An Immunohistochemical Study of the Pathways of the Influence of Dopamine on Orexinergic Neurons in the Perifornical Area of the Hypothalamus
Tóm tắt
Confocal microscopy was used to analyze double immunolabeling and provided evidence of the locations of a large number of tyrosine hydroxylase-immunopositive processes around the bodies of orexinergic neurons located in the perifornical area of the hypothalamus in rats. The bodies of orexinergic neurons were found to bear dopamine D1 receptors. A high level of colocalization of dopamine D1 and D2 receptors was found in the perifornical area, which is evidence for the formation of heterodimeric D1/D2 complexes. After i.p. administration of the selective D1 receptor antagonist SCH 39166, neurons in the perifornical area showed increases in the optical density of c-Fos protein in both orexinergic neurons and their adjacent GABA neurons. These data provide evidence that dopamine is able to influence orexinergic neurons both via a direct route involving D1- and D2-dependent signal pathways and via influences on GABA neurons.
Tài liệu tham khảo
I. Yu. Morina and A. L. Mikhrina, “Involvement of catecholamines in the regulation of orexinergic neurons in the mammalian brain,” Med. Akad. Zh., 17, No. 4, (2017).
I. V. Romanova, “Morphofunctional interaction of CART peptide and dopaminergic neurons in the brain,” Zh. Evolyuts. Biokhim. Fiziol., 49, No. 1, 78–84 (2013).
I. V. Romanova, A. L. Mikhrina, and A. O. Shpakov, “Localization of types 1 and 2 dopamine receptors on the bodies of COMT-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats,” Dokl. Akad. Nauk., 472, No. 5, 608–611 (2017).
I. V. Romanova, A. L. Mikhrina, and A. O. Shpakov, “Immunohistochemical evidence for the localization of dopamine receptors on neuropeptide Y-expressing neurons in the rat arcuate nuclei,” Zh. Evolyuts. Biokhim. Fiziol., 54, No. 3, 220–222 (2018).
M. V. Ugryumov, Mechanisms of Neuroendocrine Regulation, Nauka, Moscow (1999).
J. M. Beaulieu and R. R. Gainetdinov, “The physiology, signaling, and pharmacology of dopamine receptors,” Pharmacol. Rev., 63, No. 1, 182–217 (2011).
L. De Lecea, T. S. Kilduff, C. Peyron, et al., “The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity,” Proc. Natl. Acad. Sci. USA, 95, 322–327 (1998).
N. Ito, T. Yabe, Y. Gamo, et al., “I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation,” Neuroscience, 157, No. 4, 720–732 (2008).
D. L. Kaufman, C. R. Houser, and A. J. Tobin, “Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions,” J. Neurochem., 56, 720–723 (1991).
J. Marcus, C. Aschkenasi, C. E. Lee, et al., “Differential expression of orexin receptors 1 and 2 in rat brain,” J. Comp. Neurol., 435, No. 1, 6–25 (2001).
K. Ohno and T. Sakurai, “Orexin neuronal circuitry: role in the regulation of sleep and wakefulness,” Front Neuroendocrinol., 29, No. 1, 70–87 (2008).
G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego (1998), 4th ed., ISBN 0-12-547617-5.
I. V. Romanova, K. V. Derkach, A. L. Mikhrina, et al., “The leptin, dopamine and serotonin receptors in hypothalamic POMC neurons of normal and obese rodents,” Neurochem. Res., 43, No. 4, 8210837 (2018).
T. Sakurai, “Orexins and orexin receptors: a family of hypothalamic neuropeptides and g protein-coupled receptors that regulate feeding behavior,” Cell, 92, 573–585 (1998).
T. Sakurai, “Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis,” Sleep Med. Rev., 9, 231–241 (2005).
T. Sakurai, “The role of orexin in motivated behaviours,” Nat. Rev. Neurosci., 15, No. 11, 719–731 (2014).
W. K. Samson and Z. T. Resch, “The hypocretin/orexin story,” Trends Endocrinol. Metab., 11, No. 7, 257–262 (2000).
R. Spinazzi, P. G. Andreirs, G. P. Rossi, and G. G. Nussdorfer, “Orexins in the regulation of the hypothalamic-pituitary-adrenal axis,” Pharmacol. Rev., 58, 46–57 (2006).
P. Terry and J. L. Katz, “A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behavior by the D1 agonist SKF38393,” Psychopharmacology, 113, No. 3–4, 328–333 (1994).
A. Yamanaka, Y. Muraki, K. Ichiki, et al., “Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner,” J. Neurophysiol., 96, 284–298 (2006).
X. Zhao, R. X. Zhang, S. Tang, et al., “Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis,” Peptide, 54, 140–147 (2014).