Amastin Knockdown in Leishmania braziliensis Affects Parasite-Macrophage Interaction and Results in Impaired Viability of Intracellular Amastigotes

PLoS Pathogens - Tập 11 Số 12 - Trang e1005296
Rita Márcia Cardoso de Paiva1, Viviane Grazielle-Silva1, Mariana Santos Cardoso2, Brenda Naemi Nakagaki1, Rondon Mendonça-Neto1, Adriana Monte Cassiano Canavaci3, Normanda Souza‐Melo4, Patrícia Massara Martinelli5, Ana Paula Fernandes3, Wanderson D. DaRocha4, Santuza Maria Ribeiro Teixeira1
1Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
2Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
3Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
4Departamento de Bioquımica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
5Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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AC Ivens, 2005, The genome of the kinetoplastid parasite, Leishmania major, Science, 309, 436, 10.1126/science.1112680

CS Peacock, 2007, Comparative genomic analysis of three Leishmania species that cause diverse human disease, Nat Genet, 39, 839, 10.1038/ng2053

DF Smith, 2007, Comparative genomics: from genotype to disease phenotype in the leishmaniases, Int J Parasitol, 37, 1173, 10.1016/j.ijpara.2007.05.015

LF Lye, 2010, Retention and loss of RNA interference pathways in trypanosomatid protozoans, PLoS Pathog, 6, e1001161, 10.1371/journal.ppat.1001161

JC Rodrigues, 2014, Biology of human pathogenic trypanosomatids: epidemiology, lifecycle and ultrastructure, Subcell Biochem, 74, 1, 10.1007/978-94-007-7305-9_1

NM El-Sayed, 2005, Comparative genomics of trypanosomatid parasitic protozoa, Science, 309, 404, 10.1126/science.1112181

SM Teixeira, 1994, A differentially expressed gene family encoding "amastin," a surface protein of Trypanosoma cruzi amastigotes, J Biol Chem, 269, 20509, 10.1016/S0021-9258(17)32022-7

Y Wu, 2000, A new developmentally regulated gene family in Leishmania amastigotes encoding a homolog of amastin surface proteins, Mol Biochem Parasitol, 110, 345, 10.1016/S0166-6851(00)00290-5

A Rochette, 2005, Characterization and developmental gene regulation of a large gene family encoding amastin surface proteins in Leishmania spp, Mol Biochem Parasitol, 140, 205, 10.1016/j.molbiopara.2005.01.006

F Real, 2013, The Genome Sequence of Leishmania (Leishmania) amazonensis: Functional Annotation and Extended Analysis of Gene Models, DNA research: an international journal for rapid publication of reports on genes and genomes, 20, 567, 10.1093/dnares/dst031

MC Motta, 2013, Predicting the proteins of Angomonas deanei, Strigomonas culicis and their respective endosymbionts reveals new aspects of the trypanosomatidae family, PLoS One, 8, e60209, 10.1371/journal.pone.0060209

AP Jackson, 2010, The evolution of amastin surface glycoproteins in trypanosomatid parasites, Mol Biol Evol, 27, 33, 10.1093/molbev/msp214

GC Cerqueira, 2008, Sequence diversity and evolution of multigene families in Trypanosoma cruzi, Mol Biochem Parasitol, 157, 65, 10.1016/j.molbiopara.2007.10.002

DC Bartholomeu, 2014, Unveiling the intracellular survival gene kit of trypanosomatid parasites, PLoS Pathog, 10, e1004399, 10.1371/journal.ppat.1004399

CB Stober, 2006, From genome to vaccines for leishmaniasis: screening 100 novel vaccine candidates against murine Leishmania major infection, Vaccine, 24, 2602, 10.1016/j.vaccine.2005.12.012

S Rafati, 2006, Amastin peptide-binding antibodies as biomarkers of active human visceral leishmaniasis, Clin Vaccine Immunol, 13, 1104, 10.1128/CVI.00188-06

SM Teixeira, 1995, Post-transcriptional elements regulating expression of mRNAs from the amastin/tuzin gene cluster of Trypanosoma cruzi, J Biol Chem, 270, 22586, 10.1074/jbc.270.38.22586

MM Kangussu-Marcolino, 2013, Distinct genomic organization, mRNA expression and cellular localization of members of two amastin sub-families present in Trypanosoma cruzi, BMC Microbiol, 13, 10, 10.1186/1471-2180-13-10

H Ngo, 1998, Double-stranded RNA induces mRNA degradation in Trypanosoma brucei, Proc Natl Acad Sci U S A, 95, 14687, 10.1073/pnas.95.25.14687

WD DaRocha, 2004, Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in Trypanosoma cruzi, Mol Biochem Parasitol, 133, 175, 10.1016/j.molbiopara.2003.10.005

NG Kolev, 2011, RNA interference in protozoan parasites: achievements and challenges, Eukaryot Cell, 10, 1156, 10.1128/EC.05114-11

KA Robinson, 2003, Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania, Mol Biochem Parasitol, 128, 217, 10.1016/S0166-6851(03)00079-3

J Baum, 2009, Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites, Nucleic Acids Res, 37, 3788, 10.1093/nar/gkp239

LA Kelley, 2009, Protein structure prediction on the Web: a case study using the Phyre server, Nat Protoc, 4, 363, 10.1038/nprot.2009.2

D Günzel, 2013, Claudins and the modulation of tight junction permeability, Physiol Rev, 93, 525, 10.1152/physrev.00019.2012

H Suzuki, 2014, Crystal structure of a claudin provides insight into the architecture of tight junctions, Science, 344, 304, 10.1126/science.1248571

CM Van Itallie, 2006, Claudins and epithelial paracellular transport, Annu Rev Physiol, 68, 403, 10.1146/annurev.physiol.68.040104.131404

VD Atayde, 2012, A single-cloning-step procedure for the generation of RNAi plasmids producing long stem-loop RNA, Mol Biochem Parasitol, 184, 55, 10.1016/j.molbiopara.2012.04.003

RC Zauli, 2012, A dysflagellar mutant of Leishmania (Viannia) braziliensis isolated from a cutaneous leishmaniasis patient, Parasit Vectors, 5, 11, 10.1186/1756-3305-5-11

F Raymond, 2012, Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species, Nucleic Acids Res, 40, 1131, 10.1093/nar/gkr834

MC Cruz, 2012, Trypanosoma cruzi: role of δ-amastin on extracellular amastigote cell invasion and differentiation, PLoS One, 7, e51804, 10.1371/journal.pone.0051804

VD Atayde, 2013, The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway, Mol Microbiol, 87, 580, 10.1111/mmi.12117

N Ueno, 2012, Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival, Trends Parasitol, 28, 335, 10.1016/j.pt.2012.05.002

EA Saada, 2014, Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane, Eukaryot Cell, 13, 1064, 10.1128/EC.00019-14

EE Schneeberger, 1992, Structure, function, and regulation of cellular tight junctions, Am J Physiol, 262, L647

K Tamura, 2013, MEGA6: Molecular Evolutionary Genetics Analysis version 6.0, Mol Biol Evol, 30, 2725, 10.1093/molbev/mst197

EF Pettersen, 2004, UCSF Chimera—a visualization system for exploratory research and analysis, J Comput Chem, 25, 1605, 10.1002/jcc.20084

PS Doyle, 1991, Leishmania donovani: long-term culture of axenic amastigotes at 37 degrees C, Exp Parasitol, 73, 326, 10.1016/0014-4894(91)90104-5

C Trapnell, 2009, TopHat: discovering splice junctions with RNA-Seq, Bioinformatics, 25, 1105, 10.1093/bioinformatics/btp120

MI Love, 2014, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol, 15, 550, 10.1186/s13059-014-0550-8

LC Afonso, 1993, Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis, Infect Immun, 61, 2952, 10.1128/IAI.61.7.2952-2959.1993

de Souza W. Técnicas de microscopia eletrônica aplicadas às ciências biológicas. 2 ed. ed. Rio de Janeiro2007.