An Organoid-Based Preclinical Model of Human Gastric Cancer

Ahmad, 2016, An update on gastric cancer, Curr Probl Surg, 53, 449, 10.1067/j.cpsurg.2016.08.001

Neugut, 1996, Epidemiology of gastric cancer, Semin Oncol, 23, 281

Gunturu, 2013, Gastric cancer and trastuzumab: first biologic therapy in gastric cancer, Ther Adv Med Oncol, 5, 143, 10.1177/1758834012469429

Manion, 2011, A comparison of equivocal immunohistochemical results with anti-HER2/neu antibodies A0485 and SP3 with corresponding FISH results in routine clinical practice, Am J Clin Pathol, 135, 845, 10.1309/AJCPIP5LOO3NGDJG

Yano, 2006, Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer, Oncol Rep, 15, 65

Abrahao-Machado, 2013, HER2 in gastric cancer: comparative analysis of three different antibodies using whole-tissue sections and tissue microarrays, World J Gastroenterol, 19, 6438, 10.3748/wjg.v19.i38.6438

Domcke, 2013, Evaluating cell lines as tumour models by comparison of genomic profiles, Nat Commun, 4, 2126, 10.1038/ncomms3126

Ertel, 2006, Pathway-specific differences between tumor cell lines and normal and tumor tissue cells, Mol Cancer, 5, 55, 10.1186/1476-4598-5-55

Gillet, 2011, Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance, Proc Natl Acad Sci U S A, 108, 18708, 10.1073/pnas.1111840108

Sandberg, 2005, Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI), Proc Natl Acad Sci U S A, 102, 2052, 10.1073/pnas.0408105102

Stein, 2004, Intractable cancers: the many faces of multidrug resistance and the many targets it presents for therapeutic attack, Curr Drug Targets, 5, 333, 10.2174/1389450043345489

Bianchini, 2014, The immune system and response to HER2-targeted treatment in breast cancer, Lancet Oncol, 15, e58, 10.1016/S1470-2045(13)70477-7

Ahmadzadeh, 2009, Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired, Blood, 114, 1537, 10.1182/blood-2008-12-195792

Chen, 2014, Intratumoral CD8(+) cytotoxic lymphocyte is a favorable prognostic marker in node-negative breast cancer, PLoS One, 9, e95475, 10.1371/journal.pone.0095475

Reissfelder, 2015, Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis, J Clin Invest, 125, 739, 10.1172/JCI74894

Wu, 2006, Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance, Acta Histochem, 108, 19, 10.1016/j.acthis.2006.01.003

Abdel-Rahman, 2016, PD-L1 expression and outcome of advanced melanoma patients treated with anti-PD-1/PD-L1 agents: a meta-analysis, Immunotherapy, 8, 1081, 10.2217/imt-2016-0025

Abdel-Rahman, 2016, Correlation between PD-L1 expression and outcome of NSCLC patients treated with anti-PD-1/PD-L1 agents: a meta-analysis, Crit Rev Oncol Hematol, 101, 75, 10.1016/j.critrevonc.2016.03.007

Abdel-Rahman, 2016, Immune checkpoints aberrations and gastric cancer: assessment of prognostic value and evaluation of therapeutic potentials, Crit Rev Oncol Hematol, 97, 65, 10.1016/j.critrevonc.2015.08.015

Takami, 2012, Cytokeratin expression profiling in gastric carcinoma: clinicopathologic significance and comparison with tumor-associated molecules, Pathobiology, 79, 154, 10.1159/000335694

Chu, 2002, Keratin expression in human tissues and neoplasms, Histopathology, 40, 403, 10.1046/j.1365-2559.2002.01387.x

Busuttil, 2018, An orthotopic mouse model of gastric cancer invasion and metastasis, Sci Rep, 8, 825, 10.1038/s41598-017-19025-y

Seidlitz, 2018, Human gastric cancer modelling using organoids, Gut

Wang, 2013, Increased myeloid-derived suppressor cells in gastric cancer correlate with cancer stage and plasma S100A8/A9 proinflammatory proteins, J Immunol, 190, 794, 10.4049/jimmunol.1202088

Shoji, 2017, The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy, Oncotarget, 8, 95083, 10.18632/oncotarget.18297

Ruschoff, 2010, HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing, Virchows Arch, 457, 299, 10.1007/s00428-010-0952-2

Slamon, 1987, Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene, Science, 235, 177, 10.1126/science.3798106

Bertaux-Skeirik, 2015, CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation, PLoS Pathog, 11, e1004663, 10.1371/journal.ppat.1004663

Engevik, 2016, The development of spasmolytic polypeptide/TFF2-expressing metaplasia (SPEM) during gastric repair is absent in the aged stomach, Cell Mol Gastroenterol Hepatol, 2, 605, 10.1016/j.jcmgh.2016.05.004

Bertaux-Skeirik, 2016, Oncogenic transformation of human-derived gastric organoids, Methods Mol Biol, 1

Huber, 2015, Orchestrating high-throughput genomic analysis with Bioconductor, Nat Meth, 12, 115, 10.1038/nmeth.3252

Anders, 2010, Differential expression analysis for sequence count data, Genome Biol, 11, R106, 10.1186/gb-2010-11-10-r106

Benjamini, 1995, Controlling the false discovery rate: a practical and powerful approach to multiple testing, J Roy Stat Soc B, 57, 289, 10.1111/j.2517-6161.1995.tb02031.x

Robinson, 2010, edgeR: a Bioconductor package for differential expression analysis of digital gene expression data, Bioinformatics, 26, 139, 10.1093/bioinformatics/btp616

Freudenberg, 2010, A semi-parametric Bayesian model for unsupervised differential co-expression analysis, BMC Bioinformatics, 11, 234, 10.1186/1471-2105-11-234

Freudenberg, 2009, CLEAN: CLustering Enrichment ANalysis, BMC Bioinformatics, 10, 234, 10.1186/1471-2105-10-234

Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method, Methods, 25, 402, 10.1006/meth.2001.1262