An overview of chagasic cardiomyopathy: pathogenic importance of oxidative stress

Anais da Academia Brasileira de Ciencias - Tập 77 Số 4 - Trang 695-715 - 2005
Michele A. Zacks1, Wen Jian-jun2, Galina Vyatkina2, Vandanajay Bhatia2, Nisha Garg3
1Galveston, , University of Texas Medical Branch, Department of Pathology, United States
2Galveston, , University of Texas Medical Branch, Department of Microbiology and Immunology, United States
3Galveston, , University of Texas Medical Branch, Department of Microbiology and Immunology and Pathology, Center for Biodefense and Emerging Infectious Diseases and Sealy Center for Vaccine Development, United States

Tóm tắt

There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress-induced injuries that may contribute to disease progression. Pathogen invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) in infectious etiologies. However, our understanding of the source and role of oxidative stress in chagasic cardiomyopathy (CCM) remains incomplete. In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, electron transport chain dysfunction and its role in sustaining oxidative stress in myocardium. We discuss the literature reporting the consequences of sustained oxidative stress in CCM pathogenesis.

Từ khóa


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