An overview of process intensification and thermo stabilization for upscaling of Peste des petits ruminants vaccines in view of global control and eradication
Tóm tắt
Peste des petits ruminants (PPR) has been recognized as a globally distributed disease affecting the small ruminant population. The disease results in severe economic losses mainly to small land holders and low input farming systems. The control of PPR is mainly achieved through vaccination with available live attenuated vaccines. The thermo labile nature of PPR virus poses a major constraint in production of quality vaccines which often results in vaccine failures. The lack of quality vaccine production jeopardize the wide vaccination coverage especially in countries with poor infrastructure due to which PPR persists endemically. The vaccine production system may require augmentation to attain consistent and quality vaccines through efforts of process intensification integrated with suitable stabilizer formulations with appropriate freeze drying cycles for improved thermo tolerance. Manufacturing of live attenuated PPR vaccines during batch cultures might introduce defective interfering particles (DIPs) as a result of high multiplicity of infection (MOI) of inoculums, which has a huge impact on virus dynamics and yield. Accumulation of DIPs adversely affects the quality of the manufactured vaccines which can be avoided through use of appropriate MOI of virus inoculums and quality control of working seed viruses. Therefore, adherence to critical manufacturing standard operating procedures in vaccine production and ongoing efforts on development of thermo tolerant vaccine will help a long way in PPR control and eradication programme globally. The present review focuses on the way forward to achieve the objectives of quality vaccine production and easy upscaling to help the global PPR control and eradication by mass vaccination as an important tool.
Tài liệu tham khảo
citation_journal_title=AAPS PharmSciTech; citation_title=New method for monitoring the process of freeze drying of biological materials; citation_author=N Alkeev, S Averin, S Gratowski; citation_volume=16; citation_issue=6; citation_publication_date=2015; citation_pages=1474-1479; citation_doi=10.1208/s12249-015-0341-x; citation_id=CR1
citation_journal_title=Pak Vet J; citation_title=Effect of various stabilizers on titre of lyophilized live-attenuated peste des petits ruminants (PPR) vaccine; citation_author=M Asim, A Rashid, AH Chaudhary; citation_volume=28; citation_issue=4; citation_publication_date=2008; citation_pages=203-204; citation_id=CR2
citation_journal_title=Biotechnol Prog; citation_title=Fluid mechanisms, cell distribution and environment in cellcube bioreactors; citation_author=JG Aunins, B Bader, A Caola, J Griffiths, M Katz, P Licari, K Ram, CS Ranucci, W Zhou; citation_volume=19; citation_publication_date=2003; citation_pages=2-8; citation_doi=10.1021/bp0256521; citation_id=CR3
Aunins JG. Viral vaccine production in cell culture. In: Encyclopedia of cell technology. 2003.
citation_journal_title=Virus Res; citation_title=Full genome sequence of peste des petits ruminants virus, a member of the Morbillivirus genus; citation_author=D Bailey, A Banyard, P Dash, A Ozkul, T Barrett; citation_volume=110; citation_issue=1; citation_publication_date=2005; citation_pages=119-124; citation_doi=10.1016/j.virusres.2005.01.013; citation_id=CR5
citation_journal_title=J Gen Virol; citation_title=Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control; citation_author=AC Banyard, S Parida, C Batten, C Oura, O Kwiatek, G Libeau; citation_volume=91; citation_issue=12; citation_publication_date=2010; citation_pages=2885-2897; citation_doi=10.1099/vir.0.025841-0; citation_id=CR6
Barrett T, Banyard, AC, Diallo A. Rinderpest and peste des petits ruminants virus: plague of large and small ruminants. In: Barrett T, Pastoret P-P, Taylor WP, editors, Molecular biology of the morbillivirus: biology of animal infections. Academic Press: London; 2006. p. 31–67.
citation_journal_title=Zoonoses Public Health; citation_title=A review on peste des petits ruminants (PPR) with special reference to PPR in Iran; citation_author=TT Bazarghani, S Charkhkar, J Doroudi, Hassan E Bani; citation_volume=53; citation_issue=1; citation_publication_date=2006; citation_pages=17-18; citation_id=CR8
citation_journal_title=Revue d’élevage et de médecine vétérinaire des pays tropicaux; citation_title=Note sur la structure du virus de la peste des petits ruminants; citation_author=P Bourdin, Vautier A Laurent; citation_volume=20; citation_issue=3; citation_publication_date=1967; citation_pages=383-386; citation_doi=10.19182/remvt.7469; citation_id=CR9
citation_journal_title=Adv Biochem Eng Biotechnol; citation_title=Growth limitations on microcarriers; citation_author=M Butler; citation_volume=34; citation_publication_date=1987; citation_pages=57-84; citation_id=CR10
citation_journal_title=J Virol; citation_title=Generation of measles virus defective interfering particles and their presence in a preparation of attenuated live-virus vaccine; citation_author=PH Calain, LA Roux; citation_volume=62; citation_issue=8; citation_publication_date=1988; citation_pages=2859-2866; citation_id=CR11
Cheng SC, Fischman HR. Lapinized Rinderpest virus and its use as a vaccine. In: Kesteven KVL, editor. Rinderpest Vaccines their production and use in the field. Washington: Food and Agriculture Organization of the United Nations; 1949. p. 47.
citation_journal_title=Chem Eng Res Des; citation_title=Bioprocess intensification through bioreactor engineering; citation_author=Y Chisti, M Moo-Young; citation_volume=74; citation_publication_date=1996; citation_pages=575-583; citation_id=CR13
citation_journal_title=J Gen Virol; citation_title=Comparison of proteins induced in cells infected with rinderpest and peste des petits ruminants viruses; citation_author=A Diallo, T Barrett, PC Lefevre, WP Taylor; citation_volume=68; citation_issue=7; citation_publication_date=1987; citation_pages=2033-2038; citation_doi=10.1099/0022-1317-68-7-2033; citation_id=CR14
citation_journal_title=Indian J Virol; citation_title=Defective interfering particles of morbillivirus: a review; citation_author=P Dhar, SK Bandyopadhyay; citation_volume=15; citation_issue=1; citation_publication_date=1999; citation_pages=1-5; citation_id=CR15
citation_journal_title=Behna Vet Med J; citation_title=Assesment of two stabilizers used for lyophilized live attenuated peste des petits ruminants (PPR) vaccine; citation_author=GF El-Bagoury, EM El-Nahas, AM Hussein, AM Mohamed; citation_volume=29; citation_issue=1; citation_publication_date=2015; citation_pages=183-188; citation_id=CR16
EMPRES Transboundary Animal Diseases Bulletin. Peste des petits ruminants. FAO Animal Production and Health Division; 2012.
citation_journal_title=J Theor Biol; citation_title=A model of the dynamics of insect cell infection at low multiplicity of infection; citation_author=G Enden, YH Zhang, JC Merchuk; citation_volume=237; citation_issue=3; citation_publication_date=2005; citation_pages=257-264; citation_doi=10.1016/j.jtbi.2005.04.013; citation_id=CR18
citation_journal_title=J Virol; citation_title=Defective interfering particle generated by internal deletion of the vesicular stomatitis virus genome; citation_author=DA Epstein, RC Herman, I Chien, RA Lazzarini; citation_volume=33; citation_issue=2; citation_publication_date=1980; citation_pages=818-829; citation_id=CR19
FAO O. Global strategy for the control and eradication of PPR. FAO and OIE. 2015.
citation_journal_title=PLoS ONE; citation_title=Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles; citation_author=T Frensing, FS Heldt, A Pflugmacher, I Behrendt, I Jordan, D Flockerzi, Y Genzel, U Reichl; citation_volume=8; citation_issue=9; citation_publication_date=2013; citation_pages=e72288; citation_doi=10.1371/journal.pone.0072288; citation_id=CR21
citation_journal_title=Appl Microbiol Biotechnol; citation_title=Impact of defective interfering particles on virus replication and antiviral host response in cell culture-based influenza vaccine production; citation_author=T Frensing, A Pflugmacher, M Bachmann, B Peschel, U Reichl; citation_volume=98; citation_issue=21; citation_publication_date=2014; citation_pages=8999-9008; citation_doi=10.1007/s00253-014-5933-y; citation_id=CR22
Galazka A, Milstien J, Zaffran M. Thermostability of vaccines. In: Global programmer for vaccines and inmunization. Geneva: WHO; 1998.
citation_journal_title=Expert Rev Vaccines; citation_title=Bioreactor concepts for cell culture-based viral vaccine production; citation_author=LE Gallo-Ramirez, A Nikolay, Y Genzel, U Reichl; citation_volume=14; citation_issue=9; citation_publication_date=2015; citation_pages=1181-1195; citation_id=CR24
Grein TA, Weidner T, Czermak P. Concepts for the production of viruses and viral vectors in cell culture. In: GowderSJT, editor. New Insights into Cell Culture Technology. 2017.
https://doi.org/10.5772/62590
. ISBN: 978-953-51-3134-2.
citation_journal_title=J Gen Virol; citation_title=Sendai virus genome synthesis and assembly are coupled: a possible mechanism to promote viral RNA polymerase processivity; citation_author=O Gubbay, J Curran, D Kolakofsky; citation_volume=82; citation_issue=12; citation_publication_date=2001; citation_pages=2895-2903; citation_doi=10.1099/0022-1317-82-12-2895; citation_id=CR26
citation_journal_title=J Wildl Dis; citation_title=Response of white-tailed deer to infection with peste des petits ruminants virus; citation_author=FM Hamdy, AH Dardiri; citation_volume=4; citation_publication_date=1976; citation_pages=516-522; citation_doi=10.7589/0090-3558-12.4.516; citation_id=CR27
citation_journal_title=Int J Biochem Cell Biol; citation_title=Paramyxovirus assembly and budding: building particles that transmit infections; citation_author=MS Harrison, T Sakaguchi, AP Schmitt; citation_volume=42; citation_issue=9; citation_publication_date=2010; citation_pages=1416-1429; citation_doi=10.1016/j.biocel.2010.04.005; citation_id=CR28
citation_journal_title=Virology; citation_title=Defective T particles of vesicular stomatitis virus: preparation, morphology, and some biologic properties; citation_author=AS Huang, JW Greenawalt, RR Wagner; citation_volume=30; citation_issue=2; citation_publication_date=1966; citation_pages=161-172; citation_doi=10.1016/0042-6822(66)90092-4; citation_id=CR29
citation_journal_title=Br Vet J; citation_title=Rinderpest in tissue culture. III: use of the attenuated strain as a vaccine for cattle; citation_author=RH Johnson; citation_volume=118; citation_issue=4; citation_publication_date=1962; citation_pages=141-150; citation_doi=10.1016/S0007-1935(17)43103-4; citation_id=CR30
citation_journal_title=J Virol; citation_title=Truncated particles produced in fish surviving infectious hematopoietic necrosis virus infection: mediators of persistence?; citation_author=CH Kim, DM Dummer, PP Chiou, JA Leong; citation_volume=73; citation_issue=1; citation_publication_date=1999; citation_pages=843-849; citation_id=CR31
citation_journal_title=Proc Natl Acad Sci; citation_title=Cycles, chaos, and evolution in virus cultures: a model of defective interfering particles; citation_author=TB Kirkwood, CR Bangham; citation_volume=91; citation_issue=18; citation_publication_date=1994; citation_pages=8685-8689; citation_doi=10.1073/pnas.91.18.8685; citation_id=CR32
citation_journal_title=Biologicals; citation_title=Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies; citation_author=OS Kumru, SB Joshi, DE Smith, CR Middaugh, T Prusik, DB Volkin; citation_volume=42; citation_issue=5; citation_publication_date=2014; citation_pages=237-259; citation_doi=10.1016/j.biologicals.2014.05.007; citation_id=CR33
citation_journal_title=J Comp Pathol; citation_title=Peste des petits ruminants (PPR) outbreak in Tajikistan; citation_author=O Kwiatek, C Minet, C Grillet, C Hurard, E Carlsson, B Karimov, E Albina, A Diallo, G Libeau; citation_volume=136; citation_issue=2; citation_publication_date=2007; citation_pages=111-119; citation_doi=10.1016/j.jcpa.2006.12.002; citation_id=CR34
citation_title=Orthomyxoviridae: the viruses and their replication; citation_inbook_title=Fields virology; citation_publication_date=1996; citation_id=CR35; citation_author=RA Lamb; citation_author=RM Krug; citation_publisher=Lippincott-Raven Press
citation_journal_title=J Virol; citation_title=Characterization of defective viral RNA produced during persistent infection of Vero cells with Murray Valley encephalitis virus; citation_author=MU Lancaster, SI Hodgetts, JS Mackenzie, N Urosevic; citation_volume=72; citation_issue=3; citation_publication_date=1998; citation_pages=2474-2482; citation_id=CR36
citation_journal_title=PLoS ONE; citation_title=Defective interfering viral particles in acute dengue infections; citation_author=D Li, WB Lott, K Lowry, A Jones, HM Thu, J Aaskov; citation_volume=6; citation_issue=4; citation_publication_date=2011; citation_pages=e19447; citation_doi=10.1371/journal.pone.0019447; citation_id=CR37
citation_journal_title=Virus Res; citation_title=Sequence analysis of the phosphoprotein gene of peste des petits ruminants (PPR) virus: editing of the gene transcript; citation_author=M Mahapatra, S Parida, BG Egziabher, A Diallo, T Barrett; citation_volume=96; citation_issue=1; citation_publication_date=2003; citation_pages=85-98; citation_doi=10.1016/S0168-1702(03)00176-X; citation_id=CR38
citation_journal_title=J Gen Virol; citation_title=Matrix protein and glycoproteins F and H of Peste-des-petits-ruminants virus function better as a homologous complex; citation_author=M Mahapatra, S Parida, MD Baron, T Barrett; citation_volume=87; citation_issue=7; citation_publication_date=2006; citation_pages=2021-2029; citation_doi=10.1099/vir.0.81721-0; citation_id=CR39
citation_journal_title=Am Pharm Rev; citation_title=LYO/TITRATION: analytical options for the measurement of residual moisture content in lyophilized biological materials; citation_author=KP Malik, C Duru, M Ahmed, P Matejtschuk; citation_volume=13; citation_issue=5; citation_publication_date=2010; citation_pages=42-47; citation_id=CR40
citation_journal_title=Vet Microbiol; citation_title=Comparison of the effect of various chemical stabilizers and lyophilization cycles on the thermostability of a Vero cell-adapted rinderpest vaccine; citation_author=JC Mariner, JA House, AE Sollod, C Stem, M Ende, CA Mebus; citation_volume=21; citation_issue=3; citation_publication_date=1990; citation_pages=195-209; citation_doi=10.1016/0378-1135(90)90032-Q; citation_id=CR41
citation_journal_title=Vaccine; citation_title=A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia; citation_author=JC Mariner, J Gachanja, SH Tindih, P Toye; citation_volume=35; citation_issue=30; citation_publication_date=2017; citation_pages=3773-3779; citation_doi=10.1016/j.vaccine.2017.05.040; citation_id=CR42
citation_journal_title=Small Rumin Res; citation_title=Experimental study of a mixed vaccine against peste des petits ruminants and capripox infection in goats in northern Cameroon; citation_author=A Martrenchar, N Zoyem, A Diallo; citation_volume=26; citation_issue=1–2; citation_publication_date=1997; citation_pages=39-44; citation_doi=10.1016/S0921-4488(96)00989-3; citation_id=CR43
citation_journal_title=J Gen Virol; citation_title=One defective interfering particle per cell prevents influenza virus-mediated cytopathology: an efficient assay system; citation_author=L McLain, SJ Armstrong, NJ Dimmock; citation_volume=69; citation_issue=6; citation_publication_date=1988; citation_pages=1415-1419; citation_doi=10.1099/0022-1317-69-6-1415; citation_id=CR44
citation_journal_title=J Virol; citation_title=The measles virus fusion protein transmembrane region modulates availability of an active glycoprotein complex and fusion efficiency; citation_author=MD Mühlebach, VH Leonard, R Cattaneo; citation_volume=82; citation_issue=22; citation_publication_date=2008; citation_pages=11437-11445; citation_doi=10.1128/JVI.00779-08; citation_id=CR45
citation_title=Mononegaviruses of veterinary importance, volume 1: pathobiology and molecular diagnosis; citation_publication_date=2013; citation_id=CR46; citation_publisher=CABI
citation_title=Molecular biology and pathogenesis of peste des petits ruminants virus; citation_publication_date=2012; citation_id=CR47; citation_author=M Munir; citation_author=S Zohari; citation_author=M Berg; citation_publisher=Springer
citation_journal_title=Emerg Infect Dis; citation_title=Molecular evolution of peste des petits ruminants virus; citation_author=M Muniraju, M Munir, AR Parthiban, AC Banyard, J Bao, Z Wang, C Ayebazibwe, G Ayelet, M Harrak, M Mahapatra, G Libeau; citation_volume=20; citation_issue=12; citation_publication_date=2014; citation_pages=2023-2033; citation_doi=10.3201/eid2012.140684; citation_id=CR48
citation_journal_title=Adv Anim Vet Sci; citation_title=Peste-des-petits-ruminants: an Indian perspective; citation_author=D Muthuchelvan, KK Rajak, MA Ramakrishnan, D Choudhary, S Bhadouriya, P Saravanan, AB Pandey, RK Singh; citation_volume=3; citation_issue=8; citation_publication_date=2015; citation_pages=422-429; citation_doi=10.14737/journal.aavs/2015/3.8.422.429; citation_id=CR49
citation_journal_title=Bull Off Int Epiz; citation_title=Contribution to the study of the virus-vaccine against rinderpest, strain Nakamura III; citation_author=DN Nguyen-Ba-Luong, null Vu-Thien-Thai; citation_volume=50; citation_publication_date=1958; citation_pages=559-563; citation_id=CR50
Ohtake S, Lechuga‐Ballesteros D, Truong‐Le V, Patzer EJ. Strategies for heat-stable vaccines. In: Wen EP, Ellis R, Pujar NS, editors. Vaccine Development and Manufacturing. 2015. p. 287–318.
Palaniswami KS, Thangavelu A, Velmurugan R. Development of thermostable peste des petits ruminants (PPR) virus vaccine and assessment of molecular changes in the F gene. In: Applications of gene-based technologies for improving animal production and health in developing countries. 2005. p. 673–678.
citation_journal_title=Vet Microbiol; citation_title=Peste des petits ruminants; citation_author=S Parida, M Muniraju, M Mahapatra, D Muthuchelvan, H Buczkowski, AC Banyard; citation_volume=181; citation_issue=1; citation_publication_date=2015; citation_pages=90-106; citation_doi=10.1016/j.vetmic.2015.08.009; citation_id=CR53
citation_journal_title=PLoS ONE; citation_title=Effect of chemical stabilizers on the thermostability and infectivity of a representative panel of freeze dried viruses; citation_author=B Pastorino, C Baronti, EA Gould, RN Charrel, X Lamballerie; citation_volume=10; citation_issue=4; citation_publication_date=2015; citation_pages=e0118963; citation_doi=10.1371/journal.pone.0118963; citation_id=CR54
citation_journal_title=J Pharm Sci; citation_title=Lyophilized drug product cake appearance: what is acceptable?; citation_author=SM Patel, SL Nail, MJ Pikal, R Geidobler, G Winter, A Hawe, J Davagnino, SR Gupta; citation_volume=106; citation_issue=7; citation_publication_date=2017; citation_pages=1706-1721; citation_doi=10.1016/j.xphs.2017.03.014; citation_id=CR55
citation_journal_title=Viruses; citation_title=Defective interfering RNAs: foes of viruses and friends of virologists; citation_author=KB Pathak, PD Nagy; citation_volume=1; citation_issue=3; citation_publication_date=2009; citation_pages=895-919; citation_doi=10.3390/v1030895; citation_id=CR56
citation_journal_title=Virology; citation_title=Vesicular stomatitis virus-A new interfering particle, intracellular structures, and virus-specific RNA; citation_author=M Petric, L Prevec; citation_volume=41; citation_issue=4; citation_publication_date=1970; citation_pages=615-630; citation_doi=10.1016/0042-6822(70)90427-7; citation_id=CR57
citation_journal_title=Vaccine; citation_title=The complexity and cost of vaccine manufacturing—An overview; citation_author=S Plotkin, JM Robinson, G Cunningham, R Iqbal, S Larsen; citation_volume=35; citation_issue=33; citation_publication_date=2017; citation_pages=4064-4071; citation_doi=10.1016/j.vaccine.2017.06.003; citation_id=CR58
citation_journal_title=Archiv fur die gesamte Virusforschung; citation_title=Studies with rinderpest virus in tissue culture. III. The stability of cultured virus and its use in virus neutralization tests; citation_author=W Plowright, RD Ferris; citation_volume=11; citation_publication_date=1962; citation_pages=516-533; citation_doi=10.1007/BF01241304; citation_id=CR59
citation_journal_title=Res Vet Sci; citation_title=Studies on rinderpest culture vaccine. III. Stability of the lyophilised product; citation_author=W Plowright, CS Rampton, WP Taylor, KA Herniman; citation_volume=11; citation_publication_date=1970; citation_pages=71-81; citation_id=CR60
citation_journal_title=Philos Trans R Soc B; citation_title=Rinderpest: the veterinary perspective on eradication; citation_author=P Roeder, J Mariner, R Kock; citation_volume=368; citation_issue=1623; citation_publication_date=2013; citation_pages=20120139; citation_doi=10.1098/rstb.2012.0139; citation_id=CR61
citation_journal_title=J Gen Virol; citation_title=The role of defective interfering particles in persistent infection of Vero cells by measles virus; citation_author=BK Rima, WB Davidson, SJ Martin; citation_volume=35; citation_issue=1; citation_publication_date=1977; citation_pages=89-97; citation_doi=10.1099/0022-1317-35-1-89; citation_id=CR62
citation_journal_title=Virol Sin; citation_title=Evaluation of efficacy of stabilizers on the thermostability of live attenuated thermo-adapted Peste des petits ruminants vaccines; citation_author=T Riyesh, V Balamurugan, A Sen, V Bhanuprakash, G Venkatesan, V Yadav, RK Singh; citation_volume=26; citation_issue=5; citation_publication_date=2011; citation_pages=324-337; citation_doi=10.1007/s12250-011-3205-x; citation_id=CR63
citation_journal_title=Arch Virol; citation_title=Peste des petits ruminants diagnosis and diagnostic tools at a glance: perspectives on global control and eradication; citation_author=R Santhamani, RP Singh, F Njeumi; citation_volume=161; citation_issue=11; citation_publication_date=2016; citation_pages=2953-2967; citation_doi=10.1007/s00705-016-3009-2; citation_id=CR64
citation_journal_title=Biologicals; citation_title=Comparative efficacy of peste des petits ruminants (PPR) vaccines; citation_author=P Saravanan, A Sen, V Balamurugan, KK Rajak, V Bhanuprakash, KS Palaniswami, K Nachimuthu, A Thangavelu, G Dhinakarraj, R Hegde, RK Singh; citation_volume=38; citation_issue=4; citation_publication_date=2010; citation_pages=479-485; citation_doi=10.1016/j.biologicals.2010.02.003; citation_id=CR65
citation_journal_title=Vaccine; citation_title=Comparative efficacy of various chemical stabilizers on the thermostability of a live-attenuated Peste des petits ruminants (PPR) vaccine; citation_author=J Sarkar, BP Sreenivasa, RP Singh, P Dhar, SK Bandyopadhyay; citation_volume=21; citation_issue=32; citation_publication_date=2003; citation_pages=4728-4735; citation_doi=10.1016/S0264-410X(03)00512-7; citation_id=CR66
citation_journal_title=Vaccine; citation_title=Towards ambient temperature-stable vaccines: the identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay; citation_author=LD Schlehuber, IJ McFadyena, Y Shua, J Carignana, W Paul Duprexa, WR Forsytha, JH Hoa, CM Kitsos, GY Lee, DA Levinsona, SC Lucier, CB Moorea, NT Nguyena, J Ramos, B André Weinstocka, J Zhang, JA Monaglea, CR Gardner, JC Alvarez; citation_volume=29; citation_publication_date=2011; citation_pages=5031-5039; citation_doi=10.1016/j.vaccine.2011.04.079; citation_id=CR67
Schlesinger S. Retroviruses, Viroids, and RNA recombination. In: Domingo E, Holland JJ, Ahlquist P, editors. RNA Genetics. Vol II. Boca Raton: CRC Press; 1987, p. 167–185.
citation_journal_title=Nature; citation_title=Thermal reactions of kenya cattle vaccinated with lapinized rinderpest virus; citation_author=GR Scott; citation_volume=174; citation_issue=4418; citation_publication_date=1954; citation_pages=44; citation_doi=10.1038/174044a0; citation_id=CR69
citation_journal_title=Vaccine; citation_title=Defective interfering influenza virus confers only short-lived protection against influenza virus disease: evidence for a role for adaptive immunity in DI virus-mediated protection in vivo; citation_author=PD Scott, B Meng, AC Marriott, AJ Easton, NJ Dimmock; citation_volume=29; citation_issue=38; citation_publication_date=2011; citation_pages=6584-6591; citation_doi=10.1016/j.vaccine.2011.06.114; citation_id=CR70
Sen A. Development and evaluation of a thermostable Peste des petits ruminants (PPR) vaccine using heavy water (D2O). Ph.D. Thesis. Division of Virology, Indian Veterinary Research Institute (IVRI); 2009.
citation_journal_title=Expert Rev Vaccines; citation_title=Vaccines against peste des petits ruminants virus; citation_author=A Sen, P Saravanan, V Balamurugan, KK Rajak, SB Sudhakar, V Bhanuprakash, S Parida, RK Singh; citation_volume=9; citation_issue=7; citation_publication_date=2010; citation_pages=785-796; citation_doi=10.1586/erv.10.74; citation_id=CR72
citation_journal_title=Futur Microbiol; citation_title=Molecular mechanisms driving respiratory syncytial virus assembly; citation_author=FY Shaikh, JE Crowe; citation_volume=1; citation_publication_date=2013; citation_pages=123-131; citation_doi=10.2217/fmb.12.132; citation_id=CR73
citation_journal_title=Virus Res; citation_title=Geographic distribution and epidemiology of Peste des petits ruminants viruses; citation_author=MS Shaila, D Shamaki, MA Forsyth, A Diallo, L Goatley, RP Kitching, T Barrett; citation_volume=143; citation_issue=2; citation_publication_date=1996; citation_pages=149-153; citation_doi=10.1016/0168-1702(96)01312-3; citation_id=CR74
citation_journal_title=Vaccine; citation_title=Strategies for improved stability of Peste des petits ruminants vaccine; citation_author=AC Silva, MJ Carrondo, PM Alves; citation_volume=29; citation_issue=31; citation_publication_date=2011; citation_pages=4983-4991; citation_doi=10.1016/j.vaccine.2011.04.102; citation_id=CR75
citation_journal_title=Vaccine; citation_title=Testing a new formulation for Peste des petits ruminants vaccine in Ethiopia; citation_author=AC Silva, M Yami, G Libeau, MJ Carrondo, PM Alves; citation_volume=32; citation_issue=24; citation_publication_date=2014; citation_pages=2878-2881; citation_doi=10.1016/j.vaccine.2014.02.039; citation_id=CR76
citation_journal_title=Rev Sci Tech; citation_title=Prevalence and distribution of Peste des petits ruminants virus infection in small ruminants in India; citation_author=RP Singh, P Saravanan, BP Sreenivasa, RK Singh, SK Bandyopadhyay; citation_volume=23; citation_issue=3; citation_publication_date=2004; citation_pages=807-819; citation_doi=10.20506/rst.23.3.1522; citation_id=CR77
citation_journal_title=VirusDisease; citation_title=Peste des petits ruminants vaccine and vaccination in India: sharing experience with disease endemic countries; citation_author=RP Singh, SK Bandyopadhyay; citation_volume=26; citation_issue=4; citation_publication_date=2015; citation_pages=215-224; citation_doi=10.1007/s13337-015-0281-9; citation_id=CR78
citation_title=Application of different types of bioreactors in bioprocesses; citation_inbook_title=Bioreactors: design, properties and applications; citation_publication_date=2011; citation_pages=55-90; citation_id=CR79; citation_author=MR Spier; citation_author=LPS Vandenberghe; citation_author=ABP Medeiros; citation_author=CR Soccol; citation_publisher=New York
Sreenivasa BP, Dhar P, Singh RP. Bandyopadhyay SK. Evaluation of an indigenously developed homologous live attenuated cell culture vaccine against Peste-des-petits-ruminants infection of small ruminants. In: Proceedings of XX annual conference of indian association of veterinary microbiologists, immunologists and specialists in infectious diseases (IAVMI), Pantnagar, Uttaranchal, India. 2000. p.84.
citation_journal_title=Appl Microbiol Biotechnol; citation_title=Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production; citation_author=F Tapia, D Vázquez-Ramírez, Y Genzel, U Reichl; citation_volume=100; citation_issue=5; citation_publication_date=2016; citation_pages=2121-2132; citation_doi=10.1007/s00253-015-7267-9; citation_id=CR81
citation_journal_title=J Gen Virol; citation_title=Multiple-hit inhibition of infection by defective interfering particles; citation_author=KA Thompson, GA Rempala, J Yin; citation_volume=90; citation_issue=4; citation_publication_date=2009; citation_pages=888-899; citation_doi=10.1099/vir.0.005249-0; citation_id=CR82
citation_journal_title=Virology; citation_title=Population dynamics of an RNA virus and its defective interfering particles in passage cultures; citation_author=KAS Thompson, J Yin; citation_volume=7; citation_publication_date=2010; citation_pages=257; citation_doi=10.1186/1743-422X-7-257; citation_id=CR83
citation_journal_title=J Virol; citation_title=Quantitative characterization of defective virus emergence by deep sequencing; citation_author=C Timm, F Akpinar, J Yin; citation_volume=88; citation_issue=5; citation_publication_date=2014; citation_pages=2623-2632; citation_doi=10.1128/JVI.02675-13; citation_id=CR84
citation_journal_title=Biochem Eng J; citation_title=Process intensification for an enhanced replication of a newly adapted RM-65 sheep pox virus strain in Vero cells grown in stirred bioreactor; citation_author=K Trabelsi, S Majoul, S Rourou, H Kallel; citation_volume=90; citation_publication_date=2014; citation_pages=131-139; citation_doi=10.1016/j.bej.2014.06.001; citation_id=CR85
citation_journal_title=Appl Microbiol Biotechnol; citation_title=Development of a measles vaccine production process in MRC-5 cells grown on Cytodex1 microcarriers and in a stirred bioreactor; citation_author=K Trablesi, S Majoul, S Rourou, H Kallel; citation_volume=93; citation_publication_date=2012; citation_pages=1031-1040; citation_doi=10.1007/s00253-011-3574-y; citation_id=CR86
Vazquez D, Genzel Y, Pieler MM, Jordan I, Sandig V, Reichl U. Intensification of MVA and influenza virus production through high-cell-density cultivation approaches. In: Vaccine Technology VI, Laura Palomares, UNAM, Mexico Manon Cox, Protein Sciences Corporation, USA Tarit Mukhopadhyay, University College London, UK Nathalie Garçon, BIOASTER Technology Research Institute, FR Eds, ECI Symposium Series. 2016.
citation_journal_title=J Virol; citation_title=Measles virus assembly within membrane rafts; citation_author=S Vincent, D Gerlier, SN Manié; citation_volume=74; citation_issue=21; citation_publication_date=2000; citation_pages=9911-9915; citation_doi=10.1128/JVI.74.21.9911-9915.2000; citation_id=CR88
citation_journal_title=Proc Natl Acad Sci; citation_title=Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus; citation_author=GW Wertz, VP Perepelitsa, LA Ball; citation_volume=95; citation_issue=7; citation_publication_date=1998; citation_pages=3501-3506; citation_doi=10.1073/pnas.95.7.3501; citation_id=CR89
citation_journal_title=Virology; citation_title=Generation of defective interfering particles by two vaccine strains of measles virus; citation_author=T Whistler, WJ Bellini, PA Rota; citation_volume=220; citation_publication_date=1996; citation_pages=480-484; citation_doi=10.1006/viro.1996.0335; citation_id=CR90
citation_journal_title=Front Microbiol; citation_title=Repeatable population dynamics among vesicular stomatitis virus lineages evolved under high co-infection; citation_author=ES Williams, NM Morales, BR Wasik, V Brusic, SP Whelan, PE Turner; citation_volume=7; citation_issue=370; citation_publication_date=2016; citation_pages=1-10; citation_id=CR91
citation_journal_title=J Virol; citation_title=Long-term replication of Sendai virus defective interfering particle nucleocapsids in stable helper cell lines; citation_author=W Willenbrink, WJ Neubert; citation_volume=68; citation_issue=12; citation_publication_date=1994; citation_pages=8413-8417; citation_id=CR92
citation_journal_title=Vaccine; citation_title=Xerovac: an ultra rapid method for the dehydration and preservation of live attenuated Rinderpest and Peste des Petits ruminants vaccines; citation_author=EE Worrall, JK Litamoi, BM Seck, G Ayelet; citation_volume=19; citation_issue=7; citation_publication_date=2000; citation_pages=834-839; citation_doi=10.1016/S0264-410X(00)00229-2; citation_id=CR93
citation_journal_title=Hum Vaccines Immunother; citation_title=A freeze-stable formulation for DTwP and DTaP vaccines; citation_author=H Xue, B Yang, DD Kristensen, D Chen; citation_volume=10; citation_issue=12; citation_publication_date=2014; citation_pages=3607-3610; citation_doi=10.4161/21645515.2014.980195; citation_id=CR94
citation_journal_title=J Vaccines Vaccin; citation_title=Comparative efficacy of stabilizers on the thermostability of Peste des petits Ruminants vaccine; citation_author=T Yaqub, MF Shahid, M Munir, M Ali, N Mukhtar, M Adid; citation_volume=7; citation_publication_date=2016; citation_pages=6; citation_doi=10.4172/2157-7560.1000344; citation_id=CR95
citation_journal_title=Mol Cells; citation_title=Characterization of homologous defective interfering RNA during persistent infection of Vero cells with Japanese encephalitis virus; citation_author=SW Yoon, SY Lee, SY Won, SH Park, SY Park, YS Jeong; citation_volume=21; citation_issue=1; citation_publication_date=2006; citation_pages=112-120; citation_id=CR96