An update on Cushing syndrome in pediatrics

Magiakou, 1994, Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy, N Engl J Med, 331, 629, 10.1056/NEJM199409083311002

Orth, 1995, Cushing's syndrome, N Engl J Med, 332, 791, 10.1056/NEJM199503233321207

Batista, 2007, Diagnostic tests for children who are referred for the investigation of Cushing syndrome, Pediatrics, 120, e575, 10.1542/peds.2006-2402

Nieman, 2008, The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline, J Clin Endocrinol Metab, 93, 1526, 10.1210/jc.2008-0125

Sharma, 2015, Cushing's syndrome: epidemiology and developments in disease management, Clin Epidemiol, 7, 281

McAteer, 2013, Predictors of survival in pediatric adrenocortical carcinoma: a Surveillance, Epidemiology, and End Results (SEER) program study, J Pediatr Surg, 48, 1025, 10.1016/j.jpedsurg.2013.02.017

Michalkiewicz, 2004, Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry, J Clin Oncol, 22, 838, 10.1200/JCO.2004.08.085

Ng, 2003, Adrenocortical carcinoma: diagnosis, evaluation and treatment, J Urol, 169, 5, 10.1016/S0022-5347(05)64023-2

Cecchetto, 2017, Outcome and prognostic factors in high-risk childhood adrenocortical carcinomas: a report from the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT), Pediatr Blood Cancer, 6, 64

Zilbermint, 2015, Protein kinase A defects and cortisol-producing adrenal tumors, Curr Opin Endocrinol Diabetes Obes, 22, 157, 10.1097/MED.0000000000000149

Brown, 2010, Cushing syndrome in the McCune-Albright syndrome, J Clin Endocrinol Metab, 95, 1508, 10.1210/jc.2009-2321

Almeida, 2010, Carney complex and other conditions associated with micronodular adrenal hyperplasias, Best Pract Res Clin Endocrinol Metab, 24, 907, 10.1016/j.beem.2010.10.006

Stratakis, 2001, Genetics of adrenocortical tumors: Carney complex. Ann Endocrinol (Paris), 62, 180

More, 2011, Ectopic ACTH syndrome in children and adolescents, J Clin Endocrinol Metab, 96, 1213, 10.1210/jc.2010-2276

Karageorgiadis, 2015, Ectopic adrenocorticotropic hormone and corticotropin-releasing hormone co-secreting tumors in children and adolescents causing cushing syndrome: a diagnostic dilemma and how to solve it, J Clin Endocrinol Metab, 100, 141, 10.1210/jc.2014-2945

Tsigos, 1996, Differential diagnosis and management of Cushing's syndrome, Annu Rev Med, 47, 443, 10.1146/annurev.med.47.1.443

Rahman, 2016, Kidney stones as an underrecognized clinical sign in pediatric Cushing disease, J Pediatr, 170, 10.1016/j.jpeds.2015.11.045

Lodish, 2010, Effects of Cushing disease on bone mineral density in a pediatric population, J Pediatr, 156, 1001, 10.1016/j.jpeds.2009.12.027

Keil, 2012, Anthropometric measures and fasting insulin levels in children before and after cure of Cushing syndrome, Clin Nutr, 31, 359, 10.1016/j.clnu.2011.11.007

Afshari, 2015, Facial plethora: modern technology for quantifying an ancient clinical sign and its use in Cushing syndrome, J Clin Endocrinol Metab, 100, 3928, 10.1210/jc.2015-2497

Elias, 2014, Late-night salivary cortisol has a better performance than urinary free cortisol in the diagnosis of Cushing's syndrome, J Clin Endocrinol Metab, 99, 2045, 10.1210/jc.2013-4262

Manetti, 2013, Usefulness of salivary cortisol in the diagnosis of hypercortisolism: comparison with serum and urinary cortisol, Eur J Endocrinol, 168, 315, 10.1530/EJE-12-0685

Gafni, 2000, Nighttime salivary cortisol measurement as a simple, noninvasive, outpatient screening test for Cushing's syndrome in children and adolescents, J Pediatr, 137, 30, 10.1067/mpd.2000.106226

Hodes, 2017, Hair cortisol in the evaluation of Cushing syndrome, Endocrine, 56, 164, 10.1007/s12020-017-1231-7

Nieman, 2015, Treatment of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline, J Clin Endocrinol Metab, 100, 2807, 10.1210/jc.2015-1818

Louiset, 2009, The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits, J Clin Endocrinol Metab, 94, 2406, 10.1210/jc.2009-0031

Chittiboina, 2015, High-resolutionF-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging for pituitary adenoma detection in Cushing disease, J Neurosurg, 122, 791, 10.3171/2014.10.JNS14911

Oldfield, 1991, Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing's syndrome, N Engl J Med, 325, 897, 10.1056/NEJM199109263251301

Juszczak, 2013, The therapy of Cushing's disease in adults and children: an update, Horm Metab Res, 45, 109

Lonser, 2013, Outcome of surgical treatment of 200 children with Cushing's disease, J Clin Endocrinol Metab, 98, 892, 10.1210/jc.2012-3604

Storr, 2014, Endonasal endoscopic transsphenoidal pituitary surgery: early experience and outcome in paediatric Cushing's disease, Clin Endocrinol (Oxf), 80, 270, 10.1111/cen.12275

Acharya, 2010, Radiotherapy in paediatric Cushing's disease: efficacy and long term follow up of pituitary function, Pituitary, 13, 293, 10.1007/s11102-010-0231-x

Thoren, 1986, Treatment of Cushing's disease in childhood and adolescence by stereotactic pituitary irradiation, Acta Paediatr Scand, 75, 388, 10.1111/j.1651-2227.1986.tb10219.x

Chan, 2007, Long-term anterior pituitary function in patients with paediatric Cushing's disease treated with pituitary radiotherapy, Eur J Endocrinol, 156, 477, 10.1530/EJE-06-0588

Xu, 2013, Hypopituitarism after stereotactic radiosurgery for pituitary adenomas, Neurosurgery, 72, 10.1227/NEU.0b013e3182846e44

Sheehan, 2013, Results of gamma knife surgery for Cushing's disease, J Neurosurg, 119, 1486, 10.3171/2013.7.JNS13217

Rieken, 2013, Long term toxicity and prognostic factors of radiation therapy for secreting and non-secreting pituitary adenomas, Radiat Oncol, 8, 18, 10.1186/1748-717X-8-18

Leavitt, 2013, Long-term evaluation of radiation-induced optic neuropathy after single-fraction stereotactic radiosurgery, Int J Radiat Oncol Biol Phys, 87, 524, 10.1016/j.ijrobp.2013.06.2047

Sattler, 2012, The incidence of second tumours and mortality in pituitary adenoma patients treated with postoperative radiotherapy versus surgery alone, Radiother Oncol, 104, 125, 10.1016/j.radonc.2012.04.024

Castinetti, 2014, Ketoconazole in Cushing's disease: is it worth a try?, J Clin Endocrinol Metab, 99, 1623, 10.1210/jc.2013-3628

Rodriguez-Galindo, 2016, Treatment of childhood adrenocortical carcinoma (ACC) with surgery plus retroperitoneal lymph node dissection (RPLND) and multiagent chemotherapy: results of the Children's Oncology Group ARAR0332 protocol, J Clin Oncol, 34

Morris, 2013, Impact and timing of bilateral adrenalectomy for refractory adrenocorticotropic hormone-dependent Cushing's syndrome, Surgery, 154, 1174, 10.1016/j.surg.2013.06.017

Osswald, 2014, Favorable long-term outcomes of bilateral adrenalectomy in Cushing's disease, Eur J Endocrinol, 171, 209, 10.1530/EJE-14-0214

Ritzel, 2013, Clinical review: outcome of bilateral adrenalectomy in Cushing's syndrome: a systematic review, J Clin Endocrinol Metab, 98, 3939, 10.1210/jc.2013-1470

Lodish, 2012, Recovery of the hypothalamic-pituitary-adrenal axis in children and adolescents after surgical cure of Cushing's disease, J Clin Endocrinol Metab, 97, 1483, 10.1210/jc.2011-2325

Hahner, 2015, High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study, J Clin Endocrinol Metab, 100, 407, 10.1210/jc.2014-3191

Shulman, 2007, Adrenal insufficiency: still a cause of morbidity and death in childhood, Pediatrics, 119, e484, 10.1542/peds.2006-1612

Bornstein, 2016, Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society Clinical Practice Guideline, J Clin Endocrinol Metab, 101, 364, 10.1210/jc.2015-1710

Gkourogianni, 2015, Death in pediatric Cushing syndrome is uncommon but still occurs, Eur J Pediatr, 174, 501, 10.1007/s00431-014-2427-y

Tirosh, 2017, Coagulation profile in patients with different etiologies for Cushing syndrome: a prospective observational study, Horm Metab Res, 49, 365, 10.1055/s-0043-100113

Magiakou, 1994, Final stature in patients with endogenous Cushing's syndrome, J Clin Endocrinol Metab, 79, 1082

Gkourogianni, 2017, Pediatric Cushing disease: disparities in disease severity and outcomes in the Hispanic and African-American populations, Pediatr Res, 82, 272, 10.1038/pr.2017.58

Keil, 2013, Quality of life and other outcomes in children treated for Cushing syndrome, J Clin Endocrinol Metab, 98, 2667, 10.1210/jc.2013-1123

Birdwell, 2016, Coagulation profile dynamics in pediatric patients with Cushing syndrome: a prospective, observational comparative study, J Pediatr, 177, 227, 10.1016/j.jpeds.2016.06.087

Lodish, 2009, Blood pressure in pediatric patients with Cushing syndrome, J Clin Endocrinol Metab, 94, 2002, 10.1210/jc.2008-2694

Lodish, 2014, Skeletal maturation in children with Cushing syndrome is not consistently delayed: the role of corticotropin, obesity, and steroid hormones, and the effect of surgical cure, J Pediatr, 164, 801, 10.1016/j.jpeds.2013.11.065

Devoe, 1997, Long-term outcome in children and adolescents after transsphenoidal surgery for Cushing's disease, J Clin Endocrinol Metab, 82, 3196

Starkman, 2013, Neuropsychiatric findings in Cushing syndrome and exogenous glucocorticoid administration, Endocrinol Metab Clin North Am, 42, 477, 10.1016/j.ecl.2013.05.010

Burgess, 1996, Sociotropy, autonomy, stress, and depression in Cushing syndrome, J Nerv Ment Dis, 184, 362, 10.1097/00005053-199606000-00006

Merke, 2005, Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome, J Clin Endocrinol Metab, 90, 2531, 10.1210/jc.2004-2488

Dorn, 2000, Cognitive function in patients with Cushing syndrome: a longitudinal perspective, Clin Nurs Res, 9, 420, 10.1177/10547730022158672

Keil, 2009, Quality of life in children and adolescents 1-year after cure of Cushing syndrome: a prospective study, Clin Endocrinol (Oxf), 71, 326, 10.1111/j.1365-2265.2008.03515.x

Keil, 2016, Cases of psychiatric morbidity in pediatric patients after remission of Cushing syndrome, Pediatrics, 137

Puar, 2016, Adrenal crisis: still a deadly event in the 21st century, Am J Med, 129, 339, 10.1016/j.amjmed.2015.08.021