An interpretable mortality prediction model for COVID-19 patients

Nature Machine Intelligence - Tập 2 Số 5 - Trang 283-288
Yan Li1, Haitao Zhang2, Jorge Gonçalves3, Yang Xiao2, Maolin Wang2, Yuqi Guo2, Changhua Sun2, Xiuchuan Tang4, Jing Liang1, Mingyang Zhang2, Xiang Huang2, Ying Xiao2, Haosen Cao2, Yanyan Chen5, Tongxin Ren6, Fang Wang1, Yaru Xiao1, Sufang Huang1, Xi Tan4, Niannian Huang7, Bo Jiao7, Cheng Cheng2, Yong Zhang8, Ailin Luo7, Laurent Mombaerts3, Junyang Jin6, Zhiguo Cao2, Shusheng Li1, Hui Xu7, Ye Yuan2
1Department of Emergency, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China
3Luxembourg Centre for System Biomedicine, Luxembourg, Luxembourg
4School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, China
5Department of Information Management, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6Huazhong University of Science and Technology – Wuxi Research Institute, Wuhan, China
7Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8School of Information Science and Engineering, Wuhan University of Science and Technology, Wuhan, China

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World Health Organization. Coronavirus Disease 2019 (COVID-19) Situation Report 46, 6 March 2020 (2020); https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200306-sitrep-46-covid-19.pdf

World Health Organization. Coronavirus Disease 2019 (COVID-19) Situation Report 68, 28 March 2020 (2020); https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200328-sitrep-68-covid-19.pdf

Huang, C. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395, 497–506 (2020).

Chen, N. et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395, 507–513 (2020).

Novel Coronavirus Pneumonia Emergency Response Epidemiology Team The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Zhonghua Liu Xing Bing Xue Za Zhi 41, 145–151 (2020).

Yang, X. et al. Clinical course and outcomes of critically ill patients with SARS CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Resp. Med. 8, 475–481 (2020).

Diagnosis and Treatment of Pneumonia Infected by the New Novel Coronavirus (the trial fifth edition) Medical Letter from the National Health Office (National Health Commission of the People’s Republic of China, 2020).

Chen, T. & Guestrin, C. XGBoost: a scalable tree boosting system. In Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining 785–794 (ACM, 2016).

Lundberg, S. et al. From local explanations to global understanding with explainable AI for trees. Nat. Mach. Intell. 2, 56–67 (2020).

Truog, R. D., Mitchell, C. & Dalley, G. Q. The toughest triage—allocating ventilators in a pandemic. N. Engl. J. Med. https://doi.org/10.1056/NEJMp2005689 (2020).

Kishaba, T., Tamaki, H., Shimaoka, Y., Fukuyama, H. & Yamashiro, S. Staging of acute exacerbation in patients with idiopathic pulmonary fibrosis. Lung 192, 141–149 (2014).

Ridker, P. M. et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 359, 2195–2207 (2008).

Sharma, S. K. et al. Aetiology, outcomes & predictors of mortality in acute respiratory distress syndrome from a tertiary care centre in North India. Indian J. Med. Res. 143, 782–792 (2016).

Bajwa, E. K. et al. Plasma C-reactive protein levels are associated with improved outcome in ARDS. Chest 136, 471–480 (2009).

Liu, X. et al. A general report on the systematic anatomy of COVID-19. J. Forensic Med. 36, 1–3 (2020).

Wang, D. et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 323, 1061–1069 (2020).

Chan, J. F. et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 395, 514–523 (2020).

Li, F., Li, W., Farzan, M. & Harrison, S. C. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science 309, 1864–1868 (2005).

Ge, X. Y. et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature 503, 535–538 (2013).

Xu, Z. et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Resp. Med. 8, 420–422 (2020).

Liu, J. et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EbioMedicine 55, 102763 (2020).