Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Một tổng quan tổng hợp về các đánh giá hệ thống và phân tích tổng hợp liên quan đến điều tra quan sát về chứng ngưng thở khi ngủ tắc nghẽn và các kết quả sức khỏe
Tóm tắt
Phân tích trước đây về các đánh giá hệ thống và phân tích tổng hợp đã cho thấy rằng chứng ngưng thở khi ngủ tắc nghẽn (OSA) có liên quan đến nhiều kết quả sức khỏe. Trong nghiên cứu này, mục tiêu chính của chúng tôi là thực hiện một đánh giá tổng hợp để đánh giá những bằng chứng có sẵn về các mối liên hệ giữa OSA và các kết quả sức khỏe. Chúng tôi đã thực hiện một phân tích tổng hợp các nghiên cứu quan sát trước đây đã báo cáo các mối liên hệ giữa OSA và các kết quả sức khỏe trong tất cả các quần thể và bối cảnh con người. Bài phân tích này đã bao gồm 66 bài báo với 136 kết quả độc nhất. Trong số 136 kết quả độc nhất, 111 kết quả có sự liên quan đáng kể (p < 0.05). Chỉ có 7 kết quả (tái thông mạch vành sau PCI, suy hô hấp sau phẫu thuật, gan nhiễm mỡ, tăng alanintransaminase (ALT), hội chứng chuyển hóa (MS), bệnh vảy nến và bệnh Parkinson) có chất lượng bằng chứng cao. Hai mươi bốn kết quả có chất lượng bằng chứng trung bình, và 80 kết quả còn lại có chất lượng bằng chứng yếu. Sáu mươi chín kết quả thể hiện sự dị thường rõ rệt. Hai mươi lăm kết quả có sự thiên lệch xuất bản. Sáu mươi ba (95%) nghiên cứu thể hiện chất lượng phương pháp học rất thấp. Trong số 66 phân tích tổng hợp khám phá 136 kết quả độc nhất, chỉ có 7 kết quả có ý nghĩa thống kê được đánh giá là có chất lượng bằng chứng cao. OSA có thể liên quan đến tăng nguy cơ tái thông mạch vành sau PCI, suy hô hấp sau phẫu thuật, gan nhiễm mỡ, tăng ALT, hội chứng chuyển hóa, bệnh vảy nến và bệnh Parkinson.
Từ khóa
#chứng ngưng thở khi ngủ tắc nghẽn #kết quả sức khỏe #phân tích tổng hợp #đánh giá hệ thống #bằng chứng sức khỏeTài liệu tham khảo
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