Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine: Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport

Molecular Pharmaceutics - Tập 2 Số 2 - Trang 157-167 - 2005
Xueqin Song1, Philip L. Lorenzi1, Christopher P. Landowski1, Balvinder S. Vig1, John M. Hilfinger1, Gordon L. Amidon1
1Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, and TSRL, Inc., 540 Avis Drive, Suite A, Ann Arbor, Michigan 48108

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Tài liệu tham khảo

Hertel L. W., 1990, Cancer Res., 50, 4422

Guchelaar H. J., 1996, Cancer Treat. Rev., 22, 31, 10.1016/S0305-7372(96)90014-6

Heinemann V., 1988, Cancer Res., 48, 4031

Huang P., 1991, Cancer Res., 51, 6117

Plunkett W., 1995, Anticancer Drugs, 6, 13, 10.1097/00001813-199512006-00002

Heinemann V., 1992, Cancer Res., 52, 539

Plunkett W., 1995, Semin. Oncol., 22, 10

Bouffard D. Y., 1993, Biochem. Pharmacol., 45, 1861, 10.1016/0006-2952(93)90444-2

Chabner B. A., 1974, J. Clin. Invest., 53, 931, 10.1172/JCI107633

Bergman A. M., 2002, Drug Resist. Updates, 5, 33

Chabner B. A., 2001, Goodman and Gilman's Pharmacologic Basis of Therapeutics, 10

Fleisher D., 1996, Adv. Drug Delivery Rev., 19, 130, 10.1016/0169-409X(95)00103-E

Han H. K., 2000, PharmSci, 2, E6

Oh D. M., 1999, Pharm. Biotechnol., 12, 88

Balimane P. V., 1998, Biochem. Biophys. Res. Commun., 250, 251, 10.1006/bbrc.1998.9298

Han H., 1998, Pharm. Res., 15, 1159

Sugawara M., 2000, J. Pharm. Sci., 89, 789, 10.1002/(SICI)1520-6017(200006)89:6<781::AID-JPS10>3.0.CO;2-7

Rubio-Aliaga I., 2002, Trends Pharmacol. Sci., 23, 440, 10.1016/S0165-6147(02)02072-2

Nielsen C., 2002, Expert Opin. Ther. Pat., 12, 1350, 10.1517/13543776.12.9.1329

Inui K., 1999, Pharm. Biotechnol., 12, 288

Meredith D., 2000, Cell. Mol. Life Sci., 57, 778, 10.1007/s000180050040

Herrera-Ruiz D., 2003, J. Pharm. Sci., 92, 714, 10.1002/jps.10303

Landowski C. P., 2003, J. Pharmacol. Exp. Ther., 306, 786, 10.1124/jpet.103.051011

Weller S., 1993, Clin. Pharmacol. Ther., 54, 605, 10.1038/clpt.1993.196

Soul-Lawton J., 1995, Antimicrob. Agents Chemother., 39, 2764, 10.1128/AAC.39.12.2759

Nakanishi T., 1997, Cancer Res., 57, 4122

Gonzalez D. E., 1998, Cancer Res., 58, 525

Hsu C. P., 1998, Pharm. Res., 15, 1381

Wentworth D. F., 1975, Biochemistry, 14, 5105, 10.1021/bi00694a012

Vig B. S., 2003, Pharm. Res., 20, 1388

Faria T. N., 2004, Mol. Pharm., 1, 76, 10.1021/mp034001k

Tamura K., 1996, Pharm. Res., 13, 1667

Friedrichsen G. M., 2002, Eur. J. Pharm. Sci., 16, 13, 10.1016/S0928-0987(02)00047-7

Kim I., 2003, J. Biol. Chem., 278, 25356

Kim I., 2004, Mol. Pharm., 1, 127

Satoh T., 2002, Drug Metab. Dispos., 30, 493, 10.1124/dmd.30.5.488

Williams F. M, 1985, Clin. Pharmacokinet., 10, 403, 10.2165/00003088-198510050-00002