An SEIQR model for childhood diseases

Journal of Mathematical Biology - Tập 59 - Trang 535-561 - 2008
David J. Gerberry1, Fabio A. Milner2
1Department of Mathematics Purdue University West Lafayette USA
2Department of Mathematics, Arizona State University, Tempe, USA

Tóm tắt

It has been shown that the inclusion of an isolated class in the classical SIR model for childhood diseases can be responsible for self-sustained oscillations. Hence, the recurrent outbreaks of such diseases can be caused by autonomous, deterministic factors. We extend the model to include a latent class (i.e. individuals who are infected with the disease, but are not yet able to pass the disease to others) and study the resulting dynamics. The existence of Hopf bifurcations is shown for the model, as well as a homoclinic bifurcation for a perturbation to the model. For historical data on scarlet fever in England, our model agrees with the epidemiological data much more closely than the model without the latent class. For other childhood diseases, our model suggests that isolation is unlikely to be a major factor in sustained oscillations.

Tài liệu tham khảo

Anderson RM, May RM (1982) Directly transmitted infectious diseases: control by vaccination. Science 215: 1053–1060 Anderson RM, May RM (1992) Infectious diseases of humans: dynamics and control. Oxford University Press, New York Bernoulli D (1976) Essai d’une nouvelle analyse de la mortalité causée par la petite vérole. Mem Math Phy Acad Roy Sci Paris (1766). English translation entitled ‘An attempt at a new analysis of the mortality caused by smallpox and of the advantages of inoculation to prevent it’ In: Bradley L (ed) Smallpox Inoculation: An Eighteenth Century Mathematical Controversy, Adult Education Department, Nottingham, 1971, p 21 Diekmann O, Heesterbeek J (2000) Mathematical epidemiology of infectious diseases: Model building, analysis and interpretation. Wiley, Chichester Doedel E (1981) Auto: a program for the automatic bifurcation analysis of autonomous systems. Congr Numer 30: 265–284 Emerson H (1937) Measles and whooping cough. Am J Public Health 27: 1–153 Feng Z (1994) A mathematical model for the dynamics of childhood diseases under the impact of isolation. Ph.D. thesis, Arizona State University Feng Z, Thieme HR (1995) Recurrent outbreaks of childhood diseases revisited: the impact of isolation. Math Biosci 128: 93–130 Gao LQ, Mena-Lorca J, Hethcote HW (1995) Four SEI endemic models with periodicity and separatrices. Math Biosci 128: 157–184 Greenhalgh D (1990) Deterministic models for common childhood diseases. Int J Syst Sci 21: 1–20 Kato T (1984) Perturbation theory for linear operators. Springer, Berlin London WP, Yorke JA (1973) Recurrent outbreaks of measles, chickenpox and mumps. Am J Epidemiol 98: 453–468 Perko L (1996) Differential equations and dynamical systems, 2nd edn. Springer, New York Thieme HR (1992) Epidemic and demographic interaction in the spread of potentially fatal diseases in growing populations. Math Biosci 111: 99–130 Thieme HR (1993) Persistence under relaxed point-dissipativity (with applications to an endemic model). SIAM J Math Anal 24: 407–435 Wiggins S (2003) Introduction to applied nonlinear dynamical systems and chaos, 2nd edn. Springer, New York Wu LI, Feng Z (2000) Homoclinic bifurcation in an SIQR model for childhood diseases. J Differ Equ 168: 150–167 Zhou J, Hethcote HW (1994) Population size dependent incidence in models for diseases without immunity. J Math Biol 32: 809–834