Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat

Journal of Comparative Neurology - Tập 178 Số 2 - Trang 225-253 - 1978
J. E. Krettek1, Joseph L. Price1
1Department of Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110.

Tóm tắt

AbstractThe efferent fiber connections of the nuclei of the amygdaloid complex with subcortical structures in the basal telencephalon, hypothalamus, midbrain, and pons have been studied in the rat and cat, using the autoradiographic method for tracing axonal connections. The cortical and thalamic projections of these nuclei have been described in previous papers (Krettek and Price, ′77b,c). Although the subcortical connections of the amygdaloid nuclei are widespread within the basal forebrain and brain stem, the projections of each nucleus have been found to be well defined, and distinct from those of the other amygdaloid nuclei.The basolateral amygdaloid nucleus projects heavily to the lateral division of the bed nucleus of the stria terminalis (BNST), to the caudal part of the substantia innominata, and to the ventral part of the corpus striatum (nucleus accumbens and ventral putamen) and the olfactory tubercle; it projects more lightly to the lateral hypothalamus. The central nucleus also projects to the lateral division of the BNST and the lateral hypothalamus, but in addition it sends fibers to the lateral part of the substantia nigra and the marginal nucleus of the brachium conjunctivum. The basomedial nucleus has projections to the ventral striatum and olfactory tubercle which are similar to those of the basolateral nucleus, but it also projects to the core of the ventromedial hypothalamic nucleus and the premammillary nucleus, and to a central zone of the BNST which overlaps the medial and lateral divisions. The medial nucleus also projects to the core of the ventromedial nucleus and the premammillary nucleus, but sends fibers to the medial division of the BNST and does not project to the ventral striatum. The posterior cortical nucleus projects to the premammillary nucleus and to the medial division of the BNST, but a projection from this nucleus to the ventromedial nucleus has not been demonstrated. Projections to the “shell” of the ventromedial nucleus have been found only from the ventral part of the subiculum and from a structure at the junction of the amygdala and the hippocampal formation, which has been termed the amygdalo‐hippocampal area (AHA). The AHA also sends fibers to the medial part of the BNST and the premammillary nucleus.Virtually no subcortical projections outside the amygdala itself have been demonstrated from the lateral nucleus, or from the olfactory cortical areas around the amygdala (the anterior cortical nucleus, the periamygdaloid cortex, and the posterior prepiriform cortex). However, portions of the endopiriform nucleus deep to the prepiriform cortex project to the ventral putamen, and to the lateral hypothalamus.

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Tài liệu tham khảo

Ban T., 1959, Experimental studies on the fiber connections of the amygdaloid nuclei in the rabbit, J. Comp. Neur., 112, 245, 10.1002/cne.901130204

10.1016/0006-8993(76)90078-0

Berman A. L., 1978, The Thalamus and Basal Telencephalon of the Cat. A Cytoarchitectonic Atlas with Stereotaxic Coordinates

10.1159/000121967

Bleier R., 1961, The Hypothalamus of the Cat: A Cytoarchitectonic Atlas in the Horsley‐Clarke Coordinate System

10.1002/cne.901630306

10.1002/cne.901660302

10.1002/cne.900870102

10.1016/0006-8993(76)90006-8

10.1136/jnnp.28.2.137

10.1007/978-1-4615-8987-7_7

10.1002/cne.901460303

10.1007/978-1-4615-8987-7_10

Dreifuss J. J., 1968, Convergence of impulses upon single hypothalamic neurons, Brain Res., 8, 167, 10.1016/0006-8993(68)90178-9

Dreifuss J. J., 1968, Contrasting effects of two identified amygdaloid efferent pathways on single hypothalamic neurons, J. Neurophysiol., 31, 237, 10.1152/jn.1968.31.2.237

10.1002/cne.900720102

10.1002/cne.900790205

10.1002/cne.900430102

Haberly L. B. andJ. L.Price1978Association and commissural fiber systems of the olfactory cortex of the rat. I. Systems originating in the piriform cortex and adjacent areas.J. Comp. Neur. in press.

10.1002/aja.1001130110

10.1159/000123728

Heimer L., 1977, The Continuing Evolution of the Limbic System Concept

10.1016/0006-8993(69)90288-1

Heimer L., 1975, Golgi Centennial Symposium, Proceedings, 177

10.1016/0304-3940(75)90041-5

10.1002/cne.901570103

Jasper H. H., 1954, A Stereotaxic Atlas of the Diencephalon of the Cat

10.1002/cne.900350502

10.1002/cne.901670402

10.1002/cne.901710204

10.1002/cne.901720408

10.1002/cne.901720409

10.1002/cne.901780205

Krieger N. R. J. S.Kauer G. M.ShepherdandP.Greengard1977Dopamine‐sensitive adenylate cyclase within laminae of the olfactory tubercle.Brain Res. in press.

10.1002/cne.901410304

10.1210/endo-91-1-107

10.1210/endo-92-5-1354

10.1002/cne.901740302

10.1016/0006-8993(73)90489-7

10.1007/978-1-4615-8987-7_13

10.1016/0006-8993(68)90177-7

Murphy J. T., 1968, Topographical differences in the responses of single hypothalamic neurons to limbic stimulation, Am. J. Physiol., 214, 1443, 10.1152/ajplegacy.1968.214.6.1443

Murphy J. T., 1868, Inhibitory interneurons in the ventromedial nucleus of the hypothalamus, Brain Res., 9, 385, 10.1016/0006-8993(68)90245-X

Natua W. J. H., 1961, Fibre degeneration following lesions of the amygdaloid complex in the monkey, J. Anat., 95, 515

10.1016/0006-8993(74)90942-1

10.1002/cne.901660103

10.1002/cne.901500208

10.1016/0006-8993(75)90469-2

10.1002/cne.901500105

10.1016/0006-8993(76)90921-5

10.1113/jphysiol.1976.sp011513

10.1016/0006-8993(77)90147-0

Rioch D. McK., 1966, A précis of preoptic, hypothalamic and hypophysial terminology with atlas, Res. Publ. Ass. nerv. ment. Dis., 20, 3

Rolls E. T., 1975, The Brain and Reward

Rolls E. T., 1973, Activation of neurons in the prefrontal cortex by brain‐stimulation reward in the rat, Brain Res., 60, 351, 10.1016/0006-8993(73)90795-6

10.1037/h0033527

10.1016/S0091-6773(72)80218-9

10.1002/cne.901690403

10.1002/cne.901610105

10.1016/0006-8993(75)90948-8

10.1002/cne.901410305

10.1016/0006-8993(75)90278-4

10.1007/978-1-4684-3084-4_2

10.1002/cne.901720104

Szentágothai J., 1968, Hypothalamic Control of the Anterior Pituitary. An Experimental‐Morphological Study

10.1016/0014-4886(76)90270-3

10.1111/j.1365-201X.1971.tb10998.x

10.4159/harvard.9780674864559

Whitten W. K., 1975, Olfaction and Taste, 389, 10.1016/B978-0-12-209750-8.50073-1

Whitten W. K., 1973, Handbook of Physiology. Vol. II, Endocrinology. Section 7, 109

10.1037/h0042033

10.1007/978-1-4615-8987-7_25

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Journal of Comparative Neurology

Tập 178 Số 2

225-253

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