An Analysis of Changes in Sensory Thresholds to Mild Tactile and Cold Stimuli after Experimental Spinal Cord Injury in the Rat

Neurorehabilitation and Neural Repair - Tập 14 Số 4 - Trang 287-300 - 2000
Amy E. Lindsey1, Rebecca L. LoVerso1, C. Amy Tovar1, Caitlin E. Hill1, Michael S. Beattie1, Jacqueline C. Bresnahan1
1From the Laboratory for Neural Repair, Department of Neuroscience, The Ohio State University, Columbus, Ohio, U.S.A.

Tóm tắt

Changes in sensory function including chronic pain and allodynia are common sequelae of spinal cord injury (SCI) in humans. The present study documents the extent and time course of mechanical allodynia and cold hyperalgesia after contusion SCI in the rat using stimulation with graded von Frey filaments (4.97–50.45 g force) and ice probes. Fore- and hind-paw withdrawal thresholds to plantar skin stimulation were determined in rats with a range of SCI severities (10-g weight dropped from 6.25, 12.5, or 25 mm using the MASCIS injury device); animals with 25-mm injuries most consistently showed decreased hind-paw withdrawal thresholds to touch and cold, which developed over several weeks after surgery. Stimulation of the torso with graded von Frey hairs was performed at specified locations on the back and sides from the neck to the haunch. Suprasegmental responses (orientation, vocalization, or escape) to mechanical stimulation of these sites were elicited infrequently in the laminectomy control rats and only during the first 3 weeks after surgery, whereas in 25-mm SCI rats, such responses were obtained for the entire 10 weeks of the study. These data suggest that rats with contusion SCI may exhibit sensory alterations relevant to human spinal cord injuries.

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Tài liệu tham khảo

10.1016/S0304-3959(96)03178-8

10.1097/00002508-199206000-00005

Davidoff G, 1991, Pain and central nervous system disease: The central pain syndromes, 77

Merskey H, 1994, Classification of chronic pain

Leijon G, 1991, Pain and central nervous system disease: The central pain syndromes, 257

10.1136/jnnp.60.4.411

Beric A, 1997, Anesthesiology clinics of North America: Pain: Nociceptive and neuropathic mechanisms, 445

10.1016/0304-3959(88)90209-6

10.1016/0165-0270(94)90144-9

10.1097/00000542-199510000-00017

10.1016/0304-3959(94)90023-X

10.1016/0304-3959(92)90041-9

10.1016/0304-3959(90)91074-S

10.1016/0304-3959(91)90186-2

10.1016/0014-4886(92)90035-O

10.1016/0304-3959(92)90070-R

10.1016/S0304-3959(96)03224-1

10.1089/neu.1997.14.517

10.1097/00001756-199506090-00003

10.1089/neu.1999.16.533

10.1016/S0304-3959(97)00216-9

10.3171/jns.1994.80.1.0097

10.1089/neu.1992.9.123

10.1089/neu.1995.12.1

10.1006/exnr.1996.0098

10.1006/exnr.1997.6695

Lindsey AE, 1998, J Neurotrauma, 15, 880

10.1080/01621459.1948.10483254

10.1002/(SICI)1097-4598(200005)23:5<793::AID-MUS18>3.0.CO;2-T

10.1212/WNL.54.8.1574

Goldberger ME, 1985, Synaptic plasticity, 77

Murray M, 1993, Restor Neurol Neurosci, 5, 37

10.1016/S0079-6123(00)28003-5

10.1016/S0006-8993(99)02173-3

10.1016/0304-3959(94)90165-1

10.1213/00000539-199205000-00005

10.1016/0014-4886(85)90118-9

10.1016/0014-4886(87)90299-8

10.1089/neu.1992.9.197

10.1126/science.288.5472.1765

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Neurorehabilitation and Neural Repair

Tập 14 Số 4

287-300

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