Anästhetikainduzierte Neurotoxizität

Der Anaesthesist - Tập 62 - Trang 101-104 - 2013
K. Becke1, M. Schreiber2, C. Philippi-Höhne3, J. Strauß4, K. Engelhard5, B. Sinner6
1Abteilung für Anästhesie und Intensivmedizin, Cnopf´sche Kinderklinik/Klinik Hallerwiese, Diakonie Neuendettelsau, Nürnberg, Deutschland
2Klinik für Anästhesiologie, Universitätsklinikum Ulm, Ulm, Deutschland
3Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Leipzig, Leipzig, Deutschland
4Klinik für Anästhesie, perioperative Medizin und Schmerztherapie, Helios Klinikum Berlin-Buch, Berlin, Deutschland
5Klinik für Anästhesiologie, Universitätsmedizin der Johannes Gutenberg-Universität, Mainz, Deutschland
6Klinik für Anästhesiologie, Universität Regensburg, Regensburg, Deutschland

Tài liệu tham khảo

Uemura E, Levin ED, Bowman RE (1985) Effects of halothane on synaptogenesis and learning behavior in rats. Exp Neurol 89:520–529 Ikonomidou C, Bosch F, Miksa M et al (1999) Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283:70–74 Jevtovic-Todorovic V, Hartman RE, Izumi Y et al (2003) Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23:876–882 Zhu C, Gao J, Karlsson N et al (2010) Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents. J Cereb Blood Flow Metab 30:1017–1030 Rizzi S, Ori C, Jevtovic-Todorovic V (2010) Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain. Ann N Y Acad Sci 1199:43–51 Paule MG, Li M, Allen RR et al (2011) Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol 33:220–230 Fredriksson A, Ponten E, Gordh T, Eriksson P (2007) Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits. Anesthesiology 107:427–436 Blaschke AJ, Staley K, Chun J (1996) Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development 122:1165–1174 Olney JW, Wozniak DF, Jevtovic-Todorovic V et al (2002) Glutamate and GABA receptor dysfunction in the fetal alcohol syndrome. Neurotox Res 4:315–325 Slikker W Jr, Zou X, Hotchkiss CE et al (2007) Ketamine-induced neuronal cell death in the perinatal rhesus monkey. Toxicol Sci 98:145–158 Lunardi N, Ori C, Erisir A, Jevtovic-Todorovic V (2010) General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats. Neurotox Res 17:179–188 Popic J, Pesic V, Milanovic D et al (2012) Propofol-induced changes in neurotrophic signaling in the developing nervous system in vivo. PLoS ONE 7:e34396 Lemkuil BP, Head BP, Pearn ML et al (2011) Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology 114:49–57 Wilder RT, Flick RP, Sprung J et al (2009) Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology 110:796–804 DiMaggio C, Sun LS, Li G (2011) Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. Anesth Analg 113:1143–1151 Kalkman CJ, Peelen L, Moons KG et al (2009) Behavior and development in children and age at the time of first anesthetic exposure. Anesthesiology 110:805–812 Flick RP, Katusic SK, Colligan RC et al (2011) Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics 128:e1053–1061 Bartels M, Althoff RR, Boomsma DI (2009) Anesthesia and cognitive performance in children: no evidence for a causal relationship. Twin Res Hum Genet 12:246–253 Hansen TG, Pedersen JK, Henneberg SW et al (2011) Academic performance in adolescence after inguinal hernia repair in infancy: a nationwide cohort study. Anesthesiology 114:1076–1085 Sprung J, Flick RP, Wilder RT et al (2009) Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology 111:302–310 Bouza H (2009) The impact of pain in the immature brain. J Matern Fetal Neonatal Med 22:722–732 Meyers EF, Muravchick S (1977) Anesthesia induction technics in pediatric patients: a controlled study of behavioral consequences. Anesth Analg 56:538–542 Ramsay JG, Rappaport BA (2011) SmartTots: a multidisciplinary effort to determine anesthetic safety in young children. Anesth Analg 113:963–964 Sun L (2010) Early childhood general anaesthesia exposure and neurocognitive development. Br J Anaesth 105(Suppl 1):61–68 Anand KJ, Garg S, Rovnaghi CR et al (2007) Ketamine reduces the cell death following inflammatory pain in newborn rat brain. Pediatr Res 62:283–290 Rokyta R, Yamamotova A, Slamberova R et al (2008) Prenatal and perinatal factors influencing nociception, addiction and behavior during ontogenetic development. Physiol Res 57 (Suppl 3):79–88 Anand KJ, Coskun V, Thrivikraman KV et al (1999) Long-term behavioral effects of repetitive pain in neonatal rat pups. Physiol Behav 66:627–637 http://www.awmf.org/leitlinien/detail/anmeldung/1/ll/006-022.html