Amfetamine and methylphenidate medications for attention-deficit/hyperactivity disorder: complementary treatment options

European Child & Adolescent Psychiatry - Tập 21 - Trang 477-492 - 2012
Paul Hodgkins1, Monica Shaw2, David Coghill3, Lily Hechtman4
1Shire Pharmaceuticals, Wayne, USA
2Norgine Pharmaceuticals, Uxbridge, UK
3Centre for Neuroscience, Division of Medical Sciences, University of Dundee, Dundee, UK
4Division of Child Psychiatry, McGill University, McGill University Health Center, Montreal Children’s Hospital, Montreal, Canada

Tóm tắt

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders among school-aged children. It is highly symptomatic and associated with significant impairment. This review examines the role of stimulant medications in the treatment of children and adolescents with ADHD. Published clinical studies that compared methylphenidate- and amfetamine-based stimulants in children and adolescents with ADHD support the therapeutic utility of stimulant treatments, and suggest robust efficacy and acceptable safety outcomes in groups treated with either stimulant. Evidence-based guidelines agree that each patient with ADHD is unique and individual treatment strategies that incorporate both drug and non-drug treatment options should be sought. In seeking to optimize individual response and outcomes to stimulant therapy, important considerations include the selection of stimulant class, the choice of long- or short-acting stimulant formulations, addressing effectively any emergent adverse effects and strategies aimed at enhancing adherence to dosing regimen and persistence on therapy.

Tài liệu tham khảo

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