Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes

Au, 1986, Membrane perturbation by aminoglycosides as a simple screen of their toxicity, Antimicrob. Agents Chemother., 30, 395, 10.1128/AAC.30.3.395 Brasseur, 1990, TAMMO: Theoretical analysis of membrane molecular organization, vol. I/1.A.6, 203 Brasseur, 1984, Interactions of aminoglycoside antibiotics with negatively-charged lipid layers: biochemical and conformational studies, Biochem. Pharmacol., 33, 629, 10.1016/0006-2952(84)90319-8 Brasseur, 1985, Interactions of streptomycin and streptomycylamine derivatives with negatively charged lipid layers: correlation between binding, conformation of complexes and inhibition of phospholipase activities, Biochem. Pharmacol., 34, 1035, 10.1016/0006-2952(85)90607-0 Brasseur, 1986, Mode of organization of amphiphilic molecules at the lipid-water interface: a conformational analysis, J. Colloid. Interf. Sci., 114, 277, 10.1016/0021-9797(86)90264-X Carlier, 1983, Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: comparative studies in vitro, Antimicrob. Agents Chemother., 23, 440, 10.1128/AAC.23.3.440 Chung, 1985, Interaction of gentamicin and spermine with bilayer membranes containing negatively-charged phospholipids, Biochemistry (US), 24, 442, 10.1021/bi00323a030 De Broe, 1984, Early effects of gentamicin, tobramycin and amikacin on the human kidney, Kidney Int., 25, 643, 10.1038/ki.1984.69 Dempsey, 1990, The actions of melittin on membranes, Biochim. Biophys. Acta, 1031, 143, 10.1016/0304-4157(90)90006-X Düzgünes, 1987, Lipid mixing during membrane aggegation and fusion: why fusion assays disagree?, Biochemistry (US), 26, 8435, 10.1021/bi00399a061 Düzgünes, 1987, Fusion of phospholipid vesicles induced by divalent cations and protons. Modulation of phase transitions, free fatty acids, monovalent cations and polyamines, 241 Düzgünes, 1988, Fluorescence assay for membrane fusion, 117 Gilbert, 1989, Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity, J. Infect. Dis., 159, 945, 10.1093/infdis/159.5.945 Giurgea-Marion, 1986, Impairment of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin at low doses, Toxicol. Appl. Pharm., 86, 271, 10.1016/0041-008X(86)90058-X Govaerts, 1990, Aminoglycoside-induced ototoxicity, Toxicol. Lett., 52, 227, 10.1016/0378-4274(90)90033-I Hoekstra, 1984, Fluorescence method for measuring the kinetics of fusion between biological membrane, Biochemistry (US), 23, 5675, 10.1021/bi00319a002 Hope, 1985, Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential, Biochim. Biophys. Acta, 812, 55, 10.1016/0005-2736(85)90521-8 Hulka, 1993, Use of poly-L-aspartic acid to inhibit aminoglycoside cochlear ototoxicity, Am. J. Otol., 14, 352 Kishore, 1990, Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. I. Polyaspartic acid binds and displaces gentamicin from negatively-charged phospholipid layers, J. Pharm. Exp. Ther., 255, 867 Kosek, 1974, Nephrotoxicity of gentamicin, Lab. Invest., 30, 48 Laurent, 1982, Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin, Biochem. Pharmacol., 31, 3861, 10.1016/0006-2952(82)90303-3 Lietman, 1985, Aminoglycosides and spectinomycin: aminocyclitols, 192 Meers, 1986, Spermine as a modulator of membrane fusion: interactions with acidic phospholipids, Biochemistry (US), 25, 3109, 10.1021/bi00359a007 Miller, 1992, Epstein-Barr virus enters B cells and epithelial cells by different routes, J. Virol., 66, 3409, 10.1128/JVI.66.6.3409-3414.1992 Mingeot-Leclercq, 1988, Biochemical mechanism of aminoglycoside-induced inhibition of phosphatidylcholine hydrolysis by lysosomal phospholipases, Biochem. Pharmacol., 37, 591, 10.1016/0006-2952(88)90130-X Mingeot-Leclercq, 1989, Ultrastructural, physico-chemical and conformational study of the interactions of gentamicin and bis(beta-diethylaminoethylether) hexestrol with negatively charged phospholipid bilayers, Biochem. Pharmacol., 38, 729, 10.1016/0006-2952(89)90225-6 Mingeot-Leclercq, 1990, Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics. II. Conformational analysis, Biochem. Pharmacol., 40, 499, 10.1016/0006-2952(90)90548-Y Mingeot-Leclercq, 1990, Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics. I. Biochemical analysis, Biochem. Pharmacol., 40, 489, 10.1016/0006-2952(90)90547-X Morgan, 1983, Melittin induces fusion of unilamellar phospholipid vesicles, Biochim. Biophys. Acta, 732, 668, 10.1016/0005-2736(83)90245-6 Ohki, 1986, Effects of cations and polyamines on the aggregation and fusion of phosphatidylserine membranes, Biochim. Biophys. Acta, 861, 177, 10.1016/0005-2736(86)90416-5 Ramsammy, 1988, The effect of gentamicin on the biophysical properties of phosphatidic acid liposomes is influenced by the O−C = O group of the lipid, Biochemistry (US), 27, 8249, 10.1021/bi00421a039 Schanck, 1992, Interactions of aminoglycosides with phospholipids. A deuterium Nuclear Magnetic Resonance study, Chem. Phys. Lipids, 62, 153, 10.1016/0009-3084(92)90093-5 Struck, 1981, Use of resonance energy transfer to monitor membrane fusion, Biochemistry (US), 20, 4093, 10.1021/bi00517a023 Tulkens, 1990, Conformational and biochemical analysis of the interactions phospholipids-aminoglycoside antibiotics in relation with their toxicity, vol. II, 63 Van Bambeke, 1993, Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells, Eur. J. Pharmacol., 247, 155, 10.1016/0922-4106(93)90073-I Van Bambeke F., M.P. Mingeot-Leclercq, R. Brasseur, P.M. Tulkens and A. Schanck, submitted, Aminoglycoside antibiotics prevent the formation of inverted micelles in negatively-charged membranes. Van Schepdael, 1991, Synthesis, antibacterial activity and toxicological evaluation (in vitro and computer-aided) of 1-C-hydroxymethyl kanamycin B and 1-C-hydroxymethyl, 6″chlorokanamycin B, J. Med. Chem., 34, 1483, 10.1021/jm00108a037 Walter, 1986, Polylysine induces pH-dependent fusion of acidic phospholipid vesicles: a model for polycation-induced fusion, Biochim. Biophys. Acta, 865, 319, 10.1016/0005-2736(86)90434-7 Williams, 1987, Three molecular steps of aminoglycoside ototoxicity demonstrated in outer hair cells, Hearing Res., 30, 11, 10.1016/0378-5955(87)90177-8 Wilschut, 1980, Studies on the mechanism of membrane fusion: Kinetics of calcium ion induced fusion of phosphatidylserine vesicles followed by a new assay for mixing of aqueous vesicle contents, Biochemistry (US), 19, 6011, 10.1021/bi00567a011 Wilschut, 1981, Calcium/magnesium specificity in membrane fusion: Kinetics of aggregation and fusion of phosphatidylserine vesicles and the role of bilayer curvature, Biochemistry (US), 20, 3126, 10.1021/bi00514a022