An Internet‐of‐Disease System for COVID‐19 Testing Using Saliva by an AI‐Controlled Microfluidic ELISA Device

Advanced Materials Technologies - Tập 7 Số 9 - 2022
Nabil H. Bhuiyan1, M. Jalal Uddin1,2, Joowon Lee1, Jun Hyeok Hong1, Joon S. Shim1,2
1Bio-IT Convergence Laboratory, Department of Electronic Convergence Engineering, KwangWoon University, Seoul 01897, Republic of Korea
2BioGeneSys Inc., 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea

Tóm tắt

AbstractThroughout coronavirus disease (COVID‐19) outbreaks, the centers for disease control and prevention (CDCP) of a country require monitoring of particular territories to provide public health guidance. In this work, the Internet of Diseases (IoD) is suggested for continuous real‐time monitoring of infectious diseases for public health. Because converging information and communication technologies (ICTs) with point‐of‐care (POC) devices to enable the IoD for continuous real‐time health monitoring and processing of clinical records are crucial, an IoD platform associating a lab‐on‐a‐chip (LOC) device to diagnose severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) from oropharyngeal saliva samples have been developed and uploaded the resulted diagnostic data into a cloud‐based system to be connected with CDCP. Moreover, a choropleth IoD map to visualize provincial infection rate is proposed along with the IoD platform. The developed platform is applied for the quantification of SARS‐CoV‐2 N‐protein antigen with a LOD as low as 0.013 ng mL−1 and the infection rate of various provinces is projected with the IoD map successfully. Thus, the proposed IoD system has the potential to become an imperative tool for the disease control and prevention centers to restrain COVID‐19 outbreaks by identifying the severity of particular regions.

Từ khóa


Tài liệu tham khảo

10.1093/nsr/nwaa141

10.1016/S2214-109X(20)30074-7

10.1126/science.abd7672

10.1155/2020/1357983

10.1016/j.rmed.2020.106026

10.1073/pnas.2019716118

10.2147/IDR.S306441

10.1039/D0LC01068E

10.1164/rccm.202004-1263PP

Gupta N., 2020, Emerg. Med. Pract., 22, e1

10.1016/S2213-2600(21)00125-9

10.1007/s41783-020-00101-0

10.1186/s13578-020-00404-4

“Coronavirus (COVID‐19) Vaccinations ” can be found underhttps://ourworldindata.org/covid-vaccinations (accessed: May 2021)

10.1016/j.ijantimicag.2020.106054

10.5001/omj.2021.107

“Interim: Implications of the Emerging SARS‐CoV‐2 Variant ” can be found underhttps://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-emerging-variant.html (accessed: June 2021)

10.1017/S0950268820001235

10.7326/M20-3012

10.2217/fvl-2020-0087

10.7326/M20-1495

10.1016/j.jaci.2020.05.020

10.1128/JCM.02020-20

10.1016/j.jcv.2020.104540

10.1021/acs.analchem.0c00784

10.1093/ajcp/aqaa112

10.1007/s10096-020-03978-6

10.4103/ijmr.IJMR_1818_20

10.1038/s41467-021-21040-7

10.1039/C9LC00104B

10.1007/s11418-017-1144-z

10.1016/j.snb.2021.131336

10.1007/s00216-008-2287-2

10.1016/0022-1759(85)90043-2

10.14429/dsj.42.4353

10.1007/s13317-017-0097-2

10.1002/ett.4115

Jain P., 2021, Emerg. Technol. Healthc., 25, 10.1002/9781119792345.ch2

Vishnu S., 2020, 2020 5th Int. Conf. Devices, Circuits Syst., 101

10.1016/j.avb.2021.101601

10.1002/jmri.27649

10.3390/s21092981

10.1021/acs.analchem.1c04827

10.1038/s41598-021-81433-y

10.1021/acs.analchem.0c05387

10.1002/col.10214

Madhu “Difference Between LoD and LoQ ”https://www.differencebetween.com/difference-between-lod-and-loq/ (accessed: November 2021).

10.1371/journal.pone.0249149

“Coronavirus Disease‐19 Republic of Korea: Cases in Korea by City/Province ”http://ncov.mohw.go.kr/en/bdBoardList.do?brdId=16&brdGubun=162&dataGubun=&ncvContSeq=&contSeq=&board_id= (accessed: June 2021).

10.1080/14737159.2020.1757437

10.1016/S2213-2600(20)30453-7

10.1002/smr.2418

Jurg van Vliet F. P., 2011, Programming Amazon EC2: Survive Your Success

10.1007/978-1-4842-7144-5_3

10.1002/minf.201500008

10.1021/acs.analchem.8b04043

Bhuiyan N. H., 2017, 2017 2nd Int. Conf. Electr. Electron. Eng., 1

Thông tin
Thông tin xuất bản

Advanced Materials Technologies

Tập 7 Số 9

Thông tin tác giả