Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ahel, 2003, Trans-editing of mischarged tRNAs, Proc. Natl. Acad. Sci. U.S.A., 100, 15422, 10.1073/pnas.2136934100
Ali, 2007, Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by “amitochondriate” protozoan parasites, Clin. Microbiol. Rev., 20, 164, 10.1128/CMR.00019-06
Alfonzo, 1999, C to U editing of the anticodon of imported mitochondrial tRNA(Trp) allows decoding of the UGA stop codon in Leishmania tarentolae, EMBO J., 18, 7056, 10.1093/emboj/18.24.7056
Antonellis, 2008, The role of aminoacyl-tRNA synthetases in genetic diseases, Annu. Rev. Genom. Human Genet., 9, 87, 10.1146/annurev.genom.9.081307.164204
Arakaki, 2010, The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs, J. Struct. Biol., 171, 238, 10.1016/j.jsb.2010.04.010
Azcarate, 2013, Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin, Br. J. Pharmacol., 169, 645, 10.1111/bph.12156
Bandi, 2001, Wolbachia in filarial nematodes: evolutionary aspects and implications for the pathogenesis and treatment of filarial diseases, Vet. Parasitol., 98, 215, 10.1016/S0304-4017(01)00432-0
Barrett, 2007, Human African trypanosomiasis: pharmacological re-engagement with a neglected disease, Br. J. Pharmacol., 152, 1155, 10.1038/sj.bjp.0707354
Berge, 2000, Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383, Bioorg. Med. Chem. Lett., 10, 1811, 10.1016/S0960-894X(00)00348-6
Bhatt, 2011, Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses, Nat. Commun., 2, 530, 10.1038/ncomms1522
Bour, 2009, Plasmodial aspartyl-tRNA synthetases and peculiarities in Plasmodium falciparum, J. Biol. Chem., 284, 18893, 10.1074/jbc.M109.015297
Brown, 2002, The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase, Bioorg. Med. Chem. Lett., 12, 3171, 10.1016/S0960-894X(02)00604-2
Bunjun, 2000, A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia, Proc. Natl. Acad. Sci. U.S.A., 97, 12997, 10.1073/pnas.230444397
Burrows, 2013, Antimalarial drug discovery - the path towards eradication, Parasitology, 1
Casewell, 1987, Mupirocin (‘pseudomonic acid’)–a promising new topical antimicrobial agent, J. Antimicrob. Chemother., 19, 1, 10.1093/jac/19.1.1
Cestari, 2013, Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African trypanosomiasis, J. Biol. Chem., 288, 14256, 10.1074/jbc.M112.447441
Charriere, 2006, Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei, Proc. Natl. Acad. Sci. U.S.A., 103, 6847, 10.1073/pnas.0602362103
Crepin, 2011, A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase, J. Mol. Biol., 405, 1056, 10.1016/j.jmb.2010.11.049
Critchley, 2005, Antibacterial activity of REP8839, a new antibiotic for topical use, Antimicrob. Agents Chemother., 49, 4247, 10.1128/AAC.49.10.4247-4252.2005
Critchley, 2009, Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections, J. Antimicrob. Chemother., 63, 954, 10.1093/jac/dkp041
Croft, 2011, Leishmaniasis chemotherapy—challenges and opportunities, Clin. Microbiol. Infect., 17, 1478, 10.1111/j.1469-0691.2011.03630.x
Danel, 2011, Asparaginyl-tRNA synthetase pre-transfer editing assay, Curr. Drug Disc. Technol., 8, 66, 10.2174/157016311794519947
de Jonge, 2006, Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours, Eur. J. Cancer, 42, 1768, 10.1016/j.ejca.2005.12.027
Derbyshire, 2012, Characterization of Plasmodium liver stage inhibition by halofuginone, ChemMedChem, 7, 844, 10.1002/cmdc.201200045
Ding, 2011, Design, synthesis, and structure–activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents, J. Med. Chem., 54, 1276, 10.1021/jm101225g
Elkin, 1999, Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone, Cancer Res., 59, 4111
Fevre, 2008, The burden of human African trypanosomiasis, PLoS Negl. Trop. Dis., 2, e333, 10.1371/journal.pntd.0000333
Folz, 1988, Anticoccidial evaluation of halofuginone, lasalocid, maduramicin, monensin and salinomycin, Vet. Parasitol., 28, 1, 10.1016/0304-4017(88)90013-1
Fukunaga, 2005, Aminoacylation complex structures of leucyl-tRNA synthetase and tRNALeu reveal two modes of discriminator-base recognition, Nat. Struct. Mol. Biol., 12, 915, 10.1038/nsmb985
Gao, 2012, Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae, J. Agric. Food Chem., 60, 9874, 10.1021/jf302857x
Geerts, 2000, Drug resistance in human helminths: current situation and lessons from livestock, Clin. Microbiol. Rev., 13, 207, 10.1128/CMR.13.2.207-222.2000
Gething, 2011, A new world malaria map: plasmodium falciparum endemicity in 2010, Malar. J., 10, 378, 10.1186/1475-2875-10-378
Gowri, 2012, Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from Leishmania major, BMC Genom., 13, 621, 10.1186/1471-2164-13-621
Green, 2009, Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity, Antimicrob. Agents Chemother., 53, 86, 10.1128/AAC.00275-08
Greenwood, 2002, Confirmation of the antibacterial mode of action of SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp, J. Antibiot. (Tokyo), 55, 423, 10.7164/antibiotics.55.423
Guo, 2009, The C-Ala domain brings together editing and aminoacylation functions on one tRNA, Science, 325, 744, 10.1126/science.1174343
Guo, 2013, Essential nontranslational functions of tRNA synthetases, Nat. Chem. Biol., 9, 145, 10.1038/nchembio.1158
Hasenoehrl, 2006, In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans, Antimicrob. Agents Chemother., 50, 3011, 10.1128/AAC.00254-06
Hoen, 2013, Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum, ChemBioChem, 14, 499, 10.1002/cbic.201200620
Hoepfner, 2012, Selective and specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin, Cell Host Microbe, 11, 654, 10.1016/j.chom.2012.04.015
Ibba, 2000, Aminoacyl-tRNA synthesis, Annu. Rev. Biochem., 69, 617, 10.1146/annurev.biochem.69.1.617
Ishiyama, 2011, Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum, J. Antibiot. (Tokyo), 64, 381, 10.1038/ja.2011.6
Istvan, 2011, Validation of isoleucine utilization targets in Plasmodium falciparum, Proc. Natl. Acad. Sci. U.S.A., 108, 1627, 10.1073/pnas.1011560108
Jackson, 2011, Protein translation in Plasmodium parasites, Trends Parasitol., 27, 467, 10.1016/j.pt.2011.05.005
Jackson, 2012, Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum, Int. J. Parasitol., 42, 177, 10.1016/j.ijpara.2011.11.008
Jarvest, 1999, Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex, Bioorg. Med. Chem. Lett., 9, 2859, 10.1016/S0960-894X(99)00488-6
Jarvest, 2002, Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens, J. Med. Chem., 45, 1959, 10.1021/jm025502x
Jarvest, 2003, Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity, Bioorg. Med. Chem. Lett., 13, 665, 10.1016/S0960-894X(02)01027-2
Kanamaru, 2001, In vitro and in vivo antibacterial activities of TAK-083, an agent for treatment of Helicobacter pylori infection, Antimicrob. Agents Chemother., 45, 2455, 10.1128/AAC.45.9.2455-2459.2001
Kawamura, 2003, Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells, J. Antibiot. (Tokyo), 56, 709, 10.7164/antibiotics.56.709
Keller, 2012, Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase, Nat. Chem. Biol., 8, 311, 10.1038/nchembio.790
Khan, 2011, Uneven spread of cis- and trans-editing aminoacyl-tRNA synthetase domains within translational compartments of P. falciparum, Sci. Rep., 1, 188, 10.1038/srep00188
Khan, 2013, Structural analysis of malaria-parasite lysyl-tRNA synthetase provides a platform for drug development, Acta Crystallogr. D Biol. Crystallogr., 69, 785, 10.1107/S0907444913001923
Khan, 2013, An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase, PLoS One, 8, e66224, 10.1371/journal.pone.0066224
Kim, 2003, Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics, Appl. Microbiol. Biotechnol., 61, 278, 10.1007/s00253-003-1243-5
Kobayashi, 1999, Catalytic asymmetric synthesis of antimalarial alkaloids febrifugine and isofebrifugine and their biological activity, J. Org. Chem., 64, 6833, 10.1021/jo990877k
Koh, 2012
Koh, 2013, Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design, Mol. Biochem. Parasitol., 189, 26, 10.1016/j.molbiopara.2013.04.007
Koon, 2011, Phase II AIDS Malignancy Consortium trial of topical halofuginone in AIDS-related Kaposi sarcoma, J. Acquir. Immune Defic. Syndr., 56, 64, 10.1097/QAI.0b013e3181fc0141
Kron, 1995, An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase, FEBS Lett., 374, 122, 10.1016/0014-5793(95)01092-S
Kron, 2003, Expression, localization and alternative function of cytoplasmic asparaginyl-tRNA synthetase in Brugia malayi, Mol. Biochem. Parasitol., 129, 33, 10.1016/S0166-6851(03)00080-X
Kron, 2012, Interleukin-8-like activity in a filarial asparaginyl-tRNA synthetase, Mol. Biochem. Parasitol., 185, 66, 10.1016/j.molbiopara.2012.06.003
Kron, 2013, Nematode asparaginyl-tRNA synthetase resolves intestinal inflammation in mice with T-cell transfer colitis, Clin. Vaccine Immunol., 20, 276, 10.1128/CVI.00594-12
Larson, 2011, The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer, J. Mol. Biol., 409, 159, 10.1016/j.jmb.2011.03.026
Larson, 2011, Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate, Biochimie, 93, 570, 10.1016/j.biochi.2010.11.015
Lee, 2006, Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration, Nature, 443, 50, 10.1038/nature05096
Lee, 2004, Aminoacyl-tRNA synthetase complexes: beyond translation, J. Cell Sci., 117, 3725, 10.1242/jcs.01342
Leung, 2011, Treatment of latent infection with Mycobacterium tuberculosis: update 2010, Eur. Respir. J., 37, 690, 10.1183/09031936.00079310
Liu, 2006, Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems, Proc. Natl. Acad. Sci. U.S.A., 103, 8840, 10.1073/pnas.0601876103
Lustigman, 2012, A research agenda for helminth diseases of humans: the problem of helminthiases, PLoS Negl. Trop. Dis., e1582, 10.1371/journal.pntd.0001582
Lv, 2012, Aminoacyl-tRNA synthetase inhibitors as potent antibacterials, Curr. Med. Chem., 19, 3550, 10.2174/092986712801323199
Merritt, 2011, Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase, Mol. Biochem. Parasitol., 177, 20, 10.1016/j.molbiopara.2011.01.003
Nacher, 2012, Helminth-infected patients with malaria: a low profile transmission hub?, Malar. J., 11, 376, 10.1186/1475-2875-11-376
Nakama, 2001, Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase, J. Biol. Chem., 276, 47387, 10.1074/jbc.M109089200
Nass, 1970, Effect of Borrelidin on the threonyl-tRNA-synthetase activity and the regulation of threonine-biosynthetic enzymes in Saccharomyces cerivisiae, Mol. Gen. Genet., 108, 28, 10.1007/BF00343181
Niemann, 2011, Mitochondrial translation in trypanosomatids: a novel target for chemotherapy?, Trends Parasitol., 27, 429, 10.1016/j.pt.2011.03.011
Ochsner, 2007, Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents, Exp. Opin. Invest. Drugs, 16, 573, 10.1517/13543784.16.5.573
Otoguro, 2003, In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia, J. Antibiot. (Tokyo), 56, 727, 10.7164/antibiotics.56.727
Prichard, 2012, A research agenda for helminth diseases of humans: intervention for control and elimination, PLoS Negl. Trop. Dis., 6, e1549, 10.1371/journal.pntd.0001549
Ramirez, 2006, Brugia malayi asparaginyl-transfer RNA synthetase induces chemotaxis of human leukocytes and activates G-protein-coupled receptors CXCR1 and CXCR2, J. Infect. Dis., 193, 1164, 10.1086/501369
Ranade, 2013, Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei. Is due to overexpression of the target?, Antimicrob. Agents Chemother., 57, 3021, 10.1128/AAC.02578-12
Rao, 1960, PA 155A: a new antibiotic, Antibiot. Chemother., 10, 312
Rateb, 2013, Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J, J. Antibiot. (Tokyo)
Rock, 2007, An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site, Science, 316, 1759, 10.1126/science.1142189
Rodriguez, 2012, New antibacterials for the treatment of toxoplasmosis; a patent review, Expert. Opin. Ther. Pat., 22, 311, 10.1517/13543776.2012.668886
Rossignol, 2010, Cryptosporidium and Giardia: treatment options and prospects for new drugs, Exp. Parasitol., 124, 45, 10.1016/j.exppara.2009.07.005
Rottenberg, 2005, Treatment of African trypanosomiasis with cordycepin and adenosine deaminase inhibitors in a mouse model, J. Infect. Dis., 192, 1658, 10.1086/496896
Ruan, 2005, A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases, J. Biol. Chem., 280, 571, 10.1074/jbc.M411039200
Schneider, 2001, Unique aspects of mitochondrial biogenesis in trypanosomatids, Int. J. Parasitol., 31, 1403, 10.1016/S0020-7519(01)00296-X
Seiradake, 2009, Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: a structural basis for the rational design of antifungal benzoxaboroles, J. Mol. Biol., 390, 196, 10.1016/j.jmb.2009.04.073
Shibata, 2011, Selective inhibitors of methionyl-tRNA synthetase have potent activity on Trypanosoma brucei infection in mice, Antimicrob. Agents Chemother., 55, 1982, 10.1128/AAC.01796-10
Shibata, 2012, Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization, J. Med. Chem., 55, 6342, 10.1021/jm300303e
Smirnova, 2012, Noncanonical functions of aminoacyl-tRNA synthetases, Biochemistry (Mosc), 77, 15, 10.1134/S0006297912010026
Sokabe, 2005, Molecular basis of alanine discrimination in editing site, Proc. Natl. Acad. Sci. U.S.A., 102, 11669, 10.1073/pnas.0502119102
Sokabe, 2009, The structure of alanyl-tRNA synthetase with editing domain, Proc. Natl. Acad. Sci. U.S.A., 106, 11028, 10.1073/pnas.0904645106
Stefanska, 2000, SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. I. Fermentation, isolation and properties, J. Antibiot. (Tokyo), 53, 345, 10.7164/antibiotics.53.345
Stuart, 2008, Kinetoplastids: related protozoan pathogens, different diseases, J. Clin. Invest., 118, 1301, 10.1172/JCI33945
Sugawara, 2013, Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites, Bioorg. Med. Chem. Lett., 23, 2302, 10.1016/j.bmcl.2013.02.075
Sukuru, 2006, Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change, J. Comput. Aided Mol. Des., 20, 159, 10.1007/s10822-006-9043-5
Tan, 2013, The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation, Nucleic Acids Res., 41, 5513, 10.1093/nar/gkt252
Tsuchiya, 2001, Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae, J. Antibiot. (Tokyo), 54, 84, 10.7164/antibiotics.54.84
Upcroft, 2001, Drug targets and mechanisms of resistance in the anaerobic protozoa, Clin. Microbiol. Rev., 14, 150, 10.1128/CMR.14.1.150-164.2001
Vondenhoff, 2011, Aminoacyl-tRNA synthetase inhibitors as potential antibiotics, Eur. J. Med. Chem., 46, 5227, 10.1016/j.ejmech.2011.08.049
Wang, 2013, 3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation, Bioorg. Med. Chem., 21, 4914, 10.1016/j.bmc.2013.06.066
Wilkinson, 2006, Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain, Bioorg. Med. Chem. Lett., 16, 5814, 10.1016/j.bmcl.2006.08.073
Wilson, 2002, Progress with parasite plastids, J. Mol. Biol., 319, 257, 10.1016/S0022-2836(02)00303-0
Xiao, 2011, Synthesis, structure, molecular docking, and structure–activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials, Bioorg. Med. Chem., 19, 1571, 10.1016/j.bmc.2011.01.051
Xiao, 2011, Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones, Eur. J. Med. Chem., 46, 4904, 10.1016/j.ejmech.2011.07.047
Yu, 2011, Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase, Org. Lett., 13, 2034, 10.1021/ol200420u
Yu, 2012, New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase, Org. Lett., 14, 4946, 10.1021/ol302298k
Zhang, 2003, Zinc-mediated amino acid discrimination in cysteinyl-tRNA synthetase, Journal of molecular biology, 327, 911, 10.1016/S0022-2836(03)00241-9
Zhang, 2013, Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors, Org. Biomol. Chem., 11, 5310, 10.1039/c3ob40236c
Zhao, 2012, Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis, Bioorg. Med. Chem., 20, 1240, 10.1016/j.bmc.2011.12.035
Zhou, 2013, ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase, Nature, 494, 121, 10.1038/nature11774
Zhu, 2010, Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents, Eur. J. Med. Chem., 45, 3864, 10.1016/j.ejmech.2010.05.040