Among the water-soluble vitamins, dietary intakes of vitamins C, B2and folate are associated with the reduced risk of diabetes in Japanese women but not men

British Journal of Nutrition - Tập 121 Số 12 - Trang 1357-1364 - 2019
Ehab S. Eshak1,2, Hiroyasu Iso1, Isao Muraki1, Akiko Tamakoshi3
1Department of Social Medicine, Public Health, Graduate School of Medicine, Osaka University, Osaka, Japan
2Public Health and Community Medicine Department, Faculty of Medicine, Minia University, Minia, Egypt
3Department of Public Health, Faculty of Medicine, Hokkaido University, Sapporo, Japan

Tóm tắt

AbstractRecent studies have shown that micronutrients are involved in the pathology of type 2 diabetes. Antioxidant effects of vitamins C and B2and homocysteine-lowering effects of vitamins B6, folate and B12may have protective roles. However, a few reports have investigated the association between dietary water-soluble vitamin intakes and risk of diabetes. In a prospective study encompassing 19 168 healthy Japanese men and women aged 40–79 years, we examined the associations between dietary intakes of water-soluble vitamins, determined by a validated self-administered FFQ, with the risk of 5-year cumulative incidence of type 2 diabetes by using the logistic regression model. Within the 5-year period, there were 494 self-reported new cases of diabetes. Higher dietary intakes of vitamins C, B2and folate were associated with lower risk of incident diabetes only in women, whereas no associations of dietary intakes of vitamins B1, B3, B5, B6and B12were observed in either sex. The multivariable OR in the highestv. the lowest quartile of intakes among women were 0·61 (95 % CI 0·44, 0·94;P-trend = 0·04) for vitamin C, 0·56 (95 % CI 0·34, 0·93;P-trend = 0·03) for vitamin B2and 0·70 (95 % CI 0·46, 0·98;P-trend = 0·03) for folate. Other than that for sex (P< 0·05), theP-interactions with age, BMI, smoking status or having a family history of diabetes were >0·10. In conclusion, higher dietary intakes of vitamins C, B2and folate, but not other water-soluble vitamins, were associated with reduced risk of type 2 diabetes in Japanese women.

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Thông tin xuất bản

British Journal of Nutrition

Tập 121 Số 12

1357-1364

Thông tin tác giả