An evaluation of the factor of depression of brain metabolism in the treatment of schizophrenia
Tóm tắt
This investigation was undertaken to determine the effect of depression of brain metabolism in the course of schizophrenia. To evaluate the effect of depression of brain metabolism without any direct stimulatory effects on the brain, patients with schizophrenia were subjected to the nitrogen inhalation therapy. Sixty-five patients ill less than one year and 34 ill for more than one year were treated. Of the patients ill less than one year, 46 per cent were improved and 34 per cent paroled. Of those ill longer than a year, 34 per cent were improved, and 9 per cent were paroled. From an analysis of these results and a comparison of those obtained with other treatments it may be concluded: (1) That the depression of brain metabolism exerts a desirable effect on the course of schizophrenia. (2) That the duration of depression is of importance. In the treatment of schizophrenia, the longer periods of depression produced by insulin hypoglycemia are more valuable than the shorter ones caused by nitrogen inhalation or metrazol.
Tài liệu tham khảo
Himwich, H. E., and Fazekas, J. F.: Factor of hypoxia in the shock therapies of schizophrenia. Arch. Neurol. and Psychiat., 47:800–807, 1942.
Alexander, F. A. D., and Himwich, H. E.: Nitrogen inhalation therapy for schizophrenia. Am. J. Psychiat., 96:643–655, 1939.
Lipetz, B.: Preliminary report on the results of the treatment of schizophrenia by nitrogen inhalation.Psychiat. Quart., 14:496–503, 1940.
Malzberg, B.: Social and Biological Aspects of Mental Disease. Pp. 330–331. State Hospitals Press. Utica, N. Y. 1940.
Pollock, H. M.: Statistical study of 1,140 dementia præcox patients treated with metrazol.Psychiat. Quart., 13:558–573, 1939.
Rivers, T. D., and Bond, E. D.: Followup results in insulin shock therapy after one to three years. Am. J. Psychiat., 98:382–384, 1941.