachi T et al (2016) Contribution to the ethnobotanical study of antidiabetic medicinal plants of the Central Middle Atlas Region (Morocco). Lazaroa 37:135–144
Hind SJ, Anas F, Lahcen Z (2017) Survey of ethnomedicinal plants used for the treatment of gastrointestinal disorders in Seksaoua Region (Western High Moroccan Atlas). Annu Res Rev Biol 16(5):1–9
Honda G, Yeşilada E, Tabata M et al (1996) Traditional medicine in Turkey. VI. Folk medicine in west Anatolia: Afyon, Kütahya, Denizli, Muğla, Aydin provinces. J Ethnopharmacol. 53(2):75–87
Idm’hand E, Msanda F, Cherifi K, (2020) Ethnobotanical study and biodiversity of medicinal plants used in the Tarfaya Province. Morocco Sheng Tai Xue Bao 40(2):134–144
IPNI (2021) International Plant Names Index. Published on the Internet http://www.ipni.org, The Royal Botanic Gardens, Kew, Harvard University Herbaria & Libraries and Australian National Botanic Gardens. Accessed on 13 Sept 2021
Kalankan G, Özkan ZC, Akbulut S (2015) Medicinal and aromatic wild plants and traditional usage of them in Mount Ida (Balıkesir/Turkey). J Appl Biol Sci 9(3):25–33
Kuchta A, Konopacka A, Waleron K et al (2021) The effect of Cistus incanus herbal tea supplementation on oxidative stress markers and lipid profile in healthy adults. Cardiol J 28(4):534–542
Lahcen SA, Hattabi LE, Benkaddour R et al (2020) Chemical composition, antioxidant, antimicrobial and antifungal activity of Moroccan Cistus creticus leaves. Chem Data Collect 26:100346
Lobón NC, de la Cruz IF, Gallego JCA (2019) Autotoxicity of diterpenes present in leaves of Cistus ladanifer L. Plants 8:27
Lukas B, Bragagna L, Starzyk K et al (2021) Polyphenol diversity and antioxidant activity of European Cistus creticus L. (Cistaceae) compared to six further, partly sympatric Cistus species. Plants 10(4):615
Maccioni S, Baldini R, Cioni PL et al (2007) In vivo volatiles emission and essential oils from different organs and pollen of Cistus albidus from Caprione (Eastern Liguria, Italy). Flavour Frag J 22:61–65
Maggi F, Lucarini D, Papa F et al (2016) Phytochemical analysis of the labdanum-poor Cistus creticus subsp. eriocephalus (Viv.) Greuter Et Burdet growing in Central Italy. Biochem Syst Ecol 66:50–57
Mansoor KA, Matalka KZ, Qa’dan FS et al (2016) Two new proanthocyanidin trimers isolated from Cistus incanus L. demonstrate potent anti-inflammatory activity and selectivity to cyclooxygenase isoenzymes inhibition. Nat Prod Res 30(17):1919–1926
Matłok N, Lachowisz S, Gorzelany J et al (2020) Influence of drying method in some bioactive compounds and the composition of volatile components in dried pink rock rose (Cistus creticus L.). Molecules 25:2596
Mastino PM, Marchetti M, Costa J et al (2017) Comparison of essential oils from Cistus species growing in Sardinia. Nat Prod Res 31(3):299–307
Mastino PM, Marchetti M, Costa J et al (2018) Interpopulation variability in the essential oil composition of Cistus creticus subsp. eriocephalus from Sardinia. Chem Biodivers 15(9): e1800151
Morales-Soto A, Oruna-Concha M, Elmore JS et al (2015) Volatile profile of Spanish Cistus plants as sources of antimicrobials for industrial applications. Ind Crops Prod 74:425–433
Moosmang S, Sturm S, Novak J et al (2020). Differentiation between Cistus L. (Sub-) Species (Cistaceae) Using NMR Metabolic Fingerprinting. Planta Med 86(15):1148–1155
Nicoletti M, Toniolo C, Venditti A et al (2014) Antioxidant activity and chemical composition of three Tunisian Cistus: Cistus monspeliensis, Cistus villosus and Cistus libanotis. Nat Prod Res 29(3):223–230
Ouhaddou H, Boubaker H, Msanda F et al (2015) An ethnobotanical study of medicinal plants of the Agadir Ida Ou Tanane Province (Southwest Morocco). J Appl Biosci 84(1):7707
Ouhaddou H, Alaoui A, Laaribya S et al (2020) Ethnobotanical survey of medicinal plants used for treating diabetes in Agadir Ida Outanane region, Southwestern Morocco. AJMAP 6:72–86
Papaefthimiou D, Papanikolaou A, Falara V et al (2014) Genus Cistus: A model for exploring labdane-type diterpenes’ biosynthesis and a natural source of high value products with biological, aromatic, and pharmacological properties. Front Chem 2:35
Rebaya A, Belghith SI, Cherif JK et al (2016) Total phenolic compounds and antioxidant potential of rockrose (Cistus salviifolius) leaves and flowers grown in Tunisia. Int J Pharmacogn Phytochem Res 8(2):327–331
Rebensburg S, Helfer M, Schneider M et al (2016) Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins. Sci Rep 6:20394
Salomé-Abarca LF, Mandrone M, Sanna C et al (2020) Metabolic variation in Cistus monspeliensis L. ecotypes correlated to their plant-fungal interactions. Phytochemistry 176:112402
Sargin SA, Selvi S, López V (2015) Ethnomedicinal plants of Sarigöl District (Manisa). Turkey J Ethnopharmacol 171:64–84
Sargin SA (2021) Plants used against obesity in Turkish folk medicine: a review. J Ethnopharmacol 270:113841
Sayah K, Marmouzi I, Mrabti HN et al (2017) Antioxidant activity and inhibitory potential of Cistus salviifolius (L.) and Cistus monspeliensis (L.) aerial parts extracts against key enzymes linked to hyperglycemia. BioMed Res Int 2017:2789482
Teixidor-Toneu I, Martin GJ, Ouhammou A et al (2016) An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas. Morocco J Ethnopharmacol 188:96–110
Tuttolomondo T, Licata M, Leto C et al (2014) Popular uses of wild plant species for medicinal purposes in the Nebrodi Regional Park (North-Eastern Sicily, Italy). J Ethnopharmacol 157:21–37
Uğur Yıldırım M, Osman Sarıhan E, Mahmood Khawar K (2021) ethnobotanical uses of roots of various plant species in Turkey. Plant Roots
Ustun O, Berrin-Ozcelik BT (2016) Bioactivities of ethanolic extract and its fractions of Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) species. Pharmacogn Magn 12:S82–S85
Valares Masa C, Gallego JCA, Natividad C et al (2016) Intra-population variation of secondary metabolites in Cistus ladanifer L. Molecules 21(7):945
Venditti A, Bianco A, Tomassini L et al (2014) A C-methylated resacetophenone from Cistus monspeliensis L. Fitoterapia 95:182–185
Venditti A, Bianco A, Bruno M et al (2015) Phytochemical study of Cistus libanotis L. Nat Prod Res 29(2):189–192
Youbi AEHE, El Mansouri L, Boukhira S et al (2016b) In vivo anti-inflammatory and analgesic effects of aqueous extract of Cistus ladanifer L. from Morocco. Am J Ther 23:e1554–e1559
Zalegh I, Akssira M, Bourhia M et al (2021) A Review on Cistus sp.: Phytochemical and Antimicrobial Activities. Plants 10(6):1214