An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients

Ng, 2005, Molecular genetic approaches for studying the etiology of diabetic nephropathy, Curr Mol Med, 5, 509, 10.2174/1566524054553504 Placha, 2006, A genome-wide linkage scan for genes controlling variation in renal function estimated by serum cystatin C levels in extended families with type 2 diabetes, Diabetes, 55, 3358, 10.2337/db06-0781 Bowden, 2004, A genome scan for diabetic nephropathy in African Americans, Kidney Int, 66, 1517, 10.1111/j.1523-1755.2004.00915.x Hirano, 1990, Biological and clinical aspects of interleukin 6, Immunol Today, 11, 443, 10.1016/0167-5699(90)90173-7 Pfafflin, 2006, Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha, Cell Physiol Biochem, 18, 199, 10.1159/000097667 Barton, 1996, The biological effects of interleukin 6, Med Res Rev, 16, 87, 10.1002/(SICI)1098-1128(199601)16:1<87::AID-MED3>3.0.CO;2-Q Moriyama, 1995, Angiotensin II stimulates interleukin-6 release from cultured mouse mesangial cells, J Am Soc Nephrol, 6, 95, 10.1681/ASN.V6195 Fishman, 1998, The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis, J Clin Invest, 102, 1369, 10.1172/JCI2629 Kitamura, 2002, Interleukin-6 polymorphism (−634C/G) in the promotor region and the progression of diabetic nephropathy in type 2 diabetes, Diabet Med, 19, 1000, 10.1046/j.1464-5491.2002.00844.x Terry, 2000, Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation, J Biol Chem, 275, 18138, 10.1074/jbc.M000379200 Nishimoto, 2006, Interleukin 6: from bench to bedside, Nat Clin Pract Rheumatol, 2, 619, 10.1038/ncprheum0338 Stehouwer, 2002, Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death, Diabetes, 51, 1157, 10.2337/diabetes.51.4.1157 Saraheimo, 2003, Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients, Diabetologia, 46, 1402, 10.1007/s00125-003-1194-5 Shikano, 2000, Usefulness of a highly sensitive urinary and serum IL-6 assay in patients with diabetic nephropathy, Nephron, 85, 81, 10.1159/000045634 Mittal, 2007, Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease, Immunogenetics, 59, 159, 10.1007/s00251-006-0182-6 Seow, 2006, Joint effect of asthma/atopy and an IL-6 gene polymorphism on lung cancer risk among lifetime non-smoking Chinese women, Carcinogenesis, 27, 1240, 10.1093/carcin/bgi309 Hamid, 2005, Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes, Diabetologia, 48, 251, 10.1007/s00125-004-1623-0 Ferrari, 2003, Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women, J Clin Endocrinol Metab, 88, 255, 10.1210/jc.2002-020092 1987 Canani, 2005, The fatty acid binding protein 2 A54T polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus, Diabetes, 54, 3326, 10.2337/diabetes.54.11.3326 Ng, 2002, Minor effect of glucose transporter 1 (GLUT1) polymorphisms on susceptibility to diabetic nephropathy in type 1 diabetes mellitus, Diabetes, 51, 2264, 10.2337/diabetes.51.7.2264 Ng, 2005, Angiotensin-I converting enzyme insertion/deletion polymorphism and diabetic nephropathy: a meta-analysis of studies reported during 1994–2004 and comprising 14,727 subjects, Diabetologia, 48, 1008, 10.1007/s00125-005-1726-2 Olsen, 1996, How often is NIDDM complicated with non-diabetic renal disease? An analysis of renal biopsies and the literature, Diabetologia, 39, 1638, 10.1007/s001250050628 Serra, 2002, Is there a need for changes in renal biopsy criteria in proteinuria in type 2 diabetes?, Diabetes Res Clin Pract, 58, 149, 10.1016/S0168-8227(02)00131-6 Christensen, 2000, Causes of albuminuria in patients with type 2 diabetes without diabetic retinopathy, Kidney Int, 58, 1719, 10.1046/j.1523-1755.2000.00333.x Warram, 1996, Effect of duration of type I diabetes on the prevalence of stages of diabetic nephropathy defined by urinary albumin/creatinine ratio, J Am Soc Nephrol, 7, 930, 10.1681/ASN.V76930 Gabriel, 2002, The structure of haplotype blocks in the human genome, Science, 296, 2225, 10.1126/science.1069424 Excoffier, 1995, Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population, Mol Biol Evol, 12, 921 Schaid, 2002, Score tests for association between traits and haplotypes when linkage phase is ambiguous, Am J Hum Genet, 70, 425, 10.1086/338688