Amylin, Food Intake, and Obesity

Wiley - Tập 10 Số 10 - Trang 1087-1091 - 2002
Tarek K. Reda1, Allan Geliebter1, F. Xavier Pi‐Sunyer1
1New York Obesity Research Center, Department of Medicine, St.-Luke's-Roosevelt Hos-pital Center, Columbia University-College of Physicians and Surgeons, New York and †Nutrition Institute, Cairo, Egypt.

Tóm tắt

AbstractAmylin, also known as islet amyloid polypeptide, identified in 1987, is a naturally occurring hormone, released by the β cells of the pancreas and consists of 37 amino acids. Amylin seems to decrease food intake through both central and peripheral mechanisms and indirectly by slowing gastric emptying. The mean basal amylin concentration is higher in obese than in lean human subjects. The amylin response to oral glucose is also greater in obese subjects, whether or not they have impaired glucose tolerance. The elevated amylin levels in obesity may lead to down‐regulation of amylin receptors and lessen the impact of postprandial amylin secretion on satiety and gastric emptying. Amylin administration may overcome resistance at target tissues, delay gastric emptying, and have potential for inducing weight loss in obese individuals.

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