An improved procedure for the synthesis of 2-morpholinoethanamine
Tóm tắt
2-Morpholinoethanamine is prepared rapidly mainly in aqueous conditions from inexpensive and commercially accessible starting materials. The process development of an effective synthetic route by utilizing morpholine as the starting material via Michael addition, hydrazinolysis, and Curtius rearrangements was undertaken. The optimal conditions were selected in the experiments. The total yield was 81.8% and it was a convenient process.
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