Alternative functions for the multifarious inflammasome

Martinon, 2009, The inflammasomes: guardians of the body, Annu Rev Immunol, 27, 229, 10.1146/annurev.immunol.021908.132715 Strowig, 2012, Inflammasomes in health and disease, Nature, 481, 278, 10.1038/nature10759 Saïd-Sadier, 2012, Alarmins, inflammasomes and immunity, Biomed J, 35, 437, 10.4103/2319-4170.104408 Rathinam, 2016, Inflammasome complexes: emerging mechanisms and effector functions, Cell, 165, 792, 10.1016/j.cell.2016.03.046 Levine, 2011, Autophagy in immunity and inflammation, Nature, 469, 323, 10.1038/nature09782 Rathinam, 2012, Regulation of inflammasome signaling, Nat Immunol, 13, 333, 10.1038/ni.2237 Shi, 2012, Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction, Nat Immunol, 13, 255, 10.1038/ni.2215 Suzuki, 2007, Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages, PLoS Pathog, 3, e111, 10.1371/journal.ppat.0030111 Wang, 2014, The microtubule-associated protein EB1 links AIM2 inflammasomes with autophagy-dependent secretion, J Biol Chem, 289, 29322, 10.1074/jbc.M114.559153 Davis, 2016 Shao, 2007, The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock, J Biol Chem, 282, 36321, 10.1074/jbc.M708182200 Gurcel, 2006, Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival, Cell, 126, 1135, 10.1016/j.cell.2006.07.033 von Moltke, 2012, Rapid induction of inflammatory lipid mediators by the inflammasome in vivo, Nature, 490, 107, 10.1038/nature11351 Sokolovska, 2013, Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function, Nat Immunol, 14, 543, 10.1038/ni.2595 Santana, 2016, Is the inflammasome relevant for epithelial cell function?, Microbes Infect, 18, 93, 10.1016/j.micinf.2015.10.007 Weinheimer-Haus, 2015, Nod-like receptor protein-3 inflammasome plays an important role during early stages of wound healing, PLoS One, 10, e0119106, 10.1371/journal.pone.0119106 Abdul-Sater, 2009, Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis, J Biol Chem, 284, 26789, 10.1074/jbc.M109.026823 Bruchard, 2015, The receptor NLRP3 is a transcriptional regulator of TH2 differentiation, Nat Immunol, 16, 859, 10.1038/ni.3202 Wilson, 2015, Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt, Nat Med, 21, 906, 10.1038/nm.3908 Kayagaki, 2011, Non-canonical inflammasome activation targets caspase-11, Nature, 479, 117, 10.1038/nature10558 Kayagaki, 2013, Noncanonical inflammasome activation by intracellular LPS independent of TLR4, Science, 341, 1246, 10.1126/science.1240248 Chung, 2016, NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis, Cell Death Differ, 23, 1331, 10.1038/cdd.2016.14