An injectable spheroid system with genetic modification for cell transplantation therapy

Lavasani, 2012, Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model, Nat Commun, 3, 608, 10.1038/ncomms1611 Haider, 2011, Genetic modification of stem cells for improved therapy of the infarcted myocardium, Mol Pharmacol, 8, 1446, 10.1021/mp2001318 Meyerrose, 2010, Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors, Adv Drug Deliv Rev, 62, 1167, 10.1016/j.addr.2010.09.013 Porada, 2010, Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery, Adv Drug Deliv Rev, 62, 1156, 10.1016/j.addr.2010.08.010 Sheyn, 2010, Genetically modified cells in regenerative medicine and tissue engineering, Adv Drug Deliv Rev, 62, 683, 10.1016/j.addr.2010.01.002 Robey, 2008, Systems approaches to preventing transplanted cell death in cardiac repair, J Mol Cell Cardiol, 45, 567, 10.1016/j.yjmcc.2008.03.009 Otsuka, 2004, Two-dimensional multiarray formation of hepatocyte spheroids on a microfabricated PEG-brush surface, Chembiochem, 5, 850, 10.1002/cbic.200300822 Landry, 1985, Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities, J Cell Biol, 101, 914, 10.1083/jcb.101.3.914 Yuasa, 1993, Importance of cell aggregation for expression of liver functions and regeneration demonstrated with primary cultured hepatocytes, J Cell Physiol, 156, 522, 10.1002/jcp.1041560311 Bartosh, 2010, Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties, Proc Natl Acad Sci U S A, 107, 13724, 10.1073/pnas.1008117107 Frith, 2010, Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential, Tissue Eng Part C Methods, 16, 735, 10.1089/ten.tec.2009.0432 Wang, 2009, 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells, Biomaterials, 30, 2705, 10.1016/j.biomaterials.2009.01.030 Endo, 2012, Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: a novel platform of genetically-modified cell transplantation, Drug Deliv Trans Res, 2, 398, 10.1007/s13346-012-0091-1 Kataoka, 2001, Block copolymer micelles for drug delivery: design, characterization and biological significance, Adv Drug Deliv Rev, 47, 113, 10.1016/S0169-409X(00)00124-1 Itaka, 2009, Recent development of nonviral gene delivery systems with virus-like structures and mechanisms, Eur J Pharm Biopharm, 71, 475, 10.1016/j.ejpb.2008.09.019 Itaka, 2011, Progress and prospects of polyplex nanomicelles for plasmid DNA delivery, Curr Gene Ther, 11, 457, 10.2174/156652311798192879 Kanayama, 2006, A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells, ChemMedChem, 1, 439, 10.1002/cmdc.200600008 Miyata, 2008, Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity, J Am Chem Soc, 130, 16287, 10.1021/ja804561g Itaka, 2010, Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity, Biomaterials, 31, 3707, 10.1016/j.biomaterials.2009.11.072 Howard, 1967, The enzymatic preparation of isolated intact parenchymal cells from rat liver, J Cell Biol, 35, 675, 10.1083/jcb.35.3.675 Berry, 1969, High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study, J Cell Biol, 43, 506, 10.1083/jcb.43.3.506 Tateno, 1996, Long-term cultivation of adult rat hepatocytes that undergo multiple cell divisions and express normal parenchymal phenotypes, Am J Pathol, 148, 383 Uchida, 2012, PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses, Mol Ther, 20, 1196, 10.1038/mt.2012.20 Chen, 2012, Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors, Biomaterials, 33, 4722, 10.1016/j.biomaterials.2012.03.017 Wurdinger, 2008, A secreted luciferase for ex vivo monitoring of in vivo processes, Nat Methods, 5, 171, 10.1038/nmeth.1177 Matsumoto, 2010, Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography, Biomed Opt Express, 1, 1209, 10.1364/BOE.1.001209 Yang, 2005, Cell sheet engineering: recreating tissues without biodegradable scaffolds, Biomaterials, 26, 6415, 10.1016/j.biomaterials.2005.04.061 Ohashi, 2007, Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets, Nat Med, 13, 880, 10.1038/nm1576 Nishida, 2004, Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium, N Engl J Med, 351, 1187, 10.1056/NEJMoa040455 Pelzer, 2009, Repopulation of vascularized bone allotransplants with recipient-derived cells: detection by laser capture microdissection and real-time PCR, J Orthop Res, 27, 1514, 10.1002/jor.20915 Kreiss, 1999, Erythropoietin secretion and physiological effect in mouse after intramuscular plasmid DNA electrotransfer, J Gene Med, 1, 245, 10.1002/(SICI)1521-2254(199907/08)1:4<245::AID-JGM49>3.0.CO;2-G Groebe, 1996, On the relation between size of necrosis and diameter of tumor spheroids, Int J Radiat Oncol Biol Phys, 34, 395, 10.1016/0360-3016(95)02065-9 Glicklis, 2004, Modeling mass transfer in hepatocyte spheroids via cell viability, spheroid size, and hepatocellular functions, Biotechnol Bioeng, 86, 672, 10.1002/bit.20086 Sakai, 2007, Technique for the control of spheroid diameter using microfabricated chips, Acta Biomater, 3, 1033, 10.1016/j.actbio.2007.06.004 Bhang, 2011, Angiogenesis in ischemic tissue produced by spheroid grafting of human adipose-derived stromal cells, Biomaterials, 32, 2734, 10.1016/j.biomaterials.2010.12.035 Yap, 2013, Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber, Biomaterials, 34, 3992, 10.1016/j.biomaterials.2013.02.011 Lee, 2012, Spherical bullet formation via E-cadherin promotes therapeutic potency of mesenchymal stem cells derived from human umbilical cord blood for myocardial infarction, Mol Ther, 20, 1424, 10.1038/mt.2012.58 Macdougall, 1996, A randomized controlled study of iron supplementation in patients treated with erythropoietin, Kidney Int, 50, 1694, 10.1038/ki.1996.487 Potapova, 2008, Culturing of human mesenchymal stem cells as three-dimensional aggregates induces functional expression of CXCR4 that regulates adhesion to endothelial cells, J Biol Chem, 283, 13100, 10.1074/jbc.M800184200