An integration-free iPSC line, ICCSICi007-A, derived from a female Alzheimer's disease patient with the APOE-ε4/ε4 alleles

Stem Cell Research - Tập 41 - Trang 101588 - 2019
Eva Díaz-Guerra1,2, Eva Rodríguez-Traver1,2, Elena P. Moreno-Jiménez1,2, Itziar de Rojas2,3, César Rodríguez4, María Orera4, Isabel Hernández2,3, Agustín Ruiz2,3, Carlos Vicario1,2
1Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
2Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
3Fundació ACE-Barcelona Alzheimer Treatment and Research Center, Barcelona, Spain
4Servicio de Bioquímica Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Tài liệu tham khảo

De Strooper, 2016, The cellular phase of Alzheimer's disease, Cell, 164, 603, 10.1016/j.cell.2015.12.056 Belloy, 2019, A quarter century of APOE and Alzheimer's disease: progress to date and the path forward, Neuron, 101, 820, 10.1016/j.neuron.2019.01.056 Vergaño-Vera, 2015, Nurr1 blocks the mitogenic effect of FGF-2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic-GABAergic neuronal phenotypes, Dev. Neurobiol., 75, 823, 10.1002/dneu.22251