An antibiotic depleted microbiome drives severe Campylobacter jejuni-mediated Type 1/17 colitis, Type 2 autoimmunity and neurologic sequelae in a mouse model

Antonopoulos, 2009, Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation, Infect. Immun., 77, 2367, 10.1128/IAI.01520-08 Bai, 2008, CCL2 recruitment of IL-6-producing CD11b+ monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity, Eur. J. Immunol., 38, 1877, 10.1002/eji.200737973 Bristol, 2000, Heritable susceptibility for colitis in mice induced by IL-10 deficiency, Inflamm. Bowel Dis., 6, 290, 10.1097/00054725-200011000-00006 Caroline, 2012, NIH image to ImageJ: 25 years of image analysis, Nat. Methods, 9, 671, 10.1038/nmeth.2089 CDC, 2014 Centers for Disease Control and Prevention, 2013 Chang, 2006, Campylobacter jejuni colonization of mice with limited enteric flora, Infect. Immun., 74, 5261, 10.1128/IAI.01094-05 Dutka-Malen, 1995, Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR, J. Clin. Microbiol., 33, 24, 10.1128/JCM.33.1.24-27.1995 Garg, 2008, Arthritis risk after acute bacterial gastroenteritis, Rheumatology (Oxford), 47, 200, 10.1093/rheumatology/kem339 Germann, 1995 Gilbert, 2002, The genetic bases for the variation in the lipo-oligosaccharide of the mucosal pathogen, Campylobacter jejuni. Biosynthesis of sialylated ganglioside mimics in the core oligosaccharide, J. Biol. Chem., 277, 327, 10.1074/jbc.M108452200 Gruenewald, 1991, Serologic evidence of Campylobacter jejuni/coli enteritis in patients with Guillain-Barre syndrome, Arch. Neurol., 48, 1080, 10.1001/archneur.1991.00530220102027 Guo, 2010, Contribution of the multidrug efflux transporter CmeABC to antibiotic resistance in different Campylobacter species, Foodborne Pathog. Dis., 7, 77, 10.1089/fpd.2009.0354 Hatzipetros, 2015, A quick phenotypic neurological scoring system for evaluating disease progression in the SOD1-G93A mouse model of ALS, J. Visual. Exp., 104, 1 Houliston, 2011, Lipooligosaccharide of Campylobacter jejuni: similarity with multiple types of mammalian glycans beyond gangliosides, J. Biol. Chem., 286, 10.1074/jbc.M110.181750 Hughes, 1997, Clinical and epidemiologic features of Guillain-Barré syndrome, J. Infect. Dis., 176, S92, 10.1086/513793 Jackson, 2013, Binational outbreak of Guillain-Barré syndrome associated with Campylobacter jejuni infection, Mexico and USA, 2011, Epidemiol. Infect., 142, 1089, 10.1017/S0950268813001908 Kamada, 2013, Control of pathogens and pathobionts by the gut microbiota, Nat. Immunol., 14, 685, 10.1038/ni.2608 Kim, 2009, Increased short- and long-term risk of inflammatory bowel disease after Salmonella or Campylobacter gastroenteritis, Gastroenterology, 137, 495, 10.1053/j.gastro.2009.04.001 Koga, 2003, Anti-GM1 antibody IgG subclass: a clinical recovery predictor in Guillain-Barré syndrome, Neurology, 60, 1514, 10.1212/01.WNL.0000061615.77865.83 Leary, 2013, 1 Lin, 2002, CmeABC functions as a multidrug efflux system in Campylobacter jejuni, Antimicrob. Agents Chemother., 46, 2124, 10.1128/AAC.46.7.2124-2131.2002 Linton, 1996, Rapid identification by PCR of the genus Campylobacter and of five Campylobacter species enteropathogenic for man and animals, Res. Microbiol., 147, 707, 10.1016/S0923-2508(97)85118-2 Louwen, 2013, A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barre syndrome, Eur. J. Clin. Microbiol. Infect. Dis., 32, 207, 10.1007/s10096-012-1733-4 Ludbrook, 1998, Multiple comparison procedures updated, Clin. Exp. Pharmacol. Physiol., 25, 1032, 10.1111/j.1440-1681.1998.tb02179.x Malik, 2014, Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity, Mucosal Immunol., 7, 802, 10.1038/mi.2013.97 Mansfield, 2007, C57BL/6 and congenic interleukin-10-deficient mice can serve as models of Campylobacter jejuni colonization and enteritis, Infect. Immun., 75, 1099, 10.1128/IAI.00833-06 McKeel, 2002, Comparison of an espB gene fecal polymerase chain reaction assay with bacteriologic isolation for detection of Citrobacter rodentium infection in mice, Comp. Med., 52, 439 Melis, 2015, Complement in therapy and disease: regulating the complement system with antibody-based therapeutics, Mol. Immunol., 67, 117, 10.1016/j.molimm.2015.01.028 Moore, 2006, The epidemiology of antibiotic resistance in Campylobacter, Microb. Infect., 8, 1955, 10.1016/j.micinf.2005.12.030 Nagalingam, 2013, The effects of intestinal microbial community structure on disease manifestation in IL-10−/− mice infected with Helicobacter hepaticus, Microbiome, 1, 15, 10.1186/2049-2618-1-15 O'Loughlin, 2015, The intestinal microbiota influences Campylobacter jejuni colonization and Extraintestinal dissemination in mice, Appl. Environ. Microbiol., 81, 4642, 10.1128/AEM.00281-15 O'Loughlin, 2015, The intestinal microbiota influences Campylobacter jejuni colonization and extraintestinal dissemination in mice, Appl. Environ. Microbiol., 81, 4642, 10.1128/AEM.00281-15 Parker, 2005, Comparison of Campylobacter jejuni Lipooligosaccharide biosynthesis loci from a variety of sources, J. Clin. Microbiol., 43, 27712781, 10.1128/JCM.43.6.2771-2781.2005 Prendergast, 1998, Lipopolysaccharides from Campylobacter jejuni O:41 strains associated with Guillain-Barré syndrome exhibit mimicry of GM1 ganglioside, Infect. Immunity, 66, 10.1128/IAI.66.8.3649-3655.1998 Rathinam, 2008, Dendritic cells from C57BL/6 mice undergo activation and induce Th1-effector cell responses against Campylobacter jejuni, Microb. Infect., 10, 1316, 10.1016/j.micinf.2008.07.030 Rathinam, 2009, Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through TLR4-MyD88 and TLR4-TRIF axes, Infect. Immun., 77, 2499, 10.1128/IAI.01562-08 Riley, 1996, Identification of murine helicobacters by PCR and restriction enzyme analyses, J. Clin. Microbiol., 34, 942, 10.1128/JCM.34.4.942-946.1996 Scallan, 2011, Foodborne illness acquired in the United States--unspecified agents, Emerg. Infect. Dis., 17, 16, 10.3201/eid1701.P21101 Schonberg-Norio, 2010, Patient-reported complications associated with Campylobacter jejuni infection, Epidemiol. Infect., 138, 1004, 10.1017/S0950268809991099 Schubert, 2015, Antibiotic-induced alterations of the murine gut microbiota and subsequent effects on colonization resistance against Clostridium difficile, MBio, 6, 10.1128/mBio.00974-15 Sekirov, 2008, Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection, Infect. Immun., 76, 4726, 10.1128/IAI.00319-08 Sheikh, 1998, Molecular mimicry in Guillain-Barré syndrome, Ann. N. Y. Acad. Sci., 845, 307, 10.1111/j.1749-6632.1998.tb09683.x Sheikh, 1998, Campylobacter jejuni lipopolysaccharides in Guillain-Barré syndrome: molecular mimicry and host susceptibility, Neurology, 51, 371, 10.1212/WNL.51.2.371 St Charles, 2017, Guillain Barre syndrome is induced in non-obese diabetic (NOD) mice following Campylobacter jejuni infection and is exacerbated by antibiotics, J. Autoimmun., 77, 11, 10.1016/j.jaut.2016.09.003 Stahl, 2014, A novel mouse model of Campylobacter jejuni gastroenteritis reveals key pro-inflammatory and tissue protective roles for Toll-like receptor signaling during infection, PLoS Pathog., 10, 10.1371/journal.ppat.1004264 Theriot, 2014, Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection, Nat. Commun., 5 Uncini, 2017, Zika virus infection and Guillain-Barre syndrome: a review focused on clinical and electrophysiological subtypes, J. Neurol. Neurosurg. Psychiatry, 88, 266, 10.1136/jnnp-2016-314310 van den Berg, 2014, Guillain-Barre syndrome: pathogenesis, diagnosis, treatment and prognosis, Nat. Rev. Neurol., 10, 469, 10.1038/nrneurol.2014.121 Willison, 2016, Guillain-Barre syndrome, Lancet, 388, 717, 10.1016/S0140-6736(16)00339-1 Wilson, 2000, Identification of ciprofloxacin-resistant Campylobacter jejuni by use of a fluorogenic PCR assay, J. Clin. Microbiol., 38, 3971, 10.1128/JCM.38.11.3971-3978.2000 Yin, 2015, Different dynamic patterns of β-lactams, quinolones, glycopeptides and macrolides on mouse gut microbial diversity, PloS O, 10 Young, 2007, Campylobacter jejuni: molecular biology and pathogenesis, Nat. Rev. Microbiol., 5, 665, 10.1038/nrmicro1718 Yuki, 2012, Guillain-Barré syndrome and anti-ganglioside antibodies: a clinician-scientist's journey, Proc. Jpn. Acad. Series B Phys. Biol. Sci., 88 Yuki, 2012, Guillain-Barre syndrome, N. Engl. J. Med., 366, 2294, 10.1056/NEJMra1114525 Yuki, 1993, A bacterium lipopolysaccharide that elicits Guillain-Barré syndrome has a GM1 ganglioside-like structure, J. Exp. Med., 178, 10.1084/jem.178.5.1771 Zhang, 2013, Myasthenia gravis and Guillain-Barré co-occurrence syndrome Zia, 2003, Health problems following Campylobacter jejuni enteritis in a Lancashire population, Rheumatology (Oxford), 42, 1083, 10.1093/rheumatology/keg303