Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Một kháng thể chống lại RANKL trong điều trị loãng xương, bệnh xương viêm và bệnh ác tính
Tóm tắt
Trong suốt những năm qua, tầm quan trọng của ligand kích hoạt thụ thể yếu tố nhân κB (RANKL) trong sinh lý học xương và bệnh sinh đã được ghi nhận một cách tỉ mỉ. Denosumab, còn được biết đến với tên gọi AMG 162, là một kháng thể đơn dòng hoàn toàn từ người chống lại RANKL và đang được nghiên cứu trong điều trị các bệnh lý xương chuyển hóa, viêm và khối u ác tính. Mục đích của bài tổng quan này là phân tích vai trò tiềm năng của denosumab trong điều trị loãng xương, viêm khớp dạng thấp, di căn xương và đa u tủy.
Từ khóa
Tài liệu tham khảo
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